Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA Clamp Nanoswitches

ACS Nano

Volumn 7, Issue 12, 2013, Pages 10863-10869

  Idili, Andrea ^a,b   Plaxco, Kevin W ^c,d   Vallée Bélisle, Alexis ^e   Ricci, Francesco ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c Center for Bioengineering   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

biomolecular switch; clamp mechanism; DNA nanomachines; ligand induced fit; molecular beacons; specificity; triplex

Indexed keywords

BIO-MOLECULAR; LIGAND-INDUCED FIT; MOLECULAR BEACON; NANOMACHINES; SPECIFICITY; TRIPLEX;

DNA; PROBES; THERMODYNAMICS;

MOLECULAR DYNAMICS;

DNA; LIGAND; NANOCOMPOSITE;

ARTICLE; BASE PAIRING; BIOTECHNOLOGY; CHEMISTRY; CONFORMATION; GENETIC ENGINEERING; GENETIC PROCEDURES; KINETICS; METHODOLOGY; MOLECULAR GENETICS; NANOTECHNOLOGY; NUCLEOTIDE SEQUENCE; PH; TEMPERATURE; THERMODYNAMICS;

BASE PAIRING; BASE SEQUENCE; BIOSENSING TECHNIQUES; BIOTECHNOLOGY; DNA; GENETIC ENGINEERING; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; NANOCOMPOSITES; NANOTECHNOLOGY; NUCLEIC ACID CONFORMATION; TEMPERATURE; THERMODYNAMICS;

EID: 84891365461     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn404305e     Document Type: Article

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