메뉴 건너뛰기




Volumn 37, Issue 1, 2008, Pages 83-90

Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF

Author keywords

ATP; Headache; Nociception; Purinergic receptors; Trigeminal neurons

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMIGRAINE AGENT; CALCITONIN GENE RELATED PEPTIDE; MK 0974; NERVE GROWTH FACTOR; OLCEGEPANT; PROTEIN KINASE C; PURINERGIC P2X3 RECEPTOR; UNCLASSIFIED DRUG; PURINERGIC P2 RECEPTOR;

EID: 50349094014     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-008-8020-5     Document Type: Review
Times cited : (124)

References (86)
  • 1
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • G Burnstock 2007 Physiology and pathophysiology of purinergic neurotransmission Physiol Rev 87 659 797
    • (2007) Physiol Rev , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 2
    • 33746701380 scopus 로고    scopus 로고
    • P2X receptors as cell-surface ATP sensors in health and disease
    • BS Khakh RA North 2006 P2X receptors as cell-surface ATP sensors in health and disease Nature 442 527 532
    • (2006) Nature , vol.442 , pp. 527-532
    • Khakh, B.S.1    North, R.A.2
  • 4
    • 34547886861 scopus 로고    scopus 로고
    • The role of nucleotides in the neuron-glia communication responsible for the brain functions
    • K Inoue S Koizumi M Tsuda 2007 The role of nucleotides in the neuron-glia communication responsible for the brain functions J Neurochem 102 1447 1458
    • (2007) J Neurochem , vol.102 , pp. 1447-1458
    • Inoue, K.1    Koizumi, S.2    Tsuda, M.3
  • 6
    • 0035211065 scopus 로고    scopus 로고
    • P2X receptors and nociception
    • BA Chizh P Illes 2001 P2X receptors and nociception Pharmacol Rev 53 553 568
    • (2001) Pharmacol Rev , vol.53 , pp. 553-568
    • Chizh, B.A.1    Illes, P.2
  • 7
    • 0842344649 scopus 로고    scopus 로고
    • 3 receptors and peripheral pain mechanisms
    • 3 receptors and peripheral pain mechanisms J Physiol 554 301 308
    • (2004) J Physiol , vol.554 , pp. 301-308
    • North, R.A.1
  • 9
    • 0041328064 scopus 로고    scopus 로고
    • 3 homomeric and heteromeric channels to acute and chronic pain
    • 3 homomeric and heteromeric channels to acute and chronic pain Expert Opin Ther Targets 7 513 522
    • (2003) Expert Opin Ther Targets , vol.7 , pp. 513-522
    • Jarvis, M.F.1
  • 12
    • 0142063000 scopus 로고    scopus 로고
    • 3 subunit: A molecular target in pain therapeutics
    • 3 subunit: a molecular target in pain therapeutics Curr Opin Investig Drugs 4 833 840
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 833-840
    • North, R.A.1
  • 16
  • 20
    • 33745158781 scopus 로고    scopus 로고
    • Purinergic P2 receptors as targets for novel analgesics
    • G Burnstock 2006 Purinergic P2 receptors as targets for novel analgesics Pharmacol Ther 110 433 454
    • (2006) Pharmacol Ther , vol.110 , pp. 433-454
    • Burnstock, G.1
  • 23
    • 33645970252 scopus 로고    scopus 로고
    • Response properties of dural nociceptors in relation to headache
    • AM Strassman D Levy 2006 Response properties of dural nociceptors in relation to headache J Neurophysiol 95 1298 1306
    • (2006) J Neurophysiol , vol.95 , pp. 1298-1306
    • Strassman, A.M.1    Levy, D.2
  • 24
    • 18844424266 scopus 로고    scopus 로고
    • Migraine as an inflammatory disorder
    • C Waeber MA Moskowitz 2005 Migraine as an inflammatory disorder Neurology 64 S9 15
    • (2005) Neurology , vol.64 , pp. 9-15
    • Waeber, C.1    Moskowitz, M.A.2
  • 25
    • 33646927486 scopus 로고    scopus 로고
    • Mast cell involvement in the pathophysiology of migraine headache: An hypothesis
    • Suppl 1
    • D Levy R Burstein AM Strassman 2006 Mast cell involvement in the pathophysiology of migraine headache: an hypothesis Headache 46 Suppl 1 S13 S18
    • (2006) Headache , vol.46
    • Levy, D.1    Burstein, R.2    Strassman, A.M.3
  • 26
    • 33845882288 scopus 로고    scopus 로고
    • Recent advances in understanding migraine mechanisms, molecules and therapeutics
    • PJ Goadsby 2007 Recent advances in understanding migraine mechanisms, molecules and therapeutics Trends Mol Med 13 39 44
    • (2007) Trends Mol Med , vol.13 , pp. 39-44
    • Goadsby, P.J.1
  • 27
    • 0028903434 scopus 로고
    • Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: Mediation by calcitonin gene-related peptide
    • M Kurosawa K Messlinger M Pawlak RF Schmidt 1995 Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: mediation by calcitonin gene-related peptide Br J Pharmacol 114 1397 402
    • (1995) Br J Pharmacol , vol.114 , pp. 1397-1402
    • Kurosawa, M.1    Messlinger, K.2    Pawlak, M.3    Schmidt, R.F.4
  • 28
    • 0029847688 scopus 로고    scopus 로고
    • Sensitization of meningeal sensory neurons and the origin of headaches
    • AM Strassman SA Raymond R Burstein 1996 Sensitization of meningeal sensory neurons and the origin of headaches Nature 384 560 564
    • (1996) Nature , vol.384 , pp. 560-564
    • Strassman, A.M.1    Raymond, S.A.2    Burstein, R.3
  • 29
    • 0036900758 scopus 로고    scopus 로고
    • Mechanical response properties of a and C primary afferent neurons innervating the rat intracranial dura
    • D Levy AM Strassman 2002 Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura J Neurophysiol 88 3021 3031
    • (2002) J Neurophysiol , vol.88 , pp. 3021-3031
    • Levy, D.1    Strassman, A.M.2
  • 30
    • 0028806454 scopus 로고
    • Calcitonin gene related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat
    • K Messlinger U Hanesch M Kurosawa M Pawlak RF Schmidt 1995 Calcitonin gene related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat Can J Physiol Pharmacol 73 1020 1024
    • (1995) Can J Physiol Pharmacol , vol.73 , pp. 1020-1024
    • Messlinger, K.1    Hanesch, U.2    Kurosawa, M.3    Pawlak, M.4    Schmidt, R.F.5
  • 31
    • 0035838309 scopus 로고    scopus 로고
    • Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients
    • P Sarchielli A Alberti A Floridi V Gallai 2001 Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients Neurology 57 132 134
    • (2001) Neurology , vol.57 , pp. 132-134
    • Sarchielli, P.1    Alberti, A.2    Floridi, A.3    Gallai, V.4
  • 32
    • 0347753785 scopus 로고    scopus 로고
    • Nerve growth factor and chronic daily headache: A potential implication for therapy
    • P Sarchielli V Gallai 2004 Nerve growth factor and chronic daily headache: a potential implication for therapy Expert Rev Neurother 4 115 127
    • (2004) Expert Rev Neurother , vol.4 , pp. 115-127
    • Sarchielli, P.1    Gallai, V.2
  • 35
    • 33847790338 scopus 로고    scopus 로고
    • Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
    • Z Zhang CS Winborn B Marquez de Prado AF Russo 2007 Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion J Neurosci 27 2693 2703
    • (2007) J Neurosci , vol.27 , pp. 2693-2703
    • Zhang, Z.1    Winborn, C.S.2    Marquez De Prado, B.3    Russo, A.F.4
  • 36
    • 0036266044 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXII. the mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
    • DR Poyner PM Sexton I Marshall DM Smith R Quirion W Born R Muff JA Fischer SM Foord 2002 International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors Pharmacol Rev 54 233 246
    • (2002) Pharmacol Rev , vol.54 , pp. 233-246
    • Poyner, D.R.1    Sexton, P.M.2    Marshall, I.3    Smith, D.M.4    Quirion, R.5    Born, W.6    Muff, R.7    Fischer, J.A.8    Foord, S.M.9
  • 37
    • 33750910190 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons
    • I Buldyrev NM Tanner HY Hsieh EG Dodd LT Nguyen A Balkowiec 2006 Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons J Neurochem 99 1338 1350
    • (2006) J Neurochem , vol.99 , pp. 1338-1350
    • Buldyrev, I.1    Tanner, N.M.2    Hsieh, H.Y.3    Dodd, E.G.4    Nguyen, L.T.5    Balkowiec, A.6
  • 38
    • 27644461793 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: Implications for the pathophysiology of migraine
    • D Levy R Burstein AM Strassman 2005 Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine Ann Neurol 58 698 705
    • (2005) Ann Neurol , vol.58 , pp. 698-705
    • Levy, D.1    Burstein, R.2    Strassman, A.M.3
  • 40
    • 0042669974 scopus 로고    scopus 로고
    • Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells
    • S Di Angelantonio R Giniatullin V Costa E Sokolova A Nistri 2003 Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells Br J Pharmacol 139 1061 1073
    • (2003) Br J Pharmacol , vol.139 , pp. 1061-1073
    • Di Angelantonio, S.1    Giniatullin, R.2    Costa, V.3    Sokolova, E.4    Nistri, A.5
  • 41
    • 3042739237 scopus 로고    scopus 로고
    • The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors
    • DL Hay AC Conner SG Howitt DM Smith DR Poyner 2004 The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors J Mol Neurosci 22 105 113
    • (2004) J Mol Neurosci , vol.22 , pp. 105-113
    • Hay, D.L.1    Conner, A.C.2    Howitt, S.G.3    Smith, D.M.4    Poyner, D.R.5
  • 42
    • 0032910607 scopus 로고    scopus 로고
    • Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro
    • A Ebersberger B Averbeck K Messlinger PW Reeh 1999 Release of substance P, calcitonin gene-related peptide and prostaglandin E2 from rat dura mater encephali following electrical and chemical stimulation in vitro Neuroscience 89 901 907
    • (1999) Neuroscience , vol.89 , pp. 901-907
    • Ebersberger, A.1    Averbeck, B.2    Messlinger, K.3    Reeh, P.W.4
  • 43
    • 30344453954 scopus 로고    scopus 로고
    • Recent advances in the diagnosis and management of migraine
    • PJ Goadsby 2006 Recent advances in the diagnosis and management of migraine BMJ 332 25 29
    • (2006) BMJ , vol.332 , pp. 25-29
    • Goadsby, P.J.1
  • 44
    • 0037319378 scopus 로고    scopus 로고
    • Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons
    • PL Durham AF Russo 2003 Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons J Neurosci 23 807 815
    • (2003) J Neurosci , vol.23 , pp. 807-815
    • Durham, P.L.1    Russo, A.F.2
  • 45
    • 40949083906 scopus 로고    scopus 로고
    • Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
    • JK Lennerz V Rühle EP Ceppa WL Neuhuber NW Bunnett EF Grady K Messlinger 2008 Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution J Comp Neurol 507 1277 1299
    • (2008) J Comp Neurol , vol.507 , pp. 1277-1299
    • Lennerz, J.K.1    Rühle, V.2    Ceppa, E.P.3    Neuhuber, W.L.4    Bunnett, N.W.5    Grady, E.F.6    Messlinger, K.7
  • 46
    • 49649113201 scopus 로고    scopus 로고
    • 3 receptor gene by calcitonin gene related peptide in trigeminal sensory neurons
    • (submitted)
    • 3 receptor gene by calcitonin gene related peptide in trigeminal sensory neurons. J Biol Chem (submitted)
    • (2008) J Biol Chem
    • Simonetti, M.1    Giniatullin, R.2    Fabbretti, E.3
  • 47
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • D Julius AI Basbaum 2001 Molecular mechanisms of nociception Nature 413 203 210
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 48
    • 0037183781 scopus 로고    scopus 로고
    • Capsaicin receptor immunoreactivity in the human trigeminal ganglion
    • M Hou R Uddman J Tajti M Kanje L Edvinsson 2002 Capsaicin receptor immunoreactivity in the human trigeminal ganglion Neurosci Lett 330 223 226
    • (2002) Neurosci Lett , vol.330 , pp. 223-226
    • Hou, M.1    Uddman, R.2    Tajti, J.3    Kanje, M.4    Edvinsson, L.5
  • 49
    • 33646432794 scopus 로고    scopus 로고
    • Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin
    • M Simonetti A Fabbro M D'Arco M Zweyer A Nistri R Giniatullin E Fabbretti 2006 Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin Mol Pain 28 2 11
    • (2006) Mol Pain , vol.28 , pp. 2-11
    • Simonetti, M.1    Fabbro, A.2    D'Arco, M.3    Zweyer, M.4    Nistri, A.5    Giniatullin, R.6    Fabbretti, E.7
  • 50
    • 21844449440 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats
    • G Natura GS von Banchet HG Schaible 2005 Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats Pain 116 194 204
    • (2005) Pain , vol.116 , pp. 194-204
    • Natura, G.1    Von Banchet, G.S.2    Schaible, H.G.3
  • 52
    • 0141634247 scopus 로고    scopus 로고
    • Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    • JK Bonnington PA McNaughton 2003 Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor J Physiol 551 433 446
    • (2003) J Physiol , vol.551 , pp. 433-446
    • Bonnington, J.K.1    McNaughton, P.A.2
  • 53
    • 33748375335 scopus 로고    scopus 로고
    • Neurotrophins: Mediators and modulators of pain
    • S Pezet SB McMahon 2006 Neurotrophins: mediators and modulators of pain Annu Rev Neurosci 29 507 538
    • (2006) Annu Rev Neurosci , vol.29 , pp. 507-538
    • Pezet, S.1    McMahon, S.B.2
  • 54
    • 0034650354 scopus 로고    scopus 로고
    • Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor
    • K Freeland YZ Liu DS Latchman 2000 Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor Biochem J 345 233 238
    • (2000) Biochem J , vol.345 , pp. 233-238
    • Freeland, K.1    Liu, Y.Z.2    Latchman, D.S.3
  • 60
    • 33749130645 scopus 로고    scopus 로고
    • Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes
    • MM Ryan HE Lockstone SJ Huffaker MT Wayland MJ Webster S Bahn 2006 Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes Mol Psychiatry 11 965 978
    • (2006) Mol Psychiatry , vol.11 , pp. 965-978
    • Ryan, M.M.1    Lockstone, H.E.2    Huffaker, S.J.3    Wayland, M.T.4    Webster, M.J.5    Bahn, S.6
  • 62
    • 9144269934 scopus 로고    scopus 로고
    • Cellular distribution and functions of P2 receptor subtypes in different systems
    • G Burnstock GE Knight 2004 Cellular distribution and functions of P2 receptor subtypes in different systems Int Rev Cytol 240 31 304
    • (2004) Int Rev Cytol , vol.240 , pp. 31-304
    • Burnstock, G.1    Knight, G.E.2
  • 63
    • 0037179755 scopus 로고    scopus 로고
    • P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • RR Ji TA Samad SX Jin R Schmoll CJ Woolf 2002 p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia Neuron 36 57 68
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 64
    • 29244484493 scopus 로고    scopus 로고
    • NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    • X Zhang J Huang PA McNaughton 2005 NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels EMBO J 24 4211 4223
    • (2005) EMBO J , vol.24 , pp. 4211-4223
    • Zhang, X.1    Huang, J.2    McNaughton, P.A.3
  • 65
    • 18644381918 scopus 로고    scopus 로고
    • TrkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors
    • X Fang L Djouhri S McMullan C Berry K Okuse SG Waxman SN Lawson 2005 TrkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors J Neurosci 25 4868 4878
    • (2005) J Neurosci , vol.25 , pp. 4868-4878
    • Fang, X.1    Djouhri, L.2    McMullan, S.3    Berry, C.4    Okuse, K.5    Waxman, S.G.6    Lawson, S.N.7
  • 67
    • 35748947241 scopus 로고    scopus 로고
    • Emerging therapies for migraine
    • PJ Goadsby 2007 Emerging therapies for migraine Nat Clin Pract Neurol 3 610 619
    • (2007) Nat Clin Pract Neurol , vol.3 , pp. 610-619
    • Goadsby, P.J.1
  • 68
    • 21344470124 scopus 로고    scopus 로고
    • The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus
    • MJ Fischer S Koulchitsky K Messlinger 2005 The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus J Neurosci 25 5877 5883
    • (2005) J Neurosci , vol.25 , pp. 5877-5883
    • Fischer, M.J.1    Koulchitsky, S.2    Messlinger, K.3
  • 71
    • 35648995321 scopus 로고    scopus 로고
    • CGRP antagonists: Unravelling the role of CGRP in migraine
    • H Doods K Arndt K Rudolf S Just 2007 CGRP antagonists: unravelling the role of CGRP in migraine Trends Pharmacol Sci 28 580 587
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 580-587
    • Doods, H.1    Arndt, K.2    Rudolf, K.3    Just, S.4
  • 74
    • 0030792234 scopus 로고    scopus 로고
    • Expression of calcitonin gene-related peptide 1 receptor mRNA in human trigeminal ganglia and cerebral arteries
    • L Edvinsson L Cantera I Jansen-Olesen R Uddman 1997 Expression of calcitonin gene-related peptide 1 receptor mRNA in human trigeminal ganglia and cerebral arteries Neurosci Lett 229 209 211
    • (1997) Neurosci Lett , vol.229 , pp. 209-211
    • Edvinsson, L.1    Cantera, L.2    Jansen-Olesen, I.3    Uddman, R.4
  • 75
    • 0036253810 scopus 로고    scopus 로고
    • Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature
    • KR Oliver A Wainwright L Edvinsson JD Pickard RG Hill 2002 Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature J Cereb Blood Flow Metab 22 620 629
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 620-629
    • Oliver, K.R.1    Wainwright, A.2    Edvinsson, L.3    Pickard, J.D.4    Hill, R.G.5
  • 76
    • 0028891578 scopus 로고
    • Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack
    • M Fanciullacci M Alessandri M Figini P Geppetti S Michelacci 1995 Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack Pain 60 119 123
    • (1995) Pain , vol.60 , pp. 119-123
    • Fanciullacci, M.1    Alessandri, M.2    Figini, M.3    Geppetti, P.4    Michelacci, S.5
  • 79
  • 81
    • 13944253331 scopus 로고    scopus 로고
    • BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation
    • KA Petersen LH Lassen S Birk L Lesko J Olesen 2005 BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation Clin Pharmacol Ther 77 202 213
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 202-213
    • Petersen, K.A.1    Lassen, L.H.2    Birk, S.3    Lesko, L.4    Olesen, J.5
  • 82
    • 14644431824 scopus 로고    scopus 로고
    • Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide. (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack
    • G Juhasz T Zsombok B Jakab J Nemeth J Szolcsanyi G Bagdy 2005 Sumatriptan causes parallel decrease in plasma calcitonin gene-related peptide. (CGRP) concentration and migraine headache during nitroglycerin induced migraine attack Cephalalgia 25 179 183
    • (2005) Cephalalgia , vol.25 , pp. 179-183
    • Juhasz, G.1    Zsombok, T.2    Jakab, B.3    Nemeth, J.4    Szolcsanyi, J.5    Bagdy, G.6
  • 83
    • 33746055765 scopus 로고    scopus 로고
    • Sumatriptan causes parallel decrease in plasma CGRP concentration and migraine headache during nitroglycerin-induced migraine attack
    • F Vanmolkot B Van der Schueren J de Hoon 2006 Sumatriptan causes parallel decrease in plasma CGRP concentration and migraine headache during nitroglycerin-induced migraine attack Cephalalgia 26 1037 1038
    • (2006) Cephalalgia , vol.26 , pp. 1037-1038
    • Vanmolkot, F.1    Van Der Schueren, B.2    De Hoon, J.3
  • 84
    • 0037005741 scopus 로고    scopus 로고
    • Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells
    • L Edvinsson R Alm D Shaw RZ Rutledge KS Koblan J Longmore SA Kane 2002 Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells Eur J Pharmacol 434 49 53
    • (2002) Eur J Pharmacol , vol.434 , pp. 49-53
    • Edvinsson, L.1    Alm, R.2    Shaw, D.3    Rutledge, R.Z.4    Koblan, K.S.5    Longmore, J.6    Kane, S.A.7
  • 85
    • 2942512592 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of BIBN 4096 BS., the first selective small molecule calcitonin gene-related peptide receptor antagonist., following single intravenous administration in healthy volunteers
    • M Iovino U Feifel CL Yong JM Wolters G Wallenstein 2004 Safety, tolerability and pharmacokinetics of BIBN 4096 BS., the first selective small molecule calcitonin gene-related peptide receptor antagonist., following single intravenous administration in healthy volunteers Cephalalgia 24 645 656
    • (2004) Cephalalgia , vol.24 , pp. 645-656
    • Iovino, M.1    Feifel, U.2    Yong, C.L.3    Wolters, J.M.4    Wallenstein, G.5
  • 86
    • 1542346238 scopus 로고    scopus 로고
    • BIBN 4096 BS Clinical Proof of Concept Study Group. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    • J Olesen HC Diener IW Husstedt PJ Goadsby D Hall U Meier S Pollentier LM Lesko 2004 BIBN 4096 BS Clinical Proof of Concept Study Group. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine N Engl J Med 350 1104 1110
    • (2004) N Engl J Med , vol.350 , pp. 1104-1110
    • Olesen, J.1    Diener, H.C.2    Husstedt, I.W.3    Goadsby, P.J.4    Hall, D.5    Meier, U.6    Pollentier, S.7    Lesko, L.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.