Expression of melanin-concentrating hormone receptor 2 protects against diet-induced obesity in male mice

Endocrinology

Volumn 155, Issue 1, 2014, Pages 81-88

  Chee, Melissa J S ^a   Pissios, Pavlos ^a   Prasad, Deepthi ^a   Maratos Flier, Eleftheria ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET INDUCED OBESITY; ENERGY BALANCE; FOOD INTAKE; GENE EXPRESSION; GENE REPRESSION; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; LIPID DIET; LOCOMOTION; MALE; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

EID: 84891397330     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1738     Document Type: Article

References (45)

1. Qu D, Ludwig DS, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 1996;380:243-247.
2. Pissios P, Bradley RL, Maratos-Flier E. Expanding the scales: the multiple roles of MCH in regulating energy balance and other biological functions. Endocr Rev. 2006;27:606-620.
3. Bittencourt JC, Presse F, Arias C, et al. The melanin-concentrating hormone system of the rat brain: an immuno-And hybridization histochemical characterization. J Comp Neurol. 1992;319:218-245.
4. Elliott JC, Harrold JA, Brodin P, et al. Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats. Brain Res Mol Brain Res. 2004;128:150-159.
5. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology. 1997;138:351-355.
6. Rossi M, Beak SA, Choi SJ, et al. Investigation of the feeding effects of melanin concentrating hormone on food intake-Action independent of galanin and the melanocortin receptors. Brain Res. 1999; 846:164-170.
7. Edwards CM, Abusnana S, Sunter D, Murphy KG, Ghatei MA, Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol. 1999;160:R7-R12.
8. Tritos NA, Vicent D, Gillette J, Ludwig DS, Flier ES, Maratos-Flier E. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes. 1998;47:1687-1692.
9. Della-Zuana O, Presse F, Ortola C, Duhault J, Nahon JL, Levens N. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int J Obes Relat Metab Disord. 2002;26:1289-1295.
10. Gomori A, Ishihara A, Ito M, et al. Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. Am J Physiol Endocrinol Metab. 2003;284:E583-E588.
11. Shearman LP, Camacho RE, Sloan et al. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. Eur J Pharmacol. 2003;475:37-47.
12. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998;396:670-674.
13. Kokkotou E, Jeon JY, Wang X, et al. Mice withMCHablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005;289:R117-R124.
14. Ludwig DS, Tritos NA, Mastaitis JW, et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001;107:379-386.
15. Alon T, Friedman JM. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J Neurosci. 2006;26:389-397.
16. Whiddon BB, Palmiter RD. Ablation of neurons expressing melanin-concentrating hormone (MCH) in adult mice improves glucose tolerance independent of MCH signaling. J Neurosci. 2013;33: 2009-2016.
17. Smith DG, Tzavara ET, Shaw J, et al. Mesolimbic dopamine supersensitivity in melanin-concentrating hormone-1 receptor-deficient mice. J Neurosci. 2005;25:914-922.
18. Pissios P, Frank L, Kennedy AR, et al. Dysregulation of the mesolimbic dopamine system and reward in MCH+/-mice. Biol Psychiatry. 2008;64:184-191.
19. Imbernon M, Beiroa D, Vázquez MJ, et al. Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways. Gastroenterology. 2013;144:636-649.
20. Bächner D, Kreienkamp H, Weise C, Buck F, Richter D. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Lett. 1999;457:522-524.
21. Chambers J, Ames RS, Bergsma D, et al. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 1999;400:261-265.
22. Shimomura Y, Mori M, Sugo T, et al. Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. Biochem Biophys Res Commun. 1999;261:622-626.
23. Chen Y, Hu C, Hsu CK, et al. Targeted disruption of the melaninconcentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology. 2002;143:2469-2477.
24. Marsh DJ, Weingarth DT, Novi DE, et al. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci U S A. 2002;99:3240-3245.
25. MacNeil DJ, Bednarek MA. MCH receptor peptide agonists and antagonists. Peptides. 2009;30:2008-2013.
26. Chung S, Parks GS, Lee C, Civelli O. Recent updates on the melaninconcentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. J Mol Neurosci. 2011;43:115-121.
27. An S, Cutler G, Zhao JJ, et al. Identification and characterization of a melanin-concentrating hormone receptor. Proc Natl Acad Sci U S A. 2001;98:7576-7581.
28. SailerAW,Sano H, Zeng Z, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001;98:7564-7569.
29. Tan CP, Sano H, Iwaasa H, et al. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics. 2002;79:785-792.
30. Wang S, Behan J, O'Neill K, et al. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. J Biol Chem. 2001;276:34664-34670.
31. Chee MJ, Pissios P, Maratos-Flier E. Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus. J Comp Neurol. 2013;521:2208-2234.
32. Hawes BE, Kil E, Green B, O'Neill K, Fried S, Graziano MP. The melanin-concentrating hormone receptor couples to multipleGproteins to activate diverse intracellular signaling pathways. Endocrinology. 2000;141:4524-4532.
33. Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E. Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. Endocrinology. 2003;144:3514-3523.
34. Paxinos G, Franklin KB. The Mouse Brain in Stereotaxic Coordinates. 2nd ed. San Diego, CA: Academic Press; 2001.
35. Bradley RL, Kokkotou EG, Maratos-Flier E, Cheatham B. Melaninconcentrating hormone regulates leptin synthesis and secretion in rat adipocytes. Diabetes. 2000;49:1073-1077.
36. Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature. 1999;400:265-269.
37. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology. 2001;142:680-686.
38. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science. 1988;240:1328-1331.
39. WuM, Dumalska I, Morozova E, van den Pol A, Alreja M. Melaninconcentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proc Natl Acad Sci U S A. 2009;106:17217-17222.
40. Sears RM, Liu RJ, Narayanan NS, et al. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. J Neurosci. 2010;30:8263-8273.
41. Sinnett-Smith J, Zhukova E, Rey O, Rozengurt E. Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cells. J Cell Physiol. 2007;211:781-790.
42. Pereira-Da-Silva M, De Souza CT, Gasparetti AL, Saad MJ, Velloso LA. Melanin-concentrating hormone induces insulin resistance through a mechanism independent of body weight gain. J Endocrinol. 2005;186:193-201.
43. Jeon JY, Bradley RL, Kokkotou EG, et al. MCH+/-mice are resistant to aging-Associated increases in body weight and insulin resistance. Diabetes. 2006;55:428-434.
44. Kong D, Vong L, Parton LE, et al. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010;12:545-552.
45. Burdakov D, Gerasimenko O, Verkhratsky A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci. 2005;25:2429-2433.