PGRN haploinsufficiency increased Wnt5a signaling in peripheral cells from frontotemporal lobar degeneration-progranulin mutation carriers

Neurobiology of Aging

Volumn 35, Issue 4, 2014, Pages 886-898

  Alquézar, Carolina ^a,f   Esteras, Noemí ^a   de la Encarnación, Ana ^a   Alzualde, Ainhoa ^b,e   Moreno, Fermín ^b,c,e   López de Munain, Adolfo ^b,c,d,e   Martín Requero, Ángeles ^a,f  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^c HOSPITAL DONOSTIA   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^f CIBER Enfermedades Respiratorias (CIBERES)   (Spain)

Author keywords

CDK6; Cell proliferation; FTLD TDP; Lymphocytes; Pertussis toxin; Wnt5a signaling

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PROGRANULIN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; WNT5A PROTEIN;

ARTICLE; BRAIN NERVE CELL; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FRONTOTEMPORAL DEMENTIA; FZD2 GENE; FZD3 GENE; FZD4 GENE; FZD5 GENE; GENE; GENE MUTATION; GENE SILENCING; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; LYMPHOBLAST; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; WNT SIGNALING PATHWAY;

CDK6; CELL PROLIFERATION; FTLD-TDP; LYMPHOCYTES; PERTUSSIS TOXIN; WNT5A SIGNALING;

CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; HETEROZYGOTE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR TARGETED THERAPY; MUTATION; NEURONS; PERTUSSIS TOXIN; PROTO-ONCOGENE PROTEINS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84891371920     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.09.021     Document Type: Article

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