Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 641-652

  Romeiro, Nelilma C ^a   Aguirre, Gabriela ^b   Hernández, Paola ^b   González, Mercedes ^b   Cerecetto, Hugo ^b   Aldana, Ignacio ^c   Pérez Silanes, Silvia ^c   Monge, Antonio ^c   Barreiro, Eliezer J ^a   Lima, Lídia M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Chagas disease; Cruzain; Docking; Quinoxaline N acylhydrazone (NAH) derivatives; Trypanosoma cruzi

Indexed keywords

ANTITRYPANOSOMAL AGENT; CRUZIPAIN; N (2 HYDROXYBENZYLIDENE) 3 METHYLQUINOXALINE 2 HYDRAZIDE; N (2 HYDROXYBENZYLIDENE) 3 PHENYLQUINOXALINE 2 HYDRAZIDE; NIFURTIMOX; QUINOXALINE N ACYLHYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MACROPHAGE; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HYDRAZONES; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; NIFURTIMOX; PROTOZOAN PROTEINS; QUINOXALINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 58549106331     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.065     Document Type: Article

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