메뉴 건너뛰기




Volumn 288, Issue 52, 2013, Pages 37216-37229

Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

AMP-ACTIVATED KINASE; GLUCOSE REGULATION; LONG-CHAIN FATTY ACIDS; METABOLIC FATE;

EID: 84891376190     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.506238     Document Type: Article
Times cited : (50)

References (69)
  • 1
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., and Schwartz, M. W. (2006) Central nervous system control of food intake and body weight. Nature 443, 289-295
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 2
    • 12144268025 scopus 로고    scopus 로고
    • Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats
    • Cruciani-Guglielmacci, C., Hervalet, A., Douared, L., Sanders, N. M., Levin, B. E., Ktorza, A., and Magnan, C. (2004) Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats. Diabetologia 47, 2032-2038
    • (2004) Diabetologia , vol.47 , pp. 2032-2038
    • Cruciani-Guglielmacci, C.1    Hervalet, A.2    Douared, L.3    Sanders, N.M.4    Levin, B.E.5    Ktorza, A.6    Magnan, C.7
  • 4
    • 33645531123 scopus 로고    scopus 로고
    • Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
    • Pocai, A., Lam, T. K., Obici, S., Gutierrez-Juarez, R., Muse, E. D., Arduini, A., and Rossetti, L. (2006) Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J. Clin. Invest. 116, 1081-1091
    • (2006) J. Clin. Invest. , vol.116 , pp. 1081-1091
    • Pocai, A.1    Lam, T.K.2    Obici, S.3    Gutierrez-Juarez, R.4    Muse, E.D.5    Arduini, A.6    Rossetti, L.7
  • 6
    • 77956772446 scopus 로고    scopus 로고
    • Sensing the fuels. Glucose and lipid signaling in the CNS controlling energy homeostasis
    • Jordan, S. D., Könner, A. C., and Brüning, J. C. (2010) Sensing the fuels. Glucose and lipid signaling in the CNS controlling energy homeostasis. Cell. Mol. Life Sci. 67, 3255-3273
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 3255-3273
    • Jordan, S.D.1    Könner, A.C.2    Brüning, J.C.3
  • 7
    • 84881367782 scopus 로고    scopus 로고
    • Metabolic signaling in fuel-induced insulin secretion
    • Prentki, M., Matschinsky, F. M., and Madiraju, S. R. (2013) Metabolic signaling in fuel-induced insulin secretion. Cell Metab. 18, 162-185
    • (2013) Cell Metab. , vol.18 , pp. 162-185
    • Prentki, M.1    Matschinsky, F.M.2    Madiraju, S.R.3
  • 8
    • 0345374578 scopus 로고    scopus 로고
    • Minireview. Malonyl CoA, AMP-activated protein kinase, and adiposity
    • Ruderman, N. B., Saha, A. K., and Kraegen, E. W. (2003) Minireview. Malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology 144, 5166-5171
    • (2003) Endocrinology , vol.144 , pp. 5166-5171
    • Ruderman, N.B.1    Saha, A.K.2    Kraegen, E.W.3
  • 10
    • 70349244719 scopus 로고    scopus 로고
    • AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
    • Murphy, B. A., Fakira, K. A., Song, Z., Beuve, A., and Routh, V. H. (2009) AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. Am. J. Physiol. Cell Physiol. 297, C750-C758
    • (2009) Am. J. Physiol. Cell Physiol. , vol.297
    • Murphy, B.A.1    Fakira, K.A.2    Song, Z.3    Beuve, A.4    Routh, V.H.5
  • 12
    • 33847022735 scopus 로고    scopus 로고
    • Role of hypothalamic adenosine 5′-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia
    • Alquier, T., Kawashima, J., Tsuji, Y., and Kahn, B. B. (2007) Role of hypothalamic adenosine 5′-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology 148, 1367-1375
    • (2007) Endocrinology , vol.148 , pp. 1367-1375
    • Alquier, T.1    Kawashima, J.2    Tsuji, Y.3    Kahn, B.B.4
  • 13
    • 40749132626 scopus 로고    scopus 로고
    • Key role for AMPactivated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    • McCrimmon, R. J., Shaw, M., Fan, X., Cheng, H., Ding, Y., Vella, M. C., Zhou, L., McNay, E. C., and Sherwin, R. S. (2008) Key role for AMPactivated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes 57, 444-450
    • (2008) Diabetes , vol.57 , pp. 444-450
    • McCrimmon, R.J.1    Shaw, M.2    Fan, X.3    Cheng, H.4    Ding, Y.5    Vella, M.C.6    Zhou, L.7    McNay, E.C.8    Sherwin, R.S.9
  • 14
    • 0242300121 scopus 로고    scopus 로고
    • Hypothalamic malonyl-CoA as a mediator of feeding behavior
    • Hu, Z., Cha, S. H., Chohnan, S., and Lane, M. D. (2003) Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc. Natl. Acad. Sci. U.S.A. 100, 12624-12629
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 12624-12629
    • Hu, Z.1    Cha, S.H.2    Chohnan, S.3    Lane, M.D.4
  • 16
    • 84883806451 scopus 로고    scopus 로고
    • Hypothalamic malonyl-CoA and the control of food intake
    • Gao, S., Moran, T. H., Lopaschuk, G. D., and Butler, A. A. (2013) Hypothalamic malonyl-CoA and the control of food intake. Physiol. Behav. 122C, 17-24
    • (2013) Physiol. Behav. , vol.122 C , pp. 17-24
    • Gao, S.1    Moran, T.H.2    Lopaschuk, G.D.3    Butler, A.A.4
  • 17
    • 28844433549 scopus 로고    scopus 로고
    • A role for hypothalamic malonyl-CoA in the control of food intake
    • Hu, Z., Dai, Y., Prentki, M., Chohnan, S., and Lane, M. D. (2005) A role for hypothalamic malonyl-CoA in the control of food intake. J. Biol. Chem. 280, 39681-39683
    • (2005) J. Biol. Chem. , vol.280 , pp. 39681-39683
    • Hu, Z.1    Dai, Y.2    Prentki, M.3    Chohnan, S.4    Lane, M.D.5
  • 18
    • 31544465941 scopus 로고    scopus 로고
    • Molecular disruption of hypothalamic nutrient sensing induces obesity
    • He, W., Lam, T. K., Obici, S., and Rossetti, L. (2006) Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat. Neurosci. 9, 227-233
    • (2006) Nat. Neurosci. , vol.9 , pp. 227-233
    • He, W.1    Lam, T.K.2    Obici, S.3    Rossetti, L.4
  • 23
    • 84878778423 scopus 로고    scopus 로고
    • Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei
    • Gao, S., Casals, N., Keung, W., Moran, T. H., and Lopaschuk, G. D. (2013) Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei. Physiol. Behav. 118, 165-170
    • (2013) Physiol. Behav. , vol.118 , pp. 165-170
    • Gao, S.1    Casals, N.2    Keung, W.3    Moran, T.H.4    Lopaschuk, G.D.5
  • 24
    • 33847746338 scopus 로고    scopus 로고
    • Glucose sensing by hypothalamic neurones and pancreatic islet cells. AMPle evidence for common mechanisms?
    • Mountjoy, P. D., and Rutter, G. A. (2007) Glucose sensing by hypothalamic neurones and pancreatic islet cells. AMPle evidence for common mechanisms? Exp. Physiol. 92, 311-319
    • (2007) Exp. Physiol. , vol.92 , pp. 311-319
    • Mountjoy, P.D.1    Rutter, G.A.2
  • 25
    • 2942553044 scopus 로고    scopus 로고
    • Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei. Involvement of astrocytes in cerebral glucose-sensing in rats
    • Guillod-Maximin, E., Lorsignol, A., Alquier, T., and Pénicaud, L. (2004) Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei. Involvement of astrocytes in cerebral glucose-sensing in rats. J. Neuroendocrinol. 16, 464-471
    • (2004) J. Neuroendocrinol. , vol.16 , pp. 464-471
    • Guillod-Maximin, E.1    Lorsignol, A.2    Alquier, T.3    Pénicaud, L.4
  • 26
    • 23244458439 scopus 로고    scopus 로고
    • Regulation of blood glucose by hypothalamic pyruvate metabolism
    • Lam, T. K., Gutierrez-Juarez, R., Pocai, A., and Rossetti, L. (2005) Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309, 943-947
    • (2005) Science , vol.309 , pp. 943-947
    • Lam, T.K.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 31
    • 51349122248 scopus 로고    scopus 로고
    • Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
    • Gavillet, M., Allaman, I., and Magistretti, P. J. (2008) Modulation of astrocytic metabolic phenotype by proinflammatory cytokines. Glia 56, 975-989
    • (2008) Glia , vol.56 , pp. 975-989
    • Gavillet, M.1    Allaman, I.2    Magistretti, P.J.3
  • 32
    • 84861012307 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia
    • 2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PloS ONE 7, e36335
    • (2012) PloS ONE , vol.7
    • Kawashima, J.1    Alquier, T.2    Tsuji, Y.3    Peroni, O.D.4    Kahn, B.B.5
  • 34
    • 34250305087 scopus 로고    scopus 로고
    • Effects of glucose and insulin on glucokinase activity in rat hypothalamus
    • Sanz, C., Roncero, I., Vázquez, P., Navas, M. A., and Blázquez, E. (2007) Effects of glucose and insulin on glucokinase activity in rat hypothalamus. J. Endocrinol. 193, 259-267
    • (2007) J. Endocrinol. , vol.193 , pp. 259-267
    • Sanz, C.1    Roncero, I.2    Vázquez, P.3    Navas, M.A.4    Blázquez, E.5
  • 35
    • 53449095050 scopus 로고    scopus 로고
    • Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1
    • Madadi, G., Dalvi, P. S., and Belsham, D. D. (2008) Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. Biochem. Biophys. Res. Commun. 376, 694-699
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 694-699
    • Madadi, G.1    Dalvi, P.S.2    Belsham, D.D.3
  • 37
    • 0027083503 scopus 로고
    • Energy metabolism in developing brain cells
    • Edmond, J. (1992) Energy metabolism in developing brain cells. Can. J. Physiol. Pharmacol. 70, S118-S129
    • (1992) Can. J. Physiol. Pharmacol. , vol.70
    • Edmond, J.1
  • 38
    • 66849089697 scopus 로고    scopus 로고
    • Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
    • Takeuchi, K., and Reue, K. (2009) Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am. J. Physiol. Endocrinol. Metab. 296, E1195-E1209
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Takeuchi, K.1    Reue, K.2
  • 42
    • 0344994496 scopus 로고    scopus 로고
    • The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes
    • Blázquez, C., Woods, A., de Ceballos, M. L., Carling, D., and Guzmán, M. (1999) The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes. J. Neurochem. 73, 1674-1682
    • (1999) J. Neurochem. , vol.73 , pp. 1674-1682
    • Blázquez, C.1    Woods, A.2    De Ceballos, M.L.3    Carling, D.4    Guzmán, M.5
  • 43
    • 0023470792 scopus 로고
    • Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
    • Edmond, J., Robbins, R. A., Bergstrom, J. D., Cole, R. A., and de Vellis, J. (1987) Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J. Neurosci. Res. 18, 551-561
    • (1987) J. Neurosci. Res. , vol.18 , pp. 551-561
    • Edmond, J.1    Robbins, R.A.2    Bergstrom, J.D.3    Cole, R.A.4    De Vellis, J.5
  • 44
    • 34250208472 scopus 로고    scopus 로고
    • Localization and effect of ectopic expression of CPT1c in CNS feeding centers
    • Dai, Y., Wolfgang, M. J., Cha, S. H., and Lane, M. D. (2007) Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem. Biophys. Res. Commun. 359, 469-474
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 469-474
    • Dai, Y.1    Wolfgang, M.J.2    Cha, S.H.3    Lane, M.D.4
  • 48
    • 79959335755 scopus 로고    scopus 로고
    • Important roles of brainspecific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding
    • Gao, S., Zhu, G., Gao, X., Wu, D., Carrasco, P., Casals, N., Hegardt, F. G., Moran, T. H., and Lopaschuk, G. D. (2011) Important roles of brainspecific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc. Natl. Acad. Sci. U.S.A. 108, 9691-9696
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 9691-9696
    • Gao, S.1    Zhu, G.2    Gao, X.3    Wu, D.4    Carrasco, P.5    Casals, N.6    Hegardt, F.G.7    Moran, T.H.8    Lopaschuk, G.D.9
  • 50
    • 0022049282 scopus 로고
    • Level of satiety. Fatty acid and glucose metabolism in three brain sites associated with feeding
    • Kasser, T. R., Harris, R. B., and Martin, R. J. (1985) Level of satiety. Fatty acid and glucose metabolism in three brain sites associated with feeding. Am. J. Physiol. 248, R447-R452
    • (1985) Am. J. Physiol. , vol.248
    • Kasser, T.R.1    Harris, R.B.2    Martin, R.J.3
  • 51
    • 0026080124 scopus 로고
    • Influence of fatty acid oxidation in lateral hypothalamus on food intake and body composition
    • Beverly, J. L., and Martin, R. J. (1991) Influence of fatty acid oxidation in lateral hypothalamus on food intake and body composition. Am. J. Physiol. 261, R339-R343
    • (1991) Am. J. Physiol. , vol.261
    • Beverly, J.L.1    Martin, R.J.2
  • 52
    • 33847634789 scopus 로고    scopus 로고
    • Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS
    • Emsley, J. G., and Macklis, J. D. (2006) Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS. Neuron Glia Biol. 2, 175-186
    • (2006) Neuron Glia Biol. , vol.2 , pp. 175-186
    • Emsley, J.G.1    MacKlis, J.D.2
  • 53
    • 0020506935 scopus 로고
    • Palmitate incorporation into different brain regions in the awake rat
    • Kimes, A. S., Sweeney, D., London, E. D., and Rapoport, S. I. (1983) Palmitate incorporation into different brain regions in the awake rat. Brain Res. 274, 291-301
    • (1983) Brain Res. , vol.274 , pp. 291-301
    • Kimes, A.S.1    Sweeney, D.2    London, E.D.3    Rapoport, S.I.4
  • 56
    • 0036429189 scopus 로고    scopus 로고
    • Concerted elevation of acyl-coenzyme A:Diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
    • Meegalla, R. L., Billheimer, J. T., and Cheng, D. (2002) Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem. Biophys. Res. Commun. 298, 317-323
    • (2002) Biochem. Biophys. Res. Commun. , vol.298 , pp. 317-323
    • Meegalla, R.L.1    Billheimer, J.T.2    Cheng, D.3
  • 57
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • Coleman, R. A., and Lee, D. P. (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43, 134-176
    • (2004) Prog. Lipid Res. , vol.43 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 58
    • 84865578156 scopus 로고    scopus 로고
    • Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice
    • Borg, M. L., Omran, S. F., Weir, J., Meikle, P. J., and Watt, M. J. (2012) Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice. J. Physiol. 590, 4377-4389
    • (2012) J. Physiol. , vol.590 , pp. 4377-4389
    • Borg, M.L.1    Omran, S.F.2    Weir, J.3    Meikle, P.J.4    Watt, M.J.5
  • 60
    • 74949110443 scopus 로고    scopus 로고
    • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons. Rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation
    • Mayer, C. M., and Belsham, D. D. (2010) Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons. Rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation. Endocrinology 151, 576-585
    • (2010) Endocrinology , vol.151 , pp. 576-585
    • Mayer, C.M.1    Belsham, D.D.2
  • 62
    • 0036065157 scopus 로고    scopus 로고
    • Glucose-sensing neurons. Are they physiologically relevant?
    • Routh, V. H. (2002) Glucose-sensing neurons. Are they physiologically relevant? Physiol. Behav. 76, 403-413
    • (2002) Physiol. Behav. , vol.76 , pp. 403-413
    • Routh, V.H.1
  • 63
    • 7044253373 scopus 로고    scopus 로고
    • A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
    • Fioramonti, X., Lorsignol, A., Taupignon, A., and Pénicaud, L. (2004) A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus. Diabetes 53, 2767-2775
    • (2004) Diabetes , vol.53 , pp. 2767-2775
    • Fioramonti, X.1    Lorsignol, A.2    Taupignon, A.3    Pénicaud, L.4
  • 64
    • 33646012618 scopus 로고    scopus 로고
    • Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels
    • Wang, R., Cruciani-Guglielmacci, C., Migrenne, S., Magnan, C., Cotero, V. E., and Routh, V. H. (2006) Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels. J. Neurophysiol. 95, 1491-1498
    • (2006) J. Neurophysiol. , vol.95 , pp. 1491-1498
    • Wang, R.1    Cruciani-Guglielmacci, C.2    Migrenne, S.3    Magnan, C.4    Cotero, V.E.5    Routh, V.H.6
  • 65
    • 79959428713 scopus 로고    scopus 로고
    • Metabolic sensing and the brain. Who, what, where, and how?
    • Levin, B. E., Magnan, C., Dunn-Meynell, A., and Le Foll, C. (2011) Metabolic sensing and the brain. Who, what, where, and how? Endocrinology 152, 2552-2557
    • (2011) Endocrinology , vol.152 , pp. 2552-2557
    • Levin, B.E.1    Magnan, C.2    Dunn-Meynell, A.3    Le Foll, C.4
  • 66
    • 3843114555 scopus 로고    scopus 로고
    • Hypothalamic responses to long-chain fatty acids are nutritionally regulated
    • Morgan, K., Obici, S., and Rossetti, L. (2004) Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J. Biol. Chem. 279, 31139-31148
    • (2004) J. Biol. Chem. , vol.279 , pp. 31139-31148
    • Morgan, K.1    Obici, S.2    Rossetti, L.3
  • 68
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., and Rossetti, L. (2002) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51, 271-275
    • (2002) Diabetes , vol.51 , pp. 271-275
    • Obici, S.1    Feng, Z.2    Morgan, K.3    Stein, D.4    Karkanias, G.5    Rossetti, L.6
  • 69
    • 79952697164 scopus 로고    scopus 로고
    • Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism
    • Schwinkendorf, D. R., Tsatsos, N. G., Gosnell, B. A., and Mashek, D. G. (2011) Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism. Int. J. Obes. (Lond) 35, 336-344
    • (2011) Int. J. Obes. (Lond) , vol.35 , pp. 336-344
    • Schwinkendorf, D.R.1    Tsatsos, N.G.2    Gosnell, B.A.3    Mashek, D.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.