Analgesia from a peripherally active κ-opioid receptor agonist in patients with chronic pancreatitis

Pain

Volumn 101, Issue 1-2, 2003, Pages 89-95

  Eisenach, James C ^a   Carpenter, Randall ^b   Curry, Regina ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ADOLOR CORPORATION   (United States)

Author keywords

Afferent inhibition; Chronic pain; Clinical trial; Pain; Visceral pain

Indexed keywords

ADL 10 0101; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; OXYHEMOGLOBIN; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; ANALGESIA; ARTICLE; BLOOD PRESSURE; BREATHING RATE; CHRONIC PAIN; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INFUSION; FEMALE; HEADACHE; HEART ARRHYTHMIA; HEART RATE; HEATING; HOT FLUSH; HUMAN; MALE; OXYGEN SATURATION; PAIN ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RESTLESSNESS; SCORING SYSTEM; SENSORY NERVE; SKIN; THERMAL EXPOSURE; VISCERAL PAIN; XEROSTOMIA;

EID: 0037223119     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(02)00259-2     Document Type: Article

References (21)

1. Beal S.L., Sheiner L.B. NONMEM User's Guide. 1992;University of California, San Francisco, CA.
2. Bickel A., Dorfs S., Schmelz M., Forster C., Uhl W., Handwerker H.O. Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain. 76:1998;317-325.
3. Chang P.C., Aicher S.A., Drake C.T. Kappa opioid receptors in rat spinal cord vary across the estrous cycle. Brain Res. 861:2000;168-172.
4. Craft R.M., Henley S.R., Haaseth R.C., Hruby V.J., Porreca F. Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration. J Pharmacol Exp Ther. 275:1995;1535-1542.
5. Dehaven-Hudkins D.L., Gauntner E.K., Gottshall S.L., Koblish M., Kumar V., Little P.J., Long S.L., Murphy D.M. Peripheral restrictions of κ opioid receptor agonists as defined by pharmacokinetic parameters correlates with behavioral indices of sedation in the rat. Soc Neurosci. 26:2000;915.
6. DiMagno E.P. Toward understanding (and management) of painful chronic pancreatitis. Gastroenterology. 116:1999;1252-1257.
7. Gadano A., Moreau R., Pessione F., Trombino C., Giuily N., Sinnassamy P., Valla D., Lebrec D. Aquaretic effects of niravoline, a kappa-opioid agonist, in patients with cirrhosis. J Hepatol. 32:2000;38-42.
8. Gear R.W., Miaskowski C., Gordon N.C., Paul S.M., Heller P.H., Levine J.D. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med. 2:1996;1248-1250.
9. Gear R.W., Miaskowski C., Gordon N.C., Paul S.M., Heller P.H., Levine J.D. Action of naloxone on gender-dependent analgesic and antianalgesic effects of nalbuphine in humans. J Pain. 1:2000;122-127.
10. Gottshall S.L., Cassel J.A., Cortes Burgos L., Daubert J.D., Dehaven R.N., Koblish M., Kumar V., Little P.J., Long S.L., Marella M., Dehaven-Hudkins D.L. Antinociception produced by ADL 10-0101, a novel peripheral κ opioid receptor agonist, in models of inflammatory hyperalgesia. Soc Neurosci. 25:1999;1221.
11. LaMotte R.H., Campbell J.N. Comparison of responses of warm and nociceptive c-fiber afferents in monkey with human judgments of thermal pain. J Neurophysiol. 41:1978;509-528.
12. Machelska H., Pflüger M., Weber W., Piranvisseh-Völk M., Daubert J.D., Dehaven R., Stein C. Peripheral effects of the kappa-opioid agonist EMD 61753 on pain and inflammation in rats and humans. J Pharmacol Exp Ther. 290:1999;354-361.
13. McNair D.M., Lorr M. An analysis of mood in neurotics. J Abnormal Soc Psychol. 69:1964;620-627.
14. Ness T.J., Gebhart G.F. Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res. 450:1988;153-169.
15. Ness T.J., Gebhart G.F. Visceral pain: a review of experimental studies. Pain. 41:1990;167-234.
16. Pande A.C., Pyke R.E., Greiner M., Cooper S.A., Benjamin R., Pierce M.W. Analgesic efficacy of the kappa-receptor agonist, enadoline, in dental surgery pain. Clin Neuropharmacol. 19:1996;92-97.
17. Pande A.C., Pyke R.E., Greiner M., Wideman G.L., Benjamin R., Pierce M.W. Analgesic efficacy of enadoline versus placebo or morphine in postsurgical pain. Clin Neuropharmacol. 19:1996;451-456.
18. Read N.W., Atitbol J.L., Bardhan K.D., Whorwell P.J., Fraitag B. Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia. Gut. 41:1997;664-668.
19. Sandner-Kiesling A., Pan H.L., Chen S.R., James R.L., Dehaven-Hudkins D.L., Dewan D.M., Eisenach J.C. Characterization of a new model of acute visceral nociception relevant to labor pain. Pain. 96:2002;13-22.
20. Sengupta J.N., Su X., Gebhart G.F. kappa, but not m or d, opioids attenuate responses to distention of afferent fibers innervating the rat colon. Gastroenterology. 111:1996;968-980.
21. Wessendorf M.W., Dooyema J. Coexistence of kappa- and delta-opioid receptors in rat spinal cord axons. Neurosci Lett. 298:2001;151-154.