Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 3, 2013, Pages 1112-1121

  Li, Jianguo ^a,b   Liu, Shouping ^a,c   Lakshminarayanan, Rajamani ^a   Bai, Yang ^a,c   Pervushin, Konstantin ^c   Verma, Chandra ^a,b,c,d   Beuerman, Roger W ^a,b,d,e,f  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b BIOINFORMATICS INSTITUTE   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f Nanyang Technological University   (Singapore)

Author keywords

Branched antimicrobial peptides; Model bacterial membrane; Molecular dynamics simulations

Indexed keywords

ANTIMICROBIAL PEPTIDE B 2088; ARGININE; GUANIDINE; LYSINE; MEMBRANE LIPID; PHOSPHATE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MEMBRANE; CELL MEMBRANE POTENTIAL; CONCENTRATION (PARAMETERS); DENSITY; DRUG ACCUMULATION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STABILITY; HYDROGEN BOND; HYDROPHOBICITY; MAMMAL; MEMBRANE PERMEABILITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SIMULATION; SOLVATE; STATIC ELECTRICITY; SURFACE PROPERTY;

ADSORPTION; AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINE; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; SOLVENTS; STATIC ELECTRICITY; TIME FACTORS; WATER;

EID: 84873801630     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2012.12.015     Document Type: Article

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