Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer

ChemBioChem

Volumn 8, Issue 18, 2007, Pages 2223-2226

  Müller, Jens ^a   Wulffen, Bernhard ^a   Pötzsch, Bernd ^a   Mayer, Günter ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Aptamers; Bivalent ligands; Coagulation; Thrombin

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; APTAMER; HD1 PROTEIN; HEPARIN; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIGAND;

ANTICOAGULATION; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANALYSIS; HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN DOMAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; THROMBIN;

EID: 38849122813     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700535     Document Type: Article

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