Effects of vitamin D on the peripheral adaptive immune system: A review

Autoimmunity Reviews

Volumn 10, Issue 12, 2011, Pages 733-743

  Peelen, Evelyn ^a,b   Knippenberg, Stephanie ^a,b   Muris, Anne Hilde ^a,b   Thewissen, Mariëlle ^a   Smolders, Joost ^a,b   Tervaert, Jan Willem Cohen ^a   Hupperts, Raymond ^a,b   Damoiseaux, Jan ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Zuyderland Medical Centre   (Netherlands)

Author keywords

Adaptive immune system; Autoimmunity; Immune homeostasis; Vitamin D

Indexed keywords

VITAMIN D;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; HOMEOSTASIS; HUMAN; IMMUNOREGULATION; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; VITAMIN SUPPLEMENTATION;

ADAPTIVE IMMUNITY; AUTOIMMUNITY; HOMEOSTASIS; HUMANS; VITAMIN D;

EID: 80053239608     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2011.05.002     Document Type: Review

References (124)

1. Abbas S., Linseisen J., Slanger T., Kropp S., Mutschelknauss E.J., Flesch-Janys D., et al. Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer-results of a large case-control study. Carcinogenesis 2008, 29:93-99.
2. Yin L., Grandi N., Raum E., Haug U., Arndt V., Brenner H. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther 2009, 30:113-125.
3. Yin L., Raum E., Haug U., Arndt V., Brenner H. Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk. Cancer Epidemiol 2009, 33:435-445.
4. Giovannucci E., Liu Y., Hollis B.W., Rimm E.B. 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008, 168:1174-1180.
5. Pilz S., Tomaschitz A., Ritz E., Pieber T.R. Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol 2009, 6:621-630.
6. Ascherio A., Munger K.L., Simon K.C. Vitamin D and multiple sclerosis. Lancet Neurol 2010, 9:599-612.
7. Hypponen E., Laara E., Reunanen A., Jarvelin M.R., Virtanen S.M. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001, 358:1500-1503.
8. Kamen D.L., Cooper G.S., Bouali H., Shaftman S.R., Hollis B.W., Gilkeson G.S. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006, 5:114-117.
9. Gatenby P.A., Lucas R.M., Engelsen O., Ponsonby A.L., Clements M. Antineutrophil cytoplasmic antibody-associated vasculitides: could geographic patterns be explained by ambient ultraviolet radiation?. Arthritis Rheum 2009, 61:1417-1424.
10. Cutolo M., Otsa K., Paolino S., Yprus M., Veldi T., Seriolo B. Vitamin D involvement in rheumatoid arthritis and systemic lupus erythaematosus. Ann Rheum Dis 2009, 68:446-447.
11. Pelajo C.F., Lopez-Benitez J.M., Miller L.C. Vitamin D and autoimmune rheumatologic disorders. Autoimmun Rev 2010, 9:507-510.
12. Hollis B.W., Wagner C.L., Drezner M.K., Binkley N.C. Circulating vitamin D3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol 2007, 103:631-634.
13. Institute of Medicine (U.S.) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary reference intakes: for calcium, phosphorus, magnesium, vitamin D, and fluoride 1997, National Academy Press, Washington, D.C.
14. Smith J.E., Goodman D.S. The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma. J Clin Invest 1971, 50:2159-2167.
15. Omdahl J.L., Morris H.A., May B.K. Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annu Rev Nutr 2002, 22:139-166.
16. Norman A.W. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006, 147:5542-5548.
17. Norman P.E., Powell J.T. Vitamin D, shedding light on the development of disease in peripheral arteries. Arterioscler Thromb Vasc Biol 2005, 25:39-46.
18. Smolders J., Peelen E., Thewissen M., Menheere P., Tervaert J.W., Hupperts R., et al. The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev 2009, 8:621-626.
19. Muller K., Haahr P.M., Diamant M., Rieneck K., Kharazmi A., Bendtzen K. 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 1992, 4:506-512.
20. Penna G., Amuchastegui S., Giarratana N., Daniel K.C., Vulcano M., Sozzani S., et al. 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol 2007, 178:145-153.
21. Provvedini D.M., Tsoukas C.D., Deftos L.J., Manolagas S.C. 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science 1983, 221:1181-1183.
22. Rigby W.F., Waugh M., Graziano R.F. Regulation of human monocyte HLA-DR and CD4 antigen expression, and antigen presentation by 1,25-dihydroxyvitamin D3. Blood 1990, 76:189-197.
23. Veldman C.M., Cantorna M.T., DeLuca H.F. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000, 374:334-338.
24. Sigmundsdottir H., Pan J., Debes G.F., Alt C., Habtezion A., Soler D., et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol 2007, 8:285-293.
25. Correale J., Ysrraelit M.C., Gaitan M.I. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 2009, 132:1146-1160.
26. Fritsche J., Mondal K., Ehrnsperger A., Andreesen R., Kreutz M. Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. Blood 2003, 102:3314-3316.
27. Gottfried E., Rehli M., Hahn J., Holler E., Andreesen R., Kreutz M. Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochem Biophys Res Commun 2006, 349:209-213.
28. Szeles L., Keresztes G., Torocsik D., Balajthy Z., Krenacs L., Poliska S., et al. 1,25-Dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol 2009, 182:2074-2083.
29. Chen S., Sims G.P., Chen X.X., Gu Y.Y., Lipsky P.E. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007, 179:1634-1647.
30. Heine G., Niesner U., Chang H.D., Steinmeyer A., Zugel U., Zuberbier T., et al. 1,25-Dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur J Immunol 2008, 38:2210-2218.
31. Marcenaro E., Ferranti B., Moretta A. NK-DC interaction: on the usefulness of auto-aggression. Autoimmun Rev 2005, 4:520-525.
32. Rigby W.F., Waugh M.G. Decreased accessory cell function and costimulatory activity by 1,25-dihydroxyvitamin D3-treated monocytes. Arthritis Rheum 1992, 35:110-119.
33. Steinman R.M., Banchereau J. Taking dendritic cells into medicine. Nature 2007, 449:419-426.
34. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu Rev Immunol 2003, 21:685-711.
35. Adorini L., Penna G. Induction of tolerogenic dendritic cells by vitamin D receptor agonists. Handb Exp Pharmacol 2009, 251-273.
36. Almerighi C., Sinistro A., Cavazza A., Ciaprini C., Rocchi G., Bergamini A. 1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine 2009, 45:190-197.
37. Kuo Y.T., Kuo C.H., Lam K.P., Chu Y.T., Wang W.L., Huang C.H., et al. Effects of vitamin D3 on expression of tumor necrosis factor-alpha and chemokines by monocytes. J Food Sci 2010, 75:H200-H204.
38. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998, 101:252-262.
39. Matilainen J.M., Husso T., Toropainen S., Seuter S., Turunen M.P., Gynther P., et al. Primary effect of 1alpha,25(OH)D on IL-10 expression in monocytes is short-term down-regulation. Biochim Biophys Acta 2010, 1803:1276-1286.
40. Muller K., Diamant M., Bendtzen K. Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin D3. Immunol Lett 1991, 28:115-120.
41. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
42. Romani N., Gruner S., Brang D., Kampgen E., Lenz A., Trockenbacher B., et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994, 180:83-93.
43. Chapuis F., Rosenzwajg M., Yagello M., Ekman M., Biberfeld P., Gluckman J.C. Differentiation of human dendritic cells from monocytes in vitro. Eur J Immunol 1997, 27:431-441.
44. Jonuleit H., Kuhn U., Muller G., Steinbrink K., Paragnik L., Schmitt E., et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 1997, 27:3135-3142.
45. Penna G., Adorini L. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000, 164:2405-2411.
46. Piemonti L., Monti P., Sironi M., Fraticelli P., Leone B.E., Dal Cin E., et al. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 2000, 164:4443-4451.
47. van Halteren A.G., van Etten E., de Jong E.C., Bouillon R., Roep B.O., Mathieu C. Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3). Diabetes 2002, 51:2119-2125.
48. Griffin M.D., Lutz W., Phan V.A., Bachman L.A., McKean D.J., Kumar R. Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA 2001, 98:6800-6805.
49. Griffin M.D., Lutz W.H., Phan V.A., Bachman L.A., McKean D.J., Kumar R. Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem Biophys Res Commun 2000, 270:701-708.
50. Kleijwegt F.S., Laban S., Duinkerken G., Joosten A.M., Zaldumbide A., Nikolic T., et al. Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J Immunol 2010, 185:1412-1418.
51. Penna G., Roncari A., Amuchastegui S., Daniel K.C., Berti E., Colonna M., et al. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood 2005, 106:3490-3497.
52. Unger W.W., Laban S., Kleijwegt F.S., van der Slik A.R., Roep B.O. Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1. Eur J Immunol 2009, 39:3147-3159.
53. Shortman K., Liu Y.J. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002, 2:151-161.
54. von Essen M.R., Kongsbak M., Schjerling P., Olgaard K., Odum N., Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010, 11:344-349.
55. Lacey D.L., Axelrod J., Chappel J.C., Kahn A.J., Teitelbaum S.L. Vitamin D affects proliferation of a murine T helper cell clone. J Immunol 1987, 138:1680-1686.
56. Mahon B.D., Gordon S.A., Cruz J., Cosman F., Cantorna M.T. Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol 2003, 134:128-132.
57. Staeva-Vieira T.P., Freedman L.P. 1,25-Dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. J Immunol 2002, 168:1181-1189.
58. Jeffery L.E., Burke F., Mura M., Zheng Y., Qureshi O.S., Hewison M., et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 2009, 183:5458-5467.
59. Lemire J.M., Adams J.S., Kermani-Arab V., Bakke A.C., Sakai R., Jordan S.C. 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro. J Immunol 1985, 134:3032-3035.
60. Vanham G., Ceuppens J.L., Bouillon R. T lymphocytes and their CD4 subset are direct targets for the inhibitory effect of calcitriol. Cell Immunol 1989, 124:320-333.
61. Thien R., Baier K., Pietschmann P., Peterlik M., Willheim M. Interactions of 1 alpha,25-dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes. J Allergy Clin Immunol 2005, 116:683-689.
62. Willheim M., Thien R., Schrattbauer K., Bajna E., Holub M., Gruber R., et al. Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J Clin Endocrinol Metab 1999, 84:3739-3744.
63. Bartels L.E., Jorgensen S.P., Agnholt J., Kelsen J., Hvas C.L., Dahlerup J.F. 1,25-Dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. Int Immunopharmacol 2007, 7:1755-1764.
64. Barrat F.J., Cua D.J., Boonstra A., Richards D.F., Crain C., Savelkoul H.F., et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002, 195:603-616.
65. Boonstra A., Barrat F.J., Crain C., Heath V.L., Savelkoul H.F., O'Garra A. 1alpha,25-dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 2001, 167:4974-4980.
66. Ikeda U., Wakita D., Ohkuri T., Chamoto K., Kitamura H., Iwakura Y., et al. 1Alpha,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells. Immunol Lett 2010, 134:7-16.
67. Nashold F.E., Hoag K.A., Goverman J., Hayes C.E. Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis. J Neuroimmunol 2001, 119:16-29.
68. Chang J.H., Cha H.R., Lee D.S., Seo K.Y., Kweon M.N. 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis. PLoS One 2010, 5:e12925.
69. Palmer M.T., Lee Y.K., Maynard C.L., Oliver J.R., Bikle D.D., Jetten A.M., et al. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J Biol Chem 2011, 286:997-1004.
70. Chang S.H., Chung Y., Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem 2010, 285:38751-38755.
71. Colin E.M., Asmawidjaja P.S., van Hamburg J.P., Mus A.M., van Driel M., Hazes J.M., et al. 1,25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 2010, 62:132-142.
72. Mattner F., Smiroldo S., Galbiati F., Muller M., Di Lucia P., Poliani P.L., et al. Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3). Eur J Immunol 2000, 30:498-508.
73. Mayne C.G., Spanier J.A., Relland L.M., Williams C.B., Hayes C.E. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol 2011, 41:822-832.
74. Smolders J., Thewissen M., Peelen E., Menheere P., Tervaert J.W., Damoiseaux J., et al. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One 2009, 4:e6635.
75. Hamzaoui K., Ben Dhifallah I., Karray E., Sassi F.H., Hamzaoui A. Vitamin D modulates peripheral immunity in patients with Behcet's disease. Clin Exp Rheumatol 2010, 28:S50-S57.
76. Baeke F., Korf H., Overbergh L., Verstuyf A., Thorrez L., Van Lommel L., et al. The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol 2011, 186:132-142.
77. Smolders J., Menheere P., Thewissen M., Peelen E., Tervaert J.W., Hupperts R., et al. Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol 2010, 121:243-246.
78. Morales-Tirado V., Wichlan D.G., Leimig T.E., Street S.E., Kasow K.A., Riberdy J.M. 1Alpha,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3. Clin Immunol 2011, 138:212-221.
79. Royal W., Mia Y., Li H., Naunton K. Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis. J Neuroimmunol 2009, 213:135-141.
80. Smolders J., Peelen E., Thewissen M., Cohen Tervaert J.W., Menheere P., Hupperts R., et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One 2010, 5.
81. Meehan M.A., Kerman R.H., Lemire J.M. 1,25-Dihydroxyvitamin D3 enhances the generation of nonspecific suppressor cells while inhibiting the induction of cytotoxic cells in a human MLR. Cell Immunol 1992, 140:400-409.
82. Lysandropoulos A.P., Jaquiery E., Jilek S., Pantaleo G., Schluep M., Du Pasquier R.A. Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects. J Neuroimmunol 2011, 233:240-244.
83. Godfrey D.I., MacDonald H.R., Kronenberg M., Smyth M.J., Van Kaer L. NKT cells: what's in a name?. Nat Rev Immunol 2004, 4:231-237.
84. Wu L., Van Kaer L. Natural killer T cells and autoimmune disease. Curr Mol Med 2009, 9:4-14.
85. Linsen L., Somers V., Stinissen P. Immunoregulation of autoimmunity by natural killer T cells. Hum Immunol 2005, 66:1193-1202.
86. Yu S., Cantorna M.T. The vitamin D receptor is required for iNKT cell development. Proc Natl Acad Sci USA 2008, 105:5207-5212.
87. Yu S., Cantorna M.T. Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice. J Immunol 2011, 186:1384-1390.
88. Morandi B., Bramanti P., Bonaccorsi I., Montalto E., Oliveri D., Pezzino G., et al. Role of natural killer cells in the pathogenesis and progression of multiple sclerosis. Pharmacol Res 2008, 57:1-5.
89. French A.R., Yokoyama W.M. Natural killer cells and autoimmunity. Arthritis Res Ther 2004, 6:8-14.
90. Baxter A.G., Smyth M.J. The role of NK cells in autoimmune disease. Autoimmunity 2002, 35:1-14.
91. Perricone R., Perricone C., De Carolis C., Shoenfeld Y. NK cells in autoimmunity: a two-edg'd weapon of the immune system. Autoimmun Rev 2008, 7:384-390.
92. Poggi A., Zocchi M.R. Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggression. Autoimmun Rev 2007, 6:295-299.
93. Merino F., Alvarez-Mon M., de la Hera A., Ales J.E., Bonilla F., Durantez A. Regulation of natural killer cytotoxicity by 1,25-dihydroxyvitamin D3. Cell Immunol 1989, 118:328-336.
94. Mathieu C., Waer M., Laureys J., Rutgeerts O., Bouillon R. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 1994, 37:552-558.
95. Kankova M., Luini W., Pedrazzoni M., Riganti F., Sironi M., Bottazzi B., et al. Impairment of cytokine production in mice fed a vitamin D3-deficient diet. Immunology 1991, 73:466-471.
96. Kaneno R., Duarte A.J., Borelli A. Natural killer activity in the experimental privational rickets. Immunol Lett 2002, 81:183-189.
97. Balogh G., de Boland A.R., Boland R., Barja P. Effect of 1,25(OH)(2)-vitamin D(3) on the activation of natural killer cells: role of protein kinase C and extracellular calcium. Exp Mol Pathol 1999, 67:63-74.
98. Kitajima I., Maruyama I., Matsubara H., Osame M., Igata A. Immune dysfunction in hypophosphatemic vitamin D-resistant rickets: immunoregulatory reaction of 1 alpha(OH) vitamin D3. Clin Immunol Immunopathol 1989, 53:24-31.
99. Leung K.H. Inhibition of human natural killer cell and lymphokine-activated killer cell cytotoxicity and differentiation by vitamin D3. Scand J Immunol 1989, 30:199-208.
100. Mariani E., Ravaglia G., Forti P., Meneghetti A., Tarozzi A., Maioli F., et al. Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians. Clin Exp Immunol 1999, 116:19-27.
101. Mariani E., Ravaglia G., Meneghetti A., Tarozzi A., Forti P., Maioli F., et al. Natural immunity and bone and muscle remodelling hormones in the elderly. Mech Ageing Dev 1998, 102:279-292.
102. Quesada J.M., Solana R., Martin A., Santamaria M., Serrano I., Martinez M.E., et al. The effect of calcitriol on natural killer cell activity in hemodialyzed patients. J Steroid Biochem 1989, 34:423-425.
103. Ravid A., Koren R., Maron L., Liberman U.A. 1,25(OH)2D3 increases cytotoxicity and exocytosis in lymphokine-activated killer cells. Mol Cell Endocrinol 1993, 96:133-139.
104. Rebut-Bonneton C., Demignon J. Effect of calcitriol on peripheral blood lymphocyte cytotoxicity. Biomed Pharmacother 1991, 45:369-372.
105. Deniz G., Erten G., Kucuksezer U.C., Kocacik D., Karagiannidis C., Aktas E., et al. Regulatory NK cells suppress antigen-specific T cell responses. J Immunol 2008, 180:850-857.
106. Provvedini D.M., Tsoukas C.D., Deftos L.J., Manolagas S.C. 1 Alpha,25-dihydroxyvitamin D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production. J Immunol 1986, 136:2734-2740.
107. Iho S., Takahashi T., Kura F., Sugiyama H., Hoshino T. The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production in human B cells. J Immunol 1986, 136:4427-4431.
108. Lemire J.M., Adams J.S., Sakai R., Jordan S.C. 1 Alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984, 74:657-661.
109. Chen W.C., Vayuvegula B., Gupta S. 1,25-Dihydroxyvitamin D3-mediated inhibition of human B cell differentiation. Clin Exp Immunol 1987, 69:639-646.
110. Heine G., Anton K., Henz B.M., Worm M. 1Alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro. Eur J Immunol 2002, 32:3395-3404.
111. Shiozawa K., Shiozawa S., Shimizu S., Fujita T. 1 Alpha,25-dihydroxyvitamin D3 inhibits pokeweed mitogen-stimulated human B-cell activation: an analysis using serum-free culture conditions. Immunology 1985, 56:161-167.
112. Matheu V., Back O., Mondoc E., Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003, 112:585-592.
113. Hypponen E., Berry D.J., Wjst M., Power C. Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. Allergy 2009, 64:613-620.
114. Vieth R. Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in nordic countries. Int J Cancer. 2004, 111:468. author reply 9.
115. Spach K.M., Nashold F.E., Dittel B.N., Hayes C.E. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J Immunol 2006, 177:6030-6037.
116. Prietl B., Pilz S., Wolf M., Tomaschitz A., Obermayer-Pietsch B., Graninger W., et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases?. Isr Med Assoc J 2010, 12:136-139.
117. Zold E., Szodoray P., Kappelmayer J., Gaal J., Csathy L., Barath S., et al. Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease. Scand J Rheumatol 2010, 39:490-497.
118. Zold E., Szodoray P., Nakken B., Barath S., Kappelmayer J., Csathy L., et al. Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease. Autoimmun Rev 2011, 10:155-162.
119. Llewellyn D.J., Lang I.A., Langa K.M., Muniz-Terrera G., Phillips C.L., Cherubini A., et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 2010, 170:1135-1141.
120. Buell J.S., Scott T.M., Dawson-Hughes B., Dallal G.E., Rosenberg I.H., Folstein M.F., et al. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci 2009, 64:888-895.
121. Knippenberg S., Bol Y., Damoiseaux J., Hupperts R., Smolders J. Vitamin D status in patients with MS is negatively correlated with depression, but not with fatigue. Acta Neurol Scand 2010, published as doi:10.1111/j.1600-0404.2010.01447.
122. Jongen M.J., van der Vijgh W.J., Lips P., Netelenbos J.C. Measurement of vitamin D metabolites in anephric subjects. Nephron 1984, 36:230-234.
123. Smolders J, Thewissen M., Theunissen R., Peelen E., Knippenberg S., Menheere P. Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis. J Neuroimmunol 2011, 235:91-97.
124. Knippenberg S, Smolders J, Thewissen M, Peelen E, Cohen Tervaert JW, Hupperts R, Damoiseaux J. Effect of vitamin D3 supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis. Multiple Sclerosis Journal in press.