Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects

Internal and Emergency Medicine

Volumn 8, Issue 1, 2013, Pages 33-40

  Bellia, Alfonso ^a   Garcovich, Caterina ^a   D'Adamo, Monica ^a   Lombardo, Mauro ^a   Tesauro, Manfredi ^a   Donadel, Giulia ^a   Gentileschi, Paolo ^a   Lauro, Davide ^a   Federici, Massimo ^a   Lauro, Renato ^a   Sbraccia, Paolo ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Inflammation; Insulin resistance; Obesity; Vitamin D

Indexed keywords

EID: 84873209859     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-011-0559-x     Document Type: Article

References (32)

1. Holick MF (2007) Vitamin D deficiency. N Engl J Med 19: 266-281.
2. Munger KL, Levin LI, Hollis BW et al (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296: 2832-2838.
3. Wang TJ, Pencina MJ, Booth SL et al (2008) Vitamin D deficiency and risk of cardiovascular disease. Circulation 29: 503-511.
4. Ford ES, Ajani UA, McGuire LC et al (2005) Concentrations of serum vitamin D and the metabolic syndrome among US adults. Diabetes Care 28: 1228-1230.
5. Scragg R, Sowers MF, Bell C et al (2004) Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 27: 2813-2818.
6. Forouhi NG, Luan J, Cooper A et al (2008) Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 57: 2619-2625.
7. Chiu KC, Chu A, Go VL et al (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79: 820-825.
8. Maestro B, Campión J, Dávila N et al (2000) Stimulation by 1, 25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J J47: 383-391.
9. Bell NH, Epstein S, Greene A et al (1985) Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 76: 370-373.
10. Wortsman J, Matsuoka LY, Chen TC et al (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72: 690-693.
11. Parikh SJ, Edelman M, Uwaifo GI et al (2004) The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89: 1196-1199.
12. Vilarrasa N, Maravall J, Estepa A et al (2007) Low 25-hydroxyvitamin D concentrations in obese women: their clinical significance and relationship with anthropometric and body composition variables. J Endocrinol Invest 30: 653-658.
13. McGill AT, Stewart JM, Lithander FE et al (2008) Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J 7: 412-421.
14. Arunabh S, Pollack S, Yeh J et al (2003) Body fat content and 25-hydroxyvitamin D levels in healthy women. J ClinEndocrinol Metab 88: 157-161.
15. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
16. Xu H, Barnes TG, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
17. Berg AH, Scherer PE (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96: 939-949.
18. Nishimura S, Manabe I, Nagasaki M et al (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
19. Veldman CM, Cantorna MT, DeLuca HF (2000) Expression of 1, 25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 374: 334-338.
20. Gysemans CA, Cardozo AK, Callewaert H et al (2005) 1, 25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology 146: 1956-1964.
21. D' Ambrosio D, Cippitelli M, Cocciolo MG et al (1998) Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-κBdownregulation in transcriptional repression of the p40 gene. J Clin Invest 101: 252-262.
22. Khera A, Vega GL, Das SR et al (2009) Sex differences in the relationship between C-reactive protein and body fat. J ClinEndocrinol Metab 94: 3251-3258.
23. Grundy SM, Cleeman JI, Daniels SR, American Heart Association; National Heart, Lung, and Blood Institute et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 25: 2735-2752.
24. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470.
25. Borissova AM, Tankova T, Kirilov G et al (2003) The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J ClinPract 57: 258-261.
26. Chiu KC, Chuang LM, Yoon C (2001) The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet 2: 2.
27. Willheim M, Thien R, Schrattbauer K et al (1999) Regulatory effects of 1alpha, 25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocyte. J Clin Endocrinol Metab 84: 3739-3744.
28. van den Berghe G, van Roosbroeck D, Vanhove P et al (2003) Bone turnover in prolonged critical illness: effect of vitamin D. J ClinEndocrinol Metab 88: 4623-4632.
29. Schleithoff SS, Zittermann A, Tenderich G et al (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 83: 754-759.
30. Koeffler HP, Amatruda T, Ikekawa N et al (1984) Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1, 25-dihydroxyvitamin D3 and its fluorinated analogues. Cancer Res 44: 5624-5628.
31. Dusso AS, Finch J, Brown A et al (1991) Extrarenal production of calcitriol in normal and uremic humans. J Clin Endocrinol Metab 72: 157-164.
32. Clement K, Viguerie N, Poitou C et al (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J18: 1657-1669.