Vitamin D and its major metabolites: Serum levels after graded oral dosing in healthy men

Osteoporosis International

Volumn 8, Issue 3, 1998, Pages 222-230

  Barger Lux, M J ^a   Heaney, R P ^b   Dowell, S ^b   Chen, T C ^c   Holick, M F ^c  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CREIGHTON UNIVERSITY   (United States)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; Vitamin D

Indexed keywords

CALCIFEDIOL; CALCITRIOL; CALCIUM ION; COLECALCIFEROL; DRUG METABOLITE; PARATHYROID HORMONE; VITAMIN D;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; MILK; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; CALCIFEDIOL; CALCITRIOL; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; PARATHYROID HORMONE; VITAMIN D;

EID: 0031671011     PISSN: 0937941X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001980050058     Document Type: Article

References (37)

1. Hollis BW. Assessment of vitamin D nutritional and hormonal status. what to measure and how to do it. Calcif Tissue Int 1996.58:4-5.
2. Civitelli R. The role of vitamin D metabolites in the treatment of osteoporosis. Calcif Tissue Int 1995:57:409-14.
3. Barger-Lux MJ, Heaney RP. Dowell S. Holick MF. Chen T. Calcium absorptive effects of major vitamin D metabolites. J Clin Endocrinol Metab 1997:82:4111-6.
4. Kinyamu HK, Gallagher JC. Balhorn KE, Patranick KM. Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. Am J Clin Nutr 1997:65:790-7.
5. Krall EA. Sahyoun N, Tannenbaum S, Dallal GE, DawsonHughes B. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med 1989:321:1777-83.
6. McKenna MJ. Franey R, Meade A, Muldowney FP. Prevention of hypovitaminosis D in the elderly. Calcif Tissue Int 1985:37:112-6.
7. 3. Eur J Clin Invest 1983:13:391-6.
8. Lips P, Graafmans WC. Oooms ME, Bezemer PD, Bouter LM. Vitamin D supplementation and fracture incidence in elderly persons. Ann Intern Med 1996:124:400-6.
9. Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr 1997:65:67-71.
10. Heaney RP, Burckhardt P. Nutrition and bone health. In: Burckhardt P. Heaney RP, editors. Nutritional aspects of osteoporosis '94, Rome, Italy: Ares-Serono Symposia Publications. 1995:419-24.
11. McKenna MJ. Defining hypovitaminosis D. In: Burckhardt P, Dawson-Hughes B. Heaney RP, editors. Nutritional Aspects of Osteoporosis '97. Berlin: Springer. 1998 (in press).
12. Chapuy MC, Chapuy P, Meunier PJ. Calcium and vitamin D supplements: effects on calcium metabolism in elderly people. Am J Clin Nutr 1987:46:324-8.
13. Lips P, Wiersinga A, van Ginkel FC. Jongen JM. Netelenbos JC, Hackeng WHL, et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects. J Clin Endocrinol Metab 1988:67:644-50.
14. 2D. Am J Clin Nutr 1990:52:701-6.
15. Honkanen R. Alhava E, Parviainen M. Talasniemi S, Mönkkönen R. The necessity and safety of calcium and vitamin D for the elderly J Am Geriatr Soc 1990:38:862-6.
16. Sorva A. Risteli J, Risteli L, Valimaki M, Tilvis R. Effects of vitamin D and calcium on markers of bone metabolism in geriatric patients with low serum 25-hvdroxy vitamin D levels. Calcif Tissue Int 1991:49:888-9.
17. 3, and calcium to prevent hip fractures in elderlywomen. N Engl J Med 1992:327:1637-42.
18. Khaw K-T, Scragg R. Murphy S. Single-dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial. Am J Clin Nutre 1994:59-1040-4.
19. Ooms ME. Roos JC. Bezemer PD. van der Vijgh WJF. Bouter LM, Lips P. Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind mal. J Clin Endocrinol Metab 1995:80:1052-8.
20. 3 supplements. Osteoporos Int 1996 Suppl 3:560-3.
21. Stamp TCB. Haddad JG. Twigg CA. Comparison of oral 25-hydroxycholecalciferol, vitamin D. and ultraviolet light as determinants of circulating 25-hydroxyvitamin D. Lancet 1977:1:1341-3.
22. Davie MWJ, Lawson DEM, Emberson C. Barnes JLC. Roberts GE. Bames ND. Vitamin D from skin: contribution 10 vitamin D status compared with oral vitamin D in normal and anticonvulsant-treated subjects. Clin Sci 1982:63:461-72.
23. Dawson-Hughes B. Dallai GE, Krall EA, Harris S, Sokoll LJ, Falconer G. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991,115:505-12.
24. Dawson-Hughes B, Hams SS, Krall EA. Dallai GE, Falconer G, Green CL. Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D. Am J Clin Nutr 1995:61:1140-5.
25. Adams ND, Gray RW, Lemann J, Cheung HS. Effects of calcitriol administration on calcium metabolism in healthy men. Kidney Int 1982:21:90-7.
26. Dawson-Hughes B, Hams SS, Finneran S. Rasmussen HM. Calcium absorption responses to calcitriol in black and white premenopausal women. J Clin Endocrinol Metab 1995:80:3068-72.
27. 3 on intestinal absorption of calcium in normal man and patients with renal failure. Metabolism 1978:27:745-53.
28. Chen TC, Turner AR. Holick MF. Method for the determination of the circulating concentration of vitamin D. J Nutr Biochem 1990:1:272-6.
29. Chen TC, Turner AR, Holick MF. Method for the determination of the circulating concentration of 25-hydroxyvitamin D. J Nutr Biochem 1990:1:315-9
30. Chen TC, Turner AR, Holick MF. Method for the determination of the circulating concentration of 1,25-dihydroxylation D. J Nutr Biochem 1990:1:320-7.
31. Byrne PM, Freaney R, McKenna MJ. Vitamin D supplementation in the elderly: review of safety and effectiveness of different regimes. Calcif Tissue Int 1995:56:518-20.
32. Lips P, Chapuy MC, Dawson-Hughes B, Pols HAP. International comparison of serum 25-hydroxyvitamin D measurements. J Bone Miner Metab 1995:10(Suppl 1):S496.
33. McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly. Am J Med 1992:93:69-77.
34. Quesada-Gómez JM, Alonso J, Bouillon R. Vitamin D insufficiency as a determinants of hip fractures. Osteoporos Int 1996;Suppl 3:342-7.
35. 3 by isotope dilution liquid chromatography/thermospray mass spectrometry. Biol Mass Spectrometry 1993:22:53-8.
36. Makoid M. Basic pharmacokinetics. 1996 (REV.97.4.27.http:// kiwi.creighton.edu/pkinbook/).
37. Dawson-Hughes B, Harris SS. Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997 (in press).