Drug promiscuity of P-glycoprotein and its mechanism of interaction with paclitaxel and doxorubicin

Soft Matter

Volumn 10, Issue 3, 2014, Pages 438-445

  Zhang, Junqiao ^a   Sun, Tianyang ^a   Liang, Lijun ^a   Wu, Tao ^a   Wang, Qi ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; GLYCOPROTEINS;

ANTICANCER DRUG; ATOMISTIC MOLECULAR DYNAMICS SIMULATIONS; DIFFERENT SUBSTRATES; INTERACTION ENERGIES; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; PUTATIVE BINDING SITES; TRANSPORT SYSTEMS;

SUBSTRATES;

ANTINEOPLASTIC AGENT; CAENORHABDITIS ELEGANS PROTEIN; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL;

ANIMAL; ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CHEMISTRY; METABOLISM; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DOXORUBICIN; MOLECULAR DYNAMICS SIMULATION; P-GLYCOPROTEIN; PACLITAXEL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84890820650     PISSN: 1744683X     EISSN: 17446848     Source Type: Journal    
DOI: 10.1039/c3sm52499j     Document Type: Article

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