PLCγ2: Where bone and immune cells find their common ground

Annals of the New York Academy of Sciences

Volumn 1192, Issue , 2010, Pages 124-130

  Faccio, Roberta ^a,b   Cremasco, Viviana ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Arthritis; Bone; Inflammation; Neutrophils; Osteoclasts; PLC 2

Indexed keywords

ACTIN; CALCITONIN RECEPTOR; CALCIUM; CATHEPSIN K; COMPLEMENT COMPONENT C5A; CYTOSKELETON PROTEIN; DIACYLGLYCEROL; FC RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C GAMMA2; PLECKSTRIN; PROTEIN SH2; PROTEIN SH3; PROTEIN TYROSINE KINASE; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; PHOSPHOLIPASE C GAMMA;

ARTHRITIS; AUTOPHOSPHORYLATION; BONE CELL; BONE EROSION; BONE REMODELING; CALCIUM SIGNALING; CALCIUM TRANSPORT; CATALYSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL MEMBRANE; CELL MIGRATION; CONFERENCE PAPER; CYTOPLASM; CYTOSKELETON; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HEMATOPOIETIC SYSTEM; HISTOLOGY; HOMEOSTASIS; HYDROLYSIS; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KNEE; LEUKOCYTE ACTIVATION; MACROPHAGE; MAST CELL; NATURAL KILLER T CELL; ONCOGENE SRC; OSTEOCLAST; OSTEOLYSIS; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNOVIOCYTE; THROMBOCYTE AGGREGATION; UPREGULATION; ANIMAL; AUTOIMMUNE DISEASE; BIOLOGICAL MODEL; BONE; GENETICS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REVIEW;

MUS;

ANIMALS; ARTHRITIS; AUTOIMMUNE DISEASES; BONE AND BONES; HOMEOSTASIS; HUMANS; IMMUNE SYSTEM; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHOLIPASE C GAMMA;

EID: 77950673823     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05217.x     Document Type: Conference Paper

References (39)

1. Tabakoff, B. et al. 1985. Ethanol inhibits the activity of the B formof monoamine oxidase in human platelet and brain tissue. Psychopharmacology (Berl.) 87: 152-156.
2. Takayanagi, H. 2005.Mechanistic insight into osteoclast differentiation in osteoimmunology. J. Mol. Med. 83: 170-179.
3. Takayanagi, H. 2005. Inflammatory bone destruction and osteoimmunology. J. Periodontal. Res. 40: 287-293.
4. Wada, T. et al. 2005. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat. Med. 11: 394-399.
5. Wei, S. et al. 2005. IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest. 115: 282-290.
6. Romas,E.& M.T. Gillespie. 2006. Inflammation-induced bone loss: can it be prevented? Rheum. Dis. Clin. North Am. 32: 759-773.
7. Genovese, M.C. et al. 2005. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N. Engl. J. Med. 353: 1114-1123.
8. Bekker, P.J. et al. 2004. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19: 1059-1066.
9. Wilde, J.I. & S.P. Watson. 2001. Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other? Cell Signal. 13: 691-701.
10. Rebecchi, M.J. & S.N. Pentyala. 2000. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80: 1291-1335.
11. Katan, M. 1998. Families of phosphoinositide-specific phospholipase C: structure and function. Biochim. Biophys. Acta 1436: 5-17.
12. Nishibe, S. et al. 1990. Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science 250: 1253-1256.
13. Nishibe, S. & G. Carpenter. 1990. Tyrosine phosphorylation and the regulation of cell growth: growth factorstimulated tyrosine phosphorylation of phospholipase C. Semin. Cancer Biol. 1: 285-292.
14. Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
15. Carpenter, G. & Q. Ji. 1999. Phospholipase C-gamma as a signal-transducing element. Exp. Cell Res. 253: 15-24.
16. Schmitz, M.L., S. Bacher & O. Dienz. 2003. NF-κB activation pathways induced by T cell costimulation. FASEB J. 17: 2187-2193.
17. Emori, Y. et al. 1989. A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositidehydrolyzing activity. J. Biol. Chem. 264: 21885-21890.
18. Ji, Q.S. et al. 1997. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc. Natl. Acad. Sci. USA 94: 2999-3003.
19. Hashimoto, A. et al. 2000. Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J. Immunol. 165: 1738-1742.
20. Wang, D. et al. 2000. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity 13: 25-35.
21. Wonerow, P. et al. 2003. A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading. J. Biol. Chem. 278: 37520-37529.
22. Graham, D.B. et al. 2007. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav- PLCgamma2 signaling axis in mice. J. Clin. Invest. 117: 3445-3452.
23. Cremasco, V. et al. 2008. Vav/Phospholipase Cgamma2- mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum. 58: 2712-2722.
24. Epple, H. et al. 2008. Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol. Cell Biol. 28: 3610-3622.
25. Mao, D. et al. 2006. PLCgamma2 regulates osteoclastogenesis via its interactionwith ITAMproteins andGAB2. J. Clin. Invest. 116: 2869-2879.
26. Karsenty, G. & E.F. Wagner. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell. 2: 389-406.
27. Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science 289: 1504-1508.
28. Teitelbaum, S.L., M.M. Tondravi & F.P. Ross. 1997. Osteoclasts, macrophages, and the molecular mechanisms of bone resorption. J. Leuk. Biol. 61: 381-388.
29. Horton,M.A. &MH. Helfrich. 1992. Antigenic markers of osteoclasts. In Biology and Physiology of the Osteoclast. Rifkin, B.R. & C.V. Gay, Eds.: 33-54. CRC Press. Boca Raton, FL.
30. Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science 289: 1504-1508.
31. Ruocco, M.G. et al. 2005. IκB kinase (IKK) β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 201: 1677-1687.
32. Xie, Z.H., I. Ambudkar & R.P. Siraganian. 2002. The adaptermolecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells. J. Immunol. 168: 4682-4691.
33. Zou, W. et al. 2007. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176: 877-888.
34. Gil-Henn, H. et al. 2007. Defective microtubuledependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J. Cell Biol. 178: 1053-1064.
35. Lowe, C. et al. 1993. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc. Natl. Acad. Sci. USA 90: 4485-4489.
36. Soriano, P. et al. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702.
37. Nakamura, I. et al. 2001.Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factormediated signals on phospholipase Cgamma in prefusion osteoclasts. J. Cell Biol. 152: 361-373.
38. Jakus, Z. et al. 2009. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J. Exp. Med. 206: 577-593.
39. Wipke, B.T. & P.M. Alen. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J. Immunol. 167: 1601-1608.