Cross-Talk between Oxysterols and Glucocorticoids: Differential Regulation of Secreted Phopholipase A2 and Impact on Oligodendrocyte Death

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Trousson, Amalia ^a,b   Makoukji, Joelle ^b   Petit, Patrice X ^c   Bernard, Sophie ^b   Slomianny, Christian ^d   Schumacher, Michael ^a   Massaad, Charbel ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT COCHIN   (France)

^d UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; 25-HYDROXYCHOLESTEROL; CHOLESTEROL; CHOLESTEROL DERIVATIVE; GLUCOCORTICOID; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; OXYSTEROL RECEPTOR; PHOSPHOLIPASE A2; PREGNANE X RECEPTOR; STEROID RECEPTOR; STEROL;

ANIMAL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; DEGENERATIVE DISEASE; GENETICS; METABOLISM; MOUSE; OLIGODENDROGLIA; PATHOLOGY;

ANIMALS; APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CHOLESTEROL; GLUCOCORTICOIDS; HYDROXYCHOLESTEROLS; MICE; NEURODEGENERATIVE DISEASES; OLIGODENDROGLIA; ORPHAN NUCLEAR RECEPTORS; PHOSPHOLIPASES A2; RECEPTORS, STEROID; STEROLS;

EID: 77951235899     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008080     Document Type: Article

References (38)

1. Dietschy JM, Turley SD, (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12: 105-112.
2. Russell DW, (2000) Oxysterol biosynthetic enzymes. Biochim Biophys Acta 1529: 126-135.
3. Lutjohann D, Papassotiropoulos A, Bjorkhem I, Locatelli S, Bagli M, et al.(2000) Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res 41: 195-198.
4. Papassotiropoulos A, Lutjohann D, Bagli M, Locatelli S, Jessen F, et al.(2002) 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiatr Res 36: 27-32.
5. Leoni V, Masterman T, Diczfalusy U, De Luca G, Hillert J, et al.(2002) Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis. Neurosci Lett 331: 163-166.
6. Teunissen CE, Dijkstra CD, Polman CH, Hoogervorst EL, von Bergmann K, et al.(2003) Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. Neurosci Lett 347: 159-162.
7. Bochelen D, Mersel M, Behr P, Lutz P, Kupferberg A, (1995) Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex. J Neurochem 65: 2194-2200.
8. Trousson A, Bernard S, Petit PX, Liere P, Pianos A, et al.(2009) 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR. J Neurochem.
9. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ, (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383: 728-731.
10. Schmidt A, Vogel R, Holloway MK, Rutledge SJ, Friedman O, et al.(1999) Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family. Mol Cell Endocrinol 155: 51-60.
11. Mitro N, Vargas L, Romeo R, Koder A, Saez E, (2007) T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Lett 581: 1721-1726.
12. Shenoy SD, Spencer TA, Mercer-Haines NA, Alipour M, Gargano MD, et al.(2004) CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metab Dispos 32: 66-71.
13. Huuskonen J, Fielding PE, Fielding CJ, (2004) Role of p160 coactivator complex in the activation of liver X receptor. Arterioscler Thromb Vasc Biol 24: 703-708.
14. Oberkofler H, Schraml E, Krempler F, Patsch W, (2003) Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha. Biochem J 371: 89-96.
15. Touqui L, Alaoui-El-Azher M, (2001) Mammalian secreted phospholipases A2 and their pathophysiological significance in inflammatory diseases. Curr Mol Med 1: 739-754.
16. Sun GY, Xu J, Jensen MD, Yu S, Wood WG, et al.(2005) Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonists. Mol Neurobiol 31: 27-41.
17. Yagami T, Ueda K, Asakura K, Hata S, Kuroda T, et al.(2002) Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. Mol Pharmacol 61: 114-126.
18. Moses GS, Jensen MD, Lue LF, Walker DG, Sun AY, et al.(2006) Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease. J Neuroinflammation 3: 28.
19. Jaulmes A, Janvier B, Andreani M, Raymondjean M, (2005) Autocrine and paracrine transcriptional regulation of type IIA secretory phospholipase A2 gene in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 25: 1161-1167.
20. Rufini S, de Vito P, Balestro N, Pescatori M, Luly P, et al.(1999) PLA(2) stimulation of Na(+)/H(+) antiport and proliferation in rat aortic smooth muscle cells. Am J Physiol 277: C814-822.
21. Specty O, Pageaux JF, Dauca M, Lagarde M, Laugier C, et al.(2001) Control of cell proliferation via transduction of sPLA(2)-I activity and possible PPAR activation at the nuclear level. FEBS Lett 490: 88-92.
22. Saegusa J, Akakura N, Wu CY, Hoogland C, Ma Z, et al.(2008) Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner. J Biol Chem 283: 26107-26115.
23. Arioka M, Cheon SH, Ikeno Y, Nakashima S, Kitamoto K, (2005) A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons. FEBS Lett 579: 2693-2701.
24. Grenier J, Trousson A, Chauchereau A, Amazit L, Lamirand A, et al.(2004) Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells. Mol Endocrinol 18: 2866-2879.
25. Grenier J, Trousson A, Chauchereau A, Cartaud J, Schumacher M, et al.(2006) Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes. Mol Endocrinol 20: 254-267.
26. Klembt Andersen L, Antoranz Contera S, Justesen J, Duch M, Hansen O, et al.(2005) Cell Volume incease in murine MC3T3-E1 pre-osteoblasts attaching onto biocompatible tantalum observed by atomic force microscopy. Eur Cells Mat 10: 61-69.
27. McNally H, Ben Borgens R, (2004) Three-dimensional imaging of living and dying neurons with atomic force microscopy. J Neurocyt 33: 251-258.
28. Bjorkhem I, Starck L, Andersson U, Lutjohann D, von Bahr S, et al.(2001) Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 42: 366-371.
29. Greger DL, Blum JW, (2007) Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. J Anim Physiol Anim Nutr (Berl) 91: 62-67.
30. Bhalla S, Ozalp C, Fang S, Xiang L, Kemper JK, (2004) Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. J Biol Chem 279: 45139-45147.
31. Stulnig TM, Oppermann U, Steffensen KR, Schuster GU, Gustafsson JA, (2002) Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes 51: 2426-2433.
32. Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, et al.(2006) Liver X receptors regulate adrenal cholesterol balance. J Clin Invest 116: 1902-1912.
33. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, et al.(2006) Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology 147: 5061-5068.
34. Steffensen KR, Holter E, Alikhani N, Eskild W, Gustafsson JA, (2003) Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene. Biochem Biophys Res Commun 312: 716-724.
35. Feutz AC, Pham-Dinh D, Allinquant B, Miehe M, Ghandour MS, (2001) An immortalized jimpy oligodendrocyte cell line: defects in cell cycle and cAMP pathway. Glia 34: 241-252.
36. Antonio V, Janvier B, Brouillet A, Andreani M, Raymondjean M, (2003) Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. Biochem J 376: 351-360.
37. Massaad C, Garlatti M, Wilson EM, Cadepond F, Barouki R, (2000) A natural sequence consisting of overlapping glucocorticoid-responsive elements mediates glucocorticoid, but not androgen, regulation of gene expression. Biochem J 350: 123-129.
38. Tallec LP, Kirsh O, Lecomte MC, Viengchareun S, Zennaro MC, et al.(2003) Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification. Mol Endocrinol 17: 2529-2542.