Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCγ2-Ca2+-NFATc1 signaling, and suppresses bone loss in mice

Bone

Volumn 60, Issue , 2014, Pages 104-111

  Kim, Ju Young ^a   Cheon, Yoon Hee ^a   Oh, Hyun Mee ^b   Rho, Mun Chual ^b   Erkhembaatar, Munkhsoyol ^a   Kim, Min Seuk ^a   Lee, Chang Hoon ^a   Kim, Jeong Joong ^a   Choi, Min Kyu ^a   Yoon, Kwon Ha ^a   Lee, Myeung Su ^a   Oh, Jaemin ^a  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Calcium oscillation; NFATc1; Oleanolic acid acetate; Osteoclast; PLC 2

Indexed keywords

ACETIC ACID DERIVATIVE; BRUTON TYROSINE KINASE; CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; OLEANOLIC ACID ACETATE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHOLIPASE C GAMMA2; PLANT EXTRACT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; VIGNA ANGULARIS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE EROSION; BONE MARROW; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; FEMUR; GROWTH INHIBITION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIGNA; VIGNA ANGULARIS;

CALCIUM OSCILLATION; NFATC1; OLEANOLIC ACID ACETATE; OSTEOCLAST; PLCΓ2;

ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CALCIUM; CELL DIFFERENTIATION; DOWN-REGULATION; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NFATC TRANSCRIPTION FACTORS; OLEANOLIC ACID; OSTEOCLASTS; PHOSPHOLIPASE C GAMMA; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 84891138187     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.12.013     Document Type: Article

References (41)

1. Eriksen E.F. Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord 2010, 11:219-227.
2. Tanaka S., Nakamura K., Takahasi N., Suda T. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol Rev 2005, 208:30-49.
3. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
4. Lorenzo J., Horowitz M., Choi Y. Osteoimmunology: interactions of the bone and immune system. Endocr Rev 2008, 29:403-440.
5. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007, 7:292-304.
6. Walsh M.C., Kim N., Kadono Y., Rho J., Lee S.Y., Lorenzo J., et al. Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol 2006, 24:33-63.
7. Faccio R., Cremasco V. PLCgamma2: where bone and immune cells find their common ground. Ann N Y Acad Sci 2010, 1192:124-130.
8. Kertesz Z., Gyori D., Kormendi S., Fekete T., Kis-Toth K., Jakus Z., et al. Phospholipase Cgamma2 is required for basal but not oestrogen deficiency-induced bone resorption. Eur J Clin Invest 2012, 42:49-60.
9. Patterson R.L., van Rossum D.B., Nikolaidis N., Gill D.L., Snyder S.H. Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci 2005, 30:688-697.
10. Wang D., Feng J., Wen R., Marine J.C., Sangster M.Y., Parganas E., et al. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity 2000, 13:25-35.
11. Takayanagi H., Kim S., Koga T., Nishina H., Isshiki M., Yoshida H., et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002, 3:889-901.
12. Kim K., Kim J.H., Lee J., Jin H.M., Lee S.H., Fisher D.E., et al. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem 2005, 280:35209-35216.
13. Choi S.W., Yeon J.T., Park K.I., Lee C.H., Youn B.S., Oh J., et al. VapB as a regulator of osteoclastogenesis via modulation of PLCgamma2-Ca(2+)-NFAT signaling. FEBS Lett 2012, 586:263-269.
14. Kwak H.B., Lee B.K., Oh J., Yeon J.T., Choi S.W., Cho H.J., et al. Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression. Bone 2010, 46:724-731.
15. Wu X., Li Z., Yang Z., Zheng C., Jing J., Chen Y., et al. Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-kappaB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear factor of activated T-cells cytoplasmic 1 signaling pathways. J Bone Miner Res 2012, 27:1298-1308.
16. Bharti A.C., Takada Y., Aggarwal B.B. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 2004, 172:5940-5947.
17. Li Y.J., Kim T.H., Kwak H.B., Lee Z.H., Lee S.Y., Jhon G.J. Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption. J Ethnopharmacol 2007, 113:191-198.
18. Itoh T., Hori Y., Atsumi T., Toriizuka K., Nakamura M., Maeyama T., et al. Hot water extract of adzuki (Vigna angularis) suppresses antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Phytother Res 2012, 26:1003-1011.
19. Sato S., Mukai Y., Yamate J., Kato J., Kurasaki M., Hatai A., et al. Effect of polyphenol-containing azuki bean (Vigna angularis) extract on blood pressure elevation and macrophage infiltration in the heart and kidney of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 2008, 35:43-49.
20. Sato S., Yamate J., Hori Y., Hatai A., Nozawa M., Sagai M. Protective effect of polyphenol-containing azuki bean (Vigna angularis) seed coats on the renal cortex in streptozotocin-induced diabetic rats. J Nutr Biochem 2005, 16:547-553.
21. Itoh T., Kita N., Kurokawa Y., Kobayashi M., Horio F., Furuichi Y. Suppressive effect of a hot water extract of adzuki beans (Vigna angularis) on hyperglycemia after sucrose loading in mice and diabetic rats. Biosci Biotechnol Biochem 2004, 68:2421-2426.
22. Mukai Y., Sato S. Polyphenol-containing azuki bean (Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats. J Nutr Biochem 2011, 22:16-21.
23. Kawai A., Fujita K. Small red bean (azuki) sheds biologically active substances as a prerequisite step for germination, one of which displays the antiviral activity against the rabies virus infectivity and infections in culture. Microbiol Immunol 2007, 51:1071-1079.
24. Leibbrandt A., Penninger J.M. RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci 2008, 1143:123-150.
25. Giner-Larza E.M., Máñez S., Recio M.C., Giner R.M., Prieto J.M., Cerdá-Nicolás M., et al. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 2001, 428:137-143.
26. Lee J.Y., Moon H., Kim C.J. Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. Biol Pharm Bull 2010, 33:230-237.
27. Li J.X., Hareyama T., Tezuka Y., Zhang Y., Miyahara T., Kadota S. Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity on osteoclast formation. Planta Med 2005, 71:673-679.
28. Bian Q., Liu S.F., Huang J.H., Yang Z., Tang D.Z., Zhou Q., et al. Oleanolic acid exerts an osteoprotective effect in ovariectomy-induced osteoporotic rats and stimulates the osteoblastic differentiation of bone mesenchymal stem cells in vitro. Menopause 2012, 19:225-233.
29. Zarubin T., Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res 2005, 15:11-18.
30. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001, 22:153-183.
31. Morrison D.K. MAP kinase pathways. Cold Spring Harb Perspect Biol 2012, 4.
32. Rauner M., Sipos W., Pietschmann P. Osteoimmunology. Int Arch Allergy Immunol 2007, 143:31-48.
33. Ji Q.S., Winnier G.E., Niswender K.D., Horstman D., Wisdom R., Magnuson M.A., et al. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci USA 1997, 94:2999-3003.
34. Shirane M., Sawa H., Kobayashi Y., Nakano T., Kitajima K., Shinkai Y., et al. Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis. Development 2001, 128:5173-5180.
35. Graham D.B., Robertson C.M., Bautista J., Mascarenhas F., Diacovo M.J., Montgrain V., et al. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest 2007, 117:3445-3452.
36. Cremasco V., Graham D.B., Novack D.V., Swat W., Faccio R. Vav/phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum 2008, 58:2712-2722.
37. Jakus Z., Simon E., Frommhold D., Sperandio M., Mocsai A. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med 2009, 206:577-593.
38. Koga T., Inui M., Inoue K., Kim S., Suematsu A., Kobayashi E., et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004, 428:758-763.
39. Mao D., Epple H., Uthgenannt B., Novack D.V., Faccio R. PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest 2006, 116:2869-2879.
40. Shinohara M., Koga T., Okamoto K., Sakaguchi S., Arai K., Yasuda H., et al. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 2008, 132:794-806.
41. Suda K., Woo J.T., Takami M., Sexton P.M., Nagai K. Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. J Cell Physiol 2002, 190:101-108.