Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells

Circulation Research

Volumn 85, Issue 8, 1999, Pages 699-706

  Grant, Maria B ^a   Tarnuzzer, Roy W ^a   Caballero, Sergio ^a   Ozeck, Mark J ^b   Davis, Margaret I ^a   Spoerri, Polyxenie E ^a   Feoktistov, Igor ^c   Biaggioni, Italo ^c   Shryock, John C ^a,b   Belardinelli, Luiz ^a,b,d  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d CV THERAPEUTICS INC   (United States)

Author keywords

Adenosine receptor; Angiogenesis; Diabetes; Hypoxia; Ischemia

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; BASIC FIBROBLAST GROWTH FACTOR; MESSENGER RNA; SOMATOMEDIN C; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOXIA; ISCHEMIA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RETINA CELL; TIME;

EID: 0033569861     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.85.8.699     Document Type: Article

References (52)

1. Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267:10931-10934.
2. Dor Y, Eli K. Ischemia-driven angiogenesis. Trends Cardiovasc Med. 1997; 7:289-294.
3. Ferrara N, Davis Smith T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4-25.
4. Gospodarowicz D, Bialecki H, Thakral TK. The angiogenic activity of the fibroblast and epidermal growth factor. Exp Eye Res. 1979;28:501-514.
5. Grant MB. Insulinlike growth factor-I in diabetic vascular complications. Curr Opin Endocr Diabetes. 1996;3:335-345.
6. Dusseau J, Hutchins P. Hypoxia-induced angiogenesis in chick chorioallantoic membranes: a role for adenosine. Respir Physiol. 1988;17:33-44.
7. Roth T, Podesta F, Stepp MA, Boeri D, Lorenzi M. Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy. Proc Natl Acad Sci U S A. 1993; 90:9640-9644.
8. Dusseau J, Hutchins P, Malbasa D. Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane. Circ Res. 1986;59:163-170.
9. Meininger CJ, Granger HJ. Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells. Am J Physiol. 1990;258: H198-H206.
10. Nees S, Herzog V, Becker BF, Bock M, Des Rosiers CH, Gerlach E. The coronary endothelium: a highly active metabolic barrier for adenosine. Basic Res Cardiol. 1985;80:515-529.
11. Sexl V, Mancusi G, Holler C, Gloria Maercker E, Schutz W. Freissmuth M. Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem. 1997;272: 5792-5799.
12. Meininger CJ, Schelling ME, Granger HJ. Adenosine and hypoxia stimulate proliferation and migration of endothelial cells. Am J Physiol. 1988;255: H554-H562.
13. Sexl V, Mancusi G, Baumgartner Parzer S, Schutz W, Freissmuth M. Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors. Br J Pharmacol. 1995;114:1577-1586.
14. Ethier MF, Chander V, Dobson JG Jr. Adenosine stimulates proliferation of human endothelial cells in culture. Am J Physiol. 1993;265:H131-H138.
15. Hudlicka O, Wright A, Ziada A. Angiogenesis in the heart and skeletal muscle. Can J Cardiol. 1986;2:120-123.
16. Van Daele P, Van Coevorden A, Roger PP, Boeynaems JM. Effects of adenine nucleotides on the proliferation of aortic endothelial cells. Circ Res. 1992;70:82-90.
17. Adair T, Montani J, Strick D, Guyton A. Vascular development in chick embryos: a possible role for adenosine. Am J Physiol. 1989;256:H240-H246.
18. Shryock J, Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am J Cardiol. 1997;79:2-10.
19. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M. Nomenclature and classification of purinoceptors. Pharmacol Rev. 1994;46:143-156.
20. Collis M, Hourani S. Adenosine receptor subtypes. Trends Pharmacol Sci. 1993;14:360-366.
21. Stiles G. Adenosine receptors. J Biol Chem. 1992;267:6451.
22. Belardinelli L, Shryock J. Does adenosine function as a retaliatory metabolite in the heart? News Physiol Sci. 1992;7:52-56.
23. Frank RN. On the pathogenesis of diabetic retinopathy: a 1990 update. Ophthalmology. 1991;98:586-593.
24. Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, O'Reilly MS, Folkman J, Dvorak HF, Brown LF, Berse B. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol. 1994;145:574-584.
25. Aiello L. Vascular endothelial growth factor: 20th-century mechanisms, 21st-century therapies. Invest Ophthalmol Vis Sci. 1997;38:1647-1652.
26. Kirkpatrick CJ, Wagner M, Hermanns I, Klein CL, Kohler H, Otto M, van Kooten TG, Bittinger F. Physiology and cell biology of the endothelium: a dynamic interface for cell communication. Int J Microcirc Clin Exp. 1997; 17:231-240.
27. Mukhopadhyay D, Nagy J, Manseau E, Dvorak H. Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium. Cancer Res. 1998;58:1278-1284.
28. Gerber H, McMurtrey A, Kowalski J, Van M, Keyt B, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: requirement for flk-1/kdr activation. J Biol Chem. 1998;273:30336-30343.
29. Miller J, Adamis A, Aiello L. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev. 1997;13:37-50.
30. Hanneken A, Lutty GA, McLeod DS, Robey F, Harvey AK, Hjelmeland LM. Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina. J Cell Physiol. 1989:138:115-120.
31. Grant MB, King GL. IGF-1 and blood vessels. Diabetes Rev. 1995;3: 113-128.
32. Feoktistov I, Sheller J, Vallejo V, Biaggioni I. Immunological identification of adenosine A2B receptors in human lung mast cells. Drug Dev Res. 1996;37:146-150.
33. Grant MG, Guay C. Plasminogen activator production by human retinal endothelial cells of nondiabetic and diabetic origin. Invest Ophthalmol Vis Sci. 1991;32:53-64.
34. Shryock JC, Ozeck MJ, Belardinelli L. Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. Mol Pharmacol. 1998;53:886-893.
35. Tarnuzzer RW, Macauley SP, Farmerie WG, Caballero S, Ghassemifar MR, Anderson JT, Robinson CP, Grant MB, Humphreys-Beher MG, Franzen L, Peck AB, Schultz GS. Competitive RNA templates for detection and quantitation of growth factors, cytokines, extracellular matrix components and matrix metalloproteinases by RT-PCR. Biotechniques. 1996;20:670-674.
36. Davis-Cox MI, Turner JN, Szarowski D, Shain W. Phorbol ester-stimulated stellation in primary cultures of astrocytes from different brain regions. Microsc Res Tech. 1994;29:319-327.
37. Shryock J, Snowdy S, Baraldi P, Cacciari B, Spalluto G, Monopoli A, Ongini E, Baker S, Belardinelli L. A2A adenosine receptor reserve for coronary vasodilation. Circulation. 1998;98:711-718.
38. Belardinelli L, Shryock J, Snowdy S, Zhang Y, Monopoli A, Lozza G, Ongini E, Olsson R, Dennis D. The A2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther. 1998;284:1066-1073.
39. Daly J, Jacobson K. Adenosine receptors: selective agonists and antagonists. In: Belardinelli L, Pelleg A, eds. Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology. Boston, Mass: Kluwer Academic Publishers; 1995:157-166.
40. Takagi H, King G, Ferrara N, Aiello L. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 1996;37:1311-1321.
41. Takagi H, King GL, Robinson GS, Ferrara N, Aiello LP. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996;37:2165-2176.
42. Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Mol Pharmacol. 1999;55:726-734.
43. Grant MB, Tarnuzzer RW, Davis MI, Caballero S, Spoerri PE, Ozeck MJ, Shryock JC, Belardinelli L. Adenosine activates mitogen activated protein kinase (MAPK) and angiogenic growth factor production in human retinal endothelial cells (HRECs). In: The Endocrine Society 8th Annual Meeting, June 27, 1998; New Orleans, La. Bethesda, Md: The Endocrine Society; 1998. Abstract.
44. Grant MB, Davis MI, Tarnuzzer RW, Caballero S, Belardinelli L. Adenosine mediates human retinal endothelial cell (HREC) chemotaxis, capillary tube formation and stimulatory signaling cascades. Invest Ophthalmol Vis Sci. 1999;40:S616.
45. D'Angelo G, Lee H, Weiner RI. cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J Cell Biochem. 1997;67:353-366.
46. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science. 1993;262:1065-1069.
47. Cook SJ, McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 1993;262:1069-1072.
48. Ray LB, Sturgill TW. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc Natl Acad Sci U S A. 1988;85:3753-3757.
49. Schonwasser DC, Marais RM, Marshall CJ, Parker PJ. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol. 1998;18:790-798.
50. Pueyo ME, Chen Y, D'Angelo G, Michael JB. Regulation of vascular endothelial growth factor expression by cAMP in rat aortic smooth muscle cells. Exp Cell Res. 1998;238:354-358.
51. Milanini J, Vinals F, Pouyssegur J, Pages G. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem. 1998;273:18165-18172.
52. Alexander SP, Cooper J, Shine J, Hill SJ. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. Br J Pharmacol. 1996;119:1286-1290.