Activation of peripheral P2X receptors is sufficient to induce central sensitization in rat medullary dorsal horn nociceptive neurons

Neuroscience Letters

Volumn 526, Issue 2, 2012, Pages 160-163

  Cherkas, Pavel S ^a   Dostrovsky, Jonathan O ^a,b   Sessle, Barry J ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Pain; Plasticity; Purinergic receptors; Trigeminal nucleus

Indexed keywords

PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MALE; MECHANICAL STIMULATION; MECHANORECEPTOR; NERVE STIMULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SPINAL CORD DORSAL HORN; TOOTH PULP;

ADENOSINE TRIPHOSPHATE; ANIMALS; DENTAL PULP; MALE; NOCICEPTORS; PHYSICAL STIMULATION; POSTERIOR HORN CELLS; PURINERGIC P2X RECEPTOR AGONISTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X; TRIGEMINAL CAUDAL NUCLEUS;

EID: 84865968854     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.007     Document Type: Article

References (25)

1. Adachi K., Shimizu K., Hu J.W., Suzuki I., Sakagami H., Koshikawa N., Sessle B.J., Shinoda M., Miyamoto M., Honda K., Iwata K. Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity. Molecular Pain 2010, 6:59.
2. Alavi A.M., Dubyak G.R., Burnstock G. Immunohistochemical evidence for ATP receptors in human dental pulp. Journal of Dental Research 2001, 80:476-483.
3. Burnstock G. P2X receptors in sensory neurones. British Journal of Anaesthesia 2000, 84:476-488.
4. Cherkas P.S., Dostrovsky J.O., Sessle B.J. Peripheral P2X mechanisms are involved in the production of central sensitization in rat dorsal horn nociceptive neurons (266.7/AA8) 2009, Society for Neuroscience, Chicago, USA.
5. Chiang C.Y., Dostrovsky J.O., Iwata K., Sessle B.J. Role of glia in orofacial pain. The Neuroscientist 2011, 17:303-320.
6. Chiang C.Y., Park S.J., Kwan C.L., Hu J.W., Sessle B.J. NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation. Journal of Neurophysiology 1998, 80:2621-2631.
7. Chiang C.Y., Wang J., Xie Y.F., Zhang S., Hu J.W., Dostrovsky J.O., Sessle B.J. Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn. Journal of Neuroscience 2007, 27:9068-9076.
8. Chiang C.Y., Zhang S., Xie Y.F., Hu J.W., Dostrovsky J.O., Salter M.W., Sessle B.J. Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn). Journal of Neurophysiology 2005, 94:1751-1760.
9. Cook S.P., Vulchanova L., Hargreaves K.M., Elde R., McCleskey E.W. Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature 1997, 387:505-508.
10. Dubner R. Plasticity in central nociceptive pathways. The Paths of Pain 1975-2005 2005, 101-115. IASP Press, Seattle. H. Merskey, J.D. Loeser, R. Dubner (Eds.).
11. Hu B., Chiang C.Y., Hu J.W., Dostrovsky J.O., Sessle B.J. P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis. Journal of Neurophysiology 2002, 88:1614-1624.
12. Hu J.W., Dostrovsky J.O., Sessle B.J. Functional properties of neurons in cat trigeminal subnucleus caudalis (medullary dorsal horn). I. Responses to oral-facial noxious and nonnoxious stimuli and projections to thalamus and subnucleus oralis. Journal of Neurophysiology 1981, 45:173-192.
13. Jennings E.A., Christie M.J., Sessle B.J. ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. Neuroreport 2006, 17:1507-1510.
14. Kim Y.S., Paik S.K., Cho Y.S., Shin H.S., Bae J.Y., Moritani M., Yoshida A., Ahn D.K., Valtschanoff J., Hwang S.J., Moon C., Bae Y.C. Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat. Journal of Comparative Neurology 2008, 506:627-639.
15. Kumar N., Cherkas P.S., Chiang C.Y., Dostrovsky J.O., Sessle B.J., Coderre T.J. Involvement of ATP in noxious stimulus-induced release of glutamate in the trigeminal subnucleus caudalis (medullary dorsal horn): a microdialysis study in anesthetized rats (764.9/CC49) 2009, Society for Neuroscience, Chicago, USA.
16. Nakagawa T., Wakamatsu K., Zhang N., Maeda S., Minami M., Satoh M., Kaneko S. Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance. Neuroscience 2007, 147:445-455.
17. Nakatsuka T., Tsuzuki K., Ling J.X., Sonobe H., Gu J.G. Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. Journal of Neurophysiology 2003, 89:3243-3252.
18. Oliveira M.C., Parada C.A., Veiga M.C., Rodrigues L.R., Barros S.P., Tambeli C.H. Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain. European Journal of Pain 2005, 9:87-93.
19. Renton T., Yiangou Y., Baecker P.A., Ford A.P., Anand P. Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. Journal of Orofacial Pain 2003, 17:245-250.
20. Salter M.W. Cellular neuroplasticity mechanisms mediating pain persistence. Journal of Orofacial Pain 2004, 18:318-324.
21. Sessle B. Orofacial pain. The Paths of Pain 1975-2005 2005, 131-150. IASP Press, Seattle. H. Merskey, J.D. Loeser, R. Dubner (Eds.).
22. Shinoda M., Ozaki N., Asai H., Nagamine K., Sugiura Y. Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats. Pain 2005, 116:42-51.
23. Staikopoulos V., Sessle B.J., Furness J.B., Jennings E.A. Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons. Neuroscience 2007, 144:208-216.
24. Vulchanova L., Riedl M.S., Shuster S.J., Buell G., Surprenant A., North R.A., Elde R. Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 1997, 36:1229-1242.
25. Yao S.T., Barden J.A., Finkelstein D.I., Bennett M.R., Lawrence A.J. Comparative study on the distribution patterns of P2X(1)-P2X(6) receptor immunoreactivity in the brainstem of the rat and the common marmoset (Callithrix jacchus): association with catecholamine cell groups. Journal of Comparative Neurology 2000, 427:485-507.