-
1
-
-
33947732977
-
Angiogenesis: an organizing principle for drug discovery?
-
doi: 10.1038/nrd2115
-
Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov (2007) 6:273-86. doi: 10.1038/nrd2115
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
2
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
doi:10.1038/nature10144
-
Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature (2011) 473:298-307. doi:10.1038/nature10144
-
(2011)
Nature
, vol.473
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
3
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
doi:10.1038/nature04483
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature (2005) 438:967-74. doi:10.1038/nature04483
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
4
-
-
69349095364
-
Anticancer strategies involving the vasculature
-
doi:10.1038/nrclinonc.2009.52
-
Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol (2009) 6:395-404. doi:10.1038/nrclinonc.2009.52
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 395-404
-
-
Heath, V.L.1
Bicknell, R.2
-
5
-
-
80052199468
-
Emerging targeted therapies in metastatic renal cell carcinoma
-
doi:10.2174/157488411797189398
-
Matrana MR, Atkinson B, Jonasch E, Tannir NM. Emerging targeted therapies in metastatic renal cell carcinoma. Curr Clin Pharmacol (2011) 6:189-98. doi:10.2174/157488411797189398
-
(2011)
Curr Clin Pharmacol
, vol.6
, pp. 189-198
-
-
Matrana, M.R.1
Atkinson, B.2
Jonasch, E.3
Tannir, N.M.4
-
6
-
-
20344379950
-
Disrupting tumour blood vessels
-
doi:10.1038/nrc1628
-
Tozer GM, Kanthou C, Baguley BC. Disrupting tumour blood vessels. Nat Rev Cancer (2005) 5:423-35. doi:10.1038/nrc1628
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 423-435
-
-
Tozer, G.M.1
Kanthou, C.2
Baguley, B.C.3
-
7
-
-
34548506467
-
Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds
-
doi:10.1007/s10555-007-9074-y
-
Giavazzi R, Bani MR, Taraboletti G. Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds. Cancer Metastasis Rev (2007) 26:481-8. doi:10.1007/s10555-007-9074-y
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 481-488
-
-
Giavazzi, R.1
Bani, M.R.2
Taraboletti, G.3
-
8
-
-
84855833686
-
Vascular disrupting agents (VDA) in oncology: advancing towards new therapeutic paradigms in the clinic
-
doi:10.2174/138945011798829366
-
Spear MA, Lorusso P, Mita A, Mita M. Vascular disrupting agents (VDA) in oncology: advancing towards new therapeutic paradigms in the clinic. Curr Drug Targets (2011) 12:2009-15. doi:10.2174/138945011798829366
-
(2011)
Curr Drug Targets
, vol.12
, pp. 2009-2015
-
-
Spear, M.A.1
Lorusso, P.2
Mita, A.3
Mita, M.4
-
9
-
-
14544305077
-
Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions
-
doi:10.1200/JCO.2005.10.022
-
Gasparini G, Longo R, Fanelli M, Teicher BA. Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions. J Clin Oncol (2005) 23:1295-311. doi:10.1200/JCO.2005.10.022
-
(2005)
J Clin Oncol
, vol.23
, pp. 1295-1311
-
-
Gasparini, G.1
Longo, R.2
Fanelli, M.3
Teicher, B.A.4
-
10
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
doi:10.1056/NEJMoa032691
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med (2004) 350:2335-42. doi:10.1056/NEJMoa032691
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
-
11
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
doi:10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med (2006) 355:2542-50. doi:10.1056/NEJMoa061884
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
-
12
-
-
84855425106
-
Incorporation of bevacizumab in the primary treatment of ovarian cancer
-
doi:10.1056/NEJMoa1104390
-
Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med (2011) 365:2473-83. doi:10.1056/NEJMoa1104390
-
(2011)
N Engl J Med
, vol.365
, pp. 2473-2483
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
Fleming, G.F.4
Monk, B.J.5
Huang, H.6
-
13
-
-
84855466019
-
A phase 3 trial of bevacizumab in ovarian cancer
-
doi:10.1056/NEJMoa1103799
-
Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med (2011) 365:2484-96. doi:10.1056/NEJMoa1103799
-
(2011)
N Engl J Med
, vol.365
, pp. 2484-2496
-
-
Perren, T.J.1
Swart, A.M.2
Pfisterer, J.3
Ledermann, J.A.4
Pujade-Lauraine, E.5
Kristensen, G.6
-
14
-
-
84875248912
-
Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial
-
doi:10.1016/S1470-2045(12)70567-3
-
Stark D, Nankivell M, Pujade-Lauraine E, Kristensen G, Elit L, Stockler M, et al. Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial. Lancet Oncol (2013) 14:236-43. doi:10.1016/S1470-2045(12)70567-3
-
(2013)
Lancet Oncol
, vol.14
, pp. 236-243
-
-
Stark, D.1
Nankivell, M.2
Pujade-Lauraine, E.3
Kristensen, G.4
Elit, L.5
Stockler, M.6
-
15
-
-
55349114392
-
Adjuvant and neoadjuvant therapy in renal cell carcinoma
-
doi:10.1097/PPO.0b013e31818675d4
-
Jonasch E, Tannir NM. Adjuvant and neoadjuvant therapy in renal cell carcinoma. Cancer J (2008) 14:315-9. doi:10.1097/PPO.0b013e31818675d4
-
(2008)
Cancer J
, vol.14
, pp. 315-319
-
-
Jonasch, E.1
Tannir, N.M.2
-
16
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
-
doi:10.1200/JCO.2009.26.1321
-
Scagliotti G, Novello S, Von Pawel J, Reck M, Pereira JR, Thomas M, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol (2010) 28:1835-42. doi:10.1200/JCO.2009.26.1321
-
(2010)
J Clin Oncol
, vol.28
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
Von Pawel, J.3
Reck, M.4
Pereira, J.R.5
Thomas, M.6
-
17
-
-
0030018743
-
A systems approach to cancer therapy (antioncogenics + standard cytotoxics ? mechanism(s) of interaction)
-
doi:10.1007/BF00437479
-
Teicher BA. A systems approach to cancer therapy (antioncogenics + standard cytotoxics ? mechanism(s) of interaction). Cancer Metastasis Rev (1996) 15:247-72. doi:10.1007/BF00437479
-
(1996)
Cancer Metastasis Rev
, vol.15
, pp. 247-272
-
-
Teicher, B.A.1
-
18
-
-
33746491709
-
Drug penetration in solid tumours
-
doi:10.1038/nrc1893
-
Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer (2006) 6:583-92. doi:10.1038/nrc1893
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 583-592
-
-
Minchinton, A.I.1
Tannock, I.F.2
-
19
-
-
12344312042
-
Cellular abnormalities of blood vessels as targets in cancer
-
doi:10.1016/j.gde.2004.12.005
-
Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev (2005) 15:102-11. doi:10.1016/j.gde.2004.12.005
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 102-111
-
-
Baluk, P.1
Hashizume, H.2
McDonald, D.M.3
-
20
-
-
0038376001
-
Imaging of angiogenesis: from microscope to clinic
-
doi:10.1038/nm0603-713
-
McDonald DM, Choyke PL. Imaging of angiogenesis: from microscope to clinic. Nat Med (2003) 9:713-25. doi:10.1038/nm0603-713
-
(2003)
Nat Med
, vol.9
, pp. 713-725
-
-
McDonald, D.M.1
Choyke, P.L.2
-
21
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
-
doi:10.1038/89889
-
Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med (2001) 7:987-9. doi:10.1038/89889
-
(2001)
Nat Med
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
22
-
-
33645738314
-
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis
-
doi:10.1158/0008-5472.CAN-05-2655
-
Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, et al. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res (2006) 66:3360-4. doi:10.1158/0008-5472.CAN-05-2655
-
(2006)
Cancer Res
, vol.66
, pp. 3360-3364
-
-
Hagendoorn, J.1
Tong, R.2
Fukumura, D.3
Lin, Q.4
Lobo, J.5
Padera, T.P.6
-
23
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
doi:10.1152/physrev.00038.2010
-
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 91:1071-121. doi:10.1152/physrev.00038.2010
-
(2011)
Physiol Rev
, vol.91
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
-
24
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
-
doi:10.1200/JCO.2012.46.3653
-
Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol (2013) 31:2205-18. doi:10.1200/JCO.2012.46.3653
-
(2013)
J Clin Oncol
, vol.31
, pp. 2205-2218
-
-
Jain, R.K.1
-
25
-
-
33645735004
-
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia
-
doi:10.1158/0008-5472.CAN-05-3295
-
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res (2006) 66:3639-48. doi:10.1158/0008-5472.CAN-05-3295
-
(2006)
Cancer Res
, vol.66
, pp. 3639-3648
-
-
Franco, M.1
Man, S.2
Chen, L.3
Emmenegger, U.4
Shaked, Y.5
Cheung, A.M.6
-
26
-
-
47949089077
-
VEGF-targeted therapy: mechanisms of anti-tumour activity
-
doi:10.1038/nrc2403
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer (2008) 8:579-91. doi:10.1038/nrc2403
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
27
-
-
70350726336
-
The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma
-
Cesca M, Frapolli R, Berndt A, Scarlato V, Richter P, Kosmehl H, et al. The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma. Neoplasia (2009) 11:1155-64.
-
(2009)
Neoplasia
, vol.11
, pp. 1155-1164
-
-
Cesca, M.1
Frapolli, R.2
Berndt, A.3
Scarlato, V.4
Richter, P.5
Kosmehl, H.6
-
28
-
-
84858447459
-
How to improve exposure of tumor cells to drugs: promoter drugs increase tumor uptake and penetration of effector drugs
-
doi:10.1016/j.addr.2011.09.007
-
Marcucci F, Corti A. How to improve exposure of tumor cells to drugs: promoter drugs increase tumor uptake and penetration of effector drugs. Adv Drug Deliv Rev (2012) 64:53-68. doi:10.1016/j.addr.2011.09.007
-
(2012)
Adv Drug Deliv Rev
, vol.64
, pp. 53-68
-
-
Marcucci, F.1
Corti, A.2
-
29
-
-
79551642429
-
Angiogenesis inhibitors: implications for combination with conventional therapies
-
doi:10.2174/138161210794455021
-
Moschetta M, Cesca M, Pretto F, Giavazzi R. Angiogenesis inhibitors: implications for combination with conventional therapies. Curr Pharm Des (2010) 16:3921-31. doi:10.2174/138161210794455021
-
(2010)
Curr Pharm Des
, vol.16
, pp. 3921-3931
-
-
Moschetta, M.1
Cesca, M.2
Pretto, F.3
Giavazzi, R.4
-
30
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
doi:10.1038/nrd1381
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov (2004) 3:391-400. doi:10.1038/nrd1381
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
31
-
-
0029949160
-
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
-
doi:10.1073/pnas.93.25.14765
-
Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A (1996) 93:14765-70. doi:10.1073/pnas.93.25.14765
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14765-14770
-
-
Yuan, F.1
Chen, Y.2
Dellian, M.3
Safabakhsh, N.4
Ferrara, N.5
Jain, R.K.6
-
32
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
doi:10.1016/j.ccr.2004.10.011
-
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell (2004) 6:553-63. doi:10.1016/j.ccr.2004.10.011
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
-
33
-
-
0038235987
-
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
-
doi:10.1038/sj.bjc.6601005
-
Wildiers H, Guetens G, De Boeck G, Verbeken E, Landuyt B, Landuyt W, et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer (2003) 88:1979-86. doi:10.1038/sj.bjc.6601005
-
(2003)
Br J Cancer
, vol.88
, pp. 1979-1986
-
-
Wildiers, H.1
Guetens, G.2
De Boeck, G.3
Verbeken, E.4
Landuyt, B.5
Landuyt, W.6
-
34
-
-
34447121919
-
Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
-
doi:10.1158/1078-0432.CCR-07-0278
-
Dickson PV, Hamner JB, Sims TL, Fraga CH, Ng CY, Rajasekeran S, et al. Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res (2007) 13:3942-50. doi:10.1158/1078-0432.CCR-07-0278
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3942-3950
-
-
Dickson, P.V.1
Hamner, J.B.2
Sims, T.L.3
Fraga, C.H.4
Ng, C.Y.5
Rajasekeran, S.6
-
35
-
-
84863722405
-
Cisplatin plus paclitaxel and maintenance of bevacizumab on tumour progression, dissemination, and survival of ovarian carcinoma xenograft models
-
doi:10.1038/bjc.2012.261
-
Oliva P, Decio A, Castiglioni V, Bassi A, Pesenti E, Cesca M, et al. Cisplatin plus paclitaxel and maintenance of bevacizumab on tumour progression, dissemination, and survival of ovarian carcinoma xenograft models. Br J Cancer (2012) 107:360-9. doi:10.1038/bjc.2012.261
-
(2012)
Br J Cancer
, vol.107
, pp. 360-369
-
-
Oliva, P.1
Decio, A.2
Castiglioni, V.3
Bassi, A.4
Pesenti, E.5
Cesca, M.6
-
36
-
-
84883062905
-
Determination of Paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging
-
doi:10.1371/journal.pone.0072532
-
Morosi L, Spinelli P, Zucchetti M, Pretto F, Carra A, D'Incalci M, et al. Determination of Paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging. PLoS ONE (2013) 8:e72532. doi:10.1371/journal.pone.0072532
-
(2013)
PLoS ONE
, vol.8
-
-
Morosi, L.1
Spinelli, P.2
Zucchetti, M.3
Pretto, F.4
Carra, A.5
D'Incalci, M.6
-
37
-
-
84859156795
-
Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model
-
doi:10.1158/1535-7163.MCT-11-0742-T
-
Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Mol Cancer Ther (2012) 11:752-62. doi:10.1158/1535-7163.MCT-11-0742-T
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 752-762
-
-
Pastuskovas, C.V.1
Mundo, E.E.2
Williams, S.P.3
Nayak, T.K.4
Ho, J.5
Ulufatu, S.6
-
38
-
-
77649134730
-
Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer
-
doi:10.1158/0008-5472.SABCS-09-6094
-
Hurvitz S, Pegram M, Lin L, Chan D, Allen H, Dichmann R, et al. Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer. Cancer Res (2009) 69(Suppl):6094. doi:10.1158/0008-5472.SABCS-09-6094
-
(2009)
Cancer Res
, vol.69
, Issue.SUPPL.
, pp. 6094
-
-
Hurvitz, S.1
Pegram, M.2
Lin, L.3
Chan, D.4
Allen, H.5
Dichmann, R.6
-
39
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
doi:10.1038/nm988
-
Willett CG, Boucher Y, Di Tomaso E, Duda DG, Munn LL, Tong RT, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med (2004) 10:145-7. doi:10.1038/nm988
-
(2004)
Nat Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
Di Tomaso, E.3
Duda, D.G.4
Munn, L.L.5
Tong, R.T.6
-
40
-
-
84855931910
-
Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs
-
doi:10.1016/j.ccr.2011.11.023
-
Van der Veldt AA, Lubberink M, Bahce I, Walraven M, De Boer MP, Greuter HN, et al. Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs. Cancer Cell (2012) 21:82-91. doi:10.1016/j.ccr.2011.11.023
-
(2012)
Cancer Cell
, vol.21
, pp. 82-91
-
-
Van der Veldt, A.A.1
Lubberink, M.2
Bahce, I.3
Walraven, M.4
De Boer, M.P.5
Greuter, H.N.6
-
41
-
-
84870909761
-
Scheduling of anticancer drugs: timing may be everything
-
doi:10.4161/cc.22187
-
Van der Veldt AA, Lammertsma AA, Smit EF. Scheduling of anticancer drugs: timing may be everything. Cell Cycle (2012) 11:4339-43. doi:10.4161/cc.22187
-
(2012)
Cell Cycle
, vol.11
, pp. 4339-4343
-
-
Van der Veldt, A.A.1
Lammertsma, A.A.2
Smit, E.F.3
-
42
-
-
84885578429
-
Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice
-
doi:10.1158/1535-7163.MCT-13-0244. [Epub ahead of print].
-
Rovida A, Castiglioni V, Decio A, Scarlato V, Scanziani E, Giavazzi R, et al. Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice. Mol Cancer Ther (2013). doi:10.1158/1535-7163.MCT-13-0244. [Epub ahead of print].
-
(2013)
Mol Cancer Ther
-
-
Rovida, A.1
Castiglioni, V.2
Decio, A.3
Scarlato, V.4
Scanziani, E.5
Giavazzi, R.6
-
43
-
-
57749092182
-
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
-
doi:10.1158/1535-7163.MCT-08-0715
-
Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther (2008) 7:3670-84. doi:10.1158/1535-7163.MCT-08-0715
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3670-3684
-
-
Ma, J.1
Waxman, D.J.2
-
44
-
-
38349145379
-
Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib
-
doi:10.1158/1535-7163.MCT-07-0584
-
Ma J, Waxman DJ. Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Mol Cancer Ther (2008) 7:79-89. doi:10.1158/1535-7163.MCT-07-0584
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 79-89
-
-
Ma, J.1
Waxman, D.J.2
-
45
-
-
35448979860
-
The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature
-
doi:10.1158/0008-5472.CAN-07-1066
-
Fenton BM, Paoni SF. The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res (2007) 67:9921-8. doi:10.1158/0008-5472.CAN-07-1066
-
(2007)
Cancer Res
, vol.67
, pp. 9921-9928
-
-
Fenton, B.M.1
Paoni, S.F.2
-
46
-
-
79953330322
-
Antiangiogenesis enhances intratumoral drug retention
-
doi:10.1158/0008-5472.CAN-10-3242
-
Ma J, Chen CS, Blute T, Waxman DJ. Antiangiogenesis enhances intratumoral drug retention. Cancer Res (2011) 71:2675-85. doi:10.1158/0008-5472.CAN-10-3242
-
(2011)
Cancer Res
, vol.71
, pp. 2675-2685
-
-
Ma, J.1
Chen, C.S.2
Blute, T.3
Waxman, D.J.4
-
47
-
-
10744223595
-
The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically
-
Garofalo A, Naumova E, Manenti L, Ghilardi C, Ghisleni G, Caniatti M, et al. The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Clin Cancer Res (2003) 9:3476-85.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3476-3485
-
-
Garofalo, A.1
Naumova, E.2
Manenti, L.3
Ghilardi, C.4
Ghisleni, G.5
Caniatti, M.6
-
48
-
-
33645657886
-
The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis
-
doi:10.1158/1078-0432.CCR-05-1615
-
Naumova E, Ubezio P, Garofalo A, Borsotti P, Cassis L, Riccardi E, et al. The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin Cancer Res (2006) 12:1839-49. doi:10.1158/1078-0432.CCR-05-1615
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1839-1849
-
-
Naumova, E.1
Ubezio, P.2
Garofalo, A.3
Borsotti, P.4
Cassis, L.5
Riccardi, E.6
-
49
-
-
0029802685
-
The microtubule-affecting drug paclitaxel has antiangiogenic activity
-
Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res (1996) 2:1843-9.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1843-1849
-
-
Belotti, D.1
Vergani, V.2
Drudis, T.3
Borsotti, P.4
Pitelli, M.R.5
Viale, G.6
-
50
-
-
35948979658
-
Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model
-
doi:10.1158/1078-0432.CCR-07-1094
-
Troiani T, Serkova NJ, Gustafson DL, Henthorn TK, Lockerbie O, Merz A, et al. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res (2007) 13:6450-8. doi:10.1158/1078-0432.CCR-07-1094
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6450-6458
-
-
Troiani, T.1
Serkova, N.J.2
Gustafson, D.L.3
Henthorn, T.K.4
Lockerbie, O.5
Merz, A.6
-
51
-
-
84874045033
-
The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts
-
doi:10.1158/1535-7163.MCT-12-0275-T
-
Bello E, Taraboletti G, Colella G, Zucchetti M, Forestieri D, Licandro SA, et al. The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther (2013) 12:131-40. doi:10.1158/1535-7163.MCT-12-0275-T
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 131-140
-
-
Bello, E.1
Taraboletti, G.2
Colella, G.3
Zucchetti, M.4
Forestieri, D.5
Licandro, S.A.6
-
52
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K, Rubin K, Sjoblom T, Buchdunger E, Sjoquist M, Heldin CH, et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res (2002) 62:5476-84.
-
(2002)
Cancer Res
, vol.62
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
Sjoblom, T.3
Buchdunger, E.4
Sjoquist, M.5
Heldin, C.H.6
-
53
-
-
34548580286
-
Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts
-
doi:10.1038/sj.bjc.6603941
-
Vlahovic G, Ponce AM, Rabbani Z, Salahuddin FK, Zgonjanin L, Spasojevic I, et al. Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts. Br J Cancer (2007) 97:735-40. doi:10.1038/sj.bjc.6603941
-
(2007)
Br J Cancer
, vol.97
, pp. 735-740
-
-
Vlahovic, G.1
Ponce, A.M.2
Rabbani, Z.3
Salahuddin, F.K.4
Zgonjanin, L.5
Spasojevic, I.6
-
54
-
-
0029120875
-
Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma
-
Teicher BA, Dupuis NP, Robinson MF, Emi Y, Goff DA. Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol Res (1995) 7:237-43.
-
(1995)
Oncol Res
, vol.7
, pp. 237-243
-
-
Teicher, B.A.1
Dupuis, N.P.2
Robinson, M.F.3
Emi, Y.4
Goff, D.A.5
-
55
-
-
70449428715
-
Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
-
doi:10.1172/JCI36308
-
Maione F, Molla F, Meda C, Latini R, Zentilin L, Giacca M, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest (2009) 119:3356-72. doi:10.1172/JCI36308
-
(2009)
J Clin Invest
, vol.119
, pp. 3356-3372
-
-
Maione, F.1
Molla, F.2
Meda, C.3
Latini, R.4
Zentilin, L.5
Giacca, M.6
-
56
-
-
84860591982
-
Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
-
doi:10.1172/JCI58976
-
Maione F, Capano S, Regano D, Zentilin L, Giacca M, Casanovas O, et al. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest (2012) 122:1832-48. doi:10.1172/JCI58976
-
(2012)
J Clin Invest
, vol.122
, pp. 1832-1848
-
-
Maione, F.1
Capano, S.2
Regano, D.3
Zentilin, L.4
Giacca, M.5
Casanovas, O.6
-
57
-
-
78549248213
-
Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors
-
doi:10.1158/0008-5472.CAN-10-2029
-
Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, et al. Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors. Cancer Res (2010) 70:9277-86. doi:10.1158/0008-5472.CAN-10-2029
-
(2010)
Cancer Res
, vol.70
, pp. 9277-9286
-
-
Escorcia, F.E.1
Henke, E.2
McDevitt, M.R.3
Villa, C.H.4
Smith-Jones, P.5
Blasberg, R.G.6
-
58
-
-
0842311621
-
Vascular targeting agents as cancer therapeutics
-
doi:10.1158/1078-0432.CCR-0642-03
-
Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res (2004) 10:415-27. doi:10.1158/1078-0432.CCR-0642-03
-
(2004)
Clin Cancer Res
, vol.10
, pp. 415-427
-
-
Thorpe, P.E.1
-
59
-
-
20344367537
-
Tumour vascular targeting
-
doi:10.1038/nrc1627
-
Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer (2005) 5:436-46. doi:10.1038/nrc1627
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 436-446
-
-
Neri, D.1
Bicknell, R.2
-
60
-
-
33644536374
-
Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors
-
doi:10.1158/0008-5472.CAN-05-2046
-
Skliarenko JV, Lunt SJ, Gordon ML, Vitkin A, Milosevic M, Hill RP. Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors. Cancer Res (2006) 66:2074-80. doi:10.1158/0008-5472.CAN-05-2046
-
(2006)
Cancer Res
, vol.66
, pp. 2074-2080
-
-
Skliarenko, J.V.1
Lunt, S.J.2
Gordon, M.L.3
Vitkin, A.4
Milosevic, M.5
Hill, R.P.6
-
61
-
-
34347231300
-
Vascular damaging agents
-
doi:10.1016/j.clon.2007.03.014
-
Patterson DM, Rustin GJ. Vascular damaging agents. Clin Oncol (R Coll Radiol) (2007) 19:443-56. doi:10.1016/j.clon.2007.03.014
-
(2007)
Clin Oncol (R Coll Radiol)
, vol.19
, pp. 443-456
-
-
Patterson, D.M.1
Rustin, G.J.2
-
62
-
-
33745135802
-
Current development status of small-molecule vascular disrupting agents
-
Chaplin DJ, Horsman MR, Siemann DW. Current development status of small-molecule vascular disrupting agents. Curr Opin Investig Drugs (2006) 7:522-8.
-
(2006)
Curr Opin Investig Drugs
, vol.7
, pp. 522-528
-
-
Chaplin, D.J.1
Horsman, M.R.2
Siemann, D.W.3
-
63
-
-
34948862788
-
Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel
-
Martinelli M, Bonezzi K, Riccardi E, Kuhn E, Frapolli R, Zucchetti M, et al. Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel. Br J Cancer (2007) 97:888-94.
-
(2007)
Br J Cancer
, vol.97
, pp. 888-894
-
-
Martinelli, M.1
Bonezzi, K.2
Riccardi, E.3
Kuhn, E.4
Frapolli, R.5
Zucchetti, M.6
-
64
-
-
9344239900
-
Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin
-
doi:10.1158/1078-0432.CCR-04-1171
-
Goto H, Yano S, Matsumori Y, Ogawa H, Blakey DC, Sone S. Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin. Clin Cancer Res (2004) 10:7671-6. doi:10.1158/1078-0432.CCR-04-1171
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7671-7676
-
-
Goto, H.1
Yano, S.2
Matsumori, Y.3
Ogawa, H.4
Blakey, D.C.5
Sone, S.6
-
65
-
-
50349097617
-
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents
-
doi:10.1016/j.ccr.2008.08.001
-
Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, et al. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell (2008) 14:263-73. doi:10.1016/j.ccr.2008.08.001
-
(2008)
Cancer Cell
, vol.14
, pp. 263-273
-
-
Shaked, Y.1
Henke, E.2
Roodhart, J.M.3
Mancuso, P.4
Langenberg, M.H.5
Colleoni, M.6
-
66
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
doi:10.1038/nrc1317
-
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer (2004) 4:253-65. doi:10.1038/nrc1317
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
67
-
-
84859402603
-
Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts
-
doi:10.1158/0008-5472.CAN-11-1919
-
Moschetta M, Pretto F, Berndt A, Galler K, Richter P, Bassi A, et al. Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts. Cancer Res (2012) 72:1814-24. doi:10.1158/0008-5472.CAN-11-1919
-
(2012)
Cancer Res
, vol.72
, pp. 1814-1824
-
-
Moschetta, M.1
Pretto, F.2
Berndt, A.3
Galler, K.4
Richter, P.5
Bassi, A.6
-
68
-
-
77956434470
-
The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma
-
doi:10.1016/j.juro.2010.07.030
-
Frey K, Schliemann C, Schwager K, Giavazzi R, Johannsen M, Neri D. The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma. J Urol (2010) 184:2540-8. doi:10.1016/j.juro.2010.07.030
-
(2010)
J Urol
, vol.184
, pp. 2540-2548
-
-
Frey, K.1
Schliemann, C.2
Schwager, K.3
Giavazzi, R.4
Johannsen, M.5
Neri, D.6
-
69
-
-
84873053339
-
Antibody-drug conjugates in cancer therapy
-
doi:10.1146/annurev-med-050311-201823
-
Sievers EL, Senter PD. Antibody-drug conjugates in cancer therapy. Annu Rev Med (2013) 64:15-29. doi:10.1146/annurev-med-050311-201823
-
(2013)
Annu Rev Med
, vol.64
, pp. 15-29
-
-
Sievers, E.L.1
Senter, P.D.2
-
70
-
-
0033178578
-
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications
-
Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res (1999) 59:3776-82.
-
(1999)
Cancer Res
, vol.59
, pp. 3776-3782
-
-
Griffon-Etienne, G.1
Boucher, Y.2
Brekken, C.3
Suit, H.D.4
Jain, R.K.5
-
71
-
-
3242699617
-
Effects of the taxanes paclitaxel and docetaxel on edema formation and interstitial fluid pressure
-
doi:10.1152/ajpheart.01052.2003
-
Bronstad A, Berg A, Reed RK. Effects of the taxanes paclitaxel and docetaxel on edema formation and interstitial fluid pressure. Am J Physiol Heart Circ Physiol (2004) 287:H963-8. doi:10.1152/ajpheart.01052.2003
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.287
-
-
Bronstad, A.1
Berg, A.2
Reed, R.K.3
-
72
-
-
20144373280
-
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications
-
doi:10.1200/JCO.2005.08.119
-
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, et al. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol (2005) 23:1951-61. doi:10.1200/JCO.2005.08.119
-
(2005)
J Clin Oncol
, vol.23
, pp. 1951-1961
-
-
Taghian, A.G.1
Abi-Raad, R.2
Assaad, S.I.3
Casty, A.4
Ancukiewicz, M.5
Yeh, E.6
-
73
-
-
84878870926
-
Phase I/II study of albumin-bound nab-paclitaxel plus gemcitabine administered to Chinese patients with advanced pancreatic cancer
-
doi:10.1007/s00280-013-2102-4
-
Zhang DS, Wang DS, Wang ZQ, Wang FH, Luo HY, Qiu MZ, et al. Phase I/II study of albumin-bound nab-paclitaxel plus gemcitabine administered to Chinese patients with advanced pancreatic cancer. Cancer Chemother Pharmacol (2013) 71:1065-72. doi:10.1007/s00280-013-2102-4
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, pp. 1065-1072
-
-
Zhang, D.S.1
Wang, D.S.2
Wang, Z.Q.3
Wang, F.H.4
Luo, H.Y.5
Qiu, M.Z.6
-
74
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
-
doi:10.1200/JCO.2011.36.5742
-
Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol (2011) 29:4548-54. doi:10.1200/JCO.2011.36.5742
-
(2011)
J Clin Oncol
, vol.29
, pp. 4548-4554
-
-
Von Hoff, D.D.1
Ramanathan, R.K.2
Borad, M.J.3
Laheru, D.A.4
Smith, L.S.5
Wood, T.E.6
-
75
-
-
84863849090
-
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer
-
doi:10.1158/2159-8290.CD-11-0242
-
Frese KK, Neesse A, Cook N, Bapiro TE, Lolkema MP, Jodrell DI, et al. nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov (2012) 2:260-9. doi:10.1158/2159-8290.CD-11-0242
-
(2012)
Cancer Discov
, vol.2
, pp. 260-269
-
-
Frese, K.K.1
Neesse, A.2
Cook, N.3
Bapiro, T.E.4
Lolkema, M.P.5
Jodrell, D.I.6
|