-
1
-
-
18344365948
-
Arthritis critically dependent on innate immune system players
-
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FMA, Boackle SA, et al. Arthritis critically dependent on innate immune system players. Immunity 2002;16:157-68.
-
(2002)
Immunity
, vol.16
, pp. 157-168
-
-
Ji, H.1
Ohmura, K.2
Mahmood, U.3
Lee, D.M.4
Hofhuis, F.M.A.5
Boackle, S.A.6
-
3
-
-
2942625705
-
Staging the initiation of autoantibody-induced arthritis: A critical role for immune complexes
-
Wipke BT, Wang Z, Nagengast W, Reichert DE, Allen PM. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J Immunol 2004;172:7694-702.
-
(2004)
J Immunol
, vol.172
, pp. 7694-7702
-
-
Wipke, B.T.1
Wang, Z.2
Nagengast, W.3
Reichert, D.E.4
Allen, P.M.5
-
4
-
-
84884236003
-
Antibody-induced arthritis: Disease mechanisms and genes involved at the effector phase of arthritis [review]
-
Nandakumar K, Holmdahl R. Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis [review]. Arthritis Res Ther 2006;8:223.
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 223
-
-
Nandakumar, K.1
Holmdahl, R.2
-
5
-
-
0035043710
-
The neutrophil: Function and regulation in innate and humoral immunity
-
Burg ND, Pillinger MH. The neutrophil: function and regulation in innate and humoral immunity. Clin Immunol 2001;99:7-17.
-
(2001)
Clin Immunol
, vol.99
, pp. 7-17
-
-
Burg, N.D.1
Pillinger, M.H.2
-
6
-
-
33344468233
-
Neutrophils and immunity: Challenges and opportunities
-
Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006;6:173-82.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 173-182
-
-
Nathan, C.1
-
7
-
-
0032781554
-
Integrin signalling in neutrophils and macrophages
-
Berton G, Lowell CA. Integrin signalling in neutrophils and macrophages. Cell Signal 1999;11:621-35.
-
(1999)
Cell Signal
, vol.11
, pp. 621-635
-
-
Berton, G.1
Lowell, C.A.2
-
8
-
-
0037145037
-
Integrins: Bidirectional, allosteric signaling machines
-
Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-87.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
9
-
-
0027459771
-
Signal transduction from the extracellular matrix
-
Juliano RL, Haskill S. Signal transduction from the extracellular matrix. J Cell Biol 1993;120:577-85.
-
(1993)
J Cell Biol
, vol.120
, pp. 577-585
-
-
Juliano, R.L.1
Haskill, S.2
-
10
-
-
0029876080
-
Integrin signaling and matrix assembly
-
Ruoslahti E. Integrin signaling and matrix assembly. Tumour Biol 1996;17:117-24.
-
(1996)
Tumour Biol
, vol.17
, pp. 117-124
-
-
Ruoslahti, E.1
-
11
-
-
30044447736
-
Immune cell migration in inflammation: Present and future therapeutic targets
-
Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 2005;6:1182-90.
-
(2005)
Nat Immunol
, vol.6
, pp. 1182-1190
-
-
Luster, A.D.1
Alon, R.2
von Andrian, U.H.3
-
12
-
-
34447314985
-
Integrin modulation and signaling in leukocyte adhesion and migration
-
Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev 2007;218:126-34.
-
(2007)
Immunol Rev
, vol.218
, pp. 126-134
-
-
Rose, D.M.1
Alon, R.2
Ginsberg, M.H.3
-
13
-
-
0029786988
-
Knockouts of Src-family kinases: Stiff bones, wimpy T cells, and bad memories
-
Lowell CA, Soriano P. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev 1996;10:1845-57.
-
(1996)
Genes Dev
, vol.10
, pp. 1845-1857
-
-
Lowell, C.A.1
Soriano, P.2
-
14
-
-
23844538589
-
The Vav family: At the crossroads of signaling pathways
-
Swat W, Fujikawa K. The Vav family: at the crossroads of signaling pathways. Immunol Res 2005;32:259-65.
-
(2005)
Immunol Res
, vol.32
, pp. 259-265
-
-
Swat, W.1
Fujikawa, K.2
-
15
-
-
3342903325
-
Vav GEFs are required for β2 integrin-dependent functions of neutrophils
-
Gakidis MAM, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, et al. Vav GEFs are required for β2 integrin-dependent functions of neutrophils. J. Cell Biol 2004;166:273-82.
-
(2004)
J. Cell Biol
, vol.166
, pp. 273-282
-
-
Gakidis, M.A.M.1
Cullere, X.2
Olson, T.3
Wilsbacher, J.L.4
Zhang, B.5
Moores, S.L.6
-
16
-
-
33746901647
-
Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
-
Graham DB, Cella M, Giurisato E, Fujikawa K, Miletic AV, Kloeppel T, et al. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol 2006;177:2349-55.
-
(2006)
J Immunol
, vol.177
, pp. 2349-2355
-
-
Graham, D.B.1
Cella, M.2
Giurisato, E.3
Fujikawa, K.4
Miletic, A.V.5
Kloeppel, T.6
-
17
-
-
0036631548
-
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
-
Turner M, Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol 2002;2:476-86.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 476-486
-
-
Turner, M.1
Billadeau, D.D.2
-
18
-
-
0035473464
-
Vav proteins, adaptors and cell signaling
-
Bustelo XR. Vav proteins, adaptors and cell signaling. Oncogene 2001;20:6372-81.
-
(2001)
Oncogene
, vol.20
, pp. 6372-6381
-
-
Bustelo, X.R.1
-
19
-
-
36049012968
-
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice
-
Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, et al. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice. J Clin Invest 2007;117:3445-52.
-
(2007)
J Clin Invest
, vol.117
, pp. 3445-3452
-
-
Graham, D.B.1
Robertson, C.M.2
Bautista, J.3
Mascarenhas, F.4
Diacovo, M.J.5
Montgrain, V.6
-
20
-
-
21644478210
-
PLCγ1 is essential for early events in integrin signalling required for cell motility
-
Jones NP, Peak J, Brader S, Eccles SA, Katan M. PLCγ1 is essential for early events in integrin signalling required for cell motility. J Cell Sci 2005;118:2695-706.
-
(2005)
J Cell Sci
, vol.118
, pp. 2695-2706
-
-
Jones, N.P.1
Peak, J.2
Brader, S.3
Eccles, S.A.4
Katan, M.5
-
21
-
-
34547866453
-
Role of phospholipase Cγ1 in cell spreading requires association with a β-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1
-
Jones NP, Katan M. Role of phospholipase Cγ1 in cell spreading requires association with a β-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Bio. 2007;27:5790-805.
-
(2007)
Mol Cell Bio
, vol.27
, pp. 5790-5805
-
-
Jones, N.P.1
Katan, M.2
-
22
-
-
0034874686
-
Regulation of phospholipase Cγ isoforms in haematopoietic cells: Why one, not the other?
-
Wilde JI, Watson SP. Regulation of phospholipase Cγ isoforms in haematopoietic cells: why one, not the other? Cell Signal 2001;13:691-701.
-
(2001)
Cell Signal
, vol.13
, pp. 691-701
-
-
Wilde, J.I.1
Watson, S.P.2
-
23
-
-
0141733167
-
A critical role for phospholipase Cγ2 in αIIbβ3-mediated platelet spreading
-
Wonerow P, Pearce AC, Vaux DJ, Watson SP. A critical role for phospholipase Cγ2 in αIIbβ3-mediated platelet spreading. J Biol Chem 2003;278:37520-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 37520-37529
-
-
Wonerow, P.1
Pearce, A.C.2
Vaux, D.J.3
Watson, S.P.4
-
24
-
-
44349124603
-
Phospholipase Cγ2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase
-
Epple H, Cremasco V, Zhang K, Mao D, Longmore GD, Faccio R. Phospholipase Cγ2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol 2008;28:3610-22.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3610-3622
-
-
Epple, H.1
Cremasco, V.2
Zhang, K.3
Mao, D.4
Longmore, G.D.5
Faccio, R.6
-
25
-
-
0033624638
-
Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors
-
Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, et al. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 2000;13:25-35.
-
(2000)
Immunity
, vol.13
, pp. 25-35
-
-
Wang, D.1
Feng, J.2
Wen, R.3
Marine, J.C.4
Sangster, M.Y.5
Parganas, E.6
-
26
-
-
10744222965
-
Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells
-
Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med 2003;198:1595-608.
-
(2003)
J Exp Med
, vol.198
, pp. 1595-1608
-
-
Fujikawa, K.1
Miletic, A.V.2
Alt, F.W.3
Faccio, R.4
Brown, T.5
Hoog, J.6
-
27
-
-
33750597150
-
PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
-
Mao D, Epple H, Uthgenannt B, Novack DV, Faccio R. PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest 2006;116:2869-79.
-
(2006)
J Clin Invest
, vol.116
, pp. 2869-2879
-
-
Mao, D.1
Epple, H.2
Uthgenannt, B.3
Novack, D.V.4
Faccio, R.5
-
28
-
-
0033118675
-
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
-
Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, et al. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity 1999;10:451-61.
-
(1999)
Immunity
, vol.10
, pp. 451-461
-
-
Korganow, A.S.1
Ji, H.2
Mangialaio, S.3
Duchatelle, V.4
Pelanda, R.5
Martin, T.6
-
29
-
-
0033974061
-
Regulatory and signaling properties of the Vav family
-
Bustelo XR. Regulatory and signaling properties of the Vav family. Mol Cell Biol 2000;20:1461-77.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1461-1477
-
-
Bustelo, X.R.1
-
30
-
-
34250320112
-
A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis
-
Katschke KJ Jr, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, et al. A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med 2007;204:1319-25.
-
(2007)
J Exp Med
, vol.204
, pp. 1319-1325
-
-
Katschke Jr, K.J.1
Helmy, K.Y.2
Steffek, M.3
Xi, H.4
Yin, J.5
Lee, W.P.6
-
31
-
-
34147120256
-
Vav proteins control MyD88-dependent oxidative burst
-
Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, et al. Vav proteins control MyD88-dependent oxidative burst. Blood 2007;109:3360-8.
-
(2007)
Blood
, vol.109
, pp. 3360-3368
-
-
Miletic, A.V.1
Graham, D.B.2
Montgrain, V.3
Fujikawa, K.4
Kloeppel, T.5
Brim, K.6
-
32
-
-
0031843293
-
Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice
-
Andrew DP, Spellberg JP, Takimoto H, Schmits R, Mak TW, Zukowski MM. Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice. Eur J Immunol 1998;28:1959-69.
-
(1998)
Eur J Immunol
, vol.28
, pp. 1959-1969
-
-
Andrew, D.P.1
Spellberg, J.P.2
Takimoto, H.3
Schmits, R.4
Mak, T.W.5
Zukowski, M.M.6
-
33
-
-
0032729875
-
Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
-
Ding ZM, Babensee JE, Simon SI, Lu H, Perrard JL, Bullard DC, et al. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 1999;163:5029-38.
-
(1999)
J Immunol
, vol.163
, pp. 5029-5038
-
-
Ding, Z.M.1
Babensee, J.E.2
Simon, S.I.3
Lu, H.4
Perrard, J.L.5
Bullard, D.C.6
-
34
-
-
30144435908
-
SLP-76 regulates Fcγ receptor and integrin signaling in neutrophils
-
Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, et al. SLP-76 regulates Fcγ receptor and integrin signaling in neutrophils. Immunity 2003;19:761-9.
-
(2003)
Immunity
, vol.19
, pp. 761-769
-
-
Newbrough, S.A.1
Mocsai, A.2
Clemens, R.A.3
Wu, J.N.4
Silverman, M.A.5
Singer, A.L.6
-
35
-
-
0033555864
-
Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck
-
Mocsai A, Ligeti E, Lowell CA, Berton G. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol 1999;162:1120-6.
-
(1999)
J Immunol
, vol.162
, pp. 1120-1126
-
-
Mocsai, A.1
Ligeti, E.2
Lowell, C.A.3
Berton, G.4
-
36
-
-
33745313872
-
The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β2 integrin affinity and valency in neutrophils, but are required for β2 integrin-mediated outside-in signaling involved in sustained adhesion
-
Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, et al. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β2 integrin affinity and valency in neutrophils, but are required for β2 integrin-mediated outside-in signaling involved in sustained adhesion. J Immunol 2006;177:604-11.
-
(2006)
J Immunol
, vol.177
, pp. 604-611
-
-
Giagulli, C.1
Ottoboni, L.2
Caveggion, E.3
Rossi, B.4
Lowell, C.5
Constantin, G.6
-
37
-
-
0345493897
-
Diverse effects of neutrophil integrin occupation on respiratory burst activation
-
Yan SR, Novak MJ. Diverse effects of neutrophil integrin occupation on respiratory burst activation. Cell Immunol 1999;195:119-26.
-
(1999)
Cell Immunol
, vol.195
, pp. 119-126
-
-
Yan, S.R.1
Novak, M.J.2
-
38
-
-
34547470906
-
Pathological role of osteoclast costimulation in arthritis-induced bone loss
-
Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, et al. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc Natl Acad Sci U S A 2007;104:11394-9.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 11394-11399
-
-
Ochi, S.1
Shinohara, M.2
Sato, K.3
Gober, H.J.4
Koga, T.5
Kodama, T.6
-
39
-
-
24944498854
-
Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
-
Genovese MC, Becker JC, Schiff M, Luggen M, Sherrer Y, Kremer J, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N Engl J Med 2005;353:1114-23.
-
(2005)
N Engl J Med
, vol.353
, pp. 1114-1123
-
-
Genovese, M.C.1
Becker, J.C.2
Schiff, M.3
Luggen, M.4
Sherrer, Y.5
Kremer, J.6
-
40
-
-
3342982829
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker PJ, Holloway DL, Rasmussen AS, Murphy R, Martin SW, Leese PT, et al. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004;19:1059-66.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
Murphy, R.4
Martin, S.W.5
Leese, P.T.6
-
41
-
-
16244368766
-
Vav3 regulates osteoclast function and bone mass
-
Faccio R, Teitelbaum SL, Fujikawa K, Chappel J, Zallone A, Tybulewicz VL, et al. Vav3 regulates osteoclast function and bone mass. Nat Med 2005;11:284-90.
-
(2005)
Nat Med
, vol.11
, pp. 284-290
-
-
Faccio, R.1
Teitelbaum, S.L.2
Fujikawa, K.3
Chappel, J.4
Zallone, A.5
Tybulewicz, V.L.6
-
43
-
-
33747150762
-
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy
-
Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, et al. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 2006;25:271-83.
-
(2006)
Immunity
, vol.25
, pp. 271-283
-
-
Hirahashi, J.1
Mekala, D.2
Van Ziffle, J.3
Xiao, L.4
Saffaripour, S.5
Wagner, D.D.6
-
44
-
-
0036168150
-
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
-
Adkison AM, Raptis SZ, Kelley DG, Pham CT. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J Clin Invest 2002;109:363-71.
-
(2002)
J Clin Invest
, vol.109
, pp. 363-371
-
-
Adkison, A.M.1
Raptis, S.Z.2
Kelley, D.G.3
Pham, C.T.4
-
45
-
-
0033046051
-
Integrin signal transduction in myeloid leukocytes
-
Lowell CA, Berton G. Integrin signal transduction in myeloid leukocytes. J Leukoc Biol 1999;65:313-20.
-
(1999)
J Leukoc Biol
, vol.65
, pp. 313-320
-
-
Lowell, C.A.1
Berton, G.2
-
46
-
-
33947620178
-
Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing
-
Clemens RA, Lenox LE, Kambayashi T, Bezman N, Maltzman JS, Nichols KE, et al. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 2007;178:4606-14.
-
(2007)
J Immunol
, vol.178
, pp. 4606-4614
-
-
Clemens, R.A.1
Lenox, L.E.2
Kambayashi, T.3
Bezman, N.4
Maltzman, J.S.5
Nichols, K.E.6
-
47
-
-
24144471857
-
Adsorptive granulocyte/monocyte apheresis for the treatment of refractory rheumatoid arthritis: An open pilot multicentre trial
-
Sanmarti R, Marsal S, Valverde J, Casado E, Lafuente R, Kashiwagi N, et al. Adsorptive granulocyte/monocyte apheresis for the treatment of refractory rheumatoid arthritis: an open pilot multicentre trial. Rheumatology (Oxford) 2005;44:1140-4.
-
(2005)
Rheumatology (Oxford)
, vol.44
, pp. 1140-1144
-
-
Sanmarti, R.1
Marsal, S.2
Valverde, J.3
Casado, E.4
Lafuente, R.5
Kashiwagi, N.6
-
48
-
-
0035423403
-
Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis
-
Wipke BT, Allen PM. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 2001;167:1601-8.
-
(2001)
J Immunol
, vol.167
, pp. 1601-1608
-
-
Wipke, B.T.1
Allen, P.M.2
|