R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: A 4-month feeding study in mice

Nutrition

Volumn 30, Issue 2, 2014, Pages 228-233

  Nikolai, Sibylle ^a   Huebbe, Patricia ^a   Metges, Cornelia C ^b   Schloesser, Anke ^a   Dose, Janina ^a   Ikuta, Naoko ^c,d   Terao, Keiji ^e   Matsugo, Seiichi ^d   Rimbach, Gerald ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

^e KIBC654R 5 5 2 Minatojima minamimachi Chuo ku   (Japan)

Author keywords

cyclodextrin; Brown adipose tissue; Energy expenditure; Lipoic acid; Mice; Uncoupling protein

Indexed keywords

GAMMA CYCLODEXTRIN; IODOTHYRONINE DEIODINASE 2; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 3; THIOCTIC ACID; THYROID PEROXIDASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; BROWN ADIPOSE TISSUE; CALORIMETRY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; ENERGY EXPENDITURE; ENERGY METABOLISM; ENZYME INDUCTION; EXPERIMENTAL MOUSE; FEMALE; GENE EXPRESSION; HOUSEKEEPING GENE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WESTERN BLOTTING;

BROWN ADIPOSE TISSUE; ENERGY EXPENDITURE; LIPOIC ACID; MICE; UNCOUPLING PROTEIN; Γ-CYCLODEXTRIN;

ADIPOSE TISSUE, BROWN; ANIMALS; CALORIMETRY, INDIRECT; DIET, HIGH-FAT; ENERGY METABOLISM; FEMALE; GAMMA-CYCLODEXTRINS; IODIDE PEROXIDASE; ION CHANNELS; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIRTUIN 3; THIOCTIC ACID; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84891128542     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2013.08.002     Document Type: Article

References (38)

1. Bustamante J., Lodge J.K., Marcocci L., Tritschler H.J., Packer L., Rihn B.H. α-Lipoic acid in liver metabolism and disease. Free Radic Biol Med 1998, 24:1023-1039.
2. Wagner A.E., Ernst I.M., Birringer M., Sancak O., Barella L., Rimbach G. A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. Oxid Med Cell Longev 2012, 2012:835970.
3. Packer L., Kraemer K., Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 2001, 17:888-895.
4. Hagen T.M., Ingersoll R.T., Lykkesfeldt J., Liu J., Wehr C.M., Vinarsky V., et al. (R)-Alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J 1999, 13:411-418.
5. Wang Y., Li X., Guo Y., Chan L., Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism 2010, 59:967-976.
6. Finlay L.A., Michels A.J., Butler J.A., Smith E.J., Monette J.S., Moreau R.F., et al. R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. Am J Physiol Regul Integr Comp Physiol 2012, 302:R587-R597.
7. Sparks L.M., Xie H., Koza R.A., Mynatt R., Hulver M.W., Bray G.A., et al. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005, 54:1926-1933.
8. Jia L., Liu Z., Sun L., Miller S.S., Ames B.N., Cotman C.W., et al. A toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci 2007, 48:339-348.
9. Ikuta N., Sugiyama H., Shimosegawa H., Nakane R., Ishida Y., Uekaji Y., et al. Analysis of the enhanced stability of R(+)-alpha lipoic acid by the complex formation with cyclodextrins. Int J Mol Sci 2013, 14:3639-3655.
10. Boesch-Saadatmandi C., Egert S., Schrader C., Coumol X., Barouki R., Muller M.J., et al. Effect of quercetin on paraoxonase 1 activity-studies in cultured cells, mice and humans. J Physiol Pharmacol 2010, 61:99-105.
11. Cremer D.R., Rabeler R., Roberts A., Lynch B. Safety evaluation of α-lipoic acid (ALA). Regul Toxicol Pharmacol 2006, 46:29-41.
12. Xiao Y., Cui J., Shi Y., Le G. Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet. Nutr Res 2011, 31:309-317.
13. Cui J., Xiao Y., Shi Y.H., Wang B., Le G.W. Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression. Nutrition 2012, 28:275-280.
14. Abadi A., Crane J.D., Ogborn D., Hettinga B., Akhtar M., Stokl A., et al. Supplementation with α-lipoic acid, CoQ10, and vitamin E augments running performance and mitochondrial function in female mice. PLoS One 2013, 8:e60722.
15. Cremer D.R., Rabeler R., Roberts A., Lynch B. Long-term safety of α-lipoic acid (ALA) consumption: a 2-year study. Regul Toxicol Pharmacol 2006, 46:193-201.
16. Packer L., Weber S.U., Rimbach G. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr 2001, 131:369S-373S.
17. Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 2009, 1790:1149-1160.
18. Kondo H., Nakatani H., Hiromi K. Invitro action of human and porcine a-amylases on cyclo-malto-oligosaccharides. Carbohydr Res 1990, 204:207-213.
19. Lumholdt L.R., Holm R., Jørgensen E.B., Larsen K.L. Invitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene. Carbohydr Res 2012, 362:56-61.
20. Iwamoto H., Ohmori M., Ohno M., Hirose J., Hiromi K., Fukada H., Takahashi K., Hashimoto H., Sakai S. Interaction between pullulanase from Klebsiella pneumoniae and cyclodextrins. J Biochem 1993, 113:93-96.
21. Belshaw N.J., Williamson G. Interaction of b-cyclodextrin with the granular starch binding domain of glucoamylase. Biochim Biophys Acta 1991, 1078:117-120.
22. Fukuda K., Teramoto Y., Goto M., Sakamoto J., Mitsuiki S., Hayashida S. Specific inhibition by cyclodextrins of raw starch digestion by fungal glucoamylase. Biosci Biotech Biochem 1992, 56:556-559.
23. Kopecky J., Clarke G., Enerbäck S., Spiegelman B., Kozak L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995, 96:2914-2923.
24. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999, 98:115-124.
25. Hokari F., Kawasaki E., Sakai A., Koshinaka K., Sakuma K., Kawanaka K. Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. J Appl Physiol 2010, 109:332-340.
26. Shi T., Wang F., Stieren E., Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 2005, 280:13560-13567.
27. Lin S.C., Li P. CIDE-A, a novel link between brown adipose tissue and obesity. Trends Mol Med 2004, 10:434-439.
28. Marsili A., Aguayo-Mazzucato C., Chen T., Kumar A., Chung M., Lunsford E.P., et al. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One 2011, 6:e20832.
29. Villena J.A., Hock M.B., Chang W.Y., Barcas J.E., Giguère V., Kralli A. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci USA 2007, 104:1418-1423.
30. Kong X., Wang R., Xue Y., Liu X., Zhang H., Chen Y., et al. Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PlosOne 2010, 5:e11707.
31. Kozak L. The genetics of brown adipocyte induction in white fat depots. Front Endocrinol (Lausanne) 2011, 2:64.
32. Bianco A.C., Silva J.E. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol 1987, 253:E255-E263.
33. Scarpace P.J., Matheny M., Pollock B.H., Tümer N. Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol 1997, 273:E226-E230.
34. Schrauwen P., Xia J., Bogardus C., Pratley R.E., Ravussin E. Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes 1999, 48:146-149.
35. Ricquier D. Respiration uncoupling and metabolism in the control of energy expenditure. Proc Nutr Soc 2005, 64:47-52.
36. Kozak L.P., Harper M.E. Mitochondrial uncoupling proteins in energy expenditure. Annu Rev Nutr 2000, 20:339-363.
37. Suzuki D., Murata Y., Oda S.-I. Changes in Ucp1, D2 (Dio2) and Glut 4 (Slc2a4) mRNA expression in response to short-term cold exposure in the house musk shrew (Suncus murinus). Exp Anim 2007, 56:279-288.
38. Vosselman M.J., van Marken Lichtenbelt W.D., Schrauwen P. Energy dissipation in brown adipose tissue: from mice to men. Mol Cell Endocrinol 2013 Apr 28, pii:S0303-7207(13)00162-7.