-
1
-
-
84987603462
-
Inhibition of ATP-gated P2X3 channels by AF-219: An effective antitussive mechanism in chronic cough
-
Abdulqawi, R., Dockry, R., Holt, K., Woodcock, A., Layton, G., McCarthy, B., et al. (2013). Inhibition of ATP-gated P2X3 channels by AF-219: an effective antitussive mechanism in chronic cough. Proceedings of the European Respiratory Society Annual Congress, abstract 1965.
-
(2013)
Proceedings of the European Respiratory Society Annual Congress
, pp. 1965
-
-
Abdulqawi, R.1
Dockry, R.2
Holt, K.3
Woodcock, A.4
Layton, G.5
McCarthy, B.6
-
2
-
-
70349845440
-
Cellular and molecular mechanisms of pain
-
doi: 10.1016/j.cell.2009., 09.028
-
Basbaum, A. I., Bautista, D. M., Scherrer, G., and Julius, D. (2009). Cellular and molecular mechanisms of pain. Cell 139, 267-284. doi: 10.1016/j.cell.2009.09.028
-
(2009)
Cell
, vol.139
, pp. 267-284
-
-
Basbaum, A.I.1
Bautista, D.M.2
Scherrer, G.3
Julius, D.4
-
3
-
-
27144549227
-
Effects of aerosolized adenosine 5'-triphosphate vs adenosine 5'-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma
-
doi: 10.1378/chest. 128.4.1905
-
Basoglu, O. K., Pelleg, A., Essilfie-Quaye, S., Brindicci, C., Barnes, P. J., and Kharitonov, S. A. (2005). Effects of aerosolized adenosine 5'-triphosphate vs adenosine 5'-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest 128, 1905-1909. doi: 10.1378/chest. 128.4.1905
-
(2005)
Chest
, vol.128
, pp. 1905-1909
-
-
Basoglu, O.K.1
Pelleg, A.2
Essilfie-Quaye, S.3
Brindicci, C.4
Barnes, P.J.5
Kharitonov, S.A.6
-
4
-
-
35448972940
-
Intravenous ATP infusions can be safely administered in the home setting: A study in pre-terminal cancer patients
-
doi: 10.1007/s10637-007-9076-1
-
Beijer, S., Gielisse, E. A., Hupperets, P. S., van den Borne, B. E., van den Beuken-van Everdingen, M., Nijziel, M. R., et al. (2007). Intravenous ATP infusions can be safely administered in the home setting: a study in pre-terminal cancer patients. Invest. New Drugs 25, 571-579. doi: 10.1007/s10637-007-9076-1
-
(2007)
Invest. New Drugs
, vol.25
, pp. 571-579
-
-
Beijer, S.1
Gielisse, E.A.2
Hupperets, P.S.3
van den Borne, B.E.4
Nijziel, M.R.5
-
5
-
-
0030854414
-
Acute nociception mediated by hindpaw P2X receptor activation in the rat
-
doi:, 10.1038/sj.bjp.0701371
-
Bland-Ward, P. A., and Humphrey, P. P. (1997). Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br. J. Pharmacol. 122, 365-371. doi: 10.1038/sj.bjp.0701371
-
(1997)
Br. J. Pharmacol
, vol.122
, pp. 365-371
-
-
Bland-Ward, P.A.1
Humphrey, P.P.2
-
6
-
-
0017190556
-
Identification of algogenic substances in human erythrocytes
-
Bleehen, T., Hobbiger, F., and Keele, C. A. (1976). Identification of algogenic substances in human erythrocytes. J. Physiol. 262, 131-149.
-
(1976)
J. Physiol
, vol.262
, pp. 131-149
-
-
Bleehen, T.1
Hobbiger, F.2
Keele, C.A.3
-
7
-
-
0017682312
-
Observations on the algogenic actions of adenosine compounds on the human skin blister base preparation
-
doi: 10.1016/0304-3959(77)90066-5
-
Bleehen, T., and Keele, C. A. (1977). Observations on the algogenic actions of adenosine compounds on the human skin blister base preparation. Pain 3, 367-377. doi: 10.1016/0304-3959(77)90066-5
-
(1977)
Pain
, vol.3
, pp. 367-377
-
-
Bleehen, T.1
Keele, C.A.2
-
8
-
-
78049425093
-
The discovery and development of analgesics: New mechanisms, new modalities
-
doi: 10., 1172/jci43195
-
Burgess, G., and Williams, D. (2010). The discovery and development of analgesics: new mechanisms, new modalities. J. Clin. Invest. 120, 3753-3759. doi: 10.1172/jci43195
-
(2010)
J. Clin. Invest
, vol.120
, pp. 3753-3759
-
-
Burgess, G.1
Williams, D.2
-
9
-
-
84865411454
-
Discovery of purinergic signalling, the initial resistance and current explosion of interest
-
doi: 10.1111/j.1476-5381.2012.02008.x
-
Burnstock, G. (2012). Discovery of purinergic signalling, the initial resistance and current explosion of interest. Br. J. Pharmacol. 167, 238-255. doi: 10.1111/j.1476-5381.2012.02008.x
-
(2012)
Br. J. Pharmacol
, vol.167
, pp. 238-255
-
-
Burnstock, G.1
-
10
-
-
84891107456
-
The paton lecture: Purinergic signalling: From discovery to current developments
-
doi: 10.1113/expphysiol.2013.071951. [Epub ahead of print]
-
Burnstock, G. (2013). The paton lecture: purinergic signalling: from discovery to current developments. Exp. Physiol. doi: 10.1113/expphysiol.2013.071951. [Epub ahead of print].
-
(2013)
Exp. Physiol
-
-
Burnstock, G.1
-
11
-
-
84867048404
-
Purinergic signaling in the airways
-
doi: 10.1124/pr.111., 005389
-
Burnstock, G., Brouns, I., Adriaensen, D., and Timmermans, J. P. (2012). Purinergic signaling in the airways. Pharmacol. Rev. 64, 834-868. doi: 10.1124/pr.111.005389
-
(2012)
Pharmacol. Rev
, vol.64
, pp. 834-868
-
-
Burnstock, G.1
Brouns, I.2
Adriaensen, D.3
Timmermans, J.P.4
-
12
-
-
84865968854
-
Activation of peripheral P2X receptors is sufficient to induce central sensitization in rat medullary dorsal horn nociceptive neurons
-
doi: 10.1016/j.neulet. 2012.08.007
-
Cherkas, P. S., Dostrovsky, J. O., and Sessle, B. J. (2012). Activation of peripheral P2X receptors is sufficient to induce central sensitization in rat medullary dorsal horn nociceptive neurons. Neurosci. Lett. 526, 160-163. doi: 10.1016/j.neulet. 2012.08.007
-
(2012)
Neurosci. Lett
, vol.526
, pp. 160-163
-
-
Cherkas, P.S.1
Dostrovsky, J.O.2
Sessle, B.J.3
-
13
-
-
77956194973
-
Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema
-
doi: 10. 4049/jimmunol.0904042
-
Cicko, S., Lucattelli, M., Müller, T., Lommatzsch, M., De Cunto, G., Cardini, S., et al. (2010). Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema. J. Immunol. 185, 688-697. doi: 10. 4049/jimmunol.0904042
-
(2010)
J. Immunol
, vol.185
, pp. 688-697
-
-
Cicko, S.1
Lucattelli, M.2
Müller, T.3
Lommatzsch, M.4
de Cunto, G.5
Cardini, S.6
-
14
-
-
24944564718
-
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP
-
doi: 10.1113/jphysiol.2005.088435
-
Cockayne, D. A., Dunn, P. M., Zhong, Y., Rong, W., Hamilton, S. G., Knight, G. E., et al. (2005). P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J. Physiol. 567, 621-639. doi: 10.1113/jphysiol.2005.088435
-
(2005)
J. Physiol
, vol.567
, pp. 621-639
-
-
Cockayne, D.A.1
Dunn, P.M.2
Zhong, Y.3
Rong, W.4
Hamilton, S.G.5
Knight, G.E.6
-
15
-
-
0014025239
-
Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'triphosphate
-
doi: 10.1038/212411a0
-
Collier, H. O., James, G. W., and Schneider, C. (1966). Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'triphosphate. Nature 212, 411-412. doi: 10.1038/212411a0
-
(1966)
Nature
, vol.212
, pp. 411-412
-
-
Collier, H.O.1
James, G.W.2
Schneider, C.3
-
16
-
-
84886092746
-
OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium
-
doi: 10.1111/bju.12266
-
Collins, V. M., Daly, D. M., Liaskos, M., McKay, N. G., Sellers, D., Chapple, C., et al. (2013). OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium. BJU Int. 112, 1018-1026. doi: 10.1111/bju.12266
-
(2013)
BJU Int
, vol.112
, pp. 1018-1026
-
-
Collins, V.M.1
Daly, D.M.2
Liaskos, M.3
McKay, N.G.4
Sellers, D.5
Chapple, C.6
-
17
-
-
0036149221
-
Cell damage excites nociceptors through release of cytosolic ATP
-
doi: 10.1016/s0304-3959(01)00372-4
-
Cook, S. P., and McCleskey, E. W. (2002). Cell damage excites nociceptors through release of cytosolic ATP. Pain 95, 41-47. doi: 10.1016/s0304-3959(01)00372-4
-
(2002)
Pain
, vol.95
, pp. 41-47
-
-
Cook, S.P.1
McCleskey, E.W.2
-
18
-
-
0019834690
-
Adenosine triphosphate-evoked vascular changes in human skin: Mechanism of action
-
doi: 10.1016/0014-2999(81) 90110-2
-
Coutts, A. A., Jorizzo, J. L., Eady, R. A., Greaves, M. W., and Burnstock, G. (1981). Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action. Eur. J. Pharmacol. 76, 391-401. doi: 10.1016/0014-2999(81) 90110-2
-
(1981)
Eur. J. Pharmacol
, vol.76
, pp. 391-401
-
-
Coutts, A.A.1
Jorizzo, J.L.2
Eady, R.A.3
Greaves, M.W.4
Burnstock, G.5
-
19
-
-
0031444212
-
A neurologic basis for the overactive bladder
-
discussion 53-56, doi: 10.1016/s0090-4295(97)00587-6
-
de Groat, W. C. (1997). A neurologic basis for the overactive bladder. Urology 50(Suppl. 6A), 36-52; discussion 53-56. doi: 10.1016/s0090-4295(97)00587-6
-
(1997)
Urology
, vol.50
, Issue.6 SUPPL. A
, pp. 36-52
-
-
de Groat, W.C.1
-
20
-
-
84870813397
-
Organization of the neural switching circuitry underlying reflex micturition
-
doi: 10. 1111/apha.12014
-
de Groat, W. C., and Wickens, C. (2013). Organization of the neural switching circuitry underlying reflex micturition. Acta Physiol. (Oxf.) 207, 66-84. doi: 10. 1111/apha.12014
-
(2013)
Acta Physiol (Oxf.)
, vol.207
, pp. 66-84
-
-
de Groat, W.C.1
Wickens, C.2
-
21
-
-
0031468013
-
ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism
-
doi: 10.1111/j.1469, 7793.1997.503bb.x
-
Ferguson, D. R., Kennedy, I., and Burton, T. J. (1997). ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism? J. Physiol. 505, 503-511. doi: 10.1111/j.14697793.1997.503bb.x
-
(1997)
J. Physiol
, vol.505
, pp. 503-511
-
-
Ferguson, D.R.1
Kennedy, I.2
Burton, T.J.3
-
22
-
-
84856298187
-
In pursuit of P2X3 antagonists: Novel therapeutics for chronic pain and afferent sensitization
-
doi: 10., 1007/s11302-011-9271-6
-
Ford, A. P. (2012). In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal. 8(Suppl. 1), 3-26. doi: 10.1007/s11302-011-9271-6
-
(2012)
Purinergic Signal
, vol.8
, Issue.1 SUPPL.
, pp. 3-26
-
-
Ford, A.P.1
-
23
-
-
79952210836
-
ATP and P2X purinoceptors in urinary tract disorders
-
doi: 10.1007/978-3-642-16499-6_22
-
Ford, A. P., and Cockayne, D. A. (2011). ATP and P2X purinoceptors in urinary tract disorders. Handb. Exp. Pharmacol. 202, 485-526. doi: 10.1007/978-3-642-16499-6_22
-
(2011)
Handb. Exp. Pharmacol
, vol.202
, pp. 485-526
-
-
Ford, A.P.1
Cockayne, D.A.2
-
24
-
-
85046632221
-
Pharmadynamic (PD) and pharmacokinetic (PK) properties of AF-219: First in class, selective, clinical P2X3 antagonist in development for chronic pain and related conditions
-
(Meeting Abstract Supplement) 887.5
-
Ford, A. P., Smith, S. A., and Dillon, M. P. (2013). Pharmadynamic (PD) and pharmacokinetic (PK) properties of AF-219: first in class, selective, clinical P2X3 antagonist in development for chronic pain and related conditions. FASEB J. 27, (Meeting Abstract Supplement) 887.5.
-
(2013)
FASEB J
, vol.27
-
-
Ford, A.P.1
Smith, S.A.2
Dillon, M.P.3
-
25
-
-
43949141253
-
The neural control of micturition
-
doi: 10.1038/nrn2401
-
Fowler, C. J., Griffiths, D., and de Groat, W. C. (2008). The neural control of micturition. Nat. Rev. Neurosci. 9, 453-466. doi: 10.1038/nrn2401
-
(2008)
Nat. Rev. Neurosci
, vol.9
, pp. 453-466
-
-
Fowler, C.J.1
Griffiths, D.2
de Groat, W.C.3
-
26
-
-
0027240457
-
An in vitro study of the properties of single vagal afferents innervating guinea-pig airways
-
doi: 10.1016/0143-4179(93)90115-q
-
Fox, A. J., Barnes, P. J., Urban, L., and Dray, A. (1993). An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J. Physiol. 469, 21-35. doi: 10.1016/0143-4179(93)90115-q
-
(1993)
J. Physiol
, vol.469
, pp. 21-35
-
-
Fox, A.J.1
Barnes, P.J.2
Urban, L.3
Dray, A.4
-
27
-
-
0029012887
-
Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig
-
doi: 10.1016/03064522(95)00115-y
-
Fox, A. J., Urban, L., Barnes, P. J., and Dray, A. (1995). Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 67, 741-752. doi: 10.1016/03064522(95)00115-y
-
(1995)
Neuroscience
, vol.67
, pp. 741-752
-
-
Fox, A.J.1
Urban, L.2
Barnes, P.J.3
Dray, A.4
-
28
-
-
77954038361
-
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
-
doi: 10.1111/j.1476-5381. 2010.00796.x
-
Gever, J. R., Soto, R., Henningsen, R. A., Martin, R. S., Hackos, D. H., Panicker, S., et al. (2010). AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br. J. Pharmacol. 160, 1387-1398. doi: 10.1111/j.1476-5381. 2010.00796.x
-
(2010)
Br. J. Pharmacol
, vol.160
, pp. 1387-1398
-
-
Gever, J.R.1
Soto, R.2
Henningsen, R.A.3
Martin, R.S.4
Hackos, D.H.5
Panicker, S.6
-
29
-
-
50349094014
-
Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF
-
doi: 10.1007/s12035-008, 8020-5
-
Giniatullin, R., Nistri, A., and Fabbretti, E. (2008). Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF. Mol. Neurobiol. 37, 83-90. doi: 10.1007/s12035-0088020-5
-
(2008)
Mol. Neurobiol
, vol.37
, pp. 83-90
-
-
Giniatullin, R.1
Nistri, A.2
Fabbretti, E.3
-
30
-
-
84879411178
-
Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors
-
doi: 10.1111/jnc.12272
-
Gnanasekaran, A., Sundukova, M., Hullugundi, S., Birsa, N., Bianchini, G., Hsueh, Y. P., et al. (2013). Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. J. Neurochem. 126, 102-112. doi: 10.1111/jnc.12272
-
(2013)
J. Neurochem
, vol.126
, pp. 102-112
-
-
Gnanasekaran, A.1
Sundukova, M.2
Hullugundi, S.3
Birsa, N.4
Bianchini, G.5
Hsueh, Y.P.6
-
31
-
-
80053173506
-
Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model
-
doi: 10.1186/1744-8069-7-77
-
Gnanasekaran, A., Sundukova, M., van den Maagdenberg, A. M., Fabbretti, E., and Nistri, A. (2011). Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. Mol. Pain 7:77. doi: 10.1186/1744-8069-7-77
-
(2011)
Mol. Pain
, vol.7
, pp. 77
-
-
Gnanasekaran, A.1
Sundukova, M.2
van den Maagdenberg, A.M.3
Fabbretti, E.4
Nistri, A.5
-
32
-
-
0030671405
-
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
-
doi: 10.1038/39639
-
Gu, J. G., and MacDermott, A. B. (1997). Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389, 749-753. doi: 10.1038/39639
-
(1997)
Nature
, vol.389
, pp. 749-753
-
-
Gu, J.G.1
Macdermott, A.B.2
-
33
-
-
84856274262
-
P2X receptor antagonists for pain management: Examination of binding and physicochemical properties
-
doi: 10.1007/s11302-011-9272-5
-
Gum, R. J., Wakefield, B., and Jarvis, M. F. (2012). P2X receptor antagonists for pain management: examination of binding and physicochemical properties. Purinergic Signal. 8, 41-56. doi: 10.1007/s11302-011-9272-5
-
(2012)
Purinergic Signal
, vol.8
, pp. 41-56
-
-
Gum, R.J.1
Wakefield, B.2
Jarvis, M.F.3
-
34
-
-
0035878949
-
Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin
-
doi: 10.1111/j.1469-7793.2001.00437.x
-
Hamilton, S. G., McMahon, S. B., and Lewin, G. R. (2001). Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J. Physiol. 534, 437-445. doi: 10.1111/j.1469-7793.2001.00437.x
-
(2001)
J. Physiol
, vol.534
, pp. 437-445
-
-
Hamilton, S.G.1
McMahon, S.B.2
Lewin, G.R.3
-
35
-
-
0032945690
-
The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat
-
doi: 10.1038/sj.bjp.0702258
-
Hamilton, S. G., Wade, A., and McMahon, S. B. (1999). The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br. J. Pharmacol. 126, 326-332. doi: 10.1038/sj.bjp.07 02258
-
(1999)
Br. J. Pharmacol
, vol.126
, pp. 326-332
-
-
Hamilton, S.G.1
Wade, A.2
McMahon, S.B.3
-
36
-
-
0034063480
-
ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia
-
doi: 10. 1093/brain/123.6.1238
-
Hamilton, S. G., Warburton, J., Bhattacharjee, A., Ward, J., and McMahon, S. B. (2000). ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia. Brain 123, 1238-1246. doi: 10. 1093/brain/123.6.1238
-
(2000)
Brain
, vol.123
, pp. 1238-1246
-
-
Hamilton, S.G.1
Warburton, J.2
Bhattacharjee, A.3
Ward, J.4
McMahon, S.B.5
-
37
-
-
0031854157
-
Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer
-
doi: 10.1023/A:1006018610986
-
Haskell, C. M., Mendoza, E., Pisters, K. M., Fossella, F. V., and Figlin, R. A. (1998). Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest. New Drugs 16, 81-85. doi: 10.1023/A:1006018610986
-
(1998)
Invest. New Drugs
, vol.16
, pp. 81-85
-
-
Haskell, C.M.1
Mendoza, E.2
Pisters, K.M.3
Fossella, F.V.4
Figlin, R.A.5
-
38
-
-
0036289827
-
ATP responses in human C nociceptors
-
doi: 10. 1016/s0304-3959(01)00469-9
-
Hilliges, M., Weidner, C., Schmelz, M., Schmidt, R., Ørstavik, K., Torebjörk, E., et al. (2002). ATP responses in human C nociceptors. Pain 98, 59-68. doi: 10. 1016/s0304-3959(01)00469-9
-
(2002)
Pain
, vol.98
, pp. 59-68
-
-
Hilliges, M.1
Weidner, C.2
Schmelz, M.3
Schmidt, R.4
ørstavik, K.5
Torebjörk, E.6
-
39
-
-
0028124387
-
Electrophysiological-anatomic correlates of ATP-triggered vagal reflex in dogs. II. Vagal afferent traffic
-
Hurt, C. M., Wang, L., Xu, J., Sterious, W., and Pelleg, A. (1994). Electrophysiological-anatomic correlates of ATP-triggered vagal reflex in dogs. II. Vagal afferent traffic. Am. J. Physiol. 267(3 Pt. 2), H1093-H1097.
-
(1994)
Am. J. Physiol
, vol.267
, Issue.3 PART 2
-
-
Hurt, C.M.1
Wang, L.2
Xu, J.3
Sterious, W.4
Pelleg, A.5
-
40
-
-
34547655975
-
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
-
doi: 10.1038/nm1617
-
Idzko, M., Hammad, H., van Nimwegen, M., Kool, M., Willart, M. A., Muskens, F., et al. (2007). Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat. Med. 13, 913-919. doi: 10. 1038/nm1617
-
(2007)
Nat. Med
, vol.13
, pp. 913-919
-
-
Idzko, M.1
Hammad, H.2
van Nimwegen, M.3
Kool, M.4
Willart, M.A.5
Muskens, F.6
-
41
-
-
61349092411
-
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain
-
doi: 10.1016/j. bmcl.2009.01.097
-
Jahangir, A., Alam, M., Carter, D. S., Dillon, M. P., Bois, D. J., Ford, A. P., et al. (2009). Identification and SAR of novel diaminopyrimidines. Part 2: the discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg. Med. Chem. Lett. 19, 1632-1635. doi: 10.1016/j. bmcl.2009.01.097
-
(2009)
Bioorg. Med. Chem. Lett
, vol.19
, pp. 1632-1635
-
-
Jahangir, A.1
Alam, M.2
Carter, D.S.3
Dillon, M.P.4
Bois, D.J.5
Ford, A.P.6
-
42
-
-
0037168683
-
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
-
doi: 10.1073/pnas. 252537299
-
Jarvis, M. F., Burgard, E. C., McGaraughty, S., Honore, P., Lynch, K., Brennan, T. J., et al. (2002). A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci. U S A 99, 17179-17184. doi: 10.1073/pnas. 252537299
-
(2002)
Proc. Natl. Acad. Sci. U S A
, vol.99
, pp. 17179-17184
-
-
Jarvis, M.F.1
Burgard, E.C.2
McGaraughty, S.3
Honore, P.4
Lynch, K.5
Brennan, T.J.6
-
43
-
-
33748569819
-
Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs
-
doi: 10.1016/j.ejphar.2006.07.034
-
Kamei, J., and Takahashi, Y. (2006). Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. Eur. J. Pharmacol. 547, 160-164. doi: 10.1016/j.ejphar.2006.07.034
-
(2006)
Eur. J. Pharmacol
, vol.547
, pp. 160-164
-
-
Kamei, J.1
Takahashi, Y.2
-
44
-
-
28844503518
-
Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
-
doi: 10.1016/j.ejphar.2005.10.030
-
Kamei, J., Takahashi, Y., Yoshikawa, Y., and Saitoh, A. (2005). Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity. Eur. J. Pharmacol. 528, 158-161. doi: 10.1016/j.ejphar.2005.10.030
-
(2005)
Eur. J. Pharmacol
, vol.528
, pp. 158-161
-
-
Kamei, J.1
Takahashi, Y.2
Yoshikawa, Y.3
Saitoh, A.4
-
46
-
-
33746701380
-
P2X receptors as cell-surface ATP sensors in health and disease
-
doi: 10.1038/nature04886
-
Khakh, B. S., and North, R. A. (2006). P2X receptors as cell-surface ATP sensors in health and disease. Nature 442, 527-532. doi: 10.1038/nature04886
-
(2006)
Nature
, vol.442
, pp. 527-532
-
-
Khakh, B.S.1
North, R.A.2
-
47
-
-
84930206674
-
Purinergic regulation of airway inflammation
-
doi: 10.1007/978-94-007-1217-1_7
-
Koeppen, M., Di Virgilio, F., Clambey, E. T., and Eltzschig, H. K. (2011). Purinergic regulation of airway inflammation. Subcell. Biochem. 55, 159-193. doi: 10. 1007/978-94-007-1217-1_7
-
(2011)
Subcell. Biochem
, vol.55
, pp. 159-193
-
-
Koeppen, M.1
Di Virgilio, F.2
Clambey, E.T.3
Eltzschig, H.K.4
-
48
-
-
57049123897
-
P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus
-
doi: 10.1152/ajplung.90360.2008
-
Kwong, K., Kollarik, M., Nassenstein, C., Ru, F., and Undem, B. J. (2008). P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L858-L865. doi: 10.1152/ajplung.90360.2008
-
(2008)
Am. J. Physiol. Lung Cell. Mol. Physiol
, vol.295
-
-
Kwong, K.1
Kollarik, M.2
Nassenstein, C.3
Ru, F.4
Undem, B.J.5
-
49
-
-
0345504109
-
Adaptation of guinea-pig vagal airway afferent neurones to mechanical stimulation
-
doi: 10.1111/j.1469-7793.1999.00239.x
-
McAlexander, M. A., Myers, A. C., and Undem, B. J. (1999). Adaptation of guinea-pig vagal airway afferent neurones to mechanical stimulation. J. Physiol. 521(Pt. 1), 239-247. doi: 10.1111/j.1469-7793.1999.00239.x
-
(1999)
J. Physiol
, vol.521
, Issue.1 PART
, pp. 239-247
-
-
McAlexander, M.A.1
Myers, A.C.2
Undem, B.J.3
-
50
-
-
0037225148
-
Experimental muscle pain and tenderness following infusion of endogenous substances in humans
-
doi: 10.1016/s1090-3801(02)00096-4
-
Mork, H., Ashina, M., Bendtsen, L., Olesen, J., and Jensen, R. (2003). Experimental muscle pain and tenderness following infusion of endogenous substances in humans. Eur. J. Pain 7, 145-153. doi: 10.1016/s1090-3801(02)00096-4
-
(2003)
Eur. J. Pain
, vol.7
, pp. 145-153
-
-
Mork, H.1
Ashina, M.2
Bendtsen, L.3
Olesen, J.4
Jensen, R.5
-
51
-
-
0032619275
-
The activation of bladder wall afferent nerves
-
doi: 10.1080/003655999750016348
-
Morrison, J. (1999). The activation of bladder wall afferent nerves. Exp. Physiol. 84, 131-136. doi: 10.1080/003655999750016348
-
(1999)
Exp. Physiol
, vol.84
, pp. 131-136
-
-
Morrison, J.1
-
52
-
-
0025870464
-
Influence of antigen on membrane properties of guinea-pig bronchial ganglion neurons
-
Myers, A. C., Undem, B. J., and Weinreich, D. (1991). Influence of antigen on membrane properties of guinea-pig bronchial ganglion neurons. J. Appl. Physiol. 71, 970-976.
-
(1991)
J. Appl. Physiol
, vol.71
, pp. 970-976
-
-
Myers, A.C.1
Undem, B.J.2
Weinreich, D.3
-
53
-
-
0031790115
-
A novel in vitro bladder pelvic nerve afferent model in the rat
-
doi: 10.1046/j.1464-410x.1998.00867.x
-
Namasivayam, S., Eardley, I., and Morrison, J. F. (1998). A novel in vitro bladder pelvic nerve afferent model in the rat. Br. J. Urol. 82, 902-905. doi: 10.1046/j.1464-410x.1998.00867.x
-
(1998)
Br. J. Urol
, vol.82
, pp. 902-905
-
-
Namasivayam, S.1
Eardley, I.2
Morrison, J.F.3
-
54
-
-
0032708267
-
Purinergic sensory neurotransmission in the urinary bladder: An in vitro study in the rat
-
doi: 10.1046/j.1464-410x.1999.00310.x
-
Namasivayam, S., Eardley, I., and Morrison, J. F. (1999). Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. BJU Int. 84, 854-860. doi: 10.1046/j.1464-410x.1999.00310.x
-
(1999)
BJU Int
, vol.84
, pp. 854-860
-
-
Namasivayam, S.1
Eardley, I.2
Morrison, J.F.3
-
55
-
-
78649709891
-
Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs
-
doi: 10. 1113/jphysiol.2010.195339
-
Nassenstein, C., Taylor-Clark, T. E., Myers, A. C., Ru, F., Nandigama, R., Bettner, W., et al. (2010). Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. J. Physiol. 588(Pt. 23), 4769-4783. doi: 10. 1113/jphysiol.2010.195339
-
(2010)
J. Physiol
, vol.588
, Issue.23 PART
, pp. 4769-4783
-
-
Nassenstein, C.1
Taylor-Clark, T.E.2
Myers, A.C.3
Ru, F.4
Nandigama, R.5
Bettner, W.6
-
56
-
-
84875426837
-
P2X receptors as drug targets
-
doi: 10.1124/mol.112.083758
-
North, R. A., and Jarvis, M. F. (2013). P2X receptors as drug targets. Mol. Pharmacol. 83, 759-769. doi: 10.1124/mol.112.083758
-
(2013)
Mol. Pharmacol
, vol.83
, pp. 759-769
-
-
North, R.A.1
Jarvis, M.F.2
-
57
-
-
0036718048
-
Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats
-
doi: 10.1016/s0022-5347(05)64631-9
-
Pandita, R. K., and Andersson, K. E. (2002). Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats. J. Urol. 168, 1230-1234. doi: 10.1016/s0022-5347(05)64631-9
-
(2002)
J. Urol
, vol.168
, pp. 1230-1234
-
-
Pandita, R.K.1
Andersson, K.E.2
-
58
-
-
11144271468
-
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways
-
doi: 10.1016/j.pain.2004.10.021
-
Parada, C. A., Reichling, D. B., and Levine, J. D. (2005). Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways. Pain 113, 185-190. doi: 10.1016/j.pain.2004.10.021
-
(2005)
Pain
, vol.113
, pp. 185-190
-
-
Parada, C.A.1
Reichling, D.B.2
Levine, J.D.3
-
59
-
-
0029750208
-
Lung mechanics during induced bronchoconstriction
-
Pellegrino, R., Wilson, O., Jenouri, G., and Rodarte, J. R. (1996). Lung mechanics during induced bronchoconstriction. J. Appl. Physiol. (1985) 81, 964-975.
-
(1996)
J. Appl. Physiol
, vol.81
, pp. 964-975
-
-
Pellegrino, R.1
Wilson, O.2
Jenouri, G.3
Rodarte, J.R.4
-
60
-
-
84893428420
-
Exogenously appliedmuscle metabolites synergisticallyevoke sensations of muscle fatigue and pain in human subjects
-
doi: 10. 1113/expphysiol.2013.075812. [Epub ahead of print]
-
Pollak, K. A., Swenson, J. D., Vanhaitsma, T. A., Hughen, R. W., Jo, D., Light, K.C., et al. (2013). Exogenously appliedmuscle metabolites synergisticallyevoke sensations of muscle fatigue and pain in human subjects. Exp. Physiol. doi: 10. 1113/expphysiol.2013.075812. [Epub ahead of print].
-
(2013)
Exp. Physiol
-
-
Pollak, K.A.1
Swenson, J.D.2
Vanhaitsma, T.A.3
Hughen, R.W.4
Jo, D.5
Light, K.C.6
-
61
-
-
84873327122
-
Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation
-
doi: 10.1016/j. neuropharm.2012.11.011
-
Prado, F. C., Araldi, D., Vieira, A. S., Oliveira-Fusaro, M. C., Tambeli, C. H., and Parada, C. A. (2013). Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation. Neuropharmacology 67, 252-258. doi: 10.1016/j. neuropharm.2012.11.011
-
(2013)
Neuropharmacology
, vol.67
, pp. 252-258
-
-
Prado, F.C.1
Araldi, D.2
Vieira, A.S.3
Oliveira-Fusaro, M.C.4
Tambeli, C.H.5
Parada, C.A.6
-
62
-
-
0029670298
-
Immunomodulation of afferent neurons in guinea-pig isolated airway
-
Riccio, M. M., Myers, A. C., and Undem, B. J. (1996). Immunomodulation of afferent neurons in guinea-pig isolated airway. J. Physiol. 491, 499-509.
-
(1996)
J. Physiol
, vol.491
, pp. 499-509
-
-
Riccio, M.M.1
Myers, A.C.2
Undem, B.J.3
-
63
-
-
0036623638
-
Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder
-
doi: 10.1113/jphysiol.2001.013469
-
Rong, W., Spyer, K. M., and Burnstock, G. (2002). Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J. Physiol. 541, 591-600. doi: 10.1113/jphysiol.2001.013469
-
(2002)
J. Physiol
, vol.541
, pp. 591-600
-
-
Rong, W.1
Spyer, K.M.2
Burnstock, G.3
-
64
-
-
84865239741
-
Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons
-
doi: 10.1523/jneurosci. 0698-12.2012
-
Serrano, A., Mo, G., Grant, R., Paré, M., O'Donnell, D., Yu, X. H., et al. (2012). Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons. J. Neurosci. 32, 11890-11896. doi: 10.1523/jneurosci. 0698-12.2012
-
(2012)
J. Neurosci
, vol.32
, pp. 11890-11896
-
-
Serrano, A.1
Mo, G.2
Grant, R.3
Paré, M.4
O'Donnell, D.5
Yu, X.H.6
-
65
-
-
20444453576
-
Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats
-
doi: 10.1016/j.pain.2005.03.042
-
Shinoda, M., Ozaki, N., Asai, H., Nagamine, K., and Sugiura, Y. (2005). Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats. Pain 116, 42-51. doi: 10.1016/j.pain.2005.03.042
-
(2005)
Pain
, vol.116
, pp. 42-51
-
-
Shinoda, M.1
Ozaki, N.2
Asai, H.3
Nagamine, K.4
Sugiura, Y.5
-
66
-
-
84891133456
-
A novel method to estimate AF-219 levels in bladder interstitium derived from drug excreted into the urine
-
(Meeting Abstract Supplement) 1103.3
-
Smith, S. A., Black, D., Song, D., and Ford, A. P. (2013). A novel method to estimate AF-219 levels in bladder interstitium derived from drug excreted into the urine. FASEB J. 27, (Meeting Abstract Supplement) 1103.3.
-
(2013)
FASEB J
, vol.27
-
-
Smith, S.A.1
Black, D.2
Song, D.3
Ford, A.P.4
-
67
-
-
84891089191
-
P2X3 receptor antagonism attenuates pelvic afferent discharge and visceromotor responses to urinary bladder distension in naïve and cyclophosphamide treated rats
-
Sun, Q., Dong, L., Zhang, G., Ford, A. P., and Rong, W. F. (2012). P2X3 receptor antagonism attenuates pelvic afferent discharge and visceromotor responses to urinary bladder distension in naïve and cyclophosphamide treated rats. Proceedings of 13th IASP World Congress of Pain, abstract 412.
-
(2012)
Proceedings of 13th IASP World Congress of Pain
, pp. 412
-
-
Sun, Q.1
Dong, L.2
Zhang, G.3
Ford, A.P.4
Rong, W.F.5
-
68
-
-
0034256565
-
Mechanical allodynia caused by intraplanar injection of P2X receptor agonist in rats: Involvement of heteromeric P2X2/3 receptor siganling in capsaicin-insensitive primary afferent neurons
-
Tsuda, M., Koizumi, S., Kita, A., Shigemoto, Y., Ueno, S., and Inoue, K. (2000). Mechanical allodynia caused by intraplanar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor siganling in capsaicin-insensitive primary afferent neurons. J. Neurosci. 20, RC90.
-
(2000)
J. Neurosci
, vol.20
-
-
Tsuda, M.1
Koizumi, S.2
Kita, A.3
Shigemoto, Y.4
Ueno, S.5
Inoue, K.6
-
69
-
-
2442717642
-
Subtypes of vagal afferent C-fibres in guinea-pig lungs
-
doi: 10.1113/jphysiol.2003.060079
-
Undem, B. J., Chuaychoo, B., Lee, M. G., Weinreich, D., Myers, A. C., and Kollarik, M. (2004). Subtypes of vagal afferent C-fibres in guinea-pig lungs. J. Physiol. 556, 905-917. doi: 10.1113/jphysiol.2003.060079
-
(2004)
J. Physiol
, vol.556
, pp. 905-917
-
-
Undem, B.J.1
Chuaychoo, B.2
Lee, M.G.3
Weinreich, D.4
Myers, A.C.5
Kollarik, M.6
-
70
-
-
0035413364
-
P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
-
Vlaskovska, M., Kasakov, L., Rong, W., Bodin, P., Bardini, M., Cockayne, D. A., et al. (2001). P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21, 5670-5677.
-
(2001)
J. Neurosci
, vol.21
, pp. 5670-5677
-
-
Vlaskovska, M.1
Kasakov, L.2
Rong, W.3
Bodin, P.4
Bardini, M.5
Cockayne, D.A.6
-
71
-
-
84879419858
-
P2X3 receptor: A novel 'CASKade' of signaling
-
doi: 10.1111/jnc.12282
-
Volonté, C., and Burnstock, G. (2013). P2X3 receptor: a novel 'CASKade' of signaling? J. Neurochem. 126, 1-3. doi: 10.1111/jnc.12282
-
(2013)
J. Neurochem
, vol.126
, pp. 1-3
-
-
Volonté, C.1
Burnstock, G.2
-
72
-
-
24644510333
-
ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells
-
doi: 10.1172/jci 24086
-
Wang, E. C., Lee, J. M., Ruiz, W. G., Balestreire, E. M., von Bodungen, M., Barrick, S., et al. (2005). ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J. Clin. Invest. 115, 2412-2422. doi: 10.1172/jci 24086
-
(2005)
J. Clin. Invest
, vol.115
, pp. 2412-2422
-
-
Wang, E.C.1
Lee, J.M.2
Ruiz, W.G.3
Balestreire, E.M.4
von Bodungen, M.5
Barrick, S.6
-
73
-
-
84865661641
-
A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres
-
doi:10.1113/jphysiol.2012.233460
-
Weigand, L. A., Ford, A. P., and Undem, B. J. (2012). A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres. J. Physiol. 590, 4109-4120. doi: 10.1113/jphysiol.2012.2 33460
-
(2012)
J. Physiol
, vol.590
, pp. 4109-4120
-
-
Weigand, L.A.1
Ford, A.P.2
Undem, B.J.3
-
74
-
-
45149107298
-
Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment
-
doi: 10.1152/ajprenal.00592.2007
-
Yu, Y., and de Groat, W. C. (2008). Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment. Am. J. Physiol. Renal Physiol. 294, F1146-F1156. doi: 10.1152/ajprenal.00592.2007
-
(2008)
Am. J. Physiol. Renal Physiol
, vol.294
-
-
Yu, Y.1
de Groat, W.C.2
-
75
-
-
78049233273
-
Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat
-
doi: 10.1016/j.brainres.2010., 09.018
-
Yu, Y., and de Groat, W. C. (2010). Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat. Brain Res. 1361, 43-53. doi: 10.1016/j.brainres.2010.09.018
-
(2010)
Brain Res
, vol.1361
, pp. 43-53
-
-
Yu, Y.1
de Groat, W.C.2
-
76
-
-
67651089976
-
Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium
-
doi:, 10.1113/jphysiol.2009.172577
-
Zagorodnyuk, V. P., Brookes, S. J., Spencer, N. J., and Gregory, S. (2009). Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium. J. Physiol. 587, 3523-3538. doi: 10.1113/jphysiol.2009.172577
-
(2009)
J. Physiol
, vol.587
, pp. 3523-3538
-
-
Zagorodnyuk, V.P.1
Brookes, S.J.2
Spencer, N.J.3
Gregory, S.4
-
77
-
-
36248938692
-
Properties of the major classes of mechanoreceptors in the guinea pig bladder
-
doi: 10.1016/j.autneu.2007.06.090
-
Zagorodnyuk, V. P., Gibbins, I. L., Costa, M., Brookes, S. J., and Gregory, S. J. (2007). Properties of the major classes of mechanoreceptors in the guinea pig bladder. J. Physiol. 585, 147-163. doi: 10.1016/j.autneu.2007.06.090
-
(2007)
J. Physiol
, vol.585
, pp. 147-163
-
-
Zagorodnyuk, V.P.1
Gibbins, I.L.2
Costa, M.3
Brookes, S.J.4
Gregory, S.J.5
|