메뉴 건너뛰기




Volumn 2, Issue 3, 2012, Pages 260-269

Nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; CYTIDINE DEAMINASE; DOCETAXEL; GEMCITABINE; KI 67 ANTIGEN; PACLITAXEL; REACTIVE OXYGEN METABOLITE; UVOMORULIN;

EID: 84863849090     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0242     Document Type: Article
Times cited : (359)

References (39)
  • 1
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 2
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605-17.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 3
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-61.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 4
    • 69949109921 scopus 로고    scopus 로고
    • Decreased blood flow with increased metabolic activity: A novel sign of pancreatic tumor aggressiveness
    • Komar G, Kauhanen S, Liukko K, Seppanen M, Kajander S, Ovaska J, et al. Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res 2009;15:5511-7.
    • (2009) Clin Cancer Res , vol.15 , pp. 5511-5517
    • Komar, G.1    Kauhanen, S.2    Liukko, K.3    Seppanen, M.4    Kajander, S.5    Ovaska, J.6
  • 5
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol 2011;29:4548-54.
    • (2011) J Clin Oncol , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3    Laheru, D.A.4    Smith, L.S.5    Wood, T.E.6
  • 6
    • 33745458519 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel: A next-generation taxane
    • Gradishar WJ. Albumin-bound paclitaxel: a next-generation taxane. Exp Opin Pharmacother 2006;7:1041-53.
    • (2006) Exp Opin Pharmacother , vol.7 , pp. 1041-1053
    • Gradishar, W.J.1
  • 7
    • 33644753906 scopus 로고    scopus 로고
    • Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel
    • Desai N, Trieu V, Yao Z, Louie L, Ci S, Yang A, et al. Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel. Clin Cancer Res 2006;12:1317-24.
    • (2006) Clin Cancer Res , vol.12 , pp. 1317-1324
    • Desai, N.1    Trieu, V.2    Yao, Z.3    Louie, L.4    Ci, S.5    Yang, A.6
  • 8
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005;23:7794-803.
    • (2005) J Clin Oncol , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3    Shaw, H.4    Desai, N.5    Bhar, P.6
  • 10
    • 33846916208 scopus 로고    scopus 로고
    • Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    • Infante JR, Matsubayashi H, Sato N, Tonascia J, Klein AP, Riall TA, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 2007;25:319-25.
    • (2007) J Clin Oncol , vol.25 , pp. 319-325
    • Infante, J.R.1    Matsubayashi, H.2    Sato, N.3    Tonascia, J.4    Klein, A.P.5    Riall, T.A.6
  • 11
    • 70350134980 scopus 로고    scopus 로고
    • SPARC expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients
    • Desai N, Trieu V, Damascelli B, Soon-Shiong P. SPARC expression correlates with tumor response to albumin-bound paclitaxel in head and neck cancer patients. Transl Oncol 2009;2:59-64.
    • (2009) Transl Oncol , vol.2 , pp. 59-64
    • Desai, N.1    Trieu, V.2    Damascelli, B.3    Soon-Shiong, P.4
  • 12
    • 79958125714 scopus 로고    scopus 로고
    • Improved response to nab-paclitaxel compared with cremophor-solubilized paclitaxel is independent of secreted protein acidic and rich in cysteine expression in non-small cell lung cancer
    • Shao H, Tang H, Salavaggione OE, Yu C, Hylander B, Tan W, et al. Improved response to nab-paclitaxel compared with cremophor-solubilized paclitaxel is independent of secreted protein acidic and rich in cysteine expression in non-small cell lung cancer. J Thorac Oncol 2011;6:998-1005.
    • (2011) J Thorac Oncol , vol.6 , pp. 998-1005
    • Shao, H.1    Tang, H.2    Salavaggione, O.E.3    Yu, C.4    Hylander, B.5    Tan, W.6
  • 13
    • 84873005149 scopus 로고    scopus 로고
    • National Institutes of Health. Phase III Study of ABI-007(Albuminbound Paclitaxel), ClinicalTrials. gov. Available from
    • National Institutes of Health. Phase III Study of ABI-007(Albuminbound Paclitaxel) Plus Gemcitabine Versus Gemcitabine in Metastatic Adenocarcinoma of the Pancreas. ClinicalTrials. gov. Available from: clinicaltrials. gov/ct2/show/NCT00844649.
    • Plus Gemcitabine Versus Gemcitabine in Metastatic Adenocarcinoma of the Pancreas
  • 14
    • 33645736793 scopus 로고    scopus 로고
    • Genetically engineered models have advantages over xenografts for preclinical studies
    • discussion 8-9
    • Becher OJ, Holland EC. Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res 2006;66:3355-8;discussion 8-9.
    • (2006) Cancer Res , vol.66 , pp. 3355-3358
    • Becher, O.J.1    Holland, E.C.2
  • 15
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese KK, Tuveson DA. Maximizing mouse cancer models. Nat Rev Cancer 2007;7:645-58.
    • (2007) Nat Rev Cancer , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 16
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5    Hruban, R.H.6
  • 17
    • 31544467540 scopus 로고    scopus 로고
    • Pathology of genetically engineered mouse models of pancreatic exocrine cancer: Consensus report and recommendations
    • Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, Boivin GP, et al. Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res 2006;66:95-106.
    • (2006) Cancer Res , vol.66 , pp. 95-106
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3    Anver, M.R.4    Biankin, A.V.5    Boivin, G.P.6
  • 18
    • 61649107667 scopus 로고    scopus 로고
    • Phase II trial of weekly nab (nanoparticle albumin-bound)-paclitaxel (nab-paclitaxel) (Abraxane) in combination with gemcitabine in patients with metastatic breast cancer (N0531)
    • Roy V, LaPlant BR, Gross GG, Bane CL, Palmieri FM. Phase II trial of weekly nab (nanoparticle albumin-bound)-paclitaxel (nab-paclitaxel) (Abraxane) in combination with gemcitabine in patients with metastatic breast cancer (N0531). Ann Oncol 2009;20:449-53.
    • (2009) Ann Oncol , vol.20 , pp. 449-453
    • Roy, V.1    LaPlant, B.R.2    Gross, G.G.3    Bane, C.L.4    Palmieri, F.M.5
  • 19
    • 43049151113 scopus 로고    scopus 로고
    • Phase I trial of nanoparticle albumin-bound paclitaxel in combination with gemcitabine in patients with thoracic malignancies
    • Stinchcombe TE, Socinski MA, Lee CB, Hayes DN, Moore DT, Goldberg RM, et al. Phase I trial of nanoparticle albumin-bound paclitaxel in combination with gemcitabine in patients with thoracic malignancies. J Thorac Oncol 2008;3:521-6.
    • (2008) J Thorac Oncol , vol.3 , pp. 521-526
    • Stinchcombe, T.E.1    Socinski, M.A.2    Lee, C.B.3    Hayes, D.N.4    Moore, D.T.5    Goldberg, R.M.6
  • 20
    • 82455192250 scopus 로고    scopus 로고
    • A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: Comparison with (19)F NMR spectroscopy
    • Bapiro TE, Richards FM, Goldgraben MA, Olive KP, Madhu B, Frese KK, et al. A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy. Cancer Chemother Pharmacol 2011;68:1243-53.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1243-1253
    • Bapiro, T.E.1    Richards, F.M.2    Goldgraben, M.A.3    Olive, K.P.4    Madhu, B.5    Frese, K.K.6
  • 21
    • 78650078496 scopus 로고    scopus 로고
    • Quantitative reactivity profiling predicts functional cysteines in proteomes
    • Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, et al. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature 2010;468:790-5.
    • (2010) Nature , vol.468 , pp. 790-795
    • Weerapana, E.1    Wang, C.2    Simon, G.M.3    Richter, F.4    Khare, S.5    Dillon, M.B.6
  • 22
    • 50349090153 scopus 로고    scopus 로고
    • Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine
    • Beumer JH, Eiseman JL, Parise RA, Joseph E, Covey JM, Egorin MJ. Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine. Clin Cancer Res 2008;14:3529-35.
    • (2008) Clin Cancer Res , vol.14 , pp. 3529-3535
    • Beumer, J.H.1    Eiseman, J.L.2    Parise, R.A.3    Joseph, E.4    Covey, J.M.5    Egorin, M.J.6
  • 23
    • 0026425674 scopus 로고
    • Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue
    • Bissery MC, Guenard D, Gueritte-Voegelein F, Lavelle F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res 1991;51:4845-52.
    • (1991) Cancer Res , vol.51 , pp. 4845-4852
    • Bissery, M.C.1    Guenard, D.2    Gueritte-Voegelein, F.3    Lavelle, F.4
  • 24
    • 0036294677 scopus 로고    scopus 로고
    • Phase II study of docetaxel in patients with pancreatic cancer previously untreated with cytotoxic chemotherapy
    • Lenzi R, Yalcin S, Evans DB, Abbruzzese JL. Phase II study of docetaxel in patients with pancreatic cancer previously untreated with cytotoxic chemotherapy. Cancer Invest 2002;20:464-72.
    • (2002) Cancer Invest , vol.20 , pp. 464-472
    • Lenzi, R.1    Yalcin, S.2    Evans, D.B.3    Abbruzzese, J.L.4
  • 25
    • 0036142182 scopus 로고    scopus 로고
    • A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma
    • Ryan DP, Kulke MH, Fuchs CS, Grossbard ML, Grossman SR, Morgan JA, et al. A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer 2002;94:97-103.
    • (2002) Cancer , vol.94 , pp. 97-103
    • Ryan, D.P.1    Kulke, M.H.2    Fuchs, C.S.3    Grossbard, M.L.4    Grossman, S.R.5    Morgan, J.A.6
  • 27
    • 0033778922 scopus 로고    scopus 로고
    • Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines
    • Kroep JR, Giaccone G, Tolis C, Voorn DA, Loves WJ, Groeningen CJ, et al. Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines. Br J Cancer 2000;83:1069-76.
    • (2000) Br J Cancer , vol.83 , pp. 1069-1076
    • Kroep, J.R.1    Giaccone, G.2    Tolis, C.3    Voorn, D.A.4    Loves, W.J.5    Groeningen, C.J.6
  • 28
    • 0032983664 scopus 로고    scopus 로고
    • Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer
    • Kroep JR, Giaccone G, Voorn DA, Smit EF, Beijnen JH, Rosing H, et al. Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer. J Clin Oncol 1999;17:2190-7.
    • (1999) J Clin Oncol , vol.17 , pp. 2190-2197
    • Kroep, J.R.1    Giaccone, G.2    Voorn, D.A.3    Smit, E.F.4    Beijnen, J.H.5    Rosing, H.6
  • 30
    • 79959984687 scopus 로고    scopus 로고
    • Integrating pharmacogenetics into gemcitabine dosing-time for a change?
    • Ciccolini J, Mercier C, Dahan L, Andre N. Integrating pharmacogenetics into gemcitabine dosing-time for a change? Nat Rev Clin Oncol 2011;8:439-44.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 439-444
    • Ciccolini, J.1    Mercier, C.2    Dahan, L.3    Andre, N.4
  • 32
    • 0028105119 scopus 로고
    • Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours
    • Ruiz van Haperen VW, Veerman G, Boven E, Noordhuis P, Vermorken JB, Peters GJ. Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours. Biochem Pharmacol 1994;48:1327-39.
    • (1994) Biochem Pharmacol , vol.48 , pp. 1327-1339
    • Ruiz van Haperen, V.W.1    Veerman, G.2    Boven, E.3    Noordhuis, P.4    Vermorken, J.B.5    Peters, G.J.6
  • 35
    • 77957166901 scopus 로고    scopus 로고
    • Influence of cytidine deaminase on antitumor activity of 2'-deoxycytidine analogs in vitro and in vivo
    • Yoshida T, Endo Y, Obata T, Kosugi Y, Sakamoto K, Sasaki T. Influence of cytidine deaminase on antitumor activity of 2'-deoxycytidine analogs in vitro and in vivo. Drug Metab Dispos 2010;38:1814-9.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1814-1819
    • Yoshida, T.1    Endo, Y.2    Obata, T.3    Kosugi, Y.4    Sakamoto, K.5    Sasaki, T.6
  • 36
    • 34648847288 scopus 로고    scopus 로고
    • Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation
    • Mercier C, Raynal C, Dahan L, Ortiz A, Evrard A, Dupuis C, et al. Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation. Pharmacogenet Genomics 2007;17:841-4.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 841-844
    • Mercier, C.1    Raynal, C.2    Dahan, L.3    Ortiz, A.4    Evrard, A.5    Dupuis, C.6
  • 37
    • 73949130114 scopus 로고    scopus 로고
    • Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies
    • Ciccolini J, Dahan L, Andre N, Evrard A, Duluc M, Blesius A, et al. Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies. J Clin Oncol 2010;28:160-5.
    • (2010) J Clin Oncol , vol.28 , pp. 160-165
    • Ciccolini, J.1    Dahan, L.2    Andre, N.3    Evrard, A.4    Duluc, M.5    Blesius, A.6
  • 38
    • 70449123573 scopus 로고    scopus 로고
    • C-Raf inhibits MAPK activation and transformation by B-Raf(V600E)
    • Karreth FA, DeNicola GM, Winter SP, Tuveson DA. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). Mol Cell 2009;36:477-86.
    • (2009) Mol Cell , vol.36 , pp. 477-486
    • Karreth, F.A.1    DeNicola, G.M.2    Winter, S.P.3    Tuveson, D.A.4
  • 39
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011;475:106-9.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3    Gopinathan, A.4    Wei, C.5    Frese, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.