Characterization of mouse small intestinal cytochrome P450 expression

Drug Metabolism and Disposition

Volumn 31, Issue 11, 2003, Pages 1346-1351

  Zhang, Qing Yu ^a   Dunbar, Debbie ^a   Kaminsky, Laurence S ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A12; CYTOCHROME P450 2A4; CYTOCHROME P450 2A5; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 2B19; CYTOCHROME P450 2B20; CYTOCHROME P450 2C; CYTOCHROME P450 2C29; CYTOCHROME P450 2C37; CYTOCHROME P450 2C38; CYTOCHROME P450 2C39; CYTOCHROME P450 2C40; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A13; CYTOCHROME P450 3A16; CYTOCHROME P450 3A25; CYTOCHROME P450 3A44; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; MESSENGER RNA; PHENOBARBITAL; RNA; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOBLOTTING; INTESTINE CELL; INTESTINE MUCOSA; KNOCKOUT MOUSE; MALE; MICROSOME; MOUSE; MOUSE STRAIN; NONHUMAN; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; SMALL INTESTINE; SPECIES DIFFERENCE; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICROSOMES; SPECIES SPECIFICITY;

ANIMALIA; EUKARYOTA; MUS MUSCULUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0142212150     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.11.1346     Document Type: Article

References (36)

1. Berg-Candolfi M, Candolfi E, and Benet LZ (1996) Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica 26:381-394.
2. Chhabra RS, Pohl RJ, and Fouts JR (1974) A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species. Drug Metab Dispos 2:443-447.
3. Coles BF, Chen GP, Kadlubar FF, and Radominska-Pandya A (2002) Interindividual variation and organ-specific patterns of glutathione S-transferase alpha, mu and pi expression in gastrointestinal tract mucosa of normal individuals. Arch Biochem Biophys 403:270-276.
4. Cummings DA and Schut HAJ (1995) Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo[4,5-F]quinoline (IQ) in male CDF1 mice. Carcinogenesis 16:2523-2529.
5. Damon M, Fautrel A, Guillouzo A, and Corcos L (1996) Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. Biochem J 317:481-486.
6. Ding X and Kaminsky LS (2003) Human extrahepatic cytochrome P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Phannacol Toxicol 43:149-173.
7. Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, and Yokoi T (2000a) Charactenzation of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica 30:943-953.
8. Emoto C, Yamazaki H, Yamasaki S, Shimada N, Nakajima M, and Yokoi T (2000b) Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro. Xenobiotica 30:971-982.
9. Fasco MJ, Silkworth JB, Dunbar DA, and Kaminsky LS (1993) Rat small intestinal cytochromes P450 probed by warfarin metabolism. Mol Pharmacol 43:226-233.
10. Gentil A and Sims P (1971) The metabolism of 7,12-dimethylbenz(a)anthracene by homogenates of the stomach and small intestine of mice. Cancer Res Clin Oncol 76:223-230.
11. Hashizume T, Imaoka S, Hiroi T, Terauchi Y, Fujii T, Miyazaki H, Kamataki T, and Funae Y (2001) CDNA cloning and expression of a novel cytochrome P450 (CYP4F12) from human small intestine. Biochem Biophys Res Commun 280:1135-1141.
12. Hietanen E and Vainio H (1973) Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharm Toxicol 33:57-64.
13. Hua Z, Zhang Q-Y, Su T, Lipinskas TW, and Ding X (1997) cDNA cloning, heterologous expression and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase. Arch Biochem Biophys 340:208-214.
14. Kaminsky LS and Fasco MJ (1992) Small intestinal cytochromes P450. Crit Rev Toxicol 21:407-422.
15. Lehrmann C, Ullrich V, and Rummel W (1973) Phenobarbital inducible drug monooxygenase activity in the small intestine of mice. Naunyn-Schmiedeberg's Arch Pharmacol 276:89-98.
16. Lin SY, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, Schuetz EG, and Thummel KE (2002) Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol Pharmacol 62:162-172.
17. Luo G, Zeldin DC, Blaisdell JA, Hodgson E, and Goldstein JA (1998) Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. Arch Biochem Biophys 357:45-57.
18. Madani S, Paine MF, Lewis L, Thummel KE, and Shen DD (1999) Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines. Pharm Res (NY) 16:1199-1205.
19. Muto N, Hirai H, Tanaka T, Itoh N, and Tanaka K (1997) Induction and inhibition of cytochrome P450 isoforms by imazalil, a food contaminant, in mouse small intestine and liver. Xenobiotica 27:1215-1223.
20. Nakamura M, Imaoka S, Amano F, and Funae Y (1998) P450 isoforms in a murine macrophage cell line, RAW264.7 and changes in the levels of P450 isoforms by treatment of cells with lipopolysaccharide and interferon-gamma. Biochim Biophys Acta 1385:101-106.
21. Obach RS, Zhang QY, Dunbar D, and Kaminsky LS (2001) Metabolic characterization of the major human small intestinal cytochrome P450s. Drug Metab Dispos 29:347-352.
22. Poland A, Palen D, and Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46:915-921.
23. Rylander T, Neve EP, Ingelman-Sundberg M, and Oscarson M (2001) Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Biochem Biophys Res Commun 281:529-535.
24. Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, and Nemoto N (2000) A novel female-specific member of the CYP3A gene subfamily in the mouse liver. Arch Biochem Biophys 377:153-162.
25. Seree EM, Villard PH, Re JL, De Meo M, Lacarelle B, Attolini L, Dumenil G, Catalin J, Durand A, and Barra Y (1996) High inducibility of mouse renal CYP2E1 gene by tobacco smoke and its possible effect on DNA single strand breaks. Biochem Biophys Res Commun 219:429-434.
26. Torronen R, Karenlampi S, and Pelkonen K (1994) Hepa-1 enzyme induction assay as an in vitro indicator of the CYP1A1-inducing potencies of laboratory rodent diets in vivo. Life Sci 55:1945-1954.
27. Towbin H, Staehelin T, and Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
28. Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, and Goldstein JA (2000) CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract. Mol Pharmacol 58:279-287.
29. Wiebel FJ, Leutz JC, and Gelboin HV (1973) Aryl hydrocarbon (benzo(a)pyrene) hydroxylase: inducible in extrahepatic tissues of mouse strains not inducible in liver. Arch Biochem Biophys 154:292-294.
30. Xie Q, Zhang QY, Zhang Y, Su T, Gu J, Kaminsky LS, and Ding X (2000) Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa and small intestine, but not in the heart. Drug Metab Dispos 28:1311-1316.
31. Ye X, Lu L, and Gill SS (1997) Suppression of cytochrome P450 Cyp2f2 mRNA levels in mice by the peroxisome proliferator diethylhexylphthalate. Biochem Biophys Res Commun 239:660-665.
32. Yoshimura T, Itoh S, Tsujikawa K, Yamada E, Ishii T, Iemura O, Kameda Y, Mimura T, and Kohama Y (1998) Effect of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 on the expression of vitamin D-responsive genes in vitamin-D-deficient mice. Pharmacology 57:286-294.
33. Zeldin DC, Foley J, Goldsworthy SM, Cook ME, Boyle JE, Ma JX, Moomaw CR, Tomer KB, Steenbergen C, and Wu S (1997) CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization and potential functional significance. Mol Pharmacol 51:931-943.
34. Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J, and Kaminsky LS (1999) Characterization of human small intestinal cytochromes P-450. Drug Metab Dispos 27:804-809.
35. Zhang QY, Wikoff J, Dunbar D, Fasco M, and Kaminsky L (1997) Regulation of cytochrome P4501A1 expression in rat small intestine. Drug Metab Dispos 25:21-26.
36. Zhang QY, Wikoff J, Dunbar D, and Kaminsky L (1996) Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metab Dispos 24:322-328.