Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet

Nutrition Research

Volumn 31, Issue 4, 2011, Pages 309-317

  Xiao, Ying ^a,b   Cui, Jue ^a,c   Shi, Yonghui ^b   Le, Guowei ^b  

^a SHANGHAI INSTITUTE OF TECHNOLOGY   (China)

^b School of Food Science and Technology   (China)

^c XUZHOU INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Antioxidants; Bone; CDNA microarray; Gene expression; High fat diet; Lipoic acid; Mice

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CATHEPSIN K; COLLAGEN TYPE 1; GELATINASE B; PROTEIN P53; SOMATOMEDIN C; THIOCTIC ACID; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DENSITY; BONE MASS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA MICROARRAY; DOWN REGULATION; DYSLIPIDEMIA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; LIPID DIET; LIPID METABOLISM; MALE; METABOLIC BALANCE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; DIETARY FATS; DIETARY SUPPLEMENTS; DOWN-REGULATION; GENE EXPRESSION; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-12 SUBUNIT P35; INTERLEUKIN-17; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOGENESIS; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THIOCTIC ACID; UP-REGULATION;

MUS;

EID: 79955446717     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2011.03.013     Document Type: Article

References (43)

1. Boukhris R., Becker K.L. Calcification of the aorta and osteoporosis. A roentgenographic study. JAMA 1972, 219:1307-1311.
2. Parhami F., Tintut Y., Beamer W.G., Gharavi N., Goodman W., Demer L.L. Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res 2001, 16:182-188.
3. Lac G., Gavalie H., Ebal E., Michaux O. Effects of a high fat diet on bone of growing rat. Correlations between visceral fat, adiponectin and bone mass density. Lipids Health Dis 2008, 7:16.
4. Hou J.C.H., Zernicke R.F., Barnard R.J. High-fat sucrose diet effects on femoral neck geometry and biomechanics. Clin Biomech 1990, 5:162-168.
5. Starkey L.J., Johnson-Down L., Gray-Donald K. Food habits of Canadians: comparison of intakes in adults and adolescents to Canada's food guide to healthy eating. Can J Diet Pract Res 2001, 6:61-69.
6. Sichieri R. Is fat intake important in the public health control of obesity?. Am J Clin Nutr 2000, 72:203-204.
7. Yang R.L., Li W., Shi Y.H., Le G.W. Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis. Nutrition 2008, 24:582-588.
8. Patel C., Ghanim H., Ravishankar S., Sia C.L., Viswanathan P., Mohanty P., et al. Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab 2007, 92:4476-4479.
9. D'Amelio P., Cristofaro M.A., Tamone C., Morra E., Bella S.D., Isaia G., et al. Role of iron metabolism and oxidative damage in postmenopausal bone loss. Bone 2008, 43:1010-1015.
10. Hamada Y., Fujii H., Fukagawa M. Role of oxidative stress in diabetic bone disorder. Bone 2009, 45:S35-S38.
11. Garrett I.R., Boyce B.F., Oretto R.O., Bonewald L., Poser J., Mundy G.R. Oxygen derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990, 85:632-639.
12. Mody N., Parhami F., Sarafian T.A., Demer L.L. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 2001, 31:509-519.
13. Sheweita S.A., Khoshhal K.I. Calcium metabolism and oxidative stress in bone fractures: role of antioxidants. Curr Drug Metab 2007, 8:519-525.
14. Xiao Y., Cui J., Li Y.X., Shi Y.H., Wang B., Le G.W., et al. Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity. Nutrition 2011, 27:214-220.
15. Sreekumar R., Unnikrishnan J., Fu A., Nygren J., Short K.R., Schimke J., et al. Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. Am J Physiol Endocrinol Metab 2002, 282:E1055-E1061.
16. Shay K.P., Moreau R.F., Smith E.J., Smith A.R., Hagen T.M. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 2009, 1790:1149-1160.
17. Flavia N.I., Mike F.Q., Cristina S. Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species. Plant Physiol Biochem 2002, 40:463-470.
18. Li Y., Zhao Y., Yu W., Jiang S. Scavenging ability on ROS of alpha-lipoic acid (ALA). Food Chem 2004, 84:563-567.
19. Scott B.C., Aruoma O.I., Evans P.J., Neill C., Van der Vliet A., Cross C.E., et al. Lipoic and dihydrolipoic acids as antioxidant. A critical evaluation. Free Radic Res 1994, 20:119-133.
20. Kim H.J., Chang E.J., Kim H.M., Lee S.B., Kim H.D., Su Kim G., et al. Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med 2006, 40:1483-1493.
21. Ha H., Lee J.H., Kim H.N., Kim H.M., Kwak H.B., Lee S., et al. Alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J Immunol 2006, 176:111-117.
22. Mishra K.P. Cell membrane oxidative damage induced by gamma-radiation and apoptotic sensitivity. J Environ Pathol Toxicol Oncol 2004, 23:61-66.
23. Amstad P.A., Krupitza G., Cerutti P. Mechanism of c-fos induction by active oxygen. Cancer Res 1992, 52:3952-3960.
24. Mohamed A.K., Bierhaus A., Schiekofer S., Tritschler H., Ziegler R., Nawroth P.P. The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 1999, 10:157-167.
25. Paigen B., Morrow A., Brandon C., Mitchell D., Holmes P. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 1985, 57:65-73.
26. Halloran B.P., Ferguson V.L., Simske S.J., Burghardt A., Venton L.L., Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res 2002, 17:1044-1050.
27. Muthusami S., Ramachandran I., Muthusamy B., Vasudevan G., Prabhu V., Subramaniam V., et al. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 2005, 360:81-86.
28. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with folin phenol reagent. J Biol Chem 1951, 193:265-275.
29. Bertin E., Ruiz J.C., Mourot J., Peiniau P., Portha B. Evaluation of dual-energy X-ray absorptiometry for body-composition assessment in rats. J Nutr 1998, 128:1550-1554.
30. Zernicke R.F., Salem G.J., Barnard R.J., Schramm E. Long-term, high-fat-sucrose diet alters rat femoral neck and vertebral morphology, bone mineral content, and mechanical properties. Bone 1995, 16:25-31.
31. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
32. Reddy A.J., Kleeberger S.R. Knockdown of NQO1 leads to decreased production of ROS after exposure to hyperoxia. Proc Am Thorac Soc 2008, 5:368.
33. Lambeth J.D. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med 2007, 43:332-347.
34. Schoppet M., Preissner K.T., Hofbauer L.C. RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function. Arterioscler Thromb Vasc Biol 2002, 22:549-553.
35. Burr D.B. The contribution of the organic matrix to bone's material properties. Bone 2002, 31:8-11.
36. Sims N.A., Clément-Lacroix P., Da Ponte F., Bouali Y., Binart N., Moriggl R., et al. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest 2000, 106:1095-1103.
37. Miyakoshi N., Richman C., Qin X., Baylink D.J., Mohan S. Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Endocrinology 1999, 140:5719-5728.
38. Wang X., Kua H.Y., Hu Y., Guo K., Zeng Q., Wu Q., et al. p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 2006, 172:115-125.
39. Asher G., Lotem J., Kama R., Sachs L., Shaul Y. NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci USA 2002, 99:3099-3104.
40. Ergen H.A., Gormus U., Narter F., Zeybek U., Bulgurcuoglu S., Isbir T. Investigation of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer. Anticancer Res 2007, 27:4107-4110.
41. Fuller K., Lean J.M., Bayley K.E., Wani M.R., Chambers T.J. A role of TGF_B in osteoclast differentiation and survival. J Cell Bio 2000, 113:2445-2453.
42. Miljkovic D.j., Cvetkovic I., Vuckovic O., Stosic-Grujicic S., Mostarica Stojkovic M., Trajkovic V. The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells. Cell Mol Life Sci 2003, 60:518-525.
43. Kitaura H., Nagata N., Fujimura Y., Hotokezaka H., Yoshida N., Nakayama K. Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas/Fas ligand interaction. J Immunol 2002, 169:4732-4738.