Vitamin D and inflammation

Nutrition and Physical Activity in Inflammatory Diseases

Volumn , Issue , 2012, Pages 75-86

  Barker, Tyler ^a  

^a Orthopedic Specialty Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84890662880     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (97)

1. Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., et al. (1981) Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proceedings of the National Academy of Sciences of the United States of America 78, 4990-4994.
2. Abe, E., Miyaura, C., Tanaka, H., Shiina, Y., Kuribayashi, T., et al. (1983) 1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cellmediated indirect mechanism. Proceedings of the National Academy of Sciences of the United States of America 80, 5583-5587.
3. Adams, J.S. and Gacad, M.A. (1985) Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. The Journal of Experimental Medicine 161, 755-765.
4. Adams, J.S., Sharma, O.P., Gacad, M.A. and Singer, F.R. (1983) Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. The Journal of Clinical Investigation 72, 1856-1860.
5. Adams, J.S., Singer, F.R., Gacad, M.A., Sharma, O.P., Hayes, M.J., et al. (1985) Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. Journal of Clinical Endocrinology and Metabolism 60, 960-966.
6. Almerighi, C., Sinistro, A., Cavazza, A., Ciaprini, C., Rocchi, G., et al. (2009) 1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine 45, 190-197.
7. Alroy, I., Towers, T.L. and Freedman, L.P. (1995) Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Molecular and Cellular Biochemistry 15, 5789-5799.
8. Baeke, F., Korf, H., Overbergh, L., van, E.E., Verstuyf, A., et al. (2010) Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. Journal of Steroid Biochemistry and Molecular Biology 121, 221-227.
9. Baeke, F., Korf, H., Overbergh, L., Verstuyf, A., Thorrez, L., et al. (2011) The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. The Journal of Immunology 186, 132-142.
10. Barbour, G.L., Coburn, J.W., Slatopolsky, E., Norman, A.W. and Horst, R.L. (1981) Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D. New England Journal of Medicine 305, 440-443.
11. Barger-Lux, M.J., Heaney, R.P., Dowell, S., Chen, T.C. and Holick, M.F. (1998) Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporosis International 8, 222-230.
12. Barnes, M.S., Horigan, G., Cashman, K.D., Hill, T.R., Forsythe, L.K., et al. (2011) Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults. The Journal of Nutrition 141, 476-481.
13. Barrat, F.J., Cua, D.J., Boonstra, A., Richards, D.F., Crain, C., et al. (2002) In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. The Journal of Experimental Medicine 195, 603-616.
14. Bartels, L.E., Jorgensen, S.P., Agnholt, J., Kelsen, J., Hvas, C.L., et al. (2007) 1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. International Immunopharmacology 7, 1755-1764.
15. Bell, N.H., Stern, P.H., Pantzer, E., Sinha, T.K. and DeLuca, H.F. (1979) Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. The Journal of Clinical Investigation 64, 218-225.
16. Bellia, A., Garcovich, C., D'Adamo, M., Lombardo, M., Tesauro, M., et al. (2011) Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects. Internal and Emergency Medicine DOI: 10.1007/s11739-011-0559-x. Berg, A.H. and Scherer, P.E. (2005) Adipose tissue, inflammation, and cardiovascular disease. Circulation Research 96, 939-949.
17. Bhalla, A.K., Amento, E.P., Clemens, T.L., Holick, M.F. and Krane, S.M. (1983) Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. Journal of Clinical Endocrinology and Metabolism 57, 1308-1310.
18. Bhalla, A.K., Amento, E.P., Serog, B. and Glimcher, L.H. (1984) 1,25-Dihydroxyvitamin D3 inhibits antigeninduced T cell activation. The Journal of Immunology 133, 1748-1754.
19. Bhalla, A.K., Amento, E.P. and Krane, S.M. (1986) Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cellular Immunology 98, 311-322.
20. Boonstra, A., Barrat, F.J., Crain, C., Heath, V.L., Savelkoul, H.F., et al. (2001) 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. The Journal of Immunology 167, 4974-4980.
21. Chen, S., Sims, G.P., Chen, X.X., Gu, Y.Y., Chen, S., et al. (2007) Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. The Journal of Immunology 179, 1634-1647.
22. Cippitelli, M. and Santoni, A. (1998) Vitamin D3: a transcriptional modulator of the interferon-gamma gene. European Journal of Immunology 28, 3017-3030.
23. Colin, E.M., Asmawidjaja, P.S., van Hamburg, J.P., Mus, A.M., van, D.M., et al. (2010) 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis and Rheumatism 62, 132-142.
24. Colston, K., Colston, M.J. and Feldman, D. (1981) 1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 108, 1083-1086.
25. Correale, J., Ysrraelit, M.C. and Gaitan, M.I. (2009) Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 132, 1146-1160.
26. D'Ambrosio, D., Cippitelli, M., Cocciolo, M.G., Mazzeo, D., Di Lucia, P., et al. (1998) Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. The Journal of Clinical Investigation 101, 252-262.
27. Dong, X., Craig, T., Xing, N., Bachman, L.A., Paya, C.V., et al. (2003) Direct transcriptional regulation of RelB by 1alpha,25-dihydroxyvitamin D3 and its analogs: physiologic and therapeutic implications for dendritic cell function. Journal of Biological Chemistry 278, 49378-49385.
28. Dusso, A.S., Brown, A.J. and Slatopolsky, E. (2005) Vitamin D. American Journal of Physiology, Renal Physiology 289, F8-F28.
29. Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., et al. (2010) T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proceedings of the National Academy of Sciences of the United States of America 107, 22593-22598.
30. Eisman, J.A., Martin, T.J., MacIntyre, I. and Moseley, J.M. (1979) 1,25-dihydroxyvitamin-D-receptor in breast cancer cells. Lancet 2, 1335-1336.
31. Farmer, P.K., He, X., Schmitz, M.L., Rubin, J. and Nanes, M.S. (2000) Inhibitory effect of NF-kappaB on 1,25-dihydroxyvitamin D(3) and retinoid X receptor function. American Journal of Physiology, Endocrinology and Metabolism 279, E213-E220.
32. Fritsche, J., Mondal, K., Ehrnsperger, A., Andreesen, R. and Kreutz, M. (2003) Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. Blood 102, 3314-3316.
33. Froicu, M., Weaver, V., Wynn, T.A., McDowell, M.A., Welsh, J.E., et al. (2003) A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Molecular Endocrinology 17, 2386-2392.
34. Gannage-Yared, M.H., Azoury, M., Mansour, I., Baddoura, R., Halaby, G., et al. (2003) Effects of a shortterm calcium and vitamin D treatment on serum cytokines, bone markers, insulin and lipid concentrations in healthy post-menopausal women. Journal of Endocrinological Investigations 26, 748-753.
35. Geldmeyer-Hilt, K., Heine, G., Hartmann, B., Baumgrass, R., Radbruch, A., et al. (2011) 1,25-dihydroxyvitamin D(3) impairs NF-kappaB activation in human naive B cells. Biochemical and Biophysical Research Communications 407, 699-702.
36. Gottfried, E., Rehli, M., Hahn, J., Holler, E., Andreesen, R., et al. (2006) Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochemical and Biophysical Research Communications 349, 209-213.
37. Gynther, P., Toropainen, S., Matilainen, J.M., Seuter, S., Carlberg, C., et al. (2011) Mechanism of 1alpha,25- dihydroxyvitamin D(3)-dependent repression of interleukin-12B. Biochimica et Biophysica Acta 1813, 810-818.
38. Hansdottir, S., Monick, M.M., Lovan, N., Powers, L., Gerke, A., et al. (2010) Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. The Journal of Immunology 184, 965-974.
39. Heine, G., Niesner, U., Chang, H.D., Steinmeyer, A., Zugel, U., et al. (2008) 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. European Journal of Immunology 38, 2210-2218.
40. Hewison, M., Freeman, L., Hughes, S.V., Evans, K.N., Bland, R., et al. (2003) Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. The Journal of Immunology 170, 5382-5390.
41. Holick, M.F. (2007) Vitamin D deficiency. New England Journal of Medicine 357, 266-281.
42. Iho, S., Kura, F., Sugiyama, H., Takahashi, T. and Hoshino, T. (1985) The role of monocytes in the suppression of PHA-induced proliferation and IL 2 production of human mononuclear cells by 1,25-dihydroxyvitamin D3. Immunology Letters 11, 331-336.
43. Inanir, A., Ozoran, K., Tutkak, H. and Mermerci, B. (2004) The effects of calcitriol therapy on serum interleukin- 1, interleukin-6 and tumour necrosis factor-alpha concentrations in post-menopausal patients with osteoporosis. The Journal of International Medical Research 32, 570-582.
44. Jeffery, L.E., Burke, F., Mura, M., Zheng, Y., Qureshi, O.S., et al. (2009) 1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3. The Journal of Immunology 183, 5458-5467.
45. Jiang, Z., Yin, X. and Jiang, Q. (2011) Natural forms of vitamin E and 13 -carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. The Journal of Immunology 186, 1173-1179.
46. Khoo, A.L., Chai, L.Y., Koenen, H.J., Kullberg, B.J., Joosten, I., et al. (2011a) 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses. The Journal of Infectious Diseases 203, 122-130.
47. Khoo, A.L., Chai, L.Y., Koenen, H.J., Sweep, F.C., Joosten, I., et al. (2011b) Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clinical and Experimental Immunology 164, 72-79.
48. Koeffler, H.P., Reichel, H., Bishop, J.E. and Norman, A.W. (1985) gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages. Biochemical and Biophysical Research Communications 127, 596-603.
49. Lappe, J.M. (2011) The role of vitamin D in human health: a paradigm shift. Journal of Evidence-Based Complementary and Alternative Medicine 16, 58-72.
50. Lemire, J.M., Adams, J.S., Kermani-Arab, V., Bakke, A.C., Sakai, R. et al. (1985) 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro. The Journal of Immunology 134, 3032-3035.
51. Lysandropoulos, A.P., Jaquiery, E., Jilek, S., Pantaleo, G., Schluep, M., et al. (2011) Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects. Journal of Neuroimmunology 233, 240-244.
52. Mahon, B.D., Gordon, S.A., Cruz, J., Cosman, F. and Cantorna, M.T. (2003a) Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. Journal of Neuroimmunology 134, 128-132.
53. Mahon, B.D., Wittke, A., Weaver, V. and Cantorna, M.T. (2003b) The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. Journal of Cellular Biochemistry 89, 922-932.
54. Manolagas, S.C., Haussler, M.R. and Deftos, L.J. (1980) 1,25-dihydroxyvitamin D3 receptors in cancer. Lancet 1, 828.
55. Martineau, A.R., Wilkinson, K.A., Newton, S.M., Floto, R.A., Norman, A.W., et al. (2007) IFN-gammaand TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. The Journal of Immunology 178, 7190-7198.
56. Matilainen, J.M., Husso, T., Toropainen, S., Seuter, S., Turunen, M.P., et al. (2010a) Primary effect of 1alpha,25(OH)D on IL-10 expression in monocytes is short-term down-regulation. Biochimica et Biophysica Acta 1803, 1276-1286.
57. Matilainen, J.M., Rasanen, A., Gynther, P. and Vaisanen, S. (2010b) The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes. Journal of Steroid Biochemistry and Molecular Biology 121, 142-145.
58. McCollum, E.V., Simmonds, N. and Becker, J.E. (1922) Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. Journal of Biological Chemistry 53, 293-312.
59. Muller, K., Diamant, M. and Bendtzen, K. (1991) Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin D3. Immunology Letters 28, 115-120.
60. Muller, K., Haahr, P.M., Diamant, M., Rieneck, K., Kharazmi, A. et al. (1992) 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 4, 506-512.
61. Nemere, I., Wilson, C., Jensen, W., Steinbeck, M., Rohe, B., et al. (2006) Mechanism of 24,25-dihydroxyvitamin D3-mediated inhibition of rapid, 1,25-dihydroxyvitamin D3-induced responses: role of reactive oxygen species. Journal of Cellular Biochemistry 99, 1572-1581.
62. Nonn, L., Peng, L., Feldman, D. and Peehl, D.M. (2006) Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Research 66, 4516-4524.
63. Papapoulos, S.E., Clemens, T.L., Fraher, L.J., Lewin, I.G., Sandler, L.M., et al. (1979) 1, 25-dihydroxycholecalciferol in the pathogenesis of the hypercalcaemia of sarcoidosis. Lancet 1, 627-630.
64. Peelen, E., Knippenberg, S., Muris, A.H., Thewissen, M., Smolders, J., et al. (2011) Effects of vitamin D on the peripheral adaptive immune system: A review. Autoimmunity Reviews 10, 733-743.
65. Penna, G. and Adorini, L. (2000) 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. Journal of Immunology 164, 2405-2411.
66. Penna, G., Armuchastequi, S., Giarratana, N., Daniel, K.C., Vulcano, M., et al. (2007) 1 Alpha,25- dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. The Journal of Immunology 178, 145-153.
67. Prabhu, A.S., Selvaraj, P. and Narayanan, P.R. (2009) Effect of 1,25 dihydroxyvitamin D3 on intracellular IFN-gamma and TNF-alpha positive T cell subsets in pulmonary tuberculosis. Cytokine 45, 105-110.
68. Provvedini, D.M. and Manolagas, S.C. (1989) 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes. Journal of Clinical Endocrinology and Metabolism 68, 774-779.
69. Provvedini, D.M., Tsoukas, C.D., Deftos, L.J. and Manolagas, S.C. (1983) 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221, 1181-1183.
70. Reichel, H., Koeffler, H.P., Barbers, R. and Norman, A.W. (1987a) Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. Journal of Clinical Endocrinology and Metabolism 65, 1201-1209.
71. Reichel, H., Koeffler, H.P., Tobler, A. and Norman, A.W. (1987b) 1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 84, 3385-3389.
72. Rigby, W.F. and Waugh, M.G. (1992) Decreased accessory cell function and costimulatory activity by 1,25-dihydroxyvitamin D3-treated monocytes. Arthritis and Rheumatism 35, 110-119.
73. Rigby, W.F., Stacy, T. and Fanger, M.W. (1984) Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). The Journal of Clinical Investigation 74, 1451-1455.
74. Rigby, W.F., Denome, S. and Fanger, M.W. (1987) Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. The Journal of Clinical Investigation 79, 1659-1664.
75. Sadeghi, K., Wessner, B., Laggner, U., Ploder, M., Tamandl, D., et al. (2006) Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. European Journal of Immunology 36, 361-370.
76. Schleithoff, S.S., Zittermann, A., Tenderich, G., Berthold, H.K., Stehle, P., et al. (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition 83, 754-759.
77. Sigmundsdottir, H., Pan, J., Debes, G.F., Alt, C., Habtezion, A., et al. (2007) DCs metabolize sunlightinduced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nature Immunology 8, 285-293.
78. Smolders, J., Peelen, E., Thewissen, M., Cohen Tervaert, J.W., Menheere, P., et al. (2010) Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS.One. 5, e15235.
79. Staeva-Vieira, T.P. and Freedman, L.P. (2002) 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. The Journal of Immunology 168, 1181-1189.
80. Stoffels, K., Overbergh, L., Giulietti, A., Verlinden, L., Bouillon, R., et al. (2006) Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. Journal of Bone and Mineral Research 21, 37-47.
81. Stoffels, K., Overbergh, L., Bouillon, R. and Mathieu, C. (2007) Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathway. Journal of Steroid Biochemistry and Molecular Biology 103, 567-571.
82. Stubbs, J.R., Idiculla, A., Slusser, J., Menard, R. and Quarles, L.D. (2010) Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD. Journal of the American Society of Nephrology 21, 353-361.
83. Szeles, L., Keresztes, G., Torocsik, D., Balajthy, Z., Krenacs, L., et al. (2009) 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. The Journal of Immunology 182, 2074-2083.
84. Takeuchi, A., Reddy, G.S., Kobayashi, T., Okano, T., Park, J., et al. (1998) Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects. The Journal of Immunology 160, 209-218.
85. Tangpricha, V., Pearce, E.N., Chen, T.C. and Holick, M.F. (2002) Vitamin D insufficiency among free-living healthy young adults. The American Journal of Medicine 112, 659-662.
86. Thien, R., Baier, K., Pietschmann, P., Peterlik, M. and Willheim, M. (2005) Interactions of 1 alpha,25- dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes. The Journal of Allergy and Clinical Immunology 116, 683-689.
87. Tsoukas, C.D., Watry, D., Escobar, S.S., Provvedini, D.M., Dinarello, C.A., et al. (1989) Inhibition of interleukin- 1 production by 1,25-dihydroxyvitamin D3. Journal of Clinical Endocrinology and Metabolism 69, 127-133.
88. Urry, Z., Xystrakis, E., Richards, D.F., McDonald, J., Sattar, Z., et al. (2009) Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. The Journal of Clinical Investigation 119, 387-398.
89. Veldman, C.M., Cantorna, M.T. and DeLuca, H.F. (2000) Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Archives of Biochemistry and Biophysics 374, 334-338.
90. Wagner, D., Hanwell, H.E., Schnabl, K., Yazdanpanah, M., Kimball, S., et al. (2011) The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. Journal of Steroid Biochemistry and Molecular Biology 126, 72-77.
91. Willheim, M., Thien, R., Schrattbauer, K., Bajna, E., Holub, M., et al. (1999) Regulatory effects of 1alpha,25- dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. Journal of Clinical Endocrinology and Metabolism 84, 3739-3744.
92. Wortsman, J., Matsuoka, L.Y., Chen, T.C., Lu, Z. and Holick, M.F. (2000) Decreased bioavailability of vitamin D in obesity. American Journal of Clinical Nutrition 72, 690-693.
93. Yu, X.P., Bellido, T. and Manolagas, S.C. (1995) Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. Proceedings of the National Academy of Sciences of the United States of America 92, 10990-10994.
94. Yusupov, E., Li-Ng, M., Pollack, S., Yeh, J.K., Mikhail, M., et al. (2010) Vitamin D and serum cytokines in a randomized clinical trial. International Journal of Endocrinology 2010.
95. Zhang, Y., Leung, D.Y.M., Richers, B.N., Liu, Y., Remigio, L.K., et al. (2012) Vitamin D inhibits monocyte/ macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. The Journal of Immunology 188, 2127-2135.
96. Zittermann, A., Dembinski, J. and Stehle, P. (2004) Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10. Pediatric Allergy and Immunology 15, 242-246.
97. Zittermann, A., Frisch, S., Berthold, H.K., Gotting, C., Kuhn, J., et al. (2009) Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. American Journal of Clinical Nutrition 89, 1321-1327.