The peripheral antinociceptive effect induced by morphine is associated with ATP-sensitive K+ channels

British Journal of Pharmacology

Volumn 129, Issue 1, 2000, Pages 110-114

  Rodrigues, A R A ^a   Duarte, I D G ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Analgesia; Apamin; Charybdotoxin; Glibenclamide; Morphine; Tolbutamide; opioid receptor agonists

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATASE; APAMIN; CALCIUM CHANNEL; CALCIUM ION; CARRAGEENAN; CESIUM; CHARYBDOTOXIN; GLIBENCLAMIDE; MORPHINE; POTASSIUM CHANNEL; POTASSIUM ION; TETRYLAMMONIUM; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; INFLAMMATION; MALE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT;

EID: 0033979607     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703038     Document Type: Article

References (36)

1. ATP channels. Annu. Rev. Physiol., 60, 667-687.
2. Bentley, G.A., Newton, S.H. & Starr, J. (1981). Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum. Br. J. Pharmacol., 73, 325-332.
3. Cook, N.S. & Quast, U. (1990). Potassium channel pharmacology. In Potassium channels: Structure, classification, function, and therapeutic potential. ed. Cook. N.S. pp. 181-255 Chichester: Ellis Horwood Limited.
4. Duarte, I.D.G., Dos Santos I.R., Lorenzetti, B.B. & Ferreira, S.H. (1992). Analgesia by direct antagonism of nociceptor sensitisation involves the arginine-nitric oxide-cGMP pathway. Eur. J. Pharmacol., 217, 225-227.
5. Edwards, G. & Weston, A.H. (1993). The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol., 33, 597-637.
6. Ferreira, S.H., Duarte, I.D.G. & Lorenzetti, B.B. (1991). The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release. Eur. J. Pharmacol., 201, 121-122.
7. Ferreira, S.H. & Nakamura, M. (1979). Prostaglandin hyper-algesia: The peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins, 18, 191-200.
8. Garcia, M.L., Hanner, M., Knaus, H.G., Koch, R., Schmalhofer, W., Slaughter, R.S. & Kaczorowski, G.J. (1997). Pharmacology of potassium channels. Advances Pharmacol., 39, 425-471.
9. + channels in the central nervous system. In: Potassium channels: Structure, classification, function, and therapeutic potential. ed. Cook. N.S. pp. 348-381 Chichester: Ellis Horwood Limited.
10. Herz, A. & Teschemacher, H.J. (1971). Activities and sites of antinociceptive action of morphine-like analgesics and kinetics of distribution following intravenous, intracerebral, and intraventricular application. Adv. Drug. Res., 6, 79-119.
11. Hille, B. (1992). Potassium channels and chloride channels. In: Ionic channels of excitable membranes. 115-139. Sinauer Associates Inc.
12. Levine, J.D. & Taiwo, Y.O. (1989). Involvement of the mu-opiate receptor in peripheral analgesia. Neuroscience, 32, 571-575.
13. + channels from mammalian skeletal muscle. Nature, 313, 316-318.
14. Nichols, C.G. & Lederer, W.J. (1991). Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am. J. Physiol., 261, H1675-H1686.
15. North, R.A. (1989). Drug receptors and the inhibition of nerve cells. Br. J. Pharmacol., 98, 13-28.
16. North, R.A. & Williams, J.T. (1985). On the potassium conductance increased by opioids in rat locus coeruleus neurones. J. Physiol., 364, 265-280.
17. H and κ-opioid receptor agonists. Br. J. Pharmacol., 110, 1049-1054.
18. 2 adrenoceptors, 7-aminobutyric acid, mu and kappa opioid receptors. J. Pharmacol. Exp. Ther., 276, 1136-1142.
19. + channel-acting drugs. Br. J. Pharmacol., 114, 1296-1302.
20. Ocaña, M., Del Pozo, E., Barrios, M., Robles, L.I. & Baeyens, J.M. (1990). An ATP-dependent potassium channel blocker antagonises morphine analgesia. Eur. J. Pharmacol., 186, 377-378.
21. + channels. Brain Res., 650, 146-148.
22. Randall, L.D. & Selitto, J.J. (1957). A method for measurement of analgesic activity on inflamed tissues. Arch. Int. Pharmacodyn., 113, 233-249.
23. + current in the human neuroblastoma cell line SH-SY5Y. Neurosci. Lett., 135, 37-40.
24. Roane, D.S. & Boyd, N.E. (1993). Reduction of food intake and morphine analgesia by central glibenclamide. Pharmacol. Biochem. Behav., 46, 205-207.
25. + channels. J. Physiol., Paris, 79, 259-264.
26. Rosati, B., Rochetti, M., Zaza, A. & Wanke, E. (1998). Sulfonylureas blockade of neural and cardiac HERG channels. FEBS Lett., 440, 125-130.
27. Satoh, M. & Minami, M. (1995). Molecular pharmacology of the opioid receptors. Pharmacol. Ther., 68, 343-364.
28. Smith, T.W., Buchan, P., Parsons, D.N. & Wilkinson, S. (1982). Peripheral antinociceptive effects of N-methyl morphine. Life Sci., 31, 1205-1208.
29. Stein, C. (1993). Peripheral mechanisms of opioid analgesia. Anesth. Analg., 76, 182-191.
30. Stein, C., Hassan, A.H.S., Przewlocki, R., Gramsch, C., Peter, K. & Herz, A. (1990). Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proc. Natl. Acad. Sci. U.S.A., 87, 5935-5939.
31. Stretton, D., Miura, M., Belvisi, M.G. & Barnes, P.J. (1992). Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. U.S.A., 89, 1325-1329.
32. Vergoni, A.V., Scarano, A. & Bertolini, A. (1992). Pinacidil potentiates morphine analgesia. Life Sci., 50, 135-138.
33. Wild, K.D., Vanderah, T., Mosberg, H.I. & Porreca, F. (1991). Opioid δ receptor subtypes are associated with different potassium channels. Eur. J. Pharmacol., 193, 135-136.
34. Yaksh, T.L. & Rudy, T.A. (1976). Analgesia mediated by a direct spinal action of narcotics. Science, 192, 1357-1358.
35. Yonehara, N. & Takiuchi, S. (1997). Involvement of calcium-activated potassium channels in the inhibitory prejunctional effect of morphine on peripheral sensory nerves. Regulat. Peptides, 68, 147-153.
36. Zimmerman, D.M., Leander, J.D., Reel, J.K. & Hynes, M.D. (1987). Use of β-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. J. Pharmacol. Exp. Ther., 241, 374-378.