Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

Xenobiotica

Volumn 38, Issue 3, 2008, Pages 239-248

  Emoto, C ^a   Yamato, Y ^a   Sato, Y ^b   Ohshita, H ^c   Katoh, M ^d   Tateno, C ^e   Yokoi, T ^d   Yoshizato, K ^e   Iwasaki, K ^a,f  

^a Pharmacokinetics Dynamics Metabolism   (Japan)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c PhoenixBio USA Corporation   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

^f Biomedical Laboratories Ltd   (Japan)

Author keywords

Chimeric mice with a humanized liver; CYP3A4; CYP3A5; Dexamethasone; Humanized liver; Induction; Non invasive method; Rifampicin

Indexed keywords

6BETA HYDROXYDEXAMETHASONE; ANTIBODY; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DEXAMETHASONE; DRUG METABOLITE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PROTEIN INDUCTION; STAINING; URINARY EXCRETION;

ANIMALS; BIOLOGICAL ASSAY; CHIMERA; CHROMATOGRAPHY; CYTOCHROME P-450 CYP3A; DEXAMETHASONE; ENZYME INDUCTION; HUMANS; IMMUNOHISTOCHEMISTRY; KINETICS; LIVER; MICE; MICROSOMES, LIVER; RECOMBINANT PROTEINS; RIFAMPIN; SUBSTRATE SPECIFICITY;

MUS;

EID: 39349089397     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250701760159     Document Type: Article

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