Respiration uncoupling and metabolism in the control of energy expenditure

Proceedings of the Nutrition Society

Volumn 64, Issue 1, 2005, Pages 47-52

  Ricquier, Daniel ^a  

^a CNRS   (France)

Author keywords

Brown adipose tissue; Energy expenditure; Respiration uncoupling; Uncoupling protein 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

BODY FAT; BROWN ADIPOSE TISSUE; CATABOLISM; COLD EXPOSURE; CONFERENCE PAPER; ENERGY BALANCE; ENERGY EXPENDITURE; EXERCISE; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HUMAN; METABOLIC REGULATION; METABOLISM; MOUSE; NONHUMAN; NUTRIENT; OBESITY; PROTEIN INDUCTION; SKELETAL MUSCLE; THERMOGENESIS; WHITE ADIPOSE TISSUE;

ADENOSINE TRIPHOSPHATE; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; CARRIER PROTEINS; ENERGY METABOLISM; HUMANS; ION CHANNELS; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; OBESITY; THERMOGENESIS;

EID: 18844458927     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2004408     Document Type: Conference Paper

References (50)

1. Alves-Guerra MC, Rousset S, Pecqueur C, Mallat Z, Blanc J, Tedgui A, Bouillaud F, Cassard-Doulcier AM, Ricquier D & Miroux B (2003) Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and non immune cells during inflammation. Journal of Biological Chemistry 278, 42307-42312.
2. Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R & Horvath TL (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochemical Pharmacology 64, 363-367.
3. Blanc J, Alves-Guerra MC, Esposito B, Rousset S, Gourdy P, Ricquier D, Tedgui A, Miroux B & Mallat Z (2003) Protective role of uncoupling protein 2 in atherosclerosis. Circulation 107, 388-390.
4. Bouchard C, Perusse L, Chagnon YC, Warden C & Ricquier D (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Human Molecular Genetics 11, 1887-1889.
5. Boss O, Hagen T & Lowell BB (2001) Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 49, 143-156.
6. Cadenas S, Echtay KS, Harper JA, Jekabsons MB, Buckingham JA, Grau E, Abuin A, Chapman H, Clapham JC & Brand MD (2002) The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. Journal of Biological Chemistry 277, 2773-2778.
7. Cannon B & Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiological Reviews 84, 277-359.
8. Chan CB, Saleh MC, Koshkin V & Wheeler MB (2004) Uncoupling protein 2 and islet function. Diabetes 53, S136-S142.
9. Clapham C, Arch JR, Chapman H, Haynes A, Lister C, Moore GB et al. (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415-418.
10. Clavel S, Paradis E, Ricquier D & Richard D (2003) Kainic acid upregulated uncoupling protein-2 mRNA expression in the mouse brain. Neuroreport 14, 2015-2017.
11. Collins P, Bing C, McGulloch P & Williams G (2002) Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans. British Journal of Cancer 86, 372-375.
12. Couplan E, Gelly C, Goubern M, Fleury C, Quesson B, Silberberg M et al. (2002a) High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their lib fiber content. Journal of Biological Chemistry 277, 43079-43088.
13. Couplan E, Gonzalez-Barroso MM, Alves-Guerra MC, Ricquier D, Goubern M & Bouillaud F (2002b) No evidence for a basal, retinoic or superoxide-induced uncoupling activity of the UCP2 present in spleen or lung mitochondria. Journal of Biological Chemistry 277, 26268-26275.
14. de Bilbao F, Arsenijevic D, Vallet P, Hjelle OP, Ottersen OP, Bouras C et al. (2004) Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. Journal of Neurochemistry 89, 1283-1293.
15. de Lange P, Lanni A, Beneduce L, Moreno M, Lombardi A, Silvestri E & Goglia F (2001) Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone. Endocrinology 142, 3414-3420.
16. Diehl AM & Hoek JB (1999) Mitochondrial uncoupling: Role of uncoupling protein anion carriers and relationship to thermogenesis and weight control 'The benefits of losing control'. Journal of Bioenergetics and Biomembranes 31, 493-505.
17. Dulloo AG & Samec S (2001) Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. British Journal of Nutrition 86, 123-139.
18. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otin M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ & Brand MD (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO Journal 22, 4103-4110.
19. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC & Brand MD (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-99.
20. Garcia-Martinez C, Sibille B, Solanes G, Darimont C, Mace K, Villaroya F & Gomez-Foix AM (2001) Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation. FASEB Journal 11, 2033-2035.
21. Garlid KD & Jaburek M (1998) The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Letters 438, 10-14.
22. Goglia F & Skulachev VP (2003) A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB Journal 17, 1585-1591.
23. Hesselink MKC, Greenhaff PL, Constantin-Teodosiu D, Hultma E, Saris WHM, Nieuwlaat R, Schaart G, Kornips E & Schrauwein P (2003) Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo. Journal of Clinical Investigation 111, 479-486.
24. Hu X, Murphy F, Karwautz A, Li T, Giotakis O, Treasure J & Collier DA (2002) Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa. Molecular Psychiatry 7, 814.
25. Ibrahim SM, Mix E, Böttcher T, Koczan D, Gold R, Rolfs A & Thiesen HJ (2000) Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis. Brain 124, 1927-1938.
26. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, Onoe K, Day NK, Good RA & Ohno H (2002) Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proceedings of the National Academy of Sciences USA 99, 9392-9397.
27. Klingenberg M & Echtay KS (2001) Uncoupling proteins: the issues from a biochemist point of view. Biochimica et Biophysica Acta 1504, 128-143.
28. Kopecky J, Clarke G, Enerback S, Spielgelman B & Kozak LP (1995) Expression of the mitochondrial uncoupling protein gene from the ap2 gene promoter prevents genetic obesity. Journal of Clinical Investigation 96, 2914-2923.
29. Kozak LP & Harper ME (2000) Mitochondrial uncoupling proteins in energy expenditure. Annual Review of Nutrition 20, 339-363.
30. Krauss S, Zhang CY & Lowell BB (2002) A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proceedings of the National Academy of Sciences USA 99, 118-122.
31. Lanouette CM, Giacobino JP, Perusse L, Lacaille M, Yvon C, Chagnon M, Kuhne F, Bouchard C, Muzzin P & Chagnon YC (2001) Association between uncoupling protein 3 gene and obesity-related phenotypes in the Quebec Family Study. Molecular Medicine 7, 433-441.
32. Ledesma A, de Lacoba MG & Rial E (2002) The mitochondrial uncoupling proteins. Genome Biology 3, 3015.1-3015.9.
33. Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO & Semenkovich CF (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nature Medicine 6, 1115-1120.
34. Luft R (1992) Luft's disease revisited. Severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control. Mount Sinai Journal of Medicine 59, 140-145.
35. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, Warden CH, Castilho RF, Melcher T, Gonzalez-Zulueta M, Nikolich K & Wieloch T (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nature Medicine 9, 1062-1068.
36. Mills EM, Banks ML, Sprague JE & Finkel T (2003) Pharmacology: uncoupling the agony from ecstasy. Nature 426, 403-404.
37. Mills EM, Xu D, Fergusson MM, Combs CA, Xu Y & Finkel T (2002) Regulation of cellular oncosis by uncoupling protein 2. Journal of Biochemical Chemistry 277, 27385-27392.
38. Nègre-Salvayre A, Hirtz C, Carrera G, Cazenave R, Troly M, Salvayre R, Penicaud L & Casteilla L (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB Journal 11, 809-815.
39. Nicholls DG & Ferguson SL (2002) Bioenergetics. Amsterdam: Academic Press.
40. Nicholls DG & Locke R (1984) Brown fat thermogenesis. Physiological Reviews 64, 1-64.
41. Paradis E, Clavel S, Bouillaud F, Ricquier D & Richard D (2003) Uncoupling protein-2: a novel player in neuroprotection. Trends in Molecular Medicine 9, 522-525.
42. Pecqueur C, Alves-Guerra MC, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F & Miroux B (2001) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. Journal of Biological Chemistry 276, 8705-8712.
43. Ricquier D & Bouillaud F (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP & AtUCP. Biochemical Journal 345, 161-179.
44. Ricquier D & Kozak LK (2003) Uncoupling proteins. In Handbook of Obesity, pp. 539-558 [GA Bray and C Bouchard, editors]. New York: Marcel Dekker Inc.
45. Ryu JW, Hong KH, Maeng JH, Kim JB, Ko J, Park JY, Lee KU, Hong MK, Park SW, Kim YH & Han KH (2004) Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated firm adhesion and transendothelial migration. Arteriosclerosis, Thrombosis and Vascular Biology 24, 864-870.
46. Sullivan PG, Dube C, Dorenbos K, Steward O & Baram TZ (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Annals of Neurology 53, 711-717.
47. Teshima Y, Akao M, Jones SP & Marban E (2003) Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circulation Research 93, 192-200.
48. Tiraby C & Langin D (2003) Conversion from white to brown adipocytes: a strategy for the control of fat mass? Trends in Endocrinology and Metabolism 14, 439-441.
49. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D & Langin D (2003) Acquirement of brown fat cell features by human white adipocytes. Journal of Biological Chemistry 278, 33370-33376.
50. Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L & Herzenberg LA (2000) Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proceedings of the National Academy of Sciences USA 97, 2680-2685.