Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis

Arthritis Research and Therapy

Volumn 12, Issue 3, 2010, Pages

  Pallu, Stéphane ^a   Francin, Pierre Jean ^b   Guillaume, Cécile ^b   Gegout Pottie, Pascale ^b   Netter, Patrick ^b   Mainard, Didier ^b   Terlain, Bernard ^b   Presle, Nathalie ^b  

^a INSERM   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGEN TYPE 2; COLLAGENASE 3; CYCLOOXYGENASE 2; MESSENGER RNA; RECOMBINANT LEPTIN; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1ALPHA; SOMATOMEDIN C; STAT3 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; LEPTIN; STAT PROTEIN;

ADULT; AGED; ARTICLE; BODY MASS; CARTILAGE CELL; CELL ISOLATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; KNEE OSTEOARTHRITIS; MALE; OBESITY; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE LEVEL; UPREGULATION; CELL CULTURE; METABOLISM; MIDDLE AGED; PATHOLOGY;

AGED; AGED, 80 AND OVER; BODY MASS INDEX; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; OBESITY; OSTEOARTHRITIS, KNEE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 77953191936     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3048     Document Type: Article

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