메뉴 건너뛰기




Volumn 122, Issue 23, 2013, Pages 3741-3748

The biology and clinical impact of genetic lesions in myeloid malignancies

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; COHESIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; DNA METHYLTRANSFERASE 3A; E1A ASSOCIATED P300 PROTEIN; HISTONE H3; MIXED LINEAGE LEUKEMIA PROTEIN; RETINOBLASTOMA BINDING PROTEIN 2; RNA; TRANSCRIPTION FACTOR EZH2;

EID: 84891083559     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-06-460295     Document Type: Review
Times cited : (48)

References (96)
  • 1
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059-2074.
    • (2013) N Engl J Med , vol.368 , Issue.22 , pp. 2059-2074
  • 2
    • 84878900540 scopus 로고    scopus 로고
    • Clonal Diversity of Recurrently Mutated Genes in myelodysplastic syndromes
    • Walter MJ, Shen D, Shao J, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 2013; 27(6):1275-1282.
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1275-1282
    • Walter, M.J.1    Shen, D.2    Shao, J.3
  • 3
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011; 364(26):2496-2506.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 4
    • 84877928684 scopus 로고    scopus 로고
    • Clonal architecture of chronic myelomonocytic leukemias
    • Itzykson R, Kosmider O, Renneville A, et al. Clonal architecture of chronic myelomonocytic leukemias. Blood. 2013;121(12):2186-2198.
    • (2013) Blood , vol.121 , Issue.12 , pp. 2186-2198
    • Itzykson, R.1    Kosmider, O.2    Renneville, A.3
  • 5
    • 84865062086 scopus 로고    scopus 로고
    • Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis
    • Traina F, Visconte V, Jankowska AM, et al. Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis. PLoS ONE. 2012;7(8): e43090.
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Traina, F.1    Visconte, V.2    Jankowska, A.M.3
  • 6
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the world health organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951.
    • (2009) Blood , Issue.1145 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 7
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-278.
    • (2012) Cell , vol.150 , Issue.2 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 8
    • 84875910316 scopus 로고    scopus 로고
    • Molecular pathophysiology of myelodysplastic syndromes
    • Lindsley RC, Ebert BL. Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol. 2013;8:21-47.
    • (2013) Annu Rev Pathol. , vol.8 , pp. 21-47
    • Lindsley, R.C.1    Ebert, B.L.2
  • 10
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478(7367):64-69.
    • (2011) Nature , vol.478 , Issue.7367 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 11
    • 80054010617 scopus 로고    scopus 로고
    • Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, Cazzola M, Boultwood J, et al; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011;365(15): 1384-1395.
    • (2011) N Engl J Med. , vol.365 , Issue.15 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 12
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • Graubert TA, Shen D, Ding L, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet. 2012; 44(1):53-57
    • (2012) Nat Genet. , vol.44 , Issue.1 , pp. 53-57
    • Graubert, T.A.1    Shen, D.2    Ding, L.3
  • 13
    • 14644431836 scopus 로고    scopus 로고
    • Mammalian polycombmediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    • Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. Mammalian polycombmediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 2005;19(5):536-541.
    • (2005) Genes Dev. , vol.19 , Issue.5 , pp. 536-541
    • Isono, K.1    Mizutani-Koseki, Y.2    Komori, T.3    Schmidt-Zachmann, M.S.4    Koseki, H.5
  • 14
    • 84877721757 scopus 로고    scopus 로고
    • SR proteins collaborate with 7SK and promoter-ssociated nascent RNA to release paused polymerase
    • Ji X, Zhou Y, Pandit S, et al. SR proteins collaborate with 7SK and promoter-ssociated nascent RNA to release paused polymerase. Cell. 2013;153(4):855-868.
    • (2013) Cell , vol.153 , Issue.4 , pp. 855-868
    • Ji, X.1    Zhou, Y.2    Pandit, S.3
  • 15
    • 80455176999 scopus 로고    scopus 로고
    • CTCFpromoted RNA polymerase 2 pausing links DNA methylation to splicing
    • Shukla S, Kavak E, Gregory M, et al. CTCFpromoted RNA polymerase 2 pausing links DNA methylation to splicing. Nature. 2011;479(7371): 74-79.
    • (2011) Nature , vol.479 , Issue.7371 , pp. 74-79
    • Shukla, S.1    Kavak, E.2    Gregory, M.3
  • 16
    • 80054792679 scopus 로고    scopus 로고
    • Alternative transcript initiation and splicing as a response to DNA damage
    • Sprung CN, Li J, Hovan D, McKay MJ, Forrester HB. Alternative transcript initiation and splicing as a response to DNA damage. PLoS ONE. 2011; 6(10):e25758.
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Sprung, C.N.1    Li, J.2    Hovan, D.3    McKay, M.J.4    Forrester, H.B.5
  • 17
    • 65549147264 scopus 로고    scopus 로고
    • DNA damage regulates alternative splicing through inhibition of RNA polymerase 2 elongation
    • Muñoz MJ, Ṕerez Santangelo MS, Paronetto MP, et al. DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. Cell. 2009;137(4):708-720.
    • (2009) Cell , vol.137 , Issue.4 , pp. 708-720
    • Muñoz, M.J.1    Ṕerez Santangelo, M.S.2    Paronetto, M.P.3
  • 18
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012; 481(7382):506-510.
    • (2012) Nature , vol.481 , Issue.7382 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3
  • 19
    • 84863337617 scopus 로고    scopus 로고
    • Clonal architecture of secondary acute myeloid leukemia
    • Walter MJ, Shen D, Ding L, et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med. 2012;366(12): 1090-1098.
    • (2012) N Engl J Med. , vol.366 , Issue.12 , pp. 1090-1098
    • Walter, M.J.1    Shen, D.2    Ding, L.3
  • 20
    • 84868554484 scopus 로고    scopus 로고
    • Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
    • Dolnik A, Engelmann JC, Scharfenberger- Schmeer M, et al. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood. 2012;120(18): e83-e92.
    • (2012) Blood , vol.120 , Issue.18
    • Dolnik, A.1    Engelmann, J.C.2    Scharfenberger-Schmeer, M.3
  • 21
    • 79952030327 scopus 로고    scopus 로고
    • Can corruption of chromosome cohesion create a conduit to cancer?
    • Xu H, Tomaszewski JM, McKay MJ. Can corruption of chromosome cohesion create a conduit to cancer? Nat Rev Cancer. 2011;11(3): 199-210
    • (2011) Nat Rev Cancer. , vol.11 , Issue.3 , pp. 199-210
    • Xu, H.1    Tomaszewski, J.M.2    McKay, M.J.3
  • 22
    • 80051874823 scopus 로고    scopus 로고
    • Mutational inactivation of STAG2 causes aneuploidy in human cancer
    • Solomon DA, Kim T, Diaz-Martinez LA, et al. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011; 333(6045):1039-1043.
    • (2011) Science , vol.333 , Issue.6045 , pp. 1039-1043
    • Solomon, D.A.1    Kim, T.2    Diaz-Martinez, L.A.3
  • 23
    • 84875127327 scopus 로고    scopus 로고
    • CTCF and cohesin: Linking gene regulatory elements with their targets
    • Merkenschlager M, Odom DT. CTCF and cohesin: linking gene regulatory elements with their targets. Cell. 2013;152(6):1285-1297.
    • (2013) Cell , vol.152 , Issue.6 , pp. 1285-1297
    • Merkenschlager, M.1    Odom, D.T.2
  • 24
    • 84875207723 scopus 로고    scopus 로고
    • Chromatin movement in the maintenance of genome stability
    • Dion V, Gasser SM. Chromatin movement in the maintenance of genome stability. Cell. 2013; 152(6):1355-1364.
    • (2013) Cell. , vol.52 , Issue.6 , pp. 1355-1364
    • Dion, V.1    Gasser, S.M.2
  • 25
    • 80052468708 scopus 로고    scopus 로고
    • A role for heterochromatin protein 1g at human telomeres
    • Canudas S, Houghtaling BR, Bhanot M, et al. A role for heterochromatin protein 1g at human telomeres. Genes Dev. 2011;25(17):1807-1819.
    • (2011) Genes Dev , vol.25 , Issue.17 , pp. 1807-1819
    • Canudas, S.1    Houghtaling, B.R.2    Bhanot, M.3
  • 26
    • 70449731229 scopus 로고    scopus 로고
    • Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells
    • Canudas S, Smith S. Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J Cell Biol. 2009;187(2):165-173.
    • (2009) J Cell Biol. , vol.187 , Issue.2 , pp. 165-173
    • Canudas, S.1    Smith, S.2
  • 27
    • 84868534644 scopus 로고    scopus 로고
    • A role for ctcf and cohesin in subtelomere chromatin organization terra transcription and telomere end protection
    • Deng Z, Wang Z, Stong N, et al. A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection. EMBO J. 2012;31(21):4165-4178.
    • (2012) EMBO J. , vol.31 , Issue.21 , pp. 4165-4178
    • Deng, Z.1    Wang, Z.2    Stong, N.3
  • 28
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med. , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 29
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan X-J, Xu J, Gu Z-H, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011; 43(4):309-315.
    • (2011) Nat Genet. , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.-J.1    Xu, J.2    Gu, Z.-H.3
  • 30
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
    • (2012) N Engl J Med. , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gönen, M.2    Figueroa, M.E.3
  • 31
    • 79960735923 scopus 로고    scopus 로고
    • Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
    • Thol F, Damm F, Lüdeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol. 2011; 29(21):2889-2896.
    • (2011) J Clin Oncol. , vol.29 , Issue.21 , pp. 2889-2896
    • Thol, F.1    Damm, F.2    Lüdeking, A.3
  • 32
    • 79960255863 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
    • Walter MJ, Ding L, Shen D, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011; 25(7):1153-1158
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1153-1158
    • Walter, M.J.1    Ding, L.2    Shen, D.3
  • 33
    • 84866749552 scopus 로고    scopus 로고
    • Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
    • Bejar R, Stevenson KE, Caughey BA, et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol. 2012; 30(27):3376-3382.
    • (2012) J Clin Oncol. , vol.30 , Issue.27 , pp. 3376-3382
    • Bejar, R.1    Stevenson, K.E.2    Caughey, B.A.3
  • 34
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX EZH2 and dnmt3a
    • Jankowska AM, Makishima H, Tiu RV, et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood. 2011;118(14): 3932-3941.
    • (2011) Blood , vol.118 , Issue.14 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3
  • 35
    • 79960210747 scopus 로고    scopus 로고
    • DNMT3A mutations in myeloproliferative neoplasms
    • Stegelmann F, Bullinger L, Schlenk RF, et al. DNMT3A mutations in myeloproliferative neoplasms. Leukemia. 2011;25(7):1217-1219.
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1217-1219
    • Stegelmann, F.1    Bullinger, L.2    Schlenk, R.F.3
  • 36
    • 84861702964 scopus 로고    scopus 로고
    • Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms
    • Brecqueville M, Rey J, Bertucci F, et al. Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms. Genes Chromosomes Cancer. 2012;51(8):743-755.
    • (2012) Genes Chromosomes Cancer , vol.51 , Issue.8 , pp. 743-755
    • Brecqueville, M.1    Rey, J.2    Bertucci, F.3
  • 37
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • Figueroa ME, Lugthart S, Li Y, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010;17(1):13-27.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3
  • 38
    • 77449149371 scopus 로고    scopus 로고
    • DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    • Shen L, Kantarjian H, Guo Y, et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010;28(4):605-613.
    • (2010) J Clin Oncol. , vol.28 , Issue.4 , pp. 605-613
    • Shen, L.1    Kantarjian, H.2    Guo, Y.3
  • 39
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood. 2012;119(24):5824-5831.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5824-5831
    • Ribeiro, A.F.1    Pratcorona, M.2    Erpelinck-Verschueren, C.3
  • 40
    • 66749152204 scopus 로고    scopus 로고
    • Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
    • Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle. 2009;8(11):1698-1710.
    • (2009) Cell Cycle , vol.8 , Issue.11 , pp. 1698-1710
    • Iyer, L.M.1    Tahiliani, M.2    Rao, A.3    Aravind, L.4
  • 41
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5- formylcytosine and 5-carboxylcytosine. Science. 2011;333(6047):1300-1303.
    • (2011) Science. , vol.333 , Issue.6047 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3
  • 42
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009;324(5929):930-935.
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 43
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010; 468(7325):839-843.
    • (2010) Nature , vol.468 , Issue.7325 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 44
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 45
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
    • (2009) N Engl J Med. , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della Valle, V.3
  • 46
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and leukemia group B study
    • Metzeler KH, Maharry K, Radmacher MD, et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 2011;29(10):1373-1381.
    • (2011) J Clin Oncol. , vol.29 , Issue.10 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3
  • 47
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet. 2009; 41(7):838-842.
    • (2009) Nat Genet. , vol.41 , Issue.7 , pp. 838-842
    • Langemeijer, S.M.1    Kuiper, R.P.2    Berends, M.3
  • 48
    • 73149094518 scopus 로고    scopus 로고
    • Groupe Francophone des My'elodysplasies. TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
    • Kosmider O, Gelsi-Boyer V, Ciudad M, et al Groupe Francophone des My'elodysplasies. TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia. Haematologica. 2009;94(12):1676-1681.
    • (2009) Haematologica , vol.94 , Issue.12 , pp. 1676-1681
    • Kosmider, O.1    Gelsi-Boyer, V.2    Ciudad, M.3
  • 49
    • 77956237515 scopus 로고    scopus 로고
    • Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1
    • Kohlmann A, Grossmann V, Klein H-U, et al. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol. 2010;28(24): 3858-3865.
    • (2010) J Clin Oncol. , vol.28 , Issue.24 , pp. 3858-3865
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.-U.3
  • 50
    • 67651065502 scopus 로고    scopus 로고
    • Genetic Characterization of TET1 TET2 and TET3 alterations in myeloid malignancies
    • Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114(1):144-147.
    • (2009) Blood , vol.114 , Issue.1 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 51
    • 67349145955 scopus 로고    scopus 로고
    • Frequent TET2 mutations in systemic mastocytosis: Clinical KITD816V and FIP1L1-PDGFRA correlates
    • Tefferi A, Levine RL, Lim K-H, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia. 2009;23(5):900-904.
    • (2009) Leukemia , vol.23 , Issue.5 , pp. 900-904
    • Tefferi, A.1    Levine, R.L.2    Lim, K.-H.3
  • 52
    • 84870766228 scopus 로고    scopus 로고
    • Aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells
    • Soucie E, Hanssens K, Mercher T, et al. In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells. Blood. 2012;120(24):4846-4849
    • (2012) Blood , vol.120 , Issue.24 , pp. 4846-4849
    • Soucie, E.1    Hanssens, K.2    Mercher, T.3
  • 53
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque L, Patel JP, Figueroa ME, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44(11):1179-1181.
    • (2012) Nat Genet. , vol.44 , Issue.11 , pp. 1179-1181
    • Busque, L.1    Patel, J.P.2    Figueroa, M.E.3
  • 54
    • 84861591789 scopus 로고    scopus 로고
    • Detectable clonal mosaicism from birth to old age and its relationship to cancer
    • Laurie CC, Laurie CA, Rice K, et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet. 2012;44(6): 642-650.
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 642-650
    • Laurie, C.C.1    Laurie, C.A.2    Rice, K.3
  • 55
    • 84861628224 scopus 로고    scopus 로고
    • Detectable clonal mosaicism and its relationship to aging and cancer
    • Jacobs KB, Yeager M, Zhou W, et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet. 2012;44(6):651-658.
    • (2012) Nat Genet , vol.44 , Issue.6 , pp. 651-658
    • Jacobs, K.B.1    Yeager, M.2    Zhou, W.3
  • 56
    • 79960062301 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • Quivoron C, Couronńe L, Della Valle V, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell. 2011;20(1): 25-38
    • (2011) Cancer Cell. , vol.20 , Issue.1 , pp. 25-38
    • Quivoron, C.1    Couronńe, L.2    Della Valle, V.3
  • 57
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell selfrenewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell selfrenewal and myeloid transformation. Cancer Cell. 2011;20(1):11-24.
    • (2011) Cancer Cell. , vol.20 , Issue.1 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3
  • 58
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stemcells and subsequent development of myeloid malignancies
    • Li Z, Cai X, Cai C-L, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stemcells and subsequent development of myeloid malignancies. Blood. 2011;118(17):4509-4518.
    • (2011) Blood , vol.118 , Issue.17 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.-L.3
  • 59
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008; 321(5897):1807-1812.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 60
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8): 765-773.
    • (2009) N Engl J Med. , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 61
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11): 1058-1066.
    • (2009) N Engl J Med. , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 62
    • 72049125350 scopus 로고    scopus 로고
    • Cancerassociated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, et al. Cancerassociated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274): 739-744.
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 63
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha;-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha;-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19(1):17-30.
    • (2011) Cancer Cell. , vol.19 , Issue.1 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 64
    • 84867420094 scopus 로고    scopus 로고
    • Cancer and altered metabolism: Potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
    • Kaelin WG Jr. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol. 2011;76: 335-345.
    • (2011) Cold Spring Harb Symp Quant Biol. , vol.76 , pp. 335-345
    • Kaelin, Jr.W.G.1
  • 65
    • 84865520089 scopus 로고    scopus 로고
    • IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
    • Sasaki M, Knobbe CB, Munger JC, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012;488(7413):656-659.
    • (2012) Nature , vol.488 , Issue.7413 , pp. 656-659
    • Sasaki, M.1    Knobbe, C.B.2    Munger, J.C.3
  • 66
    • 84870557152 scopus 로고    scopus 로고
    • Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
    • Fathi AT, Sadrzadeh H, Borger DR, et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. Blood. 2012;120(23):4649-4652.
    • (2012) Blood , vol.120 , Issue.23 , pp. 4649-4652
    • Fathi, A.T.1    Sadrzadeh, H.2    Borger, D.R.3
  • 67
    • 84879374380 scopus 로고    scopus 로고
    • Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
    • DiNardo CD, Propert KJ, Loren AW, et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood. 2013;121(24): 4917-4924.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4917-4924
    • Dinardo, C.D.1    Propert, K.J.2    Loren, A.W.3
  • 68
    • 84875496294 scopus 로고    scopus 로고
    • (R)-2-Hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
    • Losman J-A, Looper RE, Koivunen P, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
    • (2013) Science , vol.339 , Issue.6127 , pp. 1621-1625
    • Losman, J.-A.1    Looper, R.E.2    Koivunen, P.3
  • 69
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132): 622-626.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    Delabarre, B.3
  • 70
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010; 42(8):722-726.
    • (2010) Nat Genet. , vol.42 , Issue.8 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 71
    • 77957987676 scopus 로고    scopus 로고
    • Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
    • Makishima H, Jankowska AM, Tiu RV, et al. Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies. Leukemia. 2010;24(10): 1799-1804.
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1799-1804
    • Makishima, H.1    Jankowska, A.M.2    Tiu, R.V.3
  • 72
    • 75749124332 scopus 로고    scopus 로고
    • Somatic Mutations Altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42(2): 181-185.
    • (2010) Nat Genet. , vol.42 , Issue.2 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3
  • 73
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • Yap DB, Chu J, Berg T, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 2011;117(8):2451-2459.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2451-2459
    • Yap, D.B.1    Chu, J.2    Berg, T.3
  • 74
    • 77952421834 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb- associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • Boultwood J, Perry J, Pellagatti A, et al. Frequent mutation of the polycomb- associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia. 2010;24(5): 1062-1065.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 1062-1065
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3
  • 75
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category
    • Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category. Blood. 2011;118(26):6920-6929.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 76
    • 77958591628 scopus 로고    scopus 로고
    • ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia
    • Gelsi-Boyer V, Trouplin V, Roquain J, et al. ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Br J Haematol. 2010; 151(4):365-375.
    • (2010) Br J Haematol , vol.151 , Issue.4 , pp. 365-375
    • Gelsi-Boyer, V.1    Trouplin, V.2    Roquain, J.3
  • 77
    • 79959317767 scopus 로고    scopus 로고
    • Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes
    • Thol F, Friesen I, Damm F, et al. Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. J Clin Oncol. 2011; 29(18):2499-2506.
    • (2011) J Clin Oncol. , vol.29 , Issue.18 , pp. 2499-2506
    • Thol, F.1    Friesen, I.2    Damm, F.3
  • 78
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • Abdel-Wahab O, Adli M, LaFave LM, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22(2):180-193.
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    Lafave, L.M.3
  • 79
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens PJ, Greenman CD, Fu B, et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 2011;144(1):27-40.
    • (2011) Cell , vol.144 , Issue.1 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3
  • 80
    • 84856424908 scopus 로고    scopus 로고
    • DNA breaks and chromosome pulverization from errors in mitosis
    • Crasta K, Ganem NJ, Dagher R, et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012;482(7383):53-58.
    • (2012) Nature , vol.482 , Issue.7383 , pp. 53-58
    • Crasta, K.1    Ganem, N.J.2    Dagher, R.3
  • 81
    • 84862907577 scopus 로고    scopus 로고
    • Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
    • Rausch T, Jones DT, Zapatka M, et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell. 2012;148(1-2):59-71.
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 59-71
    • Rausch, T.1    Jones, D.T.2    Zapatka, M.3
  • 82
    • 77950388949 scopus 로고    scopus 로고
    • Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms
    • Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood. 2010; 115(10):2003-2007.
    • (2010) Blood , vol.115 , Issue.10 , pp. 2003-2007
    • Schaub, F.X.1    Looser, R.2    Li, S.3
  • 83
    • 84874033050 scopus 로고    scopus 로고
    • BCRABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia
    • Wang X, Tripodi J, Kremyanskaya M, et al. BCRABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia. Blood. 2013;121(7): 1238-1239.
    • (2013) Blood , vol.121 , Issue.7 , pp. 1238-1239
    • Wang, X.1    Tripodi, J.2    Kremyanskaya, M.3
  • 84
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2- negative myeloproliferative neoplasm
    • Hou Y, Song L, Zhu P, et al. Single-cell exome sequencing and monoclonal evolution of a JAK2- negative myeloproliferative neoplasm. Cell. 2012; 148(5):873-885.
    • (2012) Cell , vol.148 , Issue.5 , pp. 873-885
    • Hou, Y.1    Song, L.2    Zhu, P.3
  • 85
    • 84866621729 scopus 로고    scopus 로고
    • Revised international prognostic scoring system for myelodysplastic syndromes
    • Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012; 120(12):2454-2465.
    • (2012) Blood , vol.120 , Issue.12 , pp. 2454-2465
    • Greenberg, P.L.1    Tuechler, H.2    Schanz, J.3
  • 86
    • 77449159028 scopus 로고    scopus 로고
    • European leukemianet. Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel on behalf of the european leukemianet
    • Döhner H, Estey EH, Amadori S, et al; European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 87
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS plus: A refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • Gangat N, Caramazza D, Vaidya R, et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29(4):392-397.
    • (2011) J Clin Oncol. , vol.29 , Issue.4 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3
  • 88
    • 79956291339 scopus 로고    scopus 로고
    • TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
    • Jädersten M, Saft L, Smith A, et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol. 2011;29(15):1971-1979.
    • (2011) J Clin Oncol. , vol.29 , Issue.15 , pp. 1971-1979
    • Jädersten, M.1    Saft, L.2    Smith, A.3
  • 89
    • 84859860919 scopus 로고    scopus 로고
    • Evaluation of dysplasia through detailed cytomorphology in 3156 patients from the düsseldorf registry on myelodysplastic syndromes
    • Germing U, Strupp C, Giagounidis A, et al. Evaluation of dysplasia through detailed cytomorphology in 3156 patients from the Düsseldorf Registry on myelodysplastic syndromes. Leuk Res. 2012;36(6):727-734.
    • (2012) Leuk Res. , vol.36 , Issue.6 , pp. 727-734
    • Germing, U.1    Strupp, C.2    Giagounidis, A.3
  • 90
    • 68549132622 scopus 로고    scopus 로고
    • Myelodysplastic syndromes
    • Orazi A, Czader MB. Myelodysplastic syndromes. Am J Clin Pathol. 2009;132(2):290-305.
    • (2009) Am J Clin Pathol. , vol.132 , Issue.2 , pp. 290-305
    • Orazi, A.1    Czader, M.B.2
  • 92
    • 84879698783 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
    • Abdel-Wahab O, Levine RL. Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood. 2013; 121(18):3563-3572.
    • (2013) Blood. , vol.121 , Issue.18 , pp. 3563-3572
    • Abdel-Wahab, O.1    Levine, R.L.2
  • 93
    • 0034890863 scopus 로고    scopus 로고
    • Hematologic malignancies
    • Gilliland DG. Hematologic malignancies. Curr Opin Hematol. 2001;8(4):189-191.
    • (2001) Curr Opin Hematol , vol.8 , Issue.4 , pp. 189-191
    • Gilliland, D.G.1
  • 94
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100(5): 1532-1542.
    • (2002) Blood. , vol.100 , Issue.5 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 95
    • 84875758730 scopus 로고    scopus 로고
    • Lessons from the cancer genome
    • Garraway LA, Lander ES. Lessons from the cancer genome. Cell. 2013;153(1):17-37.
    • (2013) Cell , vol.153 , Issue.1 , pp. 17-37
    • Garraway, L.A.1    Lander, E.S.2
  • 96
    • 70449486011 scopus 로고    scopus 로고
    • Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis
    • Malcovati L, Della Porta MG, Pietra D, et al. Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Blood. 2009;114(17): 3538-3545.
    • (2009) Blood , vol.114 , Issue.17 , pp. 3538-3545
    • Malcovati, L.1    Della Porta, M.G.2    Pietra, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.