-
1
-
-
0141988568
-
Fundamental concepts of the angiogenic process
-
Folkman J. Fundamental concepts of the angiogenic process. Curr Mol Med 2003; 3: 643-51.
-
(2003)
Curr Mol Med
, vol.3
, pp. 643-651
-
-
Folkman, J.1
-
2
-
-
30744479430
-
Angiogenesis in life, disease and medicine
-
Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-6.
-
(2005)
Nature
, vol.438
, pp. 932-936
-
-
Carmeliet, P.1
-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-9.
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goeddel, D.V.4
Ferrara, N.5
-
5
-
-
0025194878
-
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
-
Senger DR, Connolly DT, Van de Water L, Feder J, Dvorak HF. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res 1990; 50: 1774-8.
-
(1990)
Cancer Res
, vol.50
, pp. 1774-1778
-
-
Senger, D.R.1
Connolly, D.T.2
Van de Water, L.3
Feder, J.4
Dvorak, H.F.5
-
6
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
7
-
-
34547657584
-
Vascular endothelial growth factor trap in non small cell lung cancer
-
Riely GJ, Miller VA. Vascular endothelial growth factor trap in non small cell lung cancer. Clin Cancer Res 2007; 13: s4623-7.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Riely, G.J.1
Miller, V.A.2
-
8
-
-
69349095364
-
Anticancer strategies involving the vasculature
-
Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009; 6: 395-404.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 395-404
-
-
Heath, V.L.1
Bicknell, R.2
-
9
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of antitumour activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of antitumour activity. Nat Rev Cancer 2008; 8: 579-91.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
10
-
-
33947423448
-
Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
-
Goodman VL, Rock EP, Dagher R, et al. Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res 2007; 13: 1367-73.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1367-1373
-
-
Goodman, V.L.1
Rock, E.P.2
Dagher, R.3
-
11
-
-
33846440150
-
Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma
-
Rock EP, Goodman V, Jiang JX, et al. Food and Drug Administration drug approval summary: Sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma. Oncologist 2007; 12: 107-13.
-
(2007)
Oncologist
, vol.12
, pp. 107-113
-
-
Rock, E.P.1
Goodman, V.2
Jiang, J.X.3
-
12
-
-
33846260566
-
Sorafenib for the treatment of advanced renal cell carcinoma
-
Kane RC, Farrell AT, Saber H, et al. Sorafenib for the treatment of advanced renal cell carcinoma. Clin Cancer Res 2006; 12: 7271-8.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7271-7278
-
-
Kane, R.C.1
Farrell, A.T.2
Saber, H.3
-
13
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
14
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006; 368: 1329-38.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
-
15
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-34.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
16
-
-
70350464165
-
Phase I and Biomarker Study of ABT-869, a Multiple Receptor Tyrosine Kinase Inhibitor, in Patients With Refractory Solid Malignancies
-
Wong CI, Koh TS, Soo R, et al. Phase I and Biomarker Study of ABT-869, a Multiple Receptor Tyrosine Kinase Inhibitor, in Patients With Refractory Solid Malignancies. J Clin Oncol 2009; 27(28): 4718-26.
-
(2009)
J Clin Oncol
, vol.27
, Issue.28
, pp. 4718-4726
-
-
Wong, C.I.1
Koh, T.S.2
Soo, R.3
-
17
-
-
77949740524
-
ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses plateletderived growth factor receptor beta and c-KIT signaling pathways
-
Ikeda AK, Judelson DR, Federman N, et al. ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses plateletderived growth factor receptor beta and c-KIT signaling pathways. Mol Cancer Ther 2010; 9: 653-60.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 653-660
-
-
Ikeda, A.K.1
Judelson, D.R.2
Federman, N.3
-
18
-
-
70349388719
-
Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
-
Rini BI, Wilding G, Hudes G, et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J Clin Oncol 2009; 27(27): 4462-8.
-
(2009)
J Clin Oncol
, vol.27
, Issue.27
, pp. 4462-4468
-
-
Rini, B.I.1
Wilding, G.2
Hudes, G.3
-
20
-
-
49649123154
-
BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
-
Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008; 68: 4774-82.
-
(2008)
Cancer Res
, vol.68
, pp. 4774-4782
-
-
Hilberg, F.1
Roth, G.J.2
Krssak, M.3
-
21
-
-
77952345253
-
BIBF 1120 for the treatment of non-small cell lung cancer
-
Reck M. BIBF 1120 for the treatment of non-small cell lung cancer. Expert Opin Investig Drugs 2010; 19: 789-94.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 789-794
-
-
Reck, M.1
-
22
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh H, Ngo VC, Fargnoli J, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 2008; 14: 6146-53.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
-
23
-
-
78049386779
-
Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors
-
Mekhail T, Masson E, Fischer B, et al. Metabolism, Excretion, and Pharmacokinetics of Oral Brivanib in Patients with Advanced or Metastatic Solid Tumors. Drug Metab Dispos 2010; 38(11): 1962-6.
-
(2010)
Drug Metab Dispos
, vol.38
, Issue.11
, pp. 1962-1966
-
-
Mekhail, T.1
Masson, E.2
Fischer, B.3
-
24
-
-
76649108900
-
The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases
-
Bhide RS, Lombardo LJ, Hunt JT, et al. The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases. Mol Cancer Ther 2010; 9: 369-78.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 369-378
-
-
Bhide, R.S.1
Lombardo, L.J.2
Hunt, J.T.3
-
25
-
-
67651242368
-
Current status of cediranib: The rapid development of a novel anti-angiogenic therapy
-
Lindsay CR, MacPherson IR, Cassidy J. Current status of cediranib: the rapid development of a novel anti-angiogenic therapy. Future Oncol 2009; 5: 421-32.
-
(2009)
Future Oncol
, vol.5
, pp. 421-432
-
-
Lindsay, C.R.1
McPherson, I.R.2
Cassidy, J.3
-
26
-
-
70349311608
-
Cediranib: Profile of a novel anti-angiogenic agent in patients with glioblastoma
-
Dietrich J, Wang D, Batchelor TT. Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma. Expert Opin Investig Drugs 2009; 18: 1549-57.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 1549-1557
-
-
Dietrich, J.1
Wang, D.2
Batchelor, T.T.3
-
27
-
-
77954720781
-
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
-
Batchelor TT, Duda DG, di Tomaso E, et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 2010; 28: 2817-23.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2817-2823
-
-
Batchelor, T.T.1
Duda, D.G.2
di Tomaso, E.3
-
28
-
-
42249087301
-
A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors
-
Sarker D, Molife R, Evans TR, et al. A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors. Clin Cancer Res 2008; 14: 2075-81.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2075-2081
-
-
Sarker, D.1
Molife, R.2
Evans, T.R.3
-
29
-
-
70149109569
-
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: Activation of AXL
-
Liu L, Greger J, Shi H, et al. Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res 2009; 69: 6871-8.
-
(2009)
Cancer Res
, vol.69
, pp. 6871-6878
-
-
Liu, L.1
Greger, J.2
Shi, H.3
-
30
-
-
70350230210
-
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
-
Qian F, Engst S, Yamaguchi K, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res 2009; 69: 8009-16.
-
(2009)
Cancer Res
, vol.69
, pp. 8009-8016
-
-
Qian, F.1
Engst, S.2
Yamaguchi, K.3
-
31
-
-
68949108390
-
Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
-
Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009; 27: 3794-801.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3794-3801
-
-
Schlumberger, M.J.1
Elisei, R.2
Bastholt, L.3
-
32
-
-
67650337802
-
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
-
Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009; 27: 3126-32.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3126-3132
-
-
Sleijfer, S.1
Ray-Coquard, I.2
Papai, Z.3
-
33
-
-
77954240822
-
Targeted therapies: Pazopanib: Carving a niche in a crowded therapeutic landscape
-
Pal SK, Figlin RA. Targeted therapies: Pazopanib: carving a niche in a crowded therapeutic landscape. Nat Rev Clin Oncol 2010; 7: 362-3.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 362-363
-
-
Pal, S.K.1
Figlin, R.A.2
-
34
-
-
57349191046
-
Sorafenib in advanced hepatocellular carcinoma
-
author reply 2498-9
-
Palmer DH. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 2498; author reply 2498-9.
-
(2008)
N Engl J Med
, vol.359
, pp. 2498
-
-
Palmer, D.H.1
-
35
-
-
77955917461
-
Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase III TARGET
-
Hutson TE, Bellmunt J, Porta C, et al. Long-term safety of sorafenib in advanced renal cell carcinoma: follow-up of patients from phase III TARGET. Eur J Cancer 2010; 46: 2432-40.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2432-2440
-
-
Hutson, T.E.1
Bellmunt, J.2
Porta, C.3
-
36
-
-
67650576673
-
Sunitinib and bevacizumab for first-line treatment of metastatic renal cell carcinoma: A systematic review and indirect comparison of clinical effectiveness
-
Thompson Coon JS, Liu Z, Hoyle M, et al. Sunitinib and bevacizumab for first-line treatment of metastatic renal cell carcinoma: a systematic review and indirect comparison of clinical effectiveness. Br J Cancer 2009; 101: 238-43.
-
(2009)
Br J Cancer
, vol.101
, pp. 238-243
-
-
Thompson Coon, J.S.1
Liu, Z.2
Hoyle, M.3
-
38
-
-
66249118670
-
Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
-
Morabito A, Piccirillo MC, Falasconi F, et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009; 14: 378-90.
-
(2009)
Oncologist
, vol.14
, pp. 378-390
-
-
Morabito, A.1
Piccirillo, M.C.2
Falasconi, F.3
-
39
-
-
57349160348
-
Exploring multi-targeting strategies for the treatment of gliomas
-
Omuro AM. Exploring multi-targeting strategies for the treatment of gliomas. Curr Opin Investig Drugs 2008; 9: 1287-95.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, pp. 1287-1295
-
-
Omuro, A.M.1
-
40
-
-
69349097400
-
Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy
-
Ebos JM, Lee CR, Kerbel RS. Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin Cancer Res 2009; 15: 5020-5.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5020-5025
-
-
Ebos, J.M.1
Lee, C.R.2
Kerbel, R.S.3
-
41
-
-
59149088848
-
Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells
-
Naldini A, Filippi I, Ardinghi C, Silini A, Giavazzi R, Carraro F. Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells. Eur J Cancer 2009; 45: 454-60.
-
(2009)
Eur J Cancer
, vol.45
, pp. 454-460
-
-
Naldini, A.1
Filippi, I.2
Ardinghi, C.3
Silini, A.4
Giavazzi, R.5
Carraro, F.6
-
42
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007; 13: 1253-9.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon II, J.E.3
-
43
-
-
33748475636
-
The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma
-
Numnum TM, Rocconi RP, Whitworth J, Barnes MN. The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma. Gynecol Oncol 2006; 102: 425-8.
-
(2006)
Gynecol Oncol
, vol.102
, pp. 425-428
-
-
Numnum, T.M.1
Rocconi, R.P.2
Whitworth, J.3
Barnes, M.N.4
-
44
-
-
33644824747
-
Improving long-term outcomes for patients with liver metastases from colorectal cancer
-
Chong G, Cunningham D. Improving long-term outcomes for patients with liver metastases from colorectal cancer. J Clin Oncol 2005; 23: 9063-6.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9063-9066
-
-
Chong, G.1
Cunningham, D.2
-
45
-
-
24644454338
-
Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab
-
Ellis LM, Curley SA, Grothey A. Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J Clin Oncol 2005; 23: 4853-5.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4853-4855
-
-
Ellis, L.M.1
Curley, S.A.2
Grothey, A.3
-
46
-
-
70350721785
-
Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: Insights from imaging
-
O'Connor JP, Carano RA, Clamp AR, et al. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res 2009; 15: 6674-82.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6674-6682
-
-
O'Connor, J.P.1
Carano, R.A.2
Clamp, A.R.3
-
47
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-50.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
49
-
-
55349114392
-
Adjuvant and neoadjuvant therapy in renal cell carcinoma
-
Jonasch E, Tannir NM. Adjuvant and neoadjuvant therapy in renal cell carcinoma. Cancer J 2008; 14: 315-9.
-
(2008)
Cancer J
, vol.14
, pp. 315-319
-
-
Jonasch, E.1
Tannir, N.M.2
-
50
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
51
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
52
-
-
33744466541
-
Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
-
Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006; 312: 1171-5.
-
(2006)
Science
, vol.312
, pp. 1171-1175
-
-
Kerbel, R.S.1
-
53
-
-
0030018743
-
A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction)
-
Teicher BA. A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction). Cancer Metastasis Rev 1996; 15: 247-72.
-
(1996)
Cancer Metastasis Rev
, vol.15
, pp. 247-272
-
-
Teicher, B.A.1
-
54
-
-
34548506467
-
Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds
-
Giavazzi R, Bani MR, Taraboletti G. Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds. Cancer Metastasis Rev 2007; 26: 481-8.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 481-488
-
-
Giavazzi, R.1
Bani, M.R.2
Taraboletti, G.3
-
55
-
-
33645657886
-
The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis
-
Naumova E, Ubezio P, Garofalo A, et al. The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin Cancer Res 2006; 12: 1839-49.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1839-1849
-
-
Naumova, E.1
Ubezio, P.2
Garofalo, A.3
-
56
-
-
70350726336
-
The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma
-
Cesca M, Frapolli R, Berndt A, et al. The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma. Neoplasia 2009; 11: 1155-64.
-
(2009)
Neoplasia
, vol.11
, pp. 1155-1164
-
-
Cesca, M.1
Frapolli, R.2
Berndt, A.3
-
57
-
-
57749092182
-
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
-
Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 2008; 7: 3670-84.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3670-3684
-
-
Ma, J.1
Waxman, D.J.2
-
58
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64: 3731-6.
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
59
-
-
40949141801
-
Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide
-
Zhou Q, Guo P, Gallo JM. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 2008; 14: 1540-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1540-1549
-
-
Zhou, Q.1
Guo, P.2
Gallo, J.M.3
-
60
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-5.
-
(2003)
J Clin Oncol
, vol.21
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
61
-
-
35448979860
-
The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature
-
Fenton BM, Paoni SF. The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res 2007; 67: 9921-8.
-
(2007)
Cancer Res
, vol.67
, pp. 9921-9928
-
-
Fenton, B.M.1
Paoni, S.F.2
-
62
-
-
38349145379
-
Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib
-
Ma J, Waxman DJ. Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Mol Cancer Ther 2008; 7: 79-89.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 79-89
-
-
Ma, J.1
Waxman, D.J.2
-
63
-
-
35948979658
-
Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model
-
Troiani T, Serkova NJ, Gustafson DL, et al. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res 2007; 13: 6450-8.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6450-6458
-
-
Troiani, T.1
Serkova, N.J.2
Gustafson, D.L.3
-
64
-
-
21744437791
-
Repopulation of cancer cells during therapy: An important cause of treatment failure
-
Kim JJ, Tannock IF. Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer 2005; 5: 516-25.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 516-525
-
-
Kim, J.J.1
Tannock, I.F.2
-
65
-
-
77954499682
-
Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study
-
In, June 4-8; Chicago, Illinois
-
Burger RA, Brady MF, Bookman MA, et al. Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study. In: ASCO Annual Meeting 2010 June 4-8; Chicago, Illinois.
-
(2010)
ASCO Annual Meeting
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
-
66
-
-
70450175957
-
Targeting angiogenesis: Progress with anti- VEGF treatment with large molecules
-
Grothey A, Galanis E. Targeting angiogenesis: progress with anti- VEGF treatment with large molecules. Nat Rev Clin Oncol 2009; 6: 507-18.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 507-518
-
-
Grothey, A.1
Galanis, E.2
-
67
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
68
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-7.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
69
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002; 347: 472-80.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
-
70
-
-
34147131736
-
Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: Rationale and clinical applications for non-small-cell lung cancer
-
Byers LA, Heymach JV. Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small-cell lung cancer. Clin Lung Cancer 2007; 8 Suppl 2: S79-85.
-
(2007)
Clin Lung Cancer
, vol.8
, Issue.SUPPL 2
-
-
Byers, L.A.1
Heymach, J.V.2
-
71
-
-
33244491058
-
Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer
-
Swinson DE, O'Byrne KJ. Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer. Clin Lung Cancer 2006; 7: 250-6.
-
(2006)
Clin Lung Cancer
, vol.7
, pp. 250-256
-
-
Swinson, D.E.1
O'Byrne, K.J.2
-
72
-
-
21744454494
-
The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression
-
Luwor RB, Lu Y, Li X, Mendelsohn J, Fan Z. The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression. Oncogene 2005; 24: 4433-41.
-
(2005)
Oncogene
, vol.24
, pp. 4433-4441
-
-
Luwor, R.B.1
Lu, Y.2
Li, X.3
Mendelsohn, J.4
Fan, Z.5
-
73
-
-
0037341379
-
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen- independent human prostate cancer growing in the bone of nude mice
-
Kim SJ, Uehara H, Karashima T, Shepherd DL, Killion JJ, Fidler IJ. Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen- independent human prostate cancer growing in the bone of nude mice. Clin Cancer Res 2003; 9: 1200-10.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1200-1210
-
-
Kim, S.J.1
Uehara, H.2
Karashima, T.3
Shepherd, D.L.4
Killion, J.J.5
Fidler, I.J.6
-
74
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S, et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001; 61: 5090-101.
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
75
-
-
66149163097
-
Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
-
Naumov GN, Nilsson MB, Cascone T, et al. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res 2009; 15: 3484-94.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3484-3494
-
-
Naumov, G.N.1
Nilsson, M.B.2
Cascone, T.3
-
76
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
-
Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007; 25: 4743-50.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4743-4750
-
-
Herbst, R.S.1
O'Neill, V.J.2
Fehrenbacher, L.3
-
77
-
-
56749102822
-
Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
-
Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008; 26: 5407-15.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5407-5415
-
-
Heymach, J.V.1
Paz-Ares, L.2
De Braud, F.3
-
78
-
-
9944220942
-
ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter
-
Loureiro RM, Maharaj AS, Dankort D, Muller WJ, D'Amore PA. ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun 2005; 326: 455-65.
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 455-465
-
-
Loureiro, R.M.1
Maharaj, A.S.2
Dankort, D.3
Muller, W.J.4
D'Amore, P.A.5
-
79
-
-
33750584030
-
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy
-
Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast RC, Jr., Le XF. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene 2006; 25: 6986-96.
-
(2006)
Oncogene
, vol.25
, pp. 6986-6996
-
-
Wen, X.F.1
Yang, G.2
Mao, W.3
Thornton, A.4
Liu, J.5
Bast Jr., R.C.6
Le, X.F.7
-
80
-
-
2942558419
-
Maximizing the potential of bevacizumab in cancer treatment
-
Bergsland E, Dickler MN. Maximizing the potential of bevacizumab in cancer treatment. Oncologist 2004; 9 Suppl 1: 36-42.
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL 1
, pp. 36-42
-
-
Bergsland, E.1
Dickler, M.N.2
-
81
-
-
33745069947
-
Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents
-
Holash J, Thurston G, Rudge JS, et al. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Rev 2006; 25: 243-52.
-
(2006)
Cancer Metastasis Rev
, vol.25
, pp. 243-252
-
-
Holash, J.1
Thurston, G.2
Rudge, J.S.3
-
82
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
-
Saltz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007; 25: 4557-61.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
-
83
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360: 563-72.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
84
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-80.
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
85
-
-
20444445920
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor- 1alpha
-
Phillips RJ, Mestas J, Gharaee-Kermani M, et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor- 1alpha. J Biol Chem 2005; 280: 22473-81.
-
(2005)
J Biol Chem
, vol.280
, pp. 22473-22481
-
-
Phillips, R.J.1
Mestas, J.2
Gharaee-Kermani, M.3
-
86
-
-
77952301116
-
Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma
-
Hainworth JD, Spigel DR, Howard AB, et al. Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma. J Clin Oncol 2010; 28: 2131-36.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2131-2136
-
-
Hainworth, J.D.1
Spigel, D.R.2
Howard, A.B.3
-
87
-
-
70349976708
-
Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: The Three Musketeers or just another quixotic combination?
-
Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009; 5: 1262-70.
-
(2009)
Mol Biosyst
, vol.5
, pp. 1262-1270
-
-
Kamrava, M.1
Bernstein, M.B.2
Camphausen, K.3
Hodge, J.W.4
-
88
-
-
44349119079
-
SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation
-
Cuneo KC, Geng L, Fu A, Orton D, Hallahan DE, Chakravarthy AB. SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int J Radiat Oncol Biol Phys 2008; 71: 873-9.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, pp. 873-879
-
-
Cuneo, K.C.1
Geng, L.2
Fu, A.3
Orton, D.4
Hallahan, D.E.5
Chakravarthy, A.B.6
-
89
-
-
0041672482
-
SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
-
Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 2003; 63: 4009-16.
-
(2003)
Cancer Res
, vol.63
, pp. 4009-4016
-
-
Schueneman, A.J.1
Himmelfarb, E.2
Geng, L.3
Tan, J.4
Donnelly, E.5
Mendel, D.6
McMahon, G.7
Hallahan, D.E.8
-
90
-
-
45249097586
-
Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
-
Lai A, Filka E, McGibbon B, et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 2008; 71: 1372-80.
-
(2008)
Int J Radiat Oncol Biol Phys
, vol.71
, pp. 1372-1380
-
-
Lai, A.1
Filka, E.2
McGibbon, B.3
-
91
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004; 10: 145-7.
-
(2004)
Nat Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
Boucher, Y.2
di Tomaso, E.3
-
92
-
-
22744435494
-
Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer
-
In, New Orleans, Louisiana
-
Willett CG, Chung D, Sahani D, et al. Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer. In: ASCO Annual Meeting 2004; New Orleans, Louisiana.
-
(2004)
ASCO Annual Meeting
-
-
Willett, C.G.1
Chung, D.2
Sahani, D.3
-
93
-
-
33747622050
-
Dendritic cells and tumor microenvironment: A dangerous liaison
-
Fricke I, Gabrilovich DI. Dendritic cells and tumor microenvironment: a dangerous liaison. Immunol Invest 2006; 35: 459-83.
-
(2006)
Immunol Invest
, vol.35
, pp. 459-483
-
-
Fricke, I.1
Gabrilovich, D.I.2
-
94
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009; 9: 162-74.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
95
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Ozao-Choy J, Ma G, Kao J, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res 2009; 69: 2514-22.
-
(2009)
Cancer Res
, vol.69
, pp. 2514-2522
-
-
Ozao-Choy, J.1
Ma, G.2
Kao, J.3
-
96
-
-
47049127786
-
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
-
Hipp MM, Hilf N, Walter S, et al. Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 2008; 111: 5610-20.
-
(2008)
Blood
, vol.111
, pp. 5610-5620
-
-
Hipp, M.M.1
Hilf, N.2
Walter, S.3
-
97
-
-
1942470411
-
Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon- alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma
-
Rini BI, Halabi S, Taylor J, Small EJ, Schilsky RL. Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon- alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res 2004; 10: 2584-6.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2584-2586
-
-
Rini, B.I.1
Halabi, S.2
Taylor, J.3
Small, E.J.4
Schilsky, R.L.5
-
98
-
-
2442737061
-
Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
-
Pyrhonen S, Salminen E, Ruutu M, et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol 1999; 17: 2859-67.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2859-2867
-
-
Pyrhonen, S.1
Salminen, E.2
Ruutu, M.3
-
99
-
-
0037454239
-
Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
-
von Marschall Z, Scholz A, Cramer T, et al. Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst 2003; 95: 437-48.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 437-448
-
-
von Marschall, Z.1
Scholz, A.2
Cramer, T.3
-
100
-
-
0029075603
-
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas
-
Singh RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ. Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 1995; 92: 4562-6.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4562-4566
-
-
Singh, R.K.1
Gutman, M.2
Bucana, C.D.3
Sanchez, R.4
Llansa, N.5
Fidler, I.J.6
-
101
-
-
34548229506
-
Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: A phase II study of the Southwest Oncology Group
-
Ryan CW, Goldman BH, Lara PN, Jr., et al. Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: a phase II study of the Southwest Oncology Group. J Clin Oncol 2007; 25: 3296-301.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3296-3301
-
-
Ryan, C.W.1
Goldman, B.H.2
Lara Jr., P.N.3
-
102
-
-
34548263735
-
Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer
-
Gollob JA, Rathmell WK, Richmond TM, et al. Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol 2007; 25: 3288-95.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3288-3295
-
-
Gollob, J.A.1
Rathmell, W.K.2
Richmond, T.M.3
-
103
-
-
62449186539
-
Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma
-
Escudier B, Szczylik C, Hutson TE, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 1280-9.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1280-1289
-
-
Escudier, B.1
Szczylik, C.2
Hutson, T.E.3
-
104
-
-
75649152090
-
FDA drug approval summary: Bevacizumab plus interferon for advanced renal cell carcinoma
-
Summers J, Cohen MH, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab plus interferon for advanced renal cell carcinoma. Oncologist 2010; 15: 104-11.
-
(2010)
Oncologist
, vol.15
, pp. 104-111
-
-
Summers, J.1
Cohen, M.H.2
Keegan, P.3
Pazdur, R.4
-
106
-
-
0141814993
-
Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase
-
Avraham HK, Lee TH, Koh Y, et al. Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase. J Biol Chem 2003; 278: 36661-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 36661-36668
-
-
Avraham, H.K.1
Lee, T.H.2
Koh, Y.3
-
107
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009; 6: 327-38.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
Sahani, D.V.4
Zhu, A.X.5
Loeffler, J.S.6
Batchelor, T.T.7
Sorensen, A.G.8
-
108
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
109
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumabrefractory metastatic renal cell carcinoma
-
Rini BI, Michaelson MD, Rosenberg JE, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumabrefractory metastatic renal cell carcinoma. J Clin Oncol 2008; 26: 3743-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
110
-
-
53749093040
-
Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
-
Schneider BP, Wang M, Radovich M, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008; 26: 4672-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4672-4678
-
-
Schneider, B.P.1
Wang, M.2
Radovich, M.3
-
111
-
-
59449108734
-
VEGF as a marker for outcome among advanced breast cancer patients receiving anti- VEGF therapy with bevacizumab and vinorelbine chemotherapy
-
Burstein HJ, Chen YH, Parker LM, et al. VEGF as a marker for outcome among advanced breast cancer patients receiving anti- VEGF therapy with bevacizumab and vinorelbine chemotherapy. Clin Cancer Res 2008; 14: 7871-7.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7871-7877
-
-
Burstein, H.J.1
Chen, Y.H.2
Parker, L.M.3
-
112
-
-
40949111793
-
Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab--an Eastern Cooperative Oncology Group Study
-
Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab--an Eastern Cooperative Oncology Group Study. Clin Cancer Res 2008; 14: 1407-12.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1407-1412
-
-
Dowlati, A.1
Gray, R.2
Sandler, A.B.3
Schiller, J.H.4
Johnson, D.H.5
-
113
-
-
33846149645
-
AZD2171, a pan- VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan- VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11: 83-95.
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
-
114
-
-
34249073831
-
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor
-
Norden-Zfoni A, Desai J, Manola J, et al. Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin Cancer Res 2007; 13: 2643-50.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2643-2650
-
-
Norden-Zfoni, A.1
Desai, J.2
Manola, J.3
-
115
-
-
43049179757
-
Successful targeted therapies for hepatocellular carcinoma: Are we really getting there?
-
Zhu AX. Successful targeted therapies for hepatocellular carcinoma: are we really getting there? Expert Rev Anticancer Ther 2008; 8: 499-505.
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, pp. 499-505
-
-
Zhu, A.X.1
-
116
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: Modulation of VEGF and VEGFrelated proteins
-
Deprimo SE, Bello CL, Smeraglia J, et al. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGFrelated proteins. J Transl Med 2007; 5: 32.
-
(2007)
J Transl Med
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
-
117
-
-
33845358271
-
A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma
-
Mita MM, Rowinsky EK, Forero L, et al. A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma. Cancer Chemother Pharmacol 2007; 59: 165-74.
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 165-174
-
-
Mita, M.M.1
Rowinsky, E.K.2
Forero, L.3
-
118
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006; 24: 16-24.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
119
-
-
33644823334
-
Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer
-
Jubb AM, Hurwitz HI, Bai W, et al. Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer. J Clin Oncol 2006; 24: 217-27.
-
(2006)
J Clin Oncol
, vol.24
, pp. 217-227
-
-
Jubb, A.M.1
Hurwitz, H.I.2
Bai, W.3
-
120
-
-
34547681379
-
Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
-
Drevs J, Siegert P, Medinger M, et al. Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007; 25: 3045-54.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3045-3054
-
-
Drevs, J.1
Siegert, P.2
Medinger, M.3
-
121
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
Saltz LB, Rosen LS, Marshall JL, et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007; 25: 4793-9.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
-
122
-
-
79551646087
-
A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents
-
In, October 30-November 1; Hollywood, Florida
-
Duda DG, Cohen KS, Ancukiewicz M, et al. A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents. In: ASCO Annual Meeting 2008 October 30-November 1; Hollywood, Florida.
-
(2008)
ASCO Annual Meeting
-
-
Duda, D.G.1
Cohen, K.S.2
Ancukiewicz, M.3
-
124
-
-
24944515034
-
Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: Results from a phase I study
-
Liu G, Rugo HS, Wilding G, et al. Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study. J Clin Oncol 2005; 23: 5464-73.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5464-5473
-
-
Liu, G.1
Rugo, H.S.2
Wilding, G.3
-
125
-
-
67650463119
-
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
-
Sorensen AG, Batchelor TT, Zhang WT, et al. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res 2009; 69: 5296-300.
-
(2009)
Cancer Res
, vol.69
, pp. 5296-5300
-
-
Sorensen, A.G.1
Batchelor, T.T.2
Zhang, W.T.3
-
126
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
-
Zhu AX, Sahani DV, Duda DG, et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol 2009; 27: 3027-35.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
-
127
-
-
70350002279
-
Adverse effects of anticancer agents that target the VEGF pathway
-
Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009; 6: 465-77.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 465-477
-
-
Chen, H.X.1
Cleck, J.N.2
-
128
-
-
34547683305
-
Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: Clinical toxicity, therapeutic target, or novel biomarker?
-
van Heeckeren WJ, Ortiz J, Cooney MM, Remick SC. Hypertension, proteinuria, and antagonism of vascular endothelial growth factor signaling: clinical toxicity, therapeutic target, or novel biomarker? J Clin Oncol 2007; 25: 2993-5.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2993-2995
-
-
van Heeckeren, W.J.1
Ortiz, J.2
Cooney, M.M.3
Remick, S.C.4
-
129
-
-
0031471950
-
Vascular endothelial growth factor/vascular permeability factor produces nitric oxidedependent hypotension. Evidence for a maintenance role in quiescent adult endothelium
-
Horowitz JR, Rivard A, van der Zee R, et al. Vascular endothelial growth factor/vascular permeability factor produces nitric oxidedependent hypotension. Evidence for a maintenance role in quiescent adult endothelium. Arterioscler Thromb Vasc Biol 1997; 17: 2793-800.
-
(1997)
Arterioscler Thromb Vasc Biol
, vol.17
, pp. 2793-2800
-
-
Horowitz, J.R.1
Rivard, A.2
van der Zee, R.3
-
130
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-34.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
131
-
-
34848865338
-
Anti-VEGF therapy for renal cell carcinoma
-
Escudier B. Anti-VEGF therapy for renal cell carcinoma. Clin Adv Hematol Oncol 2007; 5: 530-1.
-
(2007)
Clin Adv Hematol Oncol
, vol.5
, pp. 530-531
-
-
Escudier, B.1
-
132
-
-
34548141828
-
Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
-
Scappaticci FA, Skillings JR, Holden SN, et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007; 99: 1232-9.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1232-1239
-
-
Scappaticci, F.A.1
Skillings, J.R.2
Holden, S.N.3
-
133
-
-
45449090215
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
Spano JP, Chodkiewicz C, Maurel J, et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet 2008; 371: 2101-8.
-
(2008)
Lancet
, vol.371
, pp. 2101-2108
-
-
Spano, J.P.1
Chodkiewicz, C.2
Maurel, J.3
-
134
-
-
20044364346
-
Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
-
Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005; 23: 792-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 792-799
-
-
Miller, K.D.1
Chap, L.I.2
Holmes, F.A.3
-
135
-
-
0037370325
-
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
-
Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111: 707-16.
-
(2003)
J Clin Invest
, vol.111
, pp. 707-716
-
-
Eremina, V.1
Sood, M.2
Haigh, J.3
-
136
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-76.
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
137
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25: 1539-44.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
138
-
-
58449096748
-
Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib
-
Bollee G, Patey N, Cazajous G, et al. Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transplant 2009; 24: 682-5.
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 682-685
-
-
Bollee, G.1
Patey, N.2
Cazajous, G.3
-
139
-
-
34848922067
-
Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome
-
Kapiteijn E, Brand A, Kroep J, Gelderblom H. Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome. Ann Oncol 2007; 18: 1745-7.
-
(2007)
Ann Oncol
, vol.18
, pp. 1745-1747
-
-
Kapiteijn, E.1
Brand, A.2
Kroep, J.3
Gelderblom, H.4
-
140
-
-
0034600837
-
Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice
-
Streit M, Velasco P, Riccardi L, et al. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. EMBO J 2000; 19: 3272-82.
-
(2000)
EMBO J
, vol.19
, pp. 3272-3282
-
-
Streit, M.1
Velasco, P.2
Riccardi, L.3
-
141
-
-
49749124673
-
Clinical pharmacokinetics of bevacizumab in patients with solid tumors
-
Lu JF, Bruno R, Eppler S, Novotny W, Lum B, Gaudreault J. Clinical pharmacokinetics of bevacizumab in patients with solid tumors. Cancer Chemother Pharmacol 2008; 62: 779-86.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 779-786
-
-
Lu, J.F.1
Bruno, R.2
Eppler, S.3
Novotny, W.4
Lum, B.5
Gaudreault, J.6
-
142
-
-
33644863001
-
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
-
Wedam SB, Low JA, Yang SX, et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 2006; 24: 769-77.
-
(2006)
J Clin Oncol
, vol.24
, pp. 769-777
-
-
Wedam, S.B.1
Low, J.A.2
Yang, S.X.3
-
143
-
-
34548169627
-
Reversible posterior leukoencephalopathy syndrome induced by sunitinib
-
Martin G, Bellido L, Cruz JJ. Reversible posterior leukoencephalopathy syndrome induced by sunitinib. J Clin Oncol 2007; 25: 3559.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3559
-
-
Martin, G.1
Bellido, L.2
Cruz, J.J.3
-
144
-
-
33750589845
-
Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006
-
Govindarajan R, Adusumilli J, Baxter DL, El-Khoueiry A, Harik SI. Reversible posterior leukoencephalopathy syndrome induced by RAF kinase inhibitor BAY 43-9006. J Clin Oncol 2006; 24: e48.
-
(2006)
J Clin Oncol
, vol.24
-
-
Govindarajan, R.1
Adusumilli, J.2
Baxter, D.L.3
El-Khoueiry, A.4
Harik, S.I.5
-
145
-
-
33750961647
-
Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors
-
Desai J, Yassa L, Marqusee E, et al. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006; 145: 660-4.
-
(2006)
Ann Intern Med
, vol.145
, pp. 660-664
-
-
Desai, J.1
Yassa, L.2
Marqusee, E.3
-
146
-
-
43749110700
-
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the11715 Study Group
-
McDermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the11715 Study Group. J Clin Oncol 2008; 26: 2178-85.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2178-2185
-
-
McDermott, D.F.1
Sosman, J.A.2
Gonzalez, R.3
-
147
-
-
46449117698
-
Motesanib diphosphate in progressive differentiated thyroid cancer
-
Sherman SI, Wirth LJ, Droz JP, et al. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 2008; 359: 31-42.
-
(2008)
N Engl J Med
, vol.359
, pp. 31-42
-
-
Sherman, S.I.1
Wirth, L.J.2
Droz, J.P.3
-
148
-
-
63149101547
-
Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy
-
Azad NS, Aragon-Ching JB, Dahut WL, et al. Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy. Clin Cancer Res 2009; 15: 1411-6.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1411-1416
-
-
Azad, N.S.1
Aragon-Ching, J.B.2
Dahut, W.L.3
-
149
-
-
59449106057
-
Cooperative group research efforts in lung cancer 2008: Focus on advanced-stage nonsmall- cell lung cancer
-
Wakelee H, Kernstine K, Vokes E, et al. Cooperative group research efforts in lung cancer 2008: focus on advanced-stage nonsmall- cell lung cancer. Clin Lung Cancer 2008; 9: 346-51.
-
(2008)
Clin Lung Cancer
, vol.9
, pp. 346-351
-
-
Wakelee, H.1
Kernstine, K.2
Vokes, E.3
-
150
-
-
49249113484
-
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
-
Azad NS, Posadas EM, Kwitkowski VE, et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008; 26: 3709-14.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3709-3714
-
-
Azad, N.S.1
Posadas, E.M.2
Kwitkowski, V.E.3
-
151
-
-
43749107912
-
Acquired resistance to tyrosine kinase inhibitors during cancer therapy
-
Engelman JA, Settleman J. Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr Opin Genet Dev 2008; 18: 73-9.
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 73-79
-
-
Engelman, J.A.1
Settleman, J.2
-
152
-
-
16644394469
-
Can tumor angiogenesis be inhibited without resistance?
-
Miller KD, Sweeney CJ, Sledge GW, Jr. Can tumor angiogenesis be inhibited without resistance? EXS 2005: 95-112.
-
(2005)
EXS
, pp. 95-112
-
-
Miller, K.D.1
Sweeney, C.J.2
Sledge Jr., G.W.3
-
153
-
-
58149190795
-
Pathways mediating resistance to vascular endothelial growth factor-targeted therapy
-
Ellis LM, Hicklin DJ. Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin Cancer Res 2008; 14: 6371-5.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6371-6375
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
154
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors. Cancer Cell 2005; 8: 299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
155
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
-
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci USA 2007; 104: 17069-74.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaers, A.J.4
Kerbel, R.S.5
-
156
-
-
4644271546
-
Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies
-
Bocci G, Man S, Green SK, et al. Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res 2004; 64: 6616-25.
-
(2004)
Cancer Res
, vol.64
, pp. 6616-6625
-
-
Bocci, G.1
Man, S.2
Green, S.K.3
-
157
-
-
0031019745
-
Isolation of putative progenitor endothelial cells for angiogenesis
-
Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-7.
-
(1997)
Science
, vol.275
, pp. 964-967
-
-
Asahara, T.1
Murohara, T.2
Sullivan, A.3
-
158
-
-
26944437515
-
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005; 7: 870-9.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
Werb, Z.4
Bergers, G.5
-
159
-
-
0347123433
-
Tumour-educated macrophages promote tumour progression and metastasis
-
Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71-8.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 71-78
-
-
Pollard, J.W.1
-
160
-
-
24944587964
-
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
-
De Palma M, Venneri MA, Galli R, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 2005; 8: 211-26.
-
(2005)
Cancer Cell
, vol.8
, pp. 211-226
-
-
De Palma, M.1
Venneri, M.A.2
Galli, R.3
-
161
-
-
0036344496
-
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
-
Hattori K, Heissig B, Wu Y, et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 2002; 8: 841-9.
-
(2002)
Nat Med
, vol.8
, pp. 841-849
-
-
Hattori, K.1
Heissig, B.2
Wu, Y.3
-
162
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438: 820-7.
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
-
164
-
-
33644643376
-
Pericytes limit tumor cell metastasis
-
Xian X, Hakansson J, Stahlberg A, Lindblom P, Betsholtz C, Gerhardt H, Semb H. Pericytes limit tumor cell metastasis. J Clin Invest 2006; 116: 642-51.
-
(2006)
J Clin Invest
, vol.116
, pp. 642-651
-
-
Xian, X.1
Hakansson, J.2
Stahlberg, A.3
Lindblom, P.4
Betsholtz, C.5
Gerhardt, H.6
Semb, H.7
-
165
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
Rubenstein JL, Kim J, Ozawa T, et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000; 2: 306-14.
-
(2000)
Neoplasia
, vol.2
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
-
166
-
-
41649112610
-
Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
-
Norden AD, Young GS, Setayesh K, et al. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 2008; 70: 779-87.
-
(2008)
Neurology
, vol.70
, pp. 779-787
-
-
Norden, A.D.1
Young, G.S.2
Setayesh, K.3
-
167
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15: 232-9.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
168
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15: 220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
169
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
Reynolds AR, Hart IR, Watson AR, et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 2009; 15: 392-400.
-
(2009)
Nat Med
, vol.15
, pp. 392-400
-
-
Reynolds, A.R.1
Hart, I.R.2
Watson, A.R.3
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