메뉴 건너뛰기




Volumn 70, Issue 7, 2011, Pages 578-587

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

Author keywords

Dementia pugilistica; Neurodegeneration with brain iron accumulation type 1; Neurofibrillary tangles; Pick disease; Progressive supranuclear palsy; Retinoblastoma protein; Subacute sclerosing panencephalitis; Tau pathology

Indexed keywords

RETINOBLASTOMA PROTEIN; TAU PROTEIN;

EID: 79959512528     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182204414     Document Type: Article
Times cited : (33)

References (60)
  • 1
    • 0038143215 scopus 로고    scopus 로고
    • Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb
    • DOI 10.1074/jbc.M301761200
    • Ma D, Zhou P, Harbour JW. Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb. J Biol Chem 2003; 278:19358-66 (Pubitemid 36799331)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 19358-19366
    • Ma, D.1    Zhou, P.2    Harbour, J.W.3
  • 2
    • 69249198349 scopus 로고    scopus 로고
    • Retinoblastoma protein: A central processing unit
    • Poznic M. Retinoblastoma protein: A central processing unit. J Biosci 2009;34:305-12
    • (2009) J Biosci , vol.34 , pp. 305-312
    • Poznic, M.1
  • 3
    • 0000589398 scopus 로고    scopus 로고
    • Implication of transcription factor E2F in regulation of DNA replication
    • Ohtani K. Implication of transcription factor E2F in regulation of DNA replication. Front Biosci 1999;4:D793-804
    • (1999) Front Biosci , vol.4
    • Ohtani, K.1
  • 4
    • 0034849106 scopus 로고    scopus 로고
    • Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis
    • Ranganathan S, Scudiere S, Bowser R. Hyperphosphorylation of the reti-noblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis. J Alzheimers Dis 2001;3:377-85 (Pubitemid 32843054)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.4 , pp. 377-385
    • Ranganathan, S.1    Scudiere, S.2    Bowser, R.3
  • 5
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblas-toma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998;18:753-61 (Pubitemid 28063408)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.2 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 7
    • 0032578795 scopus 로고    scopus 로고
    • pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F
    • Chew YP, Ellis M, Wilkie S, et al. pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F. Oncogene 1998;17:2177-86 (Pubitemid 28515371)
    • (1998) Oncogene , vol.17 , Issue.17 , pp. 2177-2186
    • Chew, Y.P.1    Ellis, M.2    Wilkie, S.3    Mittnacht, S.4
  • 8
    • 0030991235 scopus 로고    scopus 로고
    • The retinoblastoma protein: A master regulator of cell cycle, differentiation and apoptosis
    • Herwig S, Strauss M. The retinoblastoma protein: A master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem 1997;246: 581-601 (Pubitemid 27252898)
    • (1997) European Journal of Biochemistry , vol.246 , Issue.3 , pp. 581-601
    • Herwig, S.1    Strauss, M.2
  • 10
    • 0036592637 scopus 로고    scopus 로고
    • Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle
    • Bowser R, Smith MA. Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle. J Alzheimers Dis 2002;4:249-54 (Pubitemid 35006056)
    • (2002) Journal of Alzheimer's Disease , vol.4 , Issue.3 , pp. 249-254
    • Bowser, R.1    Smith, M.A.2
  • 11
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt T, Rodel L, Gartner U, et al. Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport 1996;7: 3047-49 (Pubitemid 26426387)
    • (1996) NeuroReport , vol.7 , Issue.18 , pp. 3047-3049
    • Arendt, T.1    Rodel, L.2    Gartner, U.3    Holzer, M.4
  • 13
    • 0030742818 scopus 로고    scopus 로고
    • Cell cycle markers in the hippocampus in Alzheimer's disease
    • DOI 10.1007/s004010050665
    • Nagy Z, Esiri MM, Cato AM, et al. Cell cycle markers in the hippocampus in Alzheimer's disease. Acta Neuropathol 1997;94:6-15 (Pubitemid 27289096)
    • (1997) Acta Neuropathologica , vol.94 , Issue.1 , pp. 6-15
    • Nagy, Zs.1    Esiri, M.M.2    Cato, A.-M.3    Smith, A.D.4
  • 14
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other nenrodegenerative conditions
    • DOI 10.1007/s004010050617
    • Nagy Z, Esiri MM, Smith AD. Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol (Berl) 1997;93:294-300 (Pubitemid 27104426)
    • (1997) Acta Neuropathologica , vol.93 , Issue.3 , pp. 294-300
    • Nagy, Zs.1    Esiri, M.M.2    Smith, A.D.3
  • 16
    • 0033037948 scopus 로고    scopus 로고
    • Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer disease
    • DOI 10.1054/mehy.1997.0680
    • McShea A, Wahl AF, Smith MA. Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer disease. Med Hypotheses 1999; 52:525-27 (Pubitemid 29322571)
    • (1999) Medical Hypotheses , vol.52 , Issue.6 , pp. 525-527
    • McShea, A.1    Wahl, A.F.2    Smith, M.A.3
  • 17
    • 0033634994 scopus 로고    scopus 로고
    • Neuronal polo-like kinase in alzheimer disease indicates cell cycle changes
    • Harris PL, Zhu X, Pamies C, et al. Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. Neurobiol Aging 2000;21: 837-41
    • (2000) Neurobiol Aging , vol.21 , pp. 837-841
    • Harris, P.L.1    Zhu, X.2    Pamies, C.3
  • 18
    • 0033636620 scopus 로고    scopus 로고
    • Neuronal CDK7 in hippocampus is related to aging and alzheimer disease
    • Zhu X, Rottkamp CA, Raina AK, et al. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiol Aging 2000;21: 807-13
    • (2000) Neurobiol Aging , vol.21 , pp. 807-813
    • Zhu, X.1    Rottkamp, C.A.2    Raina, A.K.3
  • 19
    • 0041419869 scopus 로고    scopus 로고
    • Increased p27, an essential component of cell cycle control, in alzheimer's disease
    • Ogawa O, Lee HG, Zhu X, et al. Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell 2003;2:105-10
    • (2003) Aging Cell , vol.2 , pp. 105-110
    • Ogawa, O.1    Lee, H.G.2    Zhu, X.3
  • 22
    • 60549117879 scopus 로고    scopus 로고
    • Retinoblastoma protein phos-phorylation at multiple sites is associated with neurofibrillary pathology in alzheimer disease
    • Thakur A, Siedlak SL, James SL, et al. Retinoblastoma protein phos-phorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int J Clin Exp Pathol 2008;1:134-46
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 134-146
    • Thakur, A.1    Siedlak, S.L.2    James, S.L.3
  • 23
    • 77949884756 scopus 로고    scopus 로고
    • Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in alzheimer disease
    • Bonda DJ, Evans TA, Santocanale C, et al. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Milano) 2009;1:382-88
    • (2009) Aging (Milano) , vol.1 , pp. 382-388
    • Bonda, D.J.1    Evans, T.A.2    Santocanale, C.3
  • 24
    • 0032229327 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cellular damage in alzheimer disease
    • Perry G, Castellani RJ, Hirai K, et al. Reactive oxygen species mediate cellular damage in Alzheimer disease. J Alzheimers Dis 1998;1:45-55
    • (1998) J Alzheimers Dis , vol.1 , pp. 45-55
    • Perry, G.1    Castellani, R.J.2    Hirai, K.3
  • 25
    • 56749098112 scopus 로고    scopus 로고
    • Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC)
    • Miklossy J, Steele JC, Yu S, et al. Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). Acta Neuropathol 2008;116:625-37
    • (2008) Acta Neuropathol , vol.116 , pp. 625-637
    • Miklossy, J.1    Steele, J.C.2    Yu, S.3
  • 26
    • 0023175260 scopus 로고
    • Filaments of Pick's bodies contain altered cytoskeletal elements
    • Perry G, Stewart D, Friedman R, et al. Filaments of Pick's bodies contain altered cytoskeletal elements. Am J Pathol 1987;127:559-68 (Pubitemid 17089817)
    • (1987) American Journal of Pathology , vol.127 , Issue.3 , pp. 559-568
    • Perry, G.1    Stewart, D.2    Friedman, R.3
  • 27
    • 0022976136 scopus 로고
    • Filamentous aggregates in Pick's disease, progressive supranuclear palsy, and Alzheimer's disease share antigenic determinants with microtubule- associated protein, tau
    • Pollock NJ, Mirra SS, Binder LI, et al. Filamentous aggregates in Pick's disease, progressive supranuclear palsy, and Alzheimer's disease share antigenic determinants with microtubule-associated protein, tau. Lancet 1986;2:1211 (Pubitemid 17179052)
    • (1986) Lancet , vol.2 , Issue.8517 , pp. 1211
    • Pollock, N.J.1    Mirra, S.S.2    Binder, L.I.3
  • 28
    • 0018968363 scopus 로고
    • Neurofibrillary pathology in progressive supranuclear palsy
    • DOI 10.1007/BF00687231
    • Ghatak NR, Nochlin D, Hadfield MG. Neurofibrillary pathology in progressive supranuclear palsy. Acta Neuropathol 1980;52:73-76 (Pubitemid 10011161)
    • (1980) Acta Neuropathologica , vol.52 , Issue.1 , pp. 73-76
    • Ghatak, N.R.1    Nochlin, D.2    Hadfield, M.G.3
  • 29
    • 0023751296 scopus 로고
    • Alz 50 recognizes abnormal filaments in alzheimer's disease and progressive supranuclear palsy
    • Tabaton M, Whitehouse PJ, Perry G, et al. Alz 50 recognizes abnormal filaments in Alzheimer's disease and progressive supranuclear palsy. Ann Neurol 1988;24:407-13
    • (1988) Ann Neurol , vol.24 , pp. 407-413
    • Tabaton, M.1    Whitehouse, P.J.2    Perry, G.3
  • 30
    • 0027978991 scopus 로고
    • Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics
    • DOI 10.1007/s004010050140
    • Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathol 1994;88:129-36 (Pubitemid 24233243)
    • (1994) Acta Neuropathologica , vol.88 , Issue.2 , pp. 129-136
    • Iwatsubo, T.1    Hasegawa, M.2    Ihara, Y.3
  • 31
    • 77952542564 scopus 로고    scopus 로고
    • Tau proteins in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis
    • Yuksel D, Yilmaz D, Uyar NY, et al. Tau proteins in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis. Brain Dev 2010;32:467-71
    • (2010) Brain Dev , vol.32 , pp. 467-471
    • Yuksel, D.1    Yilmaz, D.2    Uyar, N.Y.3
  • 32
    • 60049091402 scopus 로고    scopus 로고
    • Tauopathies with parkinsonism: Clinical spectrum, neuropathologic basis, biological markers, and treatment options
    • Ludolph AC, Kassubek J, Landwehrmeyer BG, et al. Tauopathies with parkinsonism: Clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur J Neurol 2009;16:297-309
    • (2009) Eur J Neurol , vol.16 , pp. 297-309
    • Ludolph, A.C.1    Kassubek, J.2    Landwehrmeyer, B.G.3
  • 34
    • 24044454395 scopus 로고    scopus 로고
    • Central nervous system injuries in sport and recreation - A systematic review
    • DOI 10.2165/00007256-200535080-00003
    • Toth C, McNeil S, Feasby T. Central nervous system injuries in sport and recreation: A systematic review. Sports Med 2005;35:685-715 (Pubitemid 41215904)
    • (2005) Sports Medicine , vol.35 , Issue.8 , pp. 685-715
    • Toth, C.1    McNeil, S.2    Feasby, T.3
  • 35
    • 40549119122 scopus 로고    scopus 로고
    • Frontal-subcortical dementias
    • DOI 10.1097/NRL.0b013e31815b0de2, PII 0012789320080300000003
    • Bonelli RM, Cummings JL. Frontal-subcortical dementias. Neurologist 2008;14:100-7 (Pubitemid 351366942)
    • (2008) Neurologist , vol.14 , Issue.2 , pp. 100-107
    • Bonelli, R.M.1    Cummings, J.L.2
  • 36
    • 0036157895 scopus 로고    scopus 로고
    • Protein aggregates and dementia: Is there a common toxicity?
    • Lovestone S, McLoughlin DM. Protein aggregates and dementia: Is there a common toxicity? J Neurol Neurosurg Psychiatry 2002;72:152-61
    • (2002) J Neurol Neurosurg Psychiatry , vol.72 , pp. 152-161
    • Lovestone, S.1    McLoughlin, D.M.2
  • 37
    • 0033836580 scopus 로고    scopus 로고
    • In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4-hydroxy-2-nonenal modification
    • DOI 10.1046/j.1471-4159.2000.0751234.x
    • Takeda A, Smith MA, Avila J, et al. In Alzheimer's disease, heme oxy-genase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. J Neurochem 2000;75:1234-41 (Pubitemid 30660513)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.3 , pp. 1234-1241
    • Takeda, A.1    Smith, M.A.2    Avila, J.3    Nunomura, A.4    Siedlak, S.L.5    Zhu, X.6    Perry, G.7    Sayre, L.M.8
  • 38
    • 0032931991 scopus 로고    scopus 로고
    • Cumulative effect of phosphorylation of pRB on regulation of E2F activity
    • Brown VD, Phillips RA, Gallie BL. Cumulative effect of phosphory-lation of pRB on regulation of E2F activity. Mol Cell Biol 1999;19: 3246-56 (Pubitemid 29193786)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.5 , pp. 3246-3256
    • Brown, V.D.1    Phillips, R.A.2    Gallie, B.L.3
  • 39
    • 0028032069 scopus 로고
    • Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation
    • Mittnacht S, Lees JA, Desai D, et al. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J 1994;13:118-27
    • (1994) EMBO J , vol.13 , pp. 118-127
    • Mittnacht, S.1    Lees, J.A.2    Desai, D.3
  • 40
    • 0025810049 scopus 로고
    • G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
    • 1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 1991;65:381-93 (Pubitemid 121002048)
    • (1991) Cell , vol.65 , Issue.3 , pp. 381-393
    • Mittnacht, S.1    Weinberg, R.A.2
  • 42
    • 0031006939 scopus 로고    scopus 로고
    • Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain
    • Vincent I, Jicha G, Rosado M, et al. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. J Neurosci 1997;17:3588-98 (Pubitemid 27200586)
    • (1997) Journal of Neuroscience , vol.17 , Issue.10 , pp. 3588-3598
    • Vincent, I.1    Jicha, G.2    Rosado, M.3    Dickson, D.W.4
  • 43
    • 0033551712 scopus 로고    scopus 로고
    • Cell cycle-related protein expression in vascular dementia and Alzheimer's disease
    • DOI 10.1016/S0304-3940(99)00509-1, PII S0304394099005091
    • Smith MZ, Nagy Z, Esiri MM. Cell cycle-related protein expression in vascular dementia and Alzheimer's disease. Neurosci Lett 1999;271: 45-48 (Pubitemid 29369191)
    • (1999) Neuroscience Letters , vol.271 , Issue.1 , pp. 45-48
    • Smith, M.Z.1    Nagy, Zs.2    Esiri, M.M.3
  • 44
    • 0033635191 scopus 로고    scopus 로고
    • The cell cycle cdc25a tyrosine phosphatase is activated in degenerating postmitotic neurons in alzheimer's disease
    • Ding XL, Husseman J, Tomashevski A, et al. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol 2000;157:1983-90
    • (2000) Am J Pathol , vol.157 , pp. 1983-1990
    • Ding, X.L.1    Husseman, J.2    Tomashevski, A.3
  • 45
    • 67651089806 scopus 로고    scopus 로고
    • Phosphorylation of mcm2 by cdc7 promotes pre-replication complex assembly during cell-cycle re-entry
    • Chuang LC, Teixeira LK, Wohlschlegel JA, et al. Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. Mol Cell 2009;35:206-16
    • (2009) Mol Cell , vol.35 , pp. 206-216
    • Chuang, L.C.1    Teixeira, L.K.2    Wohlschlegel, J.A.3
  • 48
    • 0033782845 scopus 로고    scopus 로고
    • Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in alzheimer disease
    • Zhu X, Rottkamp CA, Boux H, et al. Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 2000;59:880-88
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 880-888
    • Zhu, X.1    Rottkamp, C.A.2    Boux, H.3
  • 53
    • 1642358352 scopus 로고    scopus 로고
    • Alzheimer's disease: The two-hit hypothesis
    • DOI 10.1016/S1474-4422(04)00707-0, PII S1474442204007070
    • Zhu X, Raina AK, Perry G, et al. Alzheimer's disease: The two-hit hypothesis. Lancet Neurol 2004;3:219-26 (Pubitemid 38373660)
    • (2004) Lancet Neurology , vol.3 , Issue.4 , pp. 219-226
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 55
    • 55249086251 scopus 로고    scopus 로고
    • Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for alzheimer disease
    • Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: A promising therapeutic target for Alzheimer disease. Curr Med Chem 2008;15:2321-28
    • (2008) Curr Med Chem , vol.15 , pp. 2321-2328
    • Gong, C.X.1    Iqbal, K.2
  • 58
    • 0033860588 scopus 로고    scopus 로고
    • Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion
    • DOI 10.1046/j.1365-2990.2000.00264.x
    • Hayashi T, Sakai K, Sasaki C, et al. Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion. Neuro-pathol Appl Neurobiol 2000;26:390-97 (Pubitemid 30609435)
    • (2000) Neuropathology and Applied Neurobiology , vol.26 , Issue.4 , pp. 390-397
    • Hayashi, T.1    Sakai, K.2    Sasaki, C.3    Zhang, W.R.4    Abe, K.5
  • 60
    • 62549114846 scopus 로고    scopus 로고
    • The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse
    • Lee HG, Casadesus G, Nunomura A, et al. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol 2009;174:891-97
    • (2009) Am J Pathol , vol.174 , pp. 891-897
    • Lee, H.G.1    Casadesus, G.2    Nunomura, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.