Role of JunB in Adenosine A2B receptor-mediated vascular endothelial growth factor production

Molecular Pharmacology

Volumn 85, Issue 1, 2014, Pages 62-73

  Ryzhov, Sergey ^a   Biktasova, Asel ^a   Goldstein, Anna E ^a   Zhang, Qinkun ^a   Biaggioni, Italo ^a   Dikov, Mikhail M ^a   Feoktistov, Igor ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CARCINOMA CELL; CELL DIFFERENTIATION; DNA FLANKING REGION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LEWIS CARCINOMA; MAST CELL; MAST CELL DEGRANULATION; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STROMA CELL;

EID: 84890692540     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.088567     Document Type: Article

References (54)

1. Adair TH (2005) Growth regulation of the vascular system: An emerging role for adenosine. Am J Physiol Regul Integr Comp Physiol 289:R283-R296.
2. Alchera E, Tacchini L, Imarisio C, Dal Ponte C, De Ponti C, Gammella E, Cairo G, Albano E, and Carini R (2008) Adenosine-dependent activation of hypoxiainducible factor-1 induces late preconditioning in liver cells. Hepatology 48: 230-239.
3. Auchampach JA, Jin X, Wan TC, Caughey GH, and Linden J (1997) Canine mast cell adenosine receptors: Cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol 52:846-860.
4. Bleasdale JE, Thakur NR, Gremban RS, Bundy GL, Fitzpatrick FA, Smith RJ, and Bunting S (1990) Selective inhibition of receptor-coupled phospholipase Cdependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther 255:756-768.
5. Borrmann T, Hinz S, Bertarelli DC, Li W, Florin NC, Scheiff AB, and Müller CE (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: Development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem 52:3994-4006.
6. Carroll SH, Wigner NA, Kulkarni N, Johnston-Cox H, Gerstenfeld LC, and Ravid K (2012) A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo. J Biol Chem 287:15718-15727.
7. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, and Bos JL (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396:474-477.
8. De Ponti C, Carini R, Alchera E, Nitti MP, Locati M, Albano E, Cairo G, and Tacchini L (2007) Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages. J Leukoc Biol 82:392-402.
9. Dong W, Li Y, Gao M, Hu M, Li X, Mai S, Guo N, Yuan S, and Song L (2012) IKKa contributes to UVB-induced VEGF expression by regulating AP-1 transactivation. Nucleic Acids Res 40:2940-2955.
10. Fang Y and Olah ME (2007) Cyclic AMP-dependent, protein kinase A-independent activation of extracellular signal-regulated kinase 1/2 following adenosine receptor stimulation in human umbilical vein endothelial cells: Role of exchange protein activated by cAMP 1 (Epac1). J Pharmacol Exp Ther 322:1189-1200.
11. Feoktistov I and Biaggioni I (1995) Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 96:1979-1986.
12. Feoktistov I and Biaggioni I (1997) Adenosine A2B receptors. Pharmacol Rev 49: 381-402.
13. Feoktistov I, Biaggioni I, and Cronstein BN (2009) Adenosine receptors in wound healing, fibrosis and angiogenesis. Handbook Exp Pharmacol 193:383-397.
14. Feoktistov I, Goldstein AE, Ryzhov S, Zeng D, Belardinelli L, Voyno-Yasenetskaya T, and Biaggioni I (2002) Differential expression of adenosine receptors in human endothelial cells: Role of A2B receptors in angiogenic factor regulation. Circ Res 90: 531-538.
15. Feoktistov I, Ryzhov S, Goldstein AE, and Biaggioni I (2003) Mast cell-mediated stimulation of angiogenesis: Cooperative interaction between A2B and A3 adenosine receptors. Circ Res 92:485-492.
16. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, and Semenza GL (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613.
17. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, and Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
18. Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, Leung E, Maclennan S, and Borea PA (2010) Adenosine modulates HIF-1a, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells. Arterioscler Thromb Vasc Biol 30:90-97.
19. Grant MB, Davis MI, Caballero S, Feoktistov I, Biaggioni I, and Belardinelli L (2001) Proliferation, migration, and ERK activation in human retinal endothelial cells through A2B adenosine receptor stimulation. Invest Ophthalmol Vis Sci 42: 2068-2073.
20. Grant MB, Tarnuzzer RW, Caballero S, Ozeck MJ, Davis MI, Spoerri PE, Feoktistov I, Biaggioni I, Shryock JC, and Belardinelli L (1999) Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. Circ Res 85:699-706.
21. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, and Johannes FJ (1996) Inhibition of protein kinase C m by various inhibitors. Differentiation from protein kinase C isoenzymes. FEBS Lett 392:77-80.
22. Hess J, Angel P, and Schorpp-Kistner M (2004) AP-1 subunits: Quarrel and harmony among siblings. J Cell Sci 117:5965-5973.
23. Ikebe D, Wang B, Suzuki H, and Kato M (2007) Suppression of keratinocyte stratification by a dominant negative JunB mutant without blocking cell proliferation. Genes Cells 12:197-207.
24. Karin M, Liu Zg, and Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240-246.
25. Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, and Ashbacher A et al. (1998) A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci USA 95: 13278-13283.
26. Kenner L, Hoebertz A, Beil FT, Keon N, Karreth F, Eferl R, Scheuch H, Szremska A, Amling M, and Schorpp-Kistner M et al. (2004) Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164:613-623.
27. Lee CC, Chen SC, Tsai SC, Wang BW, Liu YC, Lee HM, and Shyu KG (2006) Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells. J Biomed Sci 13:143-156.
28. Licht AH, Pein OT, Florin L, Hartenstein B, Reuter H, Arnold B, Lichter P, Angel P, and Schorpp-Kistner M (2006) JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta. J Cell Biol 175:981-991.
29. Linden J, Thai T, Figler H, Jin X, and Robeva AS (1999) Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 56: 705-713.
30. Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, Maclennan S, Baraldi PG, and Borea PA (2005) A3 adenosine receptors modulate hypoxia-inducible factor-1a expression in human a375 melanoma cells. Neoplasia 7:894-903.
31. Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, Maclennan S, and Borea PA (2006) Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells. Biochem Pharmacol 72:19-31.
32. Nesbitt SA and Horton MA (1992) A nonradioactive biochemical characterization of membrane proteins using enhanced chemiluminescence. Anal Biochem 206: 267-272.
33. Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, and Feoktistov I et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-1831.
34. Pagès G and Pouysségur J (2005) Transcriptional regulation of the vascular endothelial growth factor gene - a concert of activating factors. Cardiovasc Res 65: 564-573.
35. Passegué E, Jochum W, Schorpp-Kistner M, Möhle-Steinlein U, and Wagner EF (2001) Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 104:21-32.
36. Ramanathan M, Luo W, Csóka B, Haskó G, Lukashev D, Sitkovsky MV, and Leibovich SJ (2009) Differential regulation of HIF-1a isoforms in murine macrophages by TLR4 and adenosine A2A receptor agonists. J Leukoc Biol 86:681-689.
37. Ramanathan M, Pinhal-Enfield G, Hao I, and Leibovich SJ (2007) Synergistic upregulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell 18:14-23.
38. Ron D and Kazanietz MG (1999) New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13:1658-1676.
39. Rothermel JD, Stec WJ, Baraniak J, Jastorff B, and Botelho LH (1983) Inhibition of glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 39,59-phosphorothioate. J Biol Chem 258:12125-12128.
40. Ryzhov S, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, and Feoktistov I (2012) Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells. J Pharmacol Exp Ther 341:764-774.
41. Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, and Feoktistov I (2011) Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b1Gr11 cells. J Immunol 187:6120-6129.
42. Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, and Feoktistov I (2008a) Host A2B adenosine receptors promote carcinoma growth. Neoplasia 10:987-995.
43. Ryzhov S, Zaynagetdinov R, Goldstein AE, Matafonov A, Biaggioni I, and Feoktistov I (2009) Differential role of the carboxy-terminus of the A2B adenosine receptor in stimulation of adenylate cyclase, phospholipase Cb, and interleukin-8. Purinergic Signal 5:289-298.
44. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, and Feoktistov I (2008b) Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J Immunol 180:7212-7220.
45. Schmidt D, Textor B, Pein OT, Licht AH, Andrecht S, Sator-Schmitt M, Fusenig NE, Angel P, and Schorpp-Kistner M (2007) Critical role for NF-kB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO J 26:710-719.
46. Schorpp-Kistner M, Wang ZQ, Angel P, and Wagner EF (1999) JunB is essential for mammalian placentation. EMBO J 18:934-948.
47. Schulte G and Fredholm BB (2003) The Gs-coupled adenosine A2B receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res 290:168-176.
48. Seidel MG, Klinger M, Freissmuth M, and Höller C (1999) Activation of mitogenactivated protein kinase by the A2A-adenosine receptor via a rap1-dependent and via a p21ras-dependent pathway. J Biol Chem 274:25833-25841.
49. Shima DT, Kuroki M, Deutsch U, Ng YS, Adamis AP, and D'Amore PA (1996) The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and posttranscriptional regulatory sequences. J Biol Chem 271:3877-3883.
50. Stork PJ and Dillon TJ (2005) Multiple roles of Rap1 in hematopoietic cells: Complementary versus antagonistic functions. Blood 106:2952-2961.
51. Textor B, Licht AH, Tuckermann JP, Jessberger R, Razin E, Angel P, Schorpp-Kistner M, and Hartenstein B (2007) JunB is required for IgE-mediated degranulation and cytokine release of mast cells. J Immunol 179:6873-6880.
52. Textor B, Sator-Schmitt M, Richter KH, Angel P, and Schorpp-Kistner M (2006) c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction. Ann N Y Acad Sci 1091:310-318.
53. Yin Y, Wang S, Sun Y, Matt Y, Colburn NH, Shu Y, and Han X (2009) JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells. Biomed Pharmacother 63:429-435.
54. Zeng D, Maa T, Wang U, Feoktistov I, Biaggioni I, and Belardinelli L (2003) Expression and function of A2B adenosine receptors in the U87MG tumor cells. Drug Dev Res 58:405-411 DOI: 10.1002/ddr.10212.