Hepatocytes

Signaling Pathways in Liver Diseases

Volumn , Issue , 2010, Pages 3-24

  Ramadori, G ^a   Ramadori, Pierluigi ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84891394893     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-00150-5_1     Document Type: Chapter

References (109)

1. Yokota S (2003) Degradation of normal and proliferated peroxisomes in rat hepatocytes regulation of peroxisomes quantity in cells. Microsc Res Tech 61(2):151-160
2. Jung J, Zheng M, Goldfarb M, Zaret KS (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284:1998-2003
3. Rossi JM, Dunn NR, Hogan BLM, Zaret KS (2001) Distinct mesodermal signals, including BMP's from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 15:1998-2009
4. Sosa-Pineda B, Wigle JT, Oliver G (2000) Hepatocyte migration during liver development requires Prox1. Nature Gen 25:254-255
5. Matsumoto K, Yoshitomi H, Rossant J, Zaret KS (2001) Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294:559-563
6. Clotman F, Lannoy VJ, Reber M et al (2002) The one-cut transcription factor HNF6 is required for normal development of the biliary tract. Development 129:1819-1828
7. Coffinier C, Gresh L, Fiette L et al (2002) Bile system morphogenesis defects and liver dysfunction upon target deletion of HNF1b. Development 129:1829-1838
8. McCright B, Lozier J, Gridley T (2002) A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 129:1075-1082
9. Lozier J, McCright B, Gridley T (2008) Notch signaling regulates bile duct morphogenesis in mice. PLOS one 3(3):e1851
10. Kiiasov AP, van Euken P, van Pelt J et al (1997) The expression of desmin and cytokeratins No. 8 and 18 in the nonhematopoietic cells of the rat liver. Ontogenez 28(3):217-222
11. Van Eyken P, Sciot R, Callea F et al (1988) The development of the intrahepatic bile ducts in man: a keratin-immunohistochemical study. Hepatology 8(6):1586-1595
12. Dudas J, Elmaouhoub A, Mansuroglu T et al (2006) Prosperorelated homeobox 1(Prox1) is a stable hepatocyte marker during liver development, injury and liver regeneration, and is absent from "oval cells". Histochem Cell Biol 126 (5):549-562
13. Shiojiri N (1997) Development and differentiation of bile ducts in the mammalian liver. Microsc Res Tech 39(4):328-335
14. Shiojiri N, Lemire JM, Fausto N (1991) Cell lineages and oval cell progenitors in rat liver development. Cancer Res 51(10):2611-2620
15. Elmaouhoub A, Dudas J, Ramadori G (2007) Kinetics of albumin-and alpha-fetoprotein-production during rat liver development. Histochem Cell Biol 128:431-443
16. Brodsky WY, Delone GV (1990) Functional control of hepatocyte proliferation. Comparison with the temporal control of cardiomyocyte proliferation. Biomed Sci 1(5):467-470
17. Medvedev ZA (1986) Age-related polyploidization of hepatocytes: the cause and possible role. A mini-review. Exp Gerontol 21(4-5):277-282
18. Rozga J (2002) Hepatocyte proliferation in health and in liver failure. Med Sci Monit 8(2):RA32-RA38
19. Gupta S (2000) Hepatic polyploidy and liver growth control. Semin Cancer Biol 10(3):161-171
20. Steiner JW, Pera AM, Taichman LB (1966) Cell population dynamics in the liver: a review of quantitative morphological techniques applied to the study of physiological and pathological growth. Exp Mol Pathol 5:146-181
21. Deng X, Chen YX, Zhang X et al (2008) Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte like cells. J Cell Physiol 217(1):138-144
22. Thorgeirsson SS, Grisham JW (2006) Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 43:2-8
23. Macchiarelli G, Motta PM (1986) The three-dimensional microstructure of the liver. A review by scanning electron microscopy. Scan Electron Microsc (Pt 3):1019-1038
24. Haussinger D (2001) Liver fibrosis and NA (+)/H (+) exchange. Gastroenterology 120(2):572-575
25. Strange RC (1984) Hepatic bile flow. Physiol Rev 64(4):1055-1102
26. Crocenzi FA, Mottino AD, Roma MG (2004) Regulation of synthesis and trafficking of canalicular transporters and its alteration in acquired hepatocellular cholestasis. Experimental therapeutic strategies for its prevention. Curr Med Chem 11(4):501-524
27. Sippel CJ, McCollum MJ, Perlmutter DH (1994) Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity. J Biol Chem 269(4):2820-2826
28. Seseke FG, Gardemann A, Jungermann K (1992) Signal propagation via gap junctions, a key step in the regulation of liver metabolism by the sympathetic hepatic nerves. FEBS Lett 301(3):265-270
29. Kanamura S, Kanai K, Watanabe J (1990) Fine structure and function of hepatocytes during development. J Electron Microsc Tech 14(2):92-105
30. Treem WR, Sokol RJ (1998) Disorders of the mitochondria. Semin Liver Dis 18(3):237-253
31. Dixon JL, Ginsberg HN (1992) Hepatic synthesis of lipoproteins and apolipoproteins. Semin Liver Dis 12(4):364-372
32. Erlinger S (1996) Do intracellular organelles have any role in transport of bile acids by hepatocytes? J Hepatol 24(Suppl 1):88-93
33. Jones AL, Spring-Mills E, Felts JM (1974) Ultrastructural concepts of drug metabolism. III. The hepatocyte: membranes, lipids, and alcohol. Am J Drug Alcohol Abuse 1(3):421-444
34. Reuben A (2003) Absolute mitochondrion. Hepatology 37(5):1228-1231
35. Thompson R, Strautnieks S (2001) BSEP: function and role in progressive familial intrahepatic cholestasis. Semin Liver Dis 21(4):545-550
36. Vlahcevic ZR (1996) Regulation of cholesterol 7 alphahydroxylase by different effectors. Ital J Gastroenterol 28(6):337-339
37. Makita T (1995) Molecular organization of hepatocyte peroxisomes. Int Rev Cytol 160:303-352
38. Brodsky WY, Uryvaeva IV (1977) Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol 50:275-332
39. Bernat RL, Borisy GG, Rothfield NF et al (1990) Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J Cell Biol 111(4):1519-1533
40. Viola-Magni MP, Rossi R, Biondi R et al (1978) Base composition changes in hepatocyte nuclei DNA of rats at different ages. Biochim Biophys Acta 520(1):38-51
41. Sigal SH, Gupta S, Gebhard DF Jr et al (1995) Evidence for a terminal differentiation process in the rat liver. Differentiation 59(1):35-42
42. Odom DT, Zizlsperger N, Gordon DB et al (2004) Control of pancreas and liver gene expression by HNF transcription factors. Science 303(5662):1378-1381
43. Bartles JR, Hubbard AL (1990) Biogenesis of the rat hepatocyte plasma membrane. Meth Enzymol 191:825-841
44. Lanzini A, Northfield TC (1991) Biliary lipid secretion in man. Eur J Clin Invest 21(3):259-272
45. Haussinger D, Hallbrucker C, Saha N et al (1992) Cell volume and bile acid excretion. Biochem J 288(Pt 2):681-689
46. Gibbons GF, Islam K, Pease JR (2000) Mobilisation of triacylglycerol stores. Biochim Biophys Acta 1483:37-57
47. Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocrin Rev 20:689-725
48. Glass CK, Ogawa S (2006) Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6:44-55
49. Kersten S, Seydoux J, Peters JM et al (1999) Peroxisome proliferator-activated receptor alpha the adaptive response to fasting. J Clin Invest 103:1489-1498
50. Kallwitz ER, McLachlan A, Cotler SJ (2008) Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J Gastroenterol 14(1):22-28
51. Gavrilova O, Haluzik M, Matsusue K et al (2003) Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, trygliceride clearance and regulation of body fat mass. J Biol Chem 278:34268-34276
52. Jungermann K, Thurman RG (1992) Hepatocyte heterogeneity in the metabolism of carbohydrates. Enzyme 46(1-3):33-58
53. Kaiser S (1998) Cell volume regulates liver phosphoenolpyruvate carboxykinase and fructose-1, 6-bisphosphatase genes. Am J Physiol 274 (3 Pt 1): G509-G517
54. Kotronen A, Juurinen L, Tiikkainen M et al (2008) Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterol 135:122-130
55. Pilkis SJ, Granner DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54:885-909
56. Kotronen A, Yki-Jarvinen H (2008) Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 28(1):27-38
57. Kotronen A, Lewitt M, Hall K et al (2008) Insulin-like growth factor binding protein 1 as a novel specific marker of hepatic insulin sensitivity. J Clin Endocrin Metab 93(12):4867-4872
58. Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96
59. Knittel T, Neubauer K, Armbrust T et al (1995) Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells. Hepatology 21(2):470-476
60. Lelbach A, Scharf JG, Ramadori G (2001) Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6. J Hepatol 35(5):558-567
61. Armbrust T, Nordmann B, Kreissig M et al (1997) C1Q synthesis by tissue mononuclear phagocytes from normal and from damaged rat liver: up-regulation by dexamethasone, down-regulation by interferon gamma, and lipopolysaccharide. Hepatology 26(1):98-106
62. Ramadori G, Rasokat H, Burger R et al (1984) Quantitative determination of complement components produced by purified hepatocytes. Clin Exp Immunol 55(1):189-196
63. Ramadori G, Sipe JD, Dinarello CA et al (1985) Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1(IL-1) and purified human IL-1. J Exp Med 162 (3):930-942
64. Ramadori G, Tedesco F, Bitter-Suermann D et al (1985) Biosynthesis of the third (C3), eighth (C8), and ninth (C9) complement components by guinea pig hepatocyte primary cultures. Immunobiology 170(3):203-210
65. Gross V, Steube K, Tran-Thi T et al (1987) The role of N-glycosylation for the plasma clearance of rat liver secretory glycoproteins. Eur J Biochem 162(1):83-88
66. Sheikh N, Tron K, Dudas J, Ramadori G (2006) Cytokineinduced neutrophil chemoattractant-1 is released by the noninjured liver in a rat acute-phase model. Lab Invest 86(8):800-814
67. Kushner I, Rzewnicki DL (1994) The acute phase response: general aspects. Baillieres Clin Rheumatol 8(3):513-530
68. Ramadori G, Christ B (1999) Cytokines and the hepatic acute-phase response. Semin Liver Dis 19(2):141-155
69. Tron K, Novosyadlyy R, Dudas J et al (2005) Upregulation of heme oxygenase-1 by turpentine oil-induced localized inflammation: involvement of interleukin-6. Lab Invest 85(3):376-387
70. Burmester H, Wolber EM, Freitag P et al (2005) Thrombopoietin production in wild type and interleukin-6 knockout mice with acute inflammation. J Interferon Cytokine Res 25(7):407-413
71. Anderson GJ (2001) Ironing out disease: inherited disorders of iron homeostasis. IUBMB Life 51(1):11-17
72. Angelucci E, Brittenham GM, McLaren CE et al (2000) Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 343(5):327-331
73. Sheikh N, Dudas J, Ramadori G (2007) Changes of gene expression of iron regulatory proteins during turpentine oilinduced acute-phase response in the rat. Lab Invest 87(7):713-725
74. Voci A, Arvigo M, Massajoli M et al (1999) IGF-I production by adult rat hepatocytes is stimulated by transforming growth factor-alpha and transforming growth factorbeta1. Eur J Endocrinol 140(6):577-582
75. Sjogren K, Liu JL, Blad K et al (1999) Liver-derived insulinlike growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A 96(12):7088-7092
76. Domene HM, Bengolea SV, Martinez AS et al (2004) Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. N Engl J Med 350(6):570-577
77. Yakar S, Setser J, Zhao H et al (2004) Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest 113(1):96-105
78. Price JA, Kovach SJ, Johnson T et al (2002) Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Hepatology 36(5):1089-1097
79. Maxwell PH, Osmond MK, Pugh CW et al (1997) Sites of erythropoietin production. Kidney Int. 51:393-401
80. Bondurant M, Koury M (1986) Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 6:2731-2733
81. Sohmiya M, Kato Y (2005) Human growth hormone and insulinlike growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats. Journal of Endocrinology 184:199-207
82. Kullak-Ublick GA, Stieger B, Meier PJ (2004) Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126(1):322-342
83. Denson LA, Auld KL, Schiek M et al (2000) Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J Biol Chem 275:8835-8843
84. Eloranta JJ, Jung D, Kullak-Ublik GA (2006) The human Na+-taurocholate cotransporting polypeptide gene is acti-vated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol Endocrinol 20:65-79
85. Kim RB (2003) Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur J Clin Invest 33(Suppl 2):1-5
86. Shih DQ, Bussen M, Sehayek M et al (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nature Gen 27:375-382
87. Gorboulev V, Ulzheimer JC, Akhoundova A et al (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16(7):871-881
88. Grundemann D, Gorboulev V, Gambaryan S et al (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372(6506):549-552
89. Michalopoulos G (1991) Control of hepatocyte proliferation in regeneration, augmentative hepatomegaly, and neoplasia. Prog Clin Biol Res 369:227-236
90. Kauffmann HM, Keppler D, Kartenbeck J et al (1997) Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Hepatology 26(4):980-985
91. Keppler D, Leier I, Jedlitschky G et al (1996) The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. Adv Enzyme Regul 36:17-29
92. Silverman JA (1999) Multidrug-resistance transporters. Pharm Biotechnol 12:353-386
93. Redinger RN (2003) The coming of age of our understanding of the enterohepatic circulation of bile salts. Am J Surg 185(2):168-172
94. Strazzabosco M, Boyer JL (1996) Regulation of intracellular pH in the hepatocyte. Mechanisms and physiological implications. J Hepatol 24(5):631-644
95. Bochkis IM, Rubins NE, White P et al (2008) Hepatocytespecific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nature Med 14(8):828-836
96. Elferink RP, Tytgat GN, Groen AK (1997) Hepatic canalicular membrane 1: the role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J 11(1):19-28
97. Erlinger S (1996) Mechanisms of hepatic transport and bile secretion. Acta Gastroenterol Belg 59(2):159-162
98. Harada M, Kawaguchi T, Kumemura H et al (2003) Where is the site that ATP7B transports copper within hepatocytes? Gastroenterology 125(6):1911-1912
99. Schilsky ML, Irani AN, Gorla GR et al (2000) Biliary copper excretion capacity in intact animals: correlation between ATP7B function, hepatic mass, and biliary copper excretion. J Biochem Mol Toxicol 14(4):210-214
100. Besinger SJ, Tontonoz P (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptor. Nature 454:470-477
101. Francanzani AL, Valenti L, Bugianesi E et al (2008) Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 48:792-798
102. Konig J, Nies AT, Cui Y et al (1999) Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1461(2):377-394
103. Lemaigre F, Zaret KS (2004) Liver development update: new embryo models, cell lineage control, and morphogenesis. Curr Opin Gen Dev 14:582-590
104. Nagel G, Volk C, Friedrich T et al (1997) A reevaluation of substrate specificity of the rat cation transporter rOCT1. J Biol Chem 272(51):31953-31956
105. Nguyen P, Leray V, Diez M et al (2008) Liver lipid metabolism. J Anim Physiol Anim Nutr 92:272-283
106. Raddatz D, Ramadori G (2007) Carbohydrate metabolism and the liver: actual aspects from physiology and disease. Z Gastroenterol 45:51-62
107. Seki S, Habu Y, Kawamura T et al (2000) The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev 174:35-46
108. Van de Werve G, Lange A, Newgard C et al (2000) New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Eur J Biochem 267(6):1533-1549
109. Watford M (1991) The urea cycle: a two-compartment system. Essays Biochem 26:49-58