P2X3 receptor: A novel 'CASKade' of signaling?

Journal of Neurochemistry

Volumn 126, Issue 1, 2013, Pages 1-3

  Volonté, Cinzia ^a   Burnstock, Geoffrey ^b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; CALMODULIN DEPENDENT SERINE PROTEIN KINASE; CD39 ANTIGEN; PROTEIN SERINE KINASE; PURINERGIC P2X RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2Y RECEPTOR; UNCLASSIFIED DRUG;

COMPLEX FORMATION; ENDOCYTOSIS; GLYCOSYLATION; HUMAN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVIEW; SIGNAL TRANSDUCTION;

GUANYLATE KINASE; HUMANS; RECEPTORS, PURINERGIC P2X3;

EID: 84879419858     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12282     Document Type: Review

References (17)

1. Amadio S., Apolloni S., D'Ambrosi N., and, Volonté C., (2011) Purinergic signalling at the plasma membrane: a multipurpose and multidirectional mode to deal with amyotrophic lateral sclerosis and multiple sclerosis. J. Neurochem. 116, 796-805.
2. Bodnar M., Wang H., Riedel T., et al,. (2011) Amino acid residues constituting the agonist binding site of the human P2X3receptor. J. Biol. Chem. 286, 2739-2749.
3. Burnstock G., (2012) Targeting the visceral purinergic system for pain control. Curr. Opin. Pharmacol. 12, 80-86.
4. Chen C. C., Akopian A. N., Sivilotti L., Colquhoun D., Burnstock G., and, Wood J. N., (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377, 428-431.
5. Cockayne D. A., Hamilton S. G., Zhu Q. M., Dunn P. M., Zhong Y., Novakovic S., Malmberg A. B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W. G., Burnstock, G., McMahon S. B., and, Ford A. P,. (2000) Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407, 1011-1015.
6. D'Arco M., Giniatullin R., Leone V., Carloni P., Birsa N., Nair A., Nistri A., and, Fabbretti E., (2009) The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons. J. Biol. Chem. 284, 21393-21401.
7. Garcia-Guzman M., Stühmer W., and, Soto F., (1997) Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. Brain Res. Mol. Brain Res. 47, 59-66.
8. Gnanasekaran A., Sundukova M., Hullugundi S., Birsa N., Bianchini G., Hseuh Y. P., Nistri A., and, Fabbretti E., (2013) CASK is a new intracellular modulator of P2X3 receptors. J. Neurochem. doi: 10.1111/jnc.12272. [Epub ahead of print].
9. Jarvis M. F., (2010) The neural-glial purinergic receptor ensemble in chronic pain states. Trends Neurosci. 33, 48-57.
10. Jindrichova M., Khafizov K., Skorinkin A., Fayuk D., Bart G., Zemkova H., and, Giniatullin R., (2011) Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor. J. Neurochem. 119, 676-685.
11. Kaan T. K., Yip P. K., Patel S., et al,. (2010) Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain 133, 2549-2564.
12. Lewis C., Neidhart S., Holy C., North R. A., Buell G., and, Surprenant A,. (1995) Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435.
13. Nair A., Simonetti M., Fabbretti E., and, Nistri A., (2010) The Cdk5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation. Cell. Mol. Neurobiol. 30, 505-509.
14. Sundukova M., Vilotti S., Abbate R., Fabbretti E., and, Nistri A., (2012) Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of the intracellular C-terminal domain. J. Neurochem. 122, 557-567.
15. Vacca F., Giustizieri M., Ciotti M. T., Mercuri N. B., and, Volonté C,. (2009) Rapid constitutive and ligand-activated endocytic trafficking of P2X receptor. J. Neurochem. 109, 1031-1041.
16. Vacca F., D'Ambrosi N., Nestola V., Amadio S., Giustizieri M., Cucchiaroni M. L., Tozzi A., Velluz M. C., Mercuri N. B., and, Volonté C., (2011) N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP. Glycobiology 21, 634-643.
17. Volonté C., Parisi C., and, Burnstock G., (2012) Purinergic signalling: what is missing and needed next? The use of transgenic mice, crystallographic analysis and MicroRNA. CNS Neurol. Disord. Drug Targets 11, 751-767.