Leptin - A link between obesity and osteoarthritis: Applications for prevention and treatment

Basic and Clinical Pharmacology and Toxicology

Volumn 114, Issue 1, 2014, Pages 103-108

  Vuolteenaho, Katriina ^a   Koskinen, Anna ^a   Moilanen, Eeva ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MATRIX METALLOPROTEINASE; NITRIC OXIDE;

CARTILAGE CELL; CATABOLISM; DISEASE SEVERITY; HAND OSTEOARTHRITIS; HUMAN; NONHUMAN; OBESITY; OSTEOARTHRITIS; PRIORITY JOURNAL; REVIEW; SYNOVIAL FLUID LEVEL;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; LEPTIN; OBESITY; OSTEOARTHRITIS; RECEPTORS, LEPTIN; SYNOVIAL FLUID;

EID: 84890703059     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12160     Document Type: Review

References (48)

1. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003;62:1145-55.
2. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 2012;64:465-74.
3. de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage 2012;20:1484-99.
4. Dennison E, Cooper C. Osteoarthritis: epidemiology and classification. Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds). Rheumatology. Mosby, Toronto, 2003;1781-91.
5. Jiang L, Rong J, Wang Y, Hu F, Bao C, Li X et al. The relationship between body mass index and hip osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine 2011;78:150-5.
6. Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine 2012;79:291-7.
7. Yusuf E, Nelissen RG, Ioan-Facsinay A, Stojanovic-Susulic V, DeGroot J, van Osch G et al. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis 2010;69:761-5.
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
9. Lam QL, Lu L. Role of leptin in immunity. Cell Mol Immunol 2007;4:1-13.
10. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.
11. Coppari R, Bjorbaek C. Leptin revisited: its mechanism of action and potential for treating diabetes. Nat Rev Drug Discov 2012;11:692-708.
12. Gualillo O. Further evidence for leptin involvement in cartilage homeostases. Osteoarthritis Cartilage 2007;15:857-60.
13. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85-97.
14. Scotece M, Conde J, Vuolteenaho K, Koskinen A, López V, Gómez-Reino J et al. Adipokines as drug targets in joint and bone disease. Drug Discov Today 2013. doi: 10.1016/j.drudis.2013.07.012. [Epub ahead of print].
15. Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum 2003;48:3118-29.
16. Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M et al. Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage 2007;15:872-83.
17. Vuolteenaho K, Koskinen A, Moilanen T, Moilanen E. Leptin levels are increased and its negative regulators, SOCS-3 and sOb-R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis. Ann Rheum Dis 2012;71:1912-3.
18. Gandhi R, Takahashi M, Syed K, Davey JR, Mahomed NN. Relationship between body habitus and joint leptin levels in a knee osteoarthritis population. J Orthop Res 2010;28:329-33.
19. Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 2006;14:690-5.
20. Ku JH, Lee CK, Joo BS, An BM, Choi SH, Wang TH et al. Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis. Clin Rheumatol 2009;28:1431-5.
21. Morroni M, De Matteis R, Palumbo C, Ferretti M, Villa I, Rubinacci A et al. In vivo leptin expression in cartilage and bone cells of growing rats and adult humans. J Anat 2004;205:291-6.
22. Järvinen K, Vuolteenaho K, Nieminen R, Moilanen T, Knowles RG, Moilanen E. Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array. Clin Exp Rheumatol 2008;26:275-82.
23. Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C. The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 2009;60:3374-7.
24. Clockaerts S, Bastiaansen-Jenniskens YM, Runhaar J, Van Osch GJ, Van Offel JF, Verhaar JA et al. The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoarthritis Cartilage 2010;18:876-82.
25. Klein-Wieringa IR, Kloppenburg M, Bastiaansen-Jenniskens YM, Yusuf E, Kwekkeboom JC, El-Bannoudi H et al. The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype. Ann Rheum Dis 2011;70:851-7.
26. Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis 2012;71:455-62.
27. Pallu S, Francin PJ, Guillaume C, Gegout-Pottie P, Netter P, Mainard D et al. Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis. Arthritis Res Ther 2010;12:R112.
28. Koskinen A, Vuolteenaho K, Korhonen R, Moilanen T, Moilanen E. Suppressor of cytokine signaling 3 is reduced in obese patients with osteoarthritis and regulates leptin responses in chondrocytes. Arthritis Rheum 2012;64:S1064.
29. Vuolteenaho K, Moilanen T, Knowles RG, Moilanen E. The role of nitric oxide in osteoarthritis. Scand J Rheumatol 2007;36:247-58.
30. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 2011;7:33-42.
31. 2, IL-6, and IL-8 production. Mediators Inflamm 2009;2009:345838.
32. Otero M, Gomez Reino JJ, Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 2003;48:404-9.
33. Otero M, Lago R, Lago F, Reino JJ, Gualillo O. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther 2005;7:R581-91.
34. Otero M, Lago R, Gomez R, Lago F, Gomez-Reino JJ, Gualillo O. Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes. Life Sci 2007;81:1452-60.
35. Conde J, Scotece M, Lopez V, Gomez R, Lago F, Pino J et al. Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes. PLoS ONE 2012;7:e52533.
36. Iliopoulos D, Malizos KN, Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis 2007;66:1616-21.
37. Koskinen A, Vuolteenaho K, Nieminen R, Moilanen T, Moilanen E. Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clin Exp Rheumatol 2011;29:57-64.
38. Figenschau Y, Knutsen G, Shahazeydi S, Johansen O, Sveinbjörnsson B. Human articular chondrocytes express functional leptin receptors. Biochem Biophys Res Commun 2001;287:190-7.
39. Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J et al. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 2010;18:1441-7.
40. Ding C, Parameswaran V, Udayan R, Burgess J, Jones G. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 2008;93:1952-8.
41. Bao JP, Chen WP, Feng J, Hu PF, Shi ZL, Wu LD. Leptin plays a catabolic role on articular cartilage. Mol Biol Rep 2010;37:3265-72.
42. Griffin TM, Huebner JL, Kraus VB, Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum 2009;60:2935-44.
43. Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med 1992;116:535-9.
44. Muthuri SG, Hui M, Doherty M, Zhang W. What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies. Arthritis Care Res (Hoboken) 2011;63:982-90.
45. Wang Y, Simpson JA, Wluka AE, Teichtahl AJ, English DR, Giles GG et al. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study. Arthritis Res Ther 2009;11:R31.
46. Richette P, Poitou C, Garnero P, Vicaut E, Bouillot JL, Lacorte JM et al. Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis. Ann Rheum Dis 2011;70:139-44.
47. Toda Y, Toda T, Takemura S, Wada T, Morimoto T, Ogawa R. Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. J Rheumatol 1998;25:2181-6.
48. Babaei A, Zarkesh-Esfahani SH, Bahrami E, Ross RJ. Restricted leptin antagonism as a therapeutic approach to treatment of autoimmune diseases. Hormones (Athens) 2011;10:16-26.