Enzyme-free nucleic acid logic circuits

Science

Volumn 314, Issue 5805, 2006, Pages 1585-1588

  Seelig, Georg ^a   Soloveichik, David ^b   Zhang, David Yu ^b   Winfree, Erik ^b  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; BIODIVERSITY; NUCLEIC ACIDS; PRODUCT DESIGN; SIGNAL DISTORTION;

BIOLOGICAL ORGANISMS; MICRORNA; SINGLE-STRANDED NUCLEIC ACIDS;

LOGIC CIRCUITS;

MICRORNA; NUCLEIC ACID;

FEEDBACK MECHANISM; NUCLEIC ACID; SIGNALING;

ARTICLE; FEEDBACK SYSTEM; INFORMATION PROCESSING; INFORMATION SCIENCE; INTEGRATED CIRCUIT; PRIORITY JOURNAL; SIGNAL PROCESSING;

ANIMALS; BASE PAIRING; BASE SEQUENCE; BIOTECHNOLOGY; COMPUTERS, MOLECULAR; DNA; DNA, SINGLE-STRANDED; LOGIC; MICE; MICRORNAS; NANOSTRUCTURES; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES;

EID: 33845411737     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132493     Document Type: Article

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25. We thank N. Dabby for a very close reading of this paper and extensive revisions. B. Yurke built the custom fluorometer used for these experiments, and we are further indebted to him for inspiration and advice. G.S. was supported by the Swiss National Science Foundation, the Center for Biological Circuit Design at the California Institute of Technology, and the NSF grant CHE-0533065 (Chemical Bonding Center) to M. N. Stojanovic. E.W. acknowledges NSF awards no. 0093846 and no. 0506468, and Human Frontier Science Program award no. RGY0074/2006-C.D.S. and D.Y.Z. were partially supported by a National Institute of Mental Health Training Grant to the Computation and Neural Systems option at the California Institute of Technology. D.Y.Z. was partially supported by a California Institute of Technology Grubstake award.