Opioid Receptors

Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management

Volumn , Issue , 2009, Pages 347-372

  Tambeli, Claudia Herrera ^a   Fischer, Luana ^b   Parada, Carlos Amilcar ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Opioid receptors; Peripheral acting opioids in inflammatory pain control; Peripheral endogenous opioid analgesia

Indexed keywords

EID: 84890710771     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470522226.ch14     Document Type: Chapter

References (195)

1. Schmitz, R. (1985). Friedrich Wilhelm Serturner and the discovery of morphine. Pharm Hist 27: 61-74.
2. Pert, C.B., Snyder, S.H. (1973). Opiate receptor: demonstration in nervous tissue. Science 179: 1011-1014.
3. Simon, E.J., Hiller, J.M., Edelman, I. (1973). Stereospecific binding of the potent narcotic analgesic (3H) etorphine to rat-brain homogenate. Proc Natl Acad Sci U S A 70: 1947-1949.
4. Terenius, L. (1973). Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex. Acta Pharmacol Toxicol (Copenh) 32: 317-320.
5. Terenius, L. (1973). Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain. Acta Pharmacol Toxicol (Copenh) 33: 377-384.
6. Martin, W.R. (1967). Opioid antagonists. Pharmacol Rev 19: 463-521.
7. Martin, W.R., Eades, C.G., Thompson, J.A., Huppler, R.E., Gilbert, P.E. (1976). The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197: 517-532.
8. Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A., Morris, H.R. (1975). Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258: 577-580.
9. Lord, J.A., Waterfield, A.A., Hughes, J., Kosterlitz, H.W. (1977). Endogenous opioid peptides: multiple agonists and receptors. Nature 267: 495-499.
10. Chang, K.J., Cooper, B.R., Hazum, E., Cuatrecasas, P. (1979). Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol 16: 91-104.
11. Kosterlitz, H.W., Paterson, S.J., Robson, L.E. (1981). Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain. Br J Pharmacol 73: 939-949.
12. Leslie, F.M., Kosterlitz, H.W. (1979). Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig. Eur J Pharmacol 56: 379 - 383.
13. Pasternak, G.W., Snyder, S.H. (1975). Identification of novel high affinity opiate receptor binding in rat brain. Nature 253: 563-565.
14. Wolozin, B.L., Nishimura, S., Pasternak, G.W. (1982). The binding of kappa-and sigma-opiates in rat brain. J Neurosci 2: 708-713.
15. Evans, C.J., Keith, D.E., Jr., Morrison, H., Magendzo, K., Edwards, R.H. (1992). Cloning of a delta opioid receptor by functional expression. Science 258: 1952-1955.
16. Kieffer, B.L., Befort, K., Gaveriaux-Ruff, C., Hirth, C.G. (1992). The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization . Proc Natl Acad Sci U S A 89: 12048-12052.
17. Knapp, R.J., Malatynska, E., Fang, L., Li, X., Babin, E., Nguyen, M., Santoro, G., Varga, E.V., Hruby, V.J., Roeske, W.R., et al. (1994). Identification of a human delta opioid receptor: cloning and expression. Life Sci 54 :PL 463-PL 469.
18. Simonin, F., Befort, K., Gaveriaux-Ruff, C., Matthes, H., Nappey, V., Lannes, B., Micheletti, G., Kieffer, B. (1994). The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Mol Pharmacol 46: 1015-1021.
19. Chen, Y., Mestek, A., Liu, J., Hurley, J.A., Yu, L. (1993). Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol 44: 8-12.
20. Thompson, R.C., Mansour, A., Akil, H., Watson, S.J. (1993). Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron 11: 903-913.
21. Wang, J.B., Imai, Y., Eppler, C.M., Gregor, P., Spivak, C.E., Uhl, G.R. (1993). Mu opiate receptor: cDNA cloning and expression. Proc Natl Acad Sci U S A 90: 10230-10234.
22. Wang, J.B., Johnson, P.S., Persico, A.M., Hawkins, A.L., Griffin, C.A., Uhl, G.R. (1994). Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett 338: 217-222.
23. Chen, Y., Mestek, A., Liu, J., Yu, L. (1993). Molecular cloning of a rat kappa opioid receptor reveals sequence similarities to the mu and delta opioid receptors. Biochem J 295 (Pt 3): 625-628.
24. Meng, F., Xie, G.X., Thompson, R.C., Mansour, A., Goldstein, A., Watson, S.J., Akil, H. (1993). Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci U S A 90: 9954-9958.
25. Simonin, F., Gaveriaux-Ruff, C., Befort, K., Matthes, H., Lannes, B., Micheletti, G., Mattei, M.G., Charron, G., Bloch, B., Kieffer, B. (1995). Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci U S A 92: 7006-7010.
26. Zhu, J., Chen, C., Xue, J.C., Kunapuli, S., DeRiel, J.K., Liu-Chen, L.Y. (1995). Cloning of a human kappa opioid receptor from the brain. Life Sci 56: PL 201-PL 207.
27. Mattia, A., Vanderah, T., Mosberg, H.I., Porreca, F. (1991). Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J Pharmacol Exp Ther 258: 583-587.
28. Attali, B., Gouarderes, C., Mazarguil, H., Audigier, Y., Cros, J. (1982). Evidence for multiple "kappa" binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord. Neuropeptides 3: 53-64.
29. Gaveriaux-Ruff, C., Peluso, J., Befort, K., Simonin, F., Zilliox, C., Kieffer, B.L. (1997). Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the delta-and kappa-opioid receptors. Brain Res Mol Brain Res 48: 298-304.
30. Pan, Y.X., Xu, J., Bolan, E., Abbadie, C., Chang, A., Zuckerman, A., Rossi, G., Pasternak, G.W. (1999). Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. Mol Pharmacol 56: 396-403.
31. Pasternak, G.W. (2004). Multiple opiate receptors: deja vu all over again. Neuropharmacology 47 (Suppl. 1): 312-323.
32. Schuller, A.G., King, M.A., Zhang, J., Bolan, E., Pan, Y.X., Morgan, D.J., Chang, A., Czick, M.E., Unterwald, E.M., Pasternak, G.W., Pintar, J.E. (1999). Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci 2: 151-156.
33. Gaveriaux-Ruff, C., Kieffer, B.L. (1999). Opioid receptors: gene structutre and function. In: Stein, C. (ed.). Opioids in Pain Control. Cambridge: Cambridge University Press, pp. 1-20.
34. Li, C.H., Chung, D. (1976). Primary structure of human beta-lipotropin. Nature 260: 622-624.
35. Li, C.H., Chung, D., Doneen, B.A. (1976). Isolation, characterization and opiate activity of beta-endorphin from human pituitary glands. Biochem Biophys Res Commun 72: 1542-1547.
36. Cox, B.M., Opheim, K.E., Teschemacher, H., Goldstein, A. (1975). A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties. Life Sci 16: 1777-1782.
37. Goldstein, A., Tachibana, S., Lowney, L.I., Hunkapiller, M., Hood, L. (1979). Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A 76: 6666-6670.
38. Teschemacher, H., Opheim, K.E., Cox, B.M., Goldstein, A. (1975). A peptide-like substance from pituitary that acts like morphine. I. Isolation. Life Sci 16: 1771-1775.
39. Akil, H., Watson, S.J., Young, E., Lewis, M.E., Khachaturian, H., Walker, J.M. (1984). Endogenous opioids: biology and function. Annu Rev Neurosci 7: 223-255.
40. Comb, M., Seeburg, P.H., Adelman, J., Eiden, L., Herbert, E. (1982). Primary structure of the human Met-and Leu-enkephalin precursor and its mRNA. Nature 295: 663-666.
41. Gubler, U., Seeburg, P., Hoffman, B.J., Gage, L.P., Udenfriend, S. (1982). Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides. Nature 295: 206-208.
42. Nakanishi, S., Inoue, A., Kita, T., Nakamura, M., Chang, A.C., Cohen, S.N., Numa, S. (1979). Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. Nature 278: 423-427.
43. Kakidani, H., Furutani, Y., Takahashi, H., Noda, M., Morimoto, Y., Hirose, T., Asai, M., Inayama, S., Nakanishi, S., Numa, S. (1982). Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature 298: 245-249.
44. Gear, R.W., Levine, J.D. (1995). Antinociception produced by an ascending spino-supraspinal pathway. J Neurosci 15: 3154-3161.
45. Schmidt, B.L., Tambeli, C.H., Levine, J.D., Gear, R.W. (2002). Mu/delta cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. Eur J Neurosci 15: 861-868.
46. Tambeli, C.H., Parada, C.A., Levine, J.D., Gear, R.W. (2002). Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat. Eur J Neurosci 16: 1547-1553.
47. Tambeli, C.H., Seo, K., Sessle, B.J., Hu, J.W. (2001). Central mu opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity. Brain Res 913: 90-94.
48. Fields, H. (2004). State-dependent opioid control of pain. Nat Rev Neurosci 5: 565-575.
49. Mansour, A., Fox, C.A., Akil, H., Watson, S.J. (1995). Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18: 22-29.
50. Mansour, A., Khachaturian, H., Lewis, M.E., Akil, H., Watson, S.J. (1988). Anatomy of CNS opioid receptors. Trends Neurosci 11: 308-314.
51. Ferreira, S.H., Nakamura, M. (1979). II-Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins 18: 191-200.
52. Wuster, M., Schulz, R., Herz, A. (1981). Multiple opiate receptors in peripheral tissue preparations. Biochem Pharmacol 30: 1883-1887.
53. Hassan, A.H., Ableitner, A., Stein, C., Herz, A. (1993). Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience 55: 185-195.
54. Zollner, C., Shaqura, M.A., Bopaiah, C.P., Mousa, S., Stein, C., Schafer, M. (2003). Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 64: 202-210.
55. Minami, M., Maekawa, K., Yabuuchi, K., Satoh, M. (1995). Double in situ hybridization study on coexistence of mu -, delta-and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Brain Res Mol Brain Res 30: 203-210.
56. Wang, H., Wessendorf, M.W. (2001). Equal proportions of small and large DRG neurons express opioid receptor mRNAs. J Comp Neurol 429: 590-600.
57. Poonyachoti, S., Kulkarni-Narla, A., Brown, D.R. (2002). Chemical coding of neurons expressing delta-and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileum. Cell Tissue Res 307: 23-33.
58. Zhou, L., Zhang, Q., Stein, C., Schafer, M. (1998). Contribution of opioid receptors on primary afferent versus sympathetic neurons to peripheral opioid analgesia . J Pharmacol Exp Ther 286: 1000-1006.
59. Stein, C., Schafer, M., Machelska, H. (2003). Attacking pain at its source: new perspectives on opioids. Nat Med 9: 1003-1008.
60. Taiwo, Y.O., Levine, J.D. (1991). Kappa-and delta-opioids block sympathetically dependent hyperalgesia. J Neurosci 11: 928-932.
61. Pertovaara, A., Wei, H. (2001). Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers. Eur J Pharmacol 429: 139-145.
62. Schafer, M.K., Bette, M., Romeo, H., Schwaeble, W., Weihe, E. (1994). Localization of kappa-opioid receptor mRNA in neuronal subpopulations of rat sensory ganglia and spinal cord. Neurosci Lett 167: 137-140.
63. Wenk, H.N., Honda, C.N. (1999). Immunohistochemical localization of delta opioid receptors in peripheral tissues. J Comp Neurol 408: 567-579.
64. Bigliardi-Qi, M., Sumanovski, L.T., Buchner, S., Rufli, T., Bigliardi, P.L. (2004). Mu-opiate receptor and beta-endorphin expression in nerve endings and keratinocytes in human skin. Dermatology 209: 183-189.
65. Bagnol, D., Mansour, A., Akil, H., Watson, S.J. (1997). Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 81: 579-591.
66. Bates, J.J., Foss, J.F., Murphy, D.B. (2004). Are peripheral opioid antagonists the solution to opioid side effects? Anesth Analg 98: 116-122.
67. Cadet, P., Bilfinger, T.V., Fimiani, C., Peter, D., Stefano, G.B. (2000). Human vascular and cardiac endothelia express mu opiate receptor transcripts. Endothelium 7: 185-191.
68. Vidal, E.L., Patel, N.A., Wu, G., Fiala, M., Chang, S.L. (1998). Interleukin-1 induces the expression of mu opioid receptors in endothelial cells. Immunopharmacology 38: 261-266.
69. Bidlack, J.M., Khimich, M., Parkhill, A.L., Sumagin, S., Sun, B., Tipton, C.M. (2006). Opioid receptors and signaling on cells from the immune system. J Neuroimmune Pharmacol 1: 260-269.
70. Bidlack, J.M. (2000). Detection and function of opioid receptors on cells from the immune system. Clin Diagn Lab Immunol 7: 719-723.
71. Kapitzke, D., Vetter, I., Cabot, P.J. (2005). Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control. Ther Clin Risk Manag 1: 279-297.
72. Chaturvedi, K., Christoffers, K.H., Singh, K., Howells, R.D. (2000). Structure and regulation of opioid receptors. Biopolymers 55: 334-346.
73. Meng, F., Hoversten, M.T., Thompson, R.C., Taylor, L., Watson, S.J., Akil, H. (1995). A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains. J Biol Chem 270: 12730-12736.
74. Minami, M., Satoh, M. (1995). Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci Res 23: 121-145.
75. Standifer, K.M., Pasternak, G.W. (1997). G proteins and opioid receptor-mediated signalling. Cell Signal 9: 237-248.
76. Ozawa, T., Nakagawa, T., Minami, M., Satoh, M. (1999). Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein. Neurosci Lett 267: 117-120.
77. Prather, P.L., Loh, H.H., Law, P.Y. (1994). Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins. Mol Pharmacol 45: 997-1003.
78. Smart, D., Hirst, R.A., Hirota, K., Grandy, D.K., Lambert, D.G. (1997). The effects of recombinant rat mu-opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase. Br J Pharmacol 120: 1165-1171.
79. Piros, E.T., Prather, P.L., Loh, H.H., Law, P.Y., Evans, C.J., Hales, T.G. (1995). Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. Mol Pharmacol 47: 1041-1049.
80. Tallent, M., Dichter, M.A., Bell, G.I., Reisine, T. (1994). The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells. Neuroscience 63: 1033-1040.
81. Duarte, I.D., Ferreira, S.H. (1992). The molecular mechanism of central analgesia induced by morphine or carbachol and the L-arginine-nitric oxide-cGMP pathway. Eur J Pharmacol 221: 171-174.
82. Ferreira, S.H., Duarte, I.D., Lorenzetti, B.B. (1991). The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release. Eur J Pharmacol 201: 121-122.
83. Rodrigues, A.R., Duarte, I.D. (2000). The peripheral antinociceptive effect induced by morphine is associated with ATP-sensitive K(+) channels. Br J Pharmacol 129: 110-114.
84. Polakiewicz, R.D., Schieferl, S.M., Gingras, A.C., Sonenberg, N., Comb, M.J. (1998). Mu-opioid receptor activates signaling pathways implicated in cell survival and translational control. J Biol Chem 273: 23534-23541.
85. Machelska, H., Stein, C. (2002). Immune mechanisms in pain control. Anesth Analg 95: 1002-1008.
86. Przewlocki, R., Hassan, A.H., Lason, W., Epplen, C., Herz, A., Stein, C. (1992). Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception. Neuroscience 48: 491-500.
87. Cabot, P.J., Carter, L., Gaiddon, C., Zhang, Q., Schafer, M., Loeffler, J.P., Stein, C. (1997). Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats. J Clin Invest 100: 142-148.
88. Mousa, S.A., Machelska, H., Schafer, M., Stein, C. (2002). Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain. J Neuroimmunol 126: 5-15.
89. Rittner, H.L., Brack, A., Stein, C. (2008). Pain and the immune system. Br J Anaesth 101: 40-44.
90. Lolait, S.J., Clements, J.A., Markwick, A.J., Cheng, C., McNally, M., Smith, A.I., Funder, J.W. (1986). Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of beta endorphin in spleen macrophages. J Clin Invest 77: 1776-1779.
91. Oates, E.L., Allaway, G.P., Armstrong, G.R., Boyajian, R.A., Kehrl, J.H., Prabhakar, B.S. (1988). Human lymphocytes produce pro-opiomelanocortin gene-related transcripts. Effects of lymphotropic viruses. J Biol Chem 263: 10041-10044.
92. Rosen, H., Behar, O., Abramsky, O., Ovadia, H. (1989). Regulated expression of proenkephalin A in normal lymphocytes. J Immunol 143: 3703-3707.
93. Carr, D.J., DeCosta, B.R., Kim, C.H., Jacobson, A.E., Guarcello, V., Rice, K.C., Blalock, J.E. (1989). Opioid receptors on cells of the immune system: evidence for delta-and kappa-classes. J Endocrinol 122: 161-168.
94. Manfredi, B., Clementi, E., Sacerdote, P., Bassetti, M., Panerai, A.E. (1995). Age-related changes in mitogen-induced beta-endorphin release from human peripheral blood mononuclear cells. Peptides 16: 699-706.
95. Stein, C., Hassan, A.H., Lehrberger, K., Giefing, J., Yassouridis, A. (1993). Local analgesic effect of endogenous opioid peptides. Lancet 342: 321-324.
96. Khodorova, A., Navarro, B., Jouaville, L.S., Murphy, J.E., Rice, F.L., Mazurkiewicz, J.E., Long-Woodward, D., Stoffel, M., Strichartz, G.R., Yukhananov, R., Davar, G. (2003). Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med 9: 1055-1061.
97. Smith, T.W., Buchan, P., Parsons, D.N., Wilkinson, S. (1982). Peripheral antinociceptive effects of N-methyl morphine. Life Sci 31: 1205-1208.
98. Joris, J.L., Dubner, R., Hargreaves, K.M. (1987). Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation? Anesth Analg 66: 1277-1281.
99. Levine, J.D., Taiwo, Y.O. (1989). Involvement of the mu-opiate receptor in peripheral analgesia. Neuroscience 32: 571-575.
100. Stein, C., Millan, M.J., Shippenberg, T.S., Peter, K., Herz, A. (1989). Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors. J Pharmacol Exp Ther 248: 1269-1275.
101. Furst, S., Riba, P., Friedmann, T., Timar, J., Al-Khrasani, M., Obara, I., Makuch, W., Spetea, M., Schutz, J., Przewlocki, R., Przewlocka, B., Schmidhammer, H. (2005). Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat. J Pharmacol Exp Ther 312: 609-618.
102. Sandner-Kiesling, A., Pan, H.L., Chen, S.R., James, R.L., DeHaven-Hudkins, D.L., Dewan, D.M., Eisenach, J.C. (2002). Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain 96: 13-22.
103. Guan, Y., Johanek, L.M., Hartke, T.V., Shim, B., Tao, Y.X., Ringkamp, M., Meyer, R.A., Raja, S.N. (2008). Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury. Pain 138: 318-329.
104. Kolesnikov, Y., El-Maarouf, A., Rutishauser, U., Pasternak, G. (2007). Reorganization of dorsal root ganglion neurons following chronic sciatic nerve constriction injury: correlation with morphine and lidocaine analgesia. Eur J Pharmacol 568: 124-133.
105. Meunier, A., Latremoliere, A., Mauborgne, A., Bourgoin, S., Kayser, V., Cesselin, F., Hamon, M., Pohl, M. (2005). Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther 11: 608-616.
106. Obara, I., Makuch, W., Spetea, M., Schutz, J., Schmidhammer, H., Przewlocki, R., Przewlocka, B. (2007). Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat. Eur J Pharmacol 558: 60-67.
107. Machelska, H., Stein, C. (2000). Pain control by immune-derived opioids. Clin Exp Pharmacol Physiol 27: 533-536.
108. Antonijevic, I., Mousa, S.A., Schafer, M., Stein, C. (1995). Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci 15: 165-172.
109. Atanassoff, P.G., Brull, S.J., Printsev, Y., Silverman, D.G. (1997). The effect of intradermal administration of lidocaine and morphine on the response to thermal stimulation. Anesth Analg 84: 1340-1343.
110. Bullingham, R.E., McQuay, H.J., Moore, R.A. (1984). Studies on the peripheral action of opioids in postoperative pain in man. Acta Anaesthesiol Belg 35 (Suppl. 35): 285-290.
111. Malo, J.L., Inouye, T., Hawkins, R., Simon, G., Turner-Warwick, M., Pepys, J. (1977). Studies in chronic allergic bronchopulmonary aspergillosis. 4. Comparison with a group of asthmatics. Thorax 32: 275-280.
112. Schulte-Steinberg, H., Weninger, E., Jokisch, D., Hofstetter, B., Misera, A., Lange, V., Stein, C. (1995). Intraperitoneal versus interpleural morphine or bupivacaine for pain after laparoscopic cholecystectomy. Anesthesiology 82: 634-640.
113. Worrich, S., Schuler, G., Janicki, P.K. (2007). Effect of local administration of transdermal fentanyl on peripheral opioid analgesia. Pain Med 8: 41-47.
114. Yarussi, A., Sands, R., Edge, S., Lema, M.J., de Leon-Casasola, O.A. (1999). Evaluation of peripheral morphine analgesia for lumpectomy and axillary node dissection: a randomized, double-blind, placebo-controlled study. Reg Anesth Pain Med 24: 142-145.
115. Binder, W., Machelska, H., Mousa, S., Schmitt, T., Riviere, P.J., Junien, J.L., Stein, C., Schafer, M. (2001). Analgesic and antiinflammatory effects of two novel kappa-opioid peptides. Anesthesiology 94: 1034-1044.
116. Pacheco, D.F., Reis, G.M., Francischi, J.N., Castro, M.S., Perez, A.C., Duarte, I.D. (2005). Delta-opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway. Life Sci 78: 54-60.
117. Bakke, M., Hu, J.W., Sessle, B.J. (1998). Morphine application to peripheral tissues modulates nociceptive jaw reflex. Neuroreport 9: 3315-3319.
118. Clemente, J.T., Parada, C.A., Veiga, M.C., Gear, R.W., Tambeli, C.H. (2004). Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint. Neurosci Lett 372: 250-255.
119. Nunez, S., Lee, J.S., Zhang, Y., Bai, G., Ro, J.Y. (2007). Role of peripheral mu-opioid receptors in inflammatory orofacial muscle pain. Neuroscience 146: 1346-1354.
120. Jeanjean, A.P., Moussaoui, S.M., Maloteaux, J.M., Laduron, P.M. (1995). Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P. Neuroscience 68: 151-157.
121. Ji, R.R., Zhang, Q., Law, P.Y., Low, H.H., Elde, R., Hokfelt, T. (1995). Expression of mu -, delta -, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation. J Neurosci 15: 8156-8166.
122. Selley, D.E., Breivogel, C.S., Childers, S.R. (1993). Modification of G protein-coupled functions by low-pH pretreatment of membranes from NG108-15 cells: increase in opioid agonist efficacy by decreased inactivation of G proteins. Mol Pharmacol 44: 731-741.
123. Woolf, C.J. (1996). Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain. Philos Trans R Soc Lond B Biol Sci 351: 441-448.
124. Zollner, C., Mousa, S.A., Fischer, O., Rittner, H.L., Shaqura, M., Brack, A., Shakibaei, M., Binder, W., Urban, F., Stein, C., Schafer, M. (2008). Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest 118: 1065-1073.
125. Aley, K.O., Green, P.G., Levine, J.D. (1995). Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. J Neurosci 15: 8031-8038.
126. Kolesnikov, Y., Pasternak, G.W. (1999). Topical opioids in mice: analgesia and reversal of tolerance by a topical N-methyl-D-aspartate antagonist. J Pharmacol Exp Ther 290: 247-252.
127. Levine, J.D., Gordon, N.C., Fields, H.L. (1979). Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain. Nature 278: 740-741.
128. Cabot, P.J., Carter, L., Schafer, M., Stein, C. (2001). Methionine-enkephalin-and dynorphin A-release from immune cells and control of inflammatory pain. Pain 93: 207-212.
129. Mousa, S.A., Shakibaei, M., Sitte, N., Schafer, M., Stein, C. (2004). Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain. Endocrinology 145: 1331-1341.
130. Cao, T., Pinter, E., Al-Rashed, S., Gerard, N., Hoult, J.R., Brain, S.D. (2000). Neurokinin-1 receptor agonists are involved in mediating neutrophil accumula tion in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice. J Immunol 164: 5424-5429.
131. Rittner, H.L., Stein, C. (2005). Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia. Eur J Pain 9: 109-112.
132. Rittner, H.L., Brack, A., Stein, C. (2008). The other side of the medal: how chemokines promote analgesia. Neurosci Lett 437: 203-208.
133. Wahl, S.M., Feldman, G.M., McCarthy, J.B. (1996). Regulation of leukocyte adhesion and signaling in inflammation and disease. J Leukoc Biol 59: 789-796.
134. Brown, E. (1997). Neutrophil adhesion and the therapy of inflammation. Semin Hematol 34: 319-326.
135. von Andrian, U.H., Mackay, C.R. (2000). T-cell function and migration. Two sides of the same coin. N Engl J Med 343: 1020-1034.
136. Machelska, H., Stein, C. (2006). Leukocyte- derived opioid peptides and inhibition of pain. J Neuroimmune Pharmacol 1: 90-97.
137. Rittner, H.L., Brack, A., Machelska, H., Mousa, S.A., Bauer, M., Schafer, M., Stein, C. (2001). Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain. Anesthesiology 95: 500-508.
138. Rittner, H.L., Labuz, D., Richter, J.F., Brack, A., Schafer, M., Stein, C., Mousa, S.A. (2007). CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo. Brain Behav Immun 21: 1021-1032.
139. Machelska, H., Mousa, S.A., Brack, A., Schopohl, J.K., Rittner, H.L., Schafer, M., Stein, C. (2002). Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1. J Neurosci 22: 5588-5596.
140. Stein, C., Gramsch, C., Herz, A. (1990). Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin. J Neurosci 10: 1292-1298.
141. Bodnar, R.J., Kelly, D.D., Brutus, M., Glusman, M. (1980). Stress-induced analgesia: neural and hormonal determinants. Neurosci Biobehav Rev 4: 87-100.
142. Binder, W., Mousa, S.A., Sitte, N., Kaiser, M., Stein, C., Schafer, M. (2004). Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue. Eur J Neurosci 20: 92-100.
143. Schafer, M., Carter, L., Stein, C. (1994). Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc Natl Acad Sci U S A 91: 4219-4223.
144. Machelska, H., Cabot, P.J., Mousa, S.A., Zhang, Q., Stein, C. (1998). Pain control in inflammation governed by selectins. Nat Med 4: 1425-1428.
145. Mogil, J.S., Grisel, J.E. (1998). Transgenic studies of pain. Pain 77: 107-128.
146. Qiu, C., Sora, I., Ren, K., Uhl, G., Dubner, R. (2000). Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice. Eur J Pharmacol 387: 163-169.
147. Roques, B.P., Noble, F., Dauge, V., Fournie-Zaluski, M.C., Beaumont, A. (1993). Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. Pharmacol Rev 45: 87-146.
148. Oliveira, M.C., Pelegrini-da-Silva, A., Parada, C.A., Tambeli, C.H. (2007). 5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue. Neuroscience 145: 708-714.
149. Tambeli, C.H., Oliveira, M.C., Clemente, J.T., Pelegrini-da-Silva, A., Parada, C.A. (2006). A novel mechanism involved in 5-hydroxytryptamine-induced nociception: the indirect activation of primary afferents. Neuroscience 141: 1517-1524.
150. Cunha, T.M., Verri, W.A., Jr., Schivo, I.R., Napimoga, M.H., Parada, C.A., Poole, S., Teixeira, M.M., Ferreira, S.H., Cunha, F.Q. (2008). Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 83: 824-832.
151. Guerrero, A.T., Verri, W.A., Jr., Cunha, T.M., Silva, T.A., Schivo, I.R., Dal-Secco, D., Canetti, C., Rocha, F.A., Parada, C.A., Cunha, F.Q., Ferreira, S.H. (2008). Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2. J Leukoc Biol 83: 122-130.
152. Bennett, G., al-Rashed, S., Hoult, J.R., Brain, S.D. (1998). Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils. Pain 77: 315-322.
153. Brack, A., Rittner, H.L., Machelska, H., Shaqura, M., Mousa, S.A., Labuz, D., Zollner, C., Schafer, M., Stein, C. (2004). Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression. Pain 108: 67-75.
154. Kobal, G. (1985). Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation. Pain 22: 151-163.
155. Koppert, W., Likar, R., Geisslinger, G., Zeck, S., Schmelz, M., Sittl, R. (1999). Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation. Anesth Analg 88: 117-122.
156. Tegeder, I., Meier, S., Burian, M., Schmidt, H., Geisslinger, G., Lotsch, J. (2003). Peripheral opioid analgesia in experimental human pain models. Brain 126: 1092-1102.
157. Likar, R., Koppert, W., Blatnig, H., Chiari, F., Sittl, R., Stein, C., Schafer, M. (2001). Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients. J Pain Symptom Manage 21: 330-337.
158. Bullingham, R., O'Sullivan, G., McQuay, H., Poppleton, P., Rolfe, M., Evans, P., Moore, A. (1983). Perineural injection of morphine fails to relieve postoperative pain in humans. Anesth Analg 62: 164-167.
159. Murphy, D.B., McCartney, C.J., Chan, V.W. (2000). Novel analgesic adjuncts for brachial plexus block: a systematic review. Anesth Analg 90: 1122-1128.
160. Picard, P.R., Tramer, M.R., McQuay, H.J., Moore, R.A. (1997). Analgesic efficacy of peripheral opioids (all except intra-articular): a qualitative systematic review of randomised controlled trials. Pain 72: 309-318.
161. Cerchietti, L.C., Navigante, A.H., Korte, M.W., Cohen, A.M., Quiroga, P.N., Villaamil, E.C., Bonomi, M.R., Roth, B.M. (2003). Potential utility of the peripheral analgesic properties of morphine in stomatitis-related pain: a pilot study. Pain 105: 265-273.
162. Duckett, J.W., Cangiano, T., Cubina, M., Howe, C., Cohen, D. (1997). Intravesical morphine analgesia after bladder surgery. J Urol 157: 1407-1409.
163. Kaczmarzyk, T., Stypulkowska, J. (2005). Assessment of the effectiveness of peripheral administration of morphine with local articaine anaesthesia for surgery in inflamed oral and maxillofacial tissues. Pain 115: 348-354.
164. Likar, R., Sittl, R., Gragger, K., Pipam, W., Blatnig, H., Breschan, C., Schalk, H.V., Stein, C., Schafer, M. (1998). Peripheral morphine analgesia in dental surgery. Pain 76: 145-150.
165. Stein, A., Yassouridis, A., Szopko, C., Helmke, K., Stein, C. (1999). Intraarticular morphine versus dexamethasone in chronic arthritis. Pain 83: 525-532.
166. Uhle, R.A., Reader, A., Nist, R., Weaver, J., Beck, M., Meyers, W.J. (1997). Peripheral opioid analgesia in teeth with symptomatic inflamed pulps. Anesth Prog 44: 90-95.
167. Zajaczkowska, R., Wnek, W., Wordliczek, J., Dobrogowski, J. (2004). Peripheral opioid analgesia in laparoscopic cholecystectomy. Reg Anesth Pain Med 29: 424-429.
168. Kalso, E., Smith, L., McQuay, H.J., Andrew Moore, R. (2002). No pain, no gain: clinical excellence and scientific rigour-lessons learned from IA morphine. Pain 98: 269-275.
169. Bryant, C.J., Harrison, S.D., Hopper, C., Harris, M. (1999). Use of intra-articular morphine for postoperative analgesia following TMJ arthroscopy. Br J Oral Maxillofac Surg 37: 391-396.
170. Furst, I.M., Kryshtalskyj, B., Weinberg, S. (2001). The use of intra-articular opioids and bupivacaine for analgesia following temporomandibular joint arthroscopy: a prospective, randomized trial. J Oral Maxillofac Surg 59: 979-983; discussion 983-974.
171. Zuniga, J.R., Ibanez, C., Kozacko, M. (2007). The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty. J Oral Maxillofac Surg 65: 1477-1485.
172. Likar, R., Schafer, M., Paulak, F., Sittl, R., Pipam, W., Schalk, H., Geissler, D., Bernatzky, G. (1997). Intraarticular morphine analgesia in chronic pain patients with osteoarthritis. Anesth Analg 84: 1313-1317.
173. Schafer, M. (1999). Peripheral opioid analgesia: from experimental to clinical studies. Curr Opin Anaesthesiol 12: 603-607.
174. Walker, J.S. (2003). Anti- inflammatory effects of opioids. Adv Exp Med Biol 521: 148-160.
175. Wilson, J.L., Walker, J.S., Antoon, J.S., Perry, M.A. (1998). Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: inhibition by kappa-opioid agonist but not by NSAID. J Rheumatol 25: 499-505.
176. Barber, A., Bartoszyk, G.D., Bender, H.M., Gottschlich, R., Greiner, H.E., Harting, J., Mauler, F., Minck, K.O., Murray, R.D., Simon, M., et al. (1994). A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753. Br J Pharmacol 113: 1317-1327.
177. DeHaven-Hudkins, D.L. (2003). Peripherally restricted opioid drugs: advances and retreats. Curr Opin Anaesthesiol 16: 541-545.
178. Eisenach, J.C., Carpenter, R., Curry, R. (2003). Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis. Pain 101: 89-95.
179. Fraitag, B., Homerin, M., Hecketsweiler, P. (1994). Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsia . Dig Dis Sci 39: 1072-1077.
180. Dapoigny, M., Abitbol, J.L., Fraitag, B. (1995). Efficacy of peripheral kappa agonist fedotozine versus placebo in treatment of irritable bowel syndrome. A multicenter dose-response study. Dig Dis Sci 40: 2244-2249.
181. Read, N.W., Abitbol, J.L., Bardhan, K.D., Whorwell, P.J., Fraitag, B. (1997). Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia. Gut 41: 664-668.
182. Callahan, M.J. (2002). Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds. J Clin Gastroenterol 35 :S 58-S 67.
183. Walker, J., Catheline, G., Guilbaud, G., Kayser, V. (1999). Lack of cross-tolerance between the antinociceptive effects of systemic morphine and asimadoline, a peripherally-selective kappa-opioid agonist, in CCI-neuropathic rats. Pain 83: 509-516.
184. Binder, W., Walker, J.S. (1998). Effect of the peripherally selective kappa-opioid agonist, asimadoline, on adjuvant arthritis. Br J Pharmacol 124: 647-654.
185. Caram-Salas, N.L., Reyes-Garcia, G., Bartoszyk, G.D., Araiza-Saldana, C.I., Ambriz-Tututi, M., Rocha-Gonzalez, H.I., Arreola-Espino, R., Cruz, S.L., Granados-Soto, V. (2007). Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol 573: 75-83.
186. Bickel, A., Dorfs, S., Schmelz, M., Forster, C., Uhl, W., Handwerker, H.O. (1998). Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain 76: 317-325.
187. Machelska, H., Pfluger, M., Weber, W., Piranvisseh-Volk, M., Daubert, J.D., Dehaven, R., Stein, C. (1999). Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans. J Pharmacol Exp Ther 290: 354-361.
188. Lotsch, J., Geisslinger, G. (2001). Morphine-6-glucuronide: an analgesic of the future? Clin Pharmacokinet 40: 485-499.
189. Obara, I., Przewlocki, R., Przewlocka, B. (2004). Local peripheral effects of mu-opioid receptor agonists in neuropathic pain in rats. Neurosci Lett 360: 85-89.
190. Rashid, M.H., Inoue, M., Toda, K., Ueda, H. (2004). Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain. J Pharmacol Exp Ther 309: 380-387.
191. Cai, B.B., Cairns, B.E., Sessle, B.J., Hu, J.W. (2001). Sex-related suppression of reflex jaw muscle activity by peripheral morphine but not GABA. Neuroreport 12: 3457-3460.
192. Likar, R., Mousa, S.A., Steinkellner, H., Koppert, W., Philippitsch, G., Stein, C., Schafer, M. (2007). Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation. Clin J Pain 23: 136-142.
193. Braz, J., Beaufour, C., Coutaux, A., Epstein, A.L., Cesselin, F., Hamon, M., Pohl, M. (2001). Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J Neurosci 21: 7881-7888.
194. Kyrkanides, S., Fiorentino, P.M., Miller, J.N., Gan, Y., Lai, Y.C., Shaftel, S.S., Puzas, J.E., Piancino, M.G., O'Banion, M.K., Tallents, R.H. (2007). Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheum 56: 2038-2048.
195. Lu, C.Y., Chou, A.K., Wu, C.L., Yang, C.H., Chen, J.T., Wu, P.C., Lin, S.H., Muhammad, R., Yang, L.C. (2002). Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats. Gene Ther 9: 1008-1014.