Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 2, 2010, Pages 369-379

  Jiang, Weiwu ^a   Wang, Lihua ^a   Kondraganti, Sudha R ^a   Fazili, Inayat S ^a   Couroucli, Xanthi I ^a   Felix, Edward A ^b   Moorthy, Bhagavatula ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXY 3 METHYLCHOLANTHRENE; 3 METHYLCHOLANTHREN 2 OL; 3 METHYLCHOLANTHRENE; APOPROTEIN; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; MESSENGER RNA; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENOTYPE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LUNG PARENCHYMA; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION;

ANIMALS; BLOTTING, WESTERN; CARCINOGENS, ENVIRONMENTAL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIVER; LUNG; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION;

EID: 78149232895     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.171173     Document Type: Article

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