Design & synthesis of N′-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 509-518

  Tripathi, Laxmi ^a   Singh, Ranjit ^a   Stables, James P ^b  

^a SHOBHIT UNIVERSITY   (India)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Anticonvulsant activity; Computational study; N' substituted pyridine 4 carohydrazides; Neurotoxicity

Indexed keywords

ALBUTOIN; ANTICONVULSIVE AGENT; CARBAMAZEPINE; GABAPENTIN; LAMOTRIGINE; METHYLPHENOBARBITAL; N' (4 PHENOXYBENZYLIDENE)PYRIDINE 4 CARBOHYDRAZIDE; N' [(3) 2 OXO 1,2 DIHYDRO 3H INDOL 3 YLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 BROMOPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 CHLORO 3 METHYLPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 CHLOROPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 FLUOROPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 METHYLPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (4 NITROPHENOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [4 (NAPHTHALEN 2 YLOXY)BENZYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; N' [[4 (1,3 BENZODIOXOL 5 YLOXY)PHENYL]METHYLIDENE]PYRIDINE 4 CARBOHYDRAZIDE; PHENYTOIN; PROGABIDE; RALITOLINE; REMACEMIDE; UNCLASSIFIED DRUG; VALPROIC ACID; ZONISAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; PREDICTION; RAT; SEIZURE; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; ANTICONVULSANTS; CELL DEATH; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ELECTROSHOCK; HYDRAZINES; MICE; MOLECULAR STRUCTURE; NEURONS; PENTYLENETETRAZOLE; PYRIDINES; RATS; SEIZURES; STEREOISOMERISM;

EID: 79151470415     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.030     Document Type: Article

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