Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4- ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 5, 2012, Pages 1665-1670

  He, Junbo ^a   Feng, Lingling ^a   Li, Jing ^a   Tao, Ruijuan ^a   Wang, Fang ^a   Liao, Xun ^a   Sun, Qiushuang ^a   Long, Qingwu ^a   Ren, Yanliang ^a   Wan, Jian ^a   He, Hongwu ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

2 Methylpyrimidine 4 ylamine; Antifungal activity; Click chemistry; PDHc E1 inhibitor

Indexed keywords

2 METHYL 5 [[4 [(2 CHLORO 5 METHYLPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]2 METHYLPYRIMIDIN 4 AMINE; 2 METHYL 5 [[4 [(2 NITROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]PYRIMIDIN 4 AMINE; 2 METHYLPYRIMIDINE 4 YLAMINE DERIVATIVE; 5 [[ 5 IODO 4 (PHENOXYMETHYL) 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 [[ 5 IODO 4 [(4 NITROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 [[4 [(2,4 DICHLOROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 [[4 [(4 CHLORO 3 METHYLPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 [[4 [(4 METHOXYPHENOXY)METHYL] 1H 1,2, TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 METHYL 5 [[4 [(2 CHLORO 4 FLUOROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 METHYL 5 [[4 [(2,4 DINITROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL] 2 METHYLPYRIMIDIN 4 AMINE; 5 METHYL 5 [[4 [(4 CHLOROPHENOXY)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHYL]PYRIMIDIN 4 AMINE; ANTIFUNGAL AGENT; METHYL 2 [4 [[1 [(4 AMINO 2 METHYLPYRIMIDIN 5 YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL]METHOXY]PHENYL]ACETATE; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE COMPLEX E1; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BOTRYTIS CINEREA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; FUSARIUM SOLANI; HYDROGEN BOND; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINES; CATALYTIC DOMAIN; CLICK CHEMISTRY; ENZYME INHIBITORS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; MOLECULAR DYNAMICS SIMULATION; PYRIMIDINES; PYRUVATE DEHYDROGENASE (LIPOAMIDE);

BOTRYOTINIA FUCKELIANA; ESCHERICHIA COLI; THANATEPHORUS CUCUMERIS;

EID: 84862777493     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.019     Document Type: Article

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