Effects of delta-9-tetrahydrocannabinol on human immune function and host defense

Chemistry and Physics of Lipids

Volumn 121, Issue 1-2, 2002, Pages 229-239

  Roth, Michael D ^a   Baldwin, Gayle C ^a   Tashkin, Donald P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alveolar macrophage; Cannabinoid; Cytokines; Immunity; Nitric oxide

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANCER GROWTH FACTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CYTOKINE; DRONABINOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; NITRIC OXIDE; RIMONABANT; TETRAHYDROCANNABINOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CELL FUNCTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DEPENDENCE; DRUG EXPOSURE; DRUG MECHANISM; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VIVO STUDY; LEUKOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

CANNABIS SATIVA;

EID: 0037207092     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(02)00159-7     Document Type: Review

References (60)

1. Baldwin G.C., Tashkin D.P., Buckley D.M., Park A.N., Dubinett S.M., Roth M.D. Marijuana and cocaine impair alveolar macrophage function and cytokine production. Am. J. Respir. Crit. Care Med. 156:1997;1606-1613.
2. Baldwin G.C., Choi R., Shey A.H., Kleerup E.C., Roth M.D., Tashkin D.P. Nitric oxide: a mediator of alveolar macrophage antimicrobial activity compromised in cocaine and marijuana smokers. Am. J. Respir. Crit. Care Med. 161:2000;A124.
3. Barbers R.G., Gong H. Jr., Tashkin D.P., Oishi J., Wallace J.M. Differential examination of bronchoalveolar lavage cells in tobacco cigarette and marijuana smokers. Am. Rev. Respir. Dis. 135:1987;1271-1275.
4. Barbers R.G., Evans M.J., Gong H. Jr., Tashkin D.P. Enhanced alveolar monocytic phagocyte (macrophage) proliferation in tobacco and marijuana smokers. Am. Rev. Respir. Dis. 143:1991;1092-1095.
5. Beals T.F., Fligiel S.E.G., Stuth S., Tashkin D.P. Morphological alterations of alveolar macrophages from marijuana smokers. Am. Rev. Respir. Dis., Part 2. 139:1989;A336.
6. Berdyshev E.V. Cannabinoid receptors and the regulation of immune response. Chem. Phys. Lipids. 108:2000;169-190.
7. Bouaboula M., Rinaldi M., Carayon P., Carillon C., Delpech B., Shire D., Le Fur G., Casellas P. Cannabinoid-receptor expression in human leukocytes. Eur. J. Biochem. 214:1993;173-180.
8. Burnette-Curley D., Cabral G.A. Differential inhibition of RAW264.7 macrophage tumoricidal activity by delta 9 tetrahydrocannabinol. Proc. Soc. Exp. Biol. Med. 210:1995;64-76.
9. Cabral G.A., Dove Pettit D.A. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J. Neuroimmunol. 83:1998;116-123.
10. Caiaffa W.T., Vlahov D., Graham N.M., Astemborski J., Solomon L., Nelson K.E., Munoz A. Drug smoking, pneumocystis carinii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users. Am. J. Respir. Crit. Care Med. 150:1994;1493-1498.
11. Carayon P., Marchand J., Dussossoy D., Derocq J.-M., Jbilo O., Bord A., Bouaboula M., Galiegue S., Mondiere P., Penarier G., Le Fur G., Defrance T., Casellas P. Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood. 92:1998;3605-3615.
12. Coffey R.G., Snella E., Johnson K., Pross S. Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitro. Int. J. Immunopharmacol. 18:1996;749-752.
13. Cunha F.Q., Moss D.W., Leal L.M., Moncada S., Liew F.Y. Induction of macrophage parasiticidal activity by Staphylococcus aureus and exotoxins through the nitric oxide synthesis pathway. Immunology. 78:1993;563-567.
14. De Visser K.E., Kast W.M. Effects of TGF-β on the immune system: implications for cancer immunotherapy. Leukemia. 13:1999;1188-1199.
15. Elenkov I.J., Webster E.L., Torpy D.J., Chrousos G.P. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: acute and chronic effects. Ann. NY Acad. Sci. 876:1999;1-11.
16. - lymphocyte subpopulation. J. Immunol. 154:1995;4294-4301.
17. Galiegue S., Mary S., Marchand J., Dussossoy D., Carriere D., Carayon P., Bouaboula M., Shire D., Le Fur G., Casellas P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232:1995;54-61.
18. Gardner B., Zhu L.X., Sharma S., Liu Q., Makriyannis A., Tashkin D.P., Dubinett S.M. Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-β Biochem. Biophys. Res. Commun. 290:2002;91-96.
19. Gerard C., Mollereau C., Vassart G., Parmentier M. Nucleotide sequence of a human cannabinoid receptor cDNA. Nucl. Acids Res. 18:1990;7142.
20. Gerard C.M., Mollereau C., Vassart G., Parmentier M. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279:1991;129-134.
21. Howlett A.C. Pharmacology of cannabinoid receptors. Annu. Rev. Pharmacol. Toxicol. 35:1995;607-634.
22. Hsieh C., Brown S., Derleth C., Mackie K. Internalization and recycling of the CB1 cannabinoid receptor. J. Neurochem. 73:1999;493-501.
23. Huang M., Wang J., Lee P., Sharma S., Mao J.T., Meissner H., Uyemura K., Modlin R., Wollman J., Dubinett S.M. Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res. 55:1995;3847-3853.
24. Huestis M.A., Gorelick D.A., Heishman S.J., Preston K.L., Nelson R.A., Moolchan E.T., Frank R.A. Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716. Arch. Gen. Psychiatr. 58:2001;322-328.
25. Jeon Y., Yang K.H., Pulaski J.T., Kaminski N.E. Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor-kappa B/Rel activation. Mol. Pharmacol. 50:1996;334-341.
26. Kaminski N.E. Regulation of the cAMP cascade, gene expression and immune function by cannabinoid receptors. J. Neuroimmunol. 83:1998;124-132.
27. + leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukoc. Biol. 59:1996;208-218.
28. Klein T.W., Newton C., Friedman H. Cannabinoid receptors and immunity. Immunol. Today. 19:1998;373-381.
29. Klein T.W., Newton C.A., Nakachi N., Friedman H. Delta9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta2 responses to Legionella pneumophila infection. J. Immunol. 164:2000;6461-6466.
30. Klein T.W., Newton C.A., Friedman H. Cannabinoids and the immune system. Pain Res. Manage. 6:2001;95-101.
31. Lau R.J., Tubergen D.G., Barr M. Jr., Domino E.F., Benowitz N., Jones R.T. Phytohemagglutinin-induced lymphocyte transformation in humans receiving delta9-tetrahydrocannabinol. Science. 192:1976;805-807.
32. Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.F., Beslot F., Bohme G.A., Imperato A., Pedrazzini T., Roques B.P., Vassart G., Fratta W., Parmentier M. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor mice. Science. 283:1999;401-404.
33. Lee M., Yang K.H., Kaminski N.E. Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J. Pharmacol. Exp. Ther. 275:1995;529-536.
34. Lefkowitz R.J. G protein-coupled receptors. J. Biol. Chem. 273:1998;18677-18680.
35. Manzanares J., Corchero J., Fuentes J.A. Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of delta(9)-tetrahydrocannabinol in rats. Brain Res. 839:1999;173-179.
36. Marchand J., Bord A., Penarier G., Laure F., Carayon P., Casellas P. Quantitative method to determine mRNA levels by reverse transcriptase-polymerase chain reaction from leukocyte subsets purified by fluorescence-activated cell sorting: application to peripheral cannabinoid receptors. Cytometry. 35:1999;227-234.
37. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
38. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:1989;145-173.
39. Mosmann T., Moore K.W. The role of IL-10 in cross-regulation of TH1 and TH2 responses. Immunol. Today. 12:1991;A49-A53.
40. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
41. Nahas G.G., Zagury D., Schwartz I.W., Nagel M.D. Evidence for the possible immunogenicity of delta 9-tetrahydrocannabinol (THC) in rodents. Nature. 243:1973;407-408.
42. Nahas G.G., Suciu-Foca N., Armand J.-P., Morishima A. Inhibition of cellular mediated immunity in marihuana smokers. Science. 183:1974;419-420.
43. Nathan C.F., Shiloh M.U. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA. 97:2000;8841-8848.
44. Newell G.R., Mansell P.W., Wilson M.B., Lynch H.K., Spitz M.R., Hersh E.M. Risk factor analysis among men referred for possible acquired immune deficiency syndrome. Prev. Med. 14:1985;81-91.
45. Newton C.A., Klein T.W., Friedman H. Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect. Immunol. 62:1994;4015-4020.
46. Nong L., Newton C., Cheng Q., Friedman H., Roth M.D., Klein T.W. Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J. Neuroimmunol. 127:2002;169-176.
47. Rachelefsky G.S., Opelz G., Mickey M.R., Lessin P., Kiuchi M., Silverstein M.J., Stiehm E.R. Intact humoral and cell-mediated immunity in chronic marijuana smoking. J. Allergy Clin. Immunol. 58:1976;483-490.
48. Roth, M.D., Yuan, M., Zoumalan, R., Mendenhall, M., Tashkin, D.P., 1999. Delta-9-tetrahydrocannabinol Suppresses Antigen-induced Proliferation and Interferon-γ Production by Human T Cells. International Cannabinoid Research Society, Burlington, Vermont, p. 42. ISBN 09658053-3-6.
49. 9 -tetrahydrocannabinol. Am. J. Respir. Cell Mol. Biol. 24:2001;1-6.
50. Salzet M., Breton C., Bisogno T., Di Marzo V. Comparative biology of the endocannabinoid system possible role in the immune response. Eur. J. Biochem. 267:2000;4917-4927.
51. Sasaki S., Miura T., Nishikawa S., Yamada K., Hirasue M., Nakane A. Protective role of nitric oxide in Staphylococcus aureus infection in mice. Infect. Immunol. 66:1998;1017-1022.
52. Schatz A.R., Lee M., Condie R.B., Pulaski J.T., Kaminski N.E. Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system. Toxicol. Appl. Pharmacol. 142:1997;278-287.
53. Sherman M.P., Campbell L.A., Gong H. Jr., Roth M.D., Tashkin D.P. Respiratory burst and microbicidal characteristics of pulmonary alveolar macrophages recovered from smokers of marijuana alone, smokers of tobacco alone, smokers of marijuana and tobacco and nonsmokers. Am. Rev. Respir. Dis. 144:1991;1351-1356.
54. Sibille Y., Reynolds H.Y. Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am. Rev. Respir. Dis. 141:1990;471-501.
55. Sogn J.A. Tumor immunology: the glass is half full. Immunity. 9:1998;757-763.
56. Tang J.L., Lancz G., Spector S., Bullock H. Marijuana and immunity: tetrahydrocannabinol-mediated inhibition of growth and phagocytic activity of the murine macrophage cell line, P388D1. Int. J. Immunopharmacol. 14:1992;253-262.
57. Tindall B., Cooper D.A., Donovan B., Barnes T., Philpot C.R., Gold J., Penny R. The Sydney AIDS Project: development of acquired immunodeficiency syndrome in a group of HIV seropositive homosexual men. Aust. NZ J. Med. 18:1988;8-15.
58. Wu T.-C., Tashkin D.P., Djahed B., Rose J.E. Pulmonary hazards of smoking marijuana as compared with tobacco. N. Engl. J. Med. 318:1988;347-351.
59. Zhang Z.F., Morgenstern H., Spitz M.R., Tashkin D.P., Yu G.P., Marshall J.R., Hsu T.C., Schantz S.P. Marijuana use and increased risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol. Biomarkers Prev. 8:1999;1071-1078.
60. Zhu L.X., Sharma S., Stolina M., Gardner B., Roth M.D., Tashkin D.P., Dubinett S.M. Delta-9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J. Immunol. 165:2000;373-380.