메뉴 건너뛰기




Volumn 14, Issue 6, 2012, Pages 500-510

Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

Author keywords

Incretin effect; Obesity; Type 2 diabetes

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; INCRETIN; INSULIN; METFORMIN; SULFONYLUREA;

EID: 84860242081     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01549.x     Document Type: Article
Times cited : (165)

References (46)
  • 1
    • 12244268666 scopus 로고    scopus 로고
    • On the physiology of GIP and GLP-1.
    • Holst JJ. On the physiology of GIP and GLP-1. Horm Metab Res 2004; 36: 747-754.
    • (2004) Horm Metab Res , vol.36 , pp. 747-754
    • Holst, J.J.1
  • 2
    • 33847682160 scopus 로고    scopus 로고
    • Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus.
    • Knop FK, Vilsbøll T, Madsbad S, Holst JJ, Krarup T. Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus. Diabetologia 2007; 50: 797-805.
    • (2007) Diabetologia , vol.50 , pp. 797-805
    • Knop, F.K.1    Vilsbøll, T.2    Madsbad, S.3    Holst, J.J.4    Krarup, T.5
  • 3
    • 34547586659 scopus 로고    scopus 로고
    • Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    • Knop FK, Vilsbøll T, Højberg PV et al. Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state? Diabetes 2007; 56: 1951-1959.
    • (2007) Diabetes , vol.56 , pp. 1951-1959
    • Knop, F.K.1    Vilsbøll, T.2    Højberg, P.V.3
  • 4
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses.
    • Nauck MA, Homberger E, Siegel EG et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986; 63: 492-498.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 5
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes.
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29: 46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 6
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993; 91: 301-307.
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 7
    • 24944459820 scopus 로고    scopus 로고
    • Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes.
    • Meier JJ, Gallwitz B, Askenas M et al. Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes. Diabetologia 2005; 48: 1872-1881.
    • (2005) Diabetologia , vol.48 , pp. 1872-1881
    • Meier, J.J.1    Gallwitz, B.2    Askenas, M.3
  • 8
    • 0345737203 scopus 로고    scopus 로고
    • Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.
    • Meier JJ, Nauck MA, Siepmann N et al. Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects. Metabolism 2003; 52: 1579-1585.
    • (2003) Metabolism , vol.52 , pp. 1579-1585
    • Meier, J.J.1    Nauck, M.A.2    Siepmann, N.3
  • 9
    • 5644221730 scopus 로고    scopus 로고
    • Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.
    • Nauck MA, El-Ouaghlidi A, Gabrys B et al. Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. Regul Pept 2004; 122: 209-217.
    • (2004) Regul Pept , vol.122 , pp. 209-217
    • Nauck, M.A.1    El-Ouaghlidi, A.2    Gabrys, B.3
  • 10
    • 0242383351 scopus 로고    scopus 로고
    • The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.
    • Vilsbøll T, Knop FK, Krarup T et al. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. J Clin Endocrinol Metab 2003; 88: 4897-4903.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4897-4903
    • Vilsbøll, T.1    Knop, F.K.2    Krarup, T.3
  • 11
    • 58149467276 scopus 로고    scopus 로고
    • Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes.
    • Højberg PV, Vilsbøll T, Rabøl R et al. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia 2009; 52: 199-207.
    • (2009) Diabetologia , vol.52 , pp. 199-207
    • Højberg, P.V.1    Vilsbøll, T.2    Rabøl, R.3
  • 12
    • 35648940236 scopus 로고    scopus 로고
    • The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
    • Knop FK, Vilsbøll T, Højberg PV et al. The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance. Regul Pept 2007; 144: 123-130.
    • (2007) Regul Pept , vol.144 , pp. 123-130
    • Knop, F.K.1    Vilsbøll, T.2    Højberg, P.V.3
  • 13
    • 77954991115 scopus 로고    scopus 로고
    • The reduced incretin effect in diabetes mellitus is completely reversible (abstract).
    • Vilsbøll T, Kosinski M, Holst JJ, Cypryk K, Knop FK. The reduced incretin effect in diabetes mellitus is completely reversible (abstract). Diabetes 2008; 57: 1465.
    • (2008) Diabetes , vol.57 , pp. 1465
    • Vilsbøll, T.1    Kosinski, M.2    Holst, J.J.3    Cypryk, K.4    Knop, F.K.5
  • 14
    • 77954944284 scopus 로고    scopus 로고
    • Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects.
    • Hansen KB, Vilsbøll T, Bagger JI, Holst JJ, Knop FK. Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects. J Clin Endocrinol Metab 2010; 95: 3309-3317.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3309-3317
    • Hansen, K.B.1    Vilsbøll, T.2    Bagger, J.I.3    Holst, J.J.4    Knop, F.K.5
  • 15
    • 33845383843 scopus 로고    scopus 로고
    • Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance.
    • Muscelli E, Mari A, Natali A et al. Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab 2006; 291: E1144-E1150.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Muscelli, E.1    Mari, A.2    Natali, A.3
  • 16
    • 48449093468 scopus 로고    scopus 로고
    • Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients.
    • Muscelli E, Mari A, Casolaro A et al. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008; 57: 1340-1348.
    • (2008) Diabetes , vol.57 , pp. 1340-1348
    • Muscelli, E.1    Mari, A.2    Casolaro, A.3
  • 17
    • 77949822066 scopus 로고    scopus 로고
    • Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes.
    • Hare KJ, Vilsbøll T, Holst JJ, Knop FK. Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes. Am J Physiol Endocrinol Metab 2010; 298: E832-E837.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Hare, K.J.1    Vilsbøll, T.2    Holst, J.J.3    Knop, F.K.4
  • 18
    • 33847634679 scopus 로고    scopus 로고
    • Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects.
    • Meier JJ, Deacon CF, Schmidt WE, Holst JJ, Nauck MA. Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects. Diabetologia 2007; 50: 806-813.
    • (2007) Diabetologia , vol.50 , pp. 806-813
    • Meier, J.J.1    Deacon, C.F.2    Schmidt, W.E.3    Holst, J.J.4    Nauck, M.A.5
  • 19
    • 2342502454 scopus 로고    scopus 로고
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus.
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2002; 25(Suppl. 1): S5-20.
    • (2002) Diabetes Care , vol.25 , Issue.SUPPL. 1
  • 20
    • 0034070572 scopus 로고    scopus 로고
    • Validation of methods for measurement of insulin secretion in humans in vivo.
    • Kjems LL, Christiansen E, Volund A, Bergman RN, Madsbad S. Validation of methods for measurement of insulin secretion in humans in vivo. Diabetes 2000; 49: 580-588.
    • (2000) Diabetes , vol.49 , pp. 580-588
    • Kjems, L.L.1    Christiansen, E.2    Volund, A.3    Bergman, R.N.4    Madsbad, S.5
  • 21
    • 0028281773 scopus 로고
    • Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide-1 in humans.
    • Ørskov C, Rabenhøj L, Wettergren A, Kofod H, Holst JJ. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide-1 in humans. Diabetes 1994; 43: 535-539.
    • (1994) Diabetes , vol.43 , pp. 535-539
    • Ørskov, C.1    Rabenhøj, L.2    Wettergren, A.3    Kofod, H.4    Holst, J.J.5
  • 22
    • 0020511159 scopus 로고
    • Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I (insulin-dependent) diabetics.
    • Krarup T, Madsbad S, Moody AJ et al. Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I (insulin-dependent) diabetics. J Clin Endocrinol Metab 1983; 56: 1306-1312.
    • (1983) J Clin Endocrinol Metab , vol.56 , pp. 1306-1312
    • Krarup, T.1    Madsbad, S.2    Moody, A.J.3
  • 23
    • 0026027919 scopus 로고
    • Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.
    • Ørskov C, Jeppesen J, Madsbad S, Holst JJ. Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 1991; 87: 415-423.
    • (1991) J Clin Invest , vol.87 , pp. 415-423
    • Ørskov, C.1    Jeppesen, J.2    Madsbad, S.3    Holst, J.J.4
  • 24
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance.
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 1992; 41: 368-377.
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 25
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 26
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion-effects on beta-cell sensitivity in type 2 and nondiabetic subjects.
    • Kjems LL, Holst JJ, Volund A, Madsbad S. The influence of GLP-1 on glucose-stimulated insulin secretion-effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 2003; 52: 380-386.
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Volund, A.3    Madsbad, S.4
  • 27
    • 2942598368 scopus 로고    scopus 로고
    • Beta cell function and its relation to insulin action in humans: a critical appraisal.
    • Ferrannini E, Mari A. Beta cell function and its relation to insulin action in humans: a critical appraisal. Diabetologia 2004; 47: 943-956.
    • (2004) Diabetologia , vol.47 , pp. 943-956
    • Ferrannini, E.1    Mari, A.2
  • 28
    • 70549111807 scopus 로고    scopus 로고
    • Evaluation of proposed oral disposition index measures in relation to the actual disposition index.
    • Retnakaran R, Qi Y, Goran MI, Hamilton JK. Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabet Med 2009; 26: 1198-1203.
    • (2009) Diabet Med , vol.26 , pp. 1198-1203
    • Retnakaran, R.1    Qi, Y.2    Goran, M.I.3    Hamilton, J.K.4
  • 29
    • 61849106040 scopus 로고    scopus 로고
    • Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.
    • Utzschneider KM, Prigeon RL, Faulenbach MV et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 2009; 32: 335-341.
    • (2009) Diabetes Care , vol.32 , pp. 335-341
    • Utzschneider, K.M.1    Prigeon, R.L.2    Faulenbach, M.V.3
  • 30
    • 0027375768 scopus 로고
    • Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.
    • Kahn SE, Prigeon RL, McCulloch DK et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993; 42: 1663-1672.
    • (1993) Diabetes , vol.42 , pp. 1663-1672
    • Kahn, S.E.1    Prigeon, R.L.2    McCulloch, D.K.3
  • 31
    • 0016380138 scopus 로고
    • Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesity.
    • Bagdade JD, Porte D Jr, Brunzell JD, Bierman EL. Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesity. J Lab Clin Med 1974; 83: 563-569.
    • (1974) J Lab Clin Med , vol.83 , pp. 563-569
    • Bagdade, J.D.1    Porte, D.2    Brunzell, J.D.3    Bierman, E.L.4
  • 32
    • 0036318476 scopus 로고    scopus 로고
    • Accurate assessment of beta-cell function-the hyperbolic correction.
    • Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function-the hyperbolic correction. Diabetes 2002; 51: S212-220.
    • (2002) Diabetes , vol.51
    • Bergman, R.N.1    Ader, M.2    Huecking, K.3    Van Citters, G.4
  • 33
    • 33645449883 scopus 로고    scopus 로고
    • The hyperbolic equilibrium between insulin sensitivity and secretion.
    • Pacini G. The hyperbolic equilibrium between insulin sensitivity and secretion. Nutr Metab Cardiovasc Dis 2006; 16(Suppl. 1): S22-27.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , Issue.SUPPL. 1
    • Pacini, G.1
  • 34
    • 12244299450 scopus 로고    scopus 로고
    • Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
    • Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA. Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 2005; 90: 493-500.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 493-500
    • Ferrannini, E.1    Gastaldelli, A.2    Miyazaki, Y.3    Matsuda, M.4    Mari, A.5    DeFronzo, R.A.6
  • 35
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion.
    • Muller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 1970; 283: 109-115.
    • (1970) N Engl J Med , vol.283 , pp. 109-115
    • Muller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 37
    • 0023109225 scopus 로고
    • Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus.
    • Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987; 64: 106-110.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 106-110
    • Reaven, G.M.1    Chen, Y.D.2    Golay, A.3    Swislocki, A.L.4    Jaspan, J.B.5
  • 38
    • 80052824604 scopus 로고    scopus 로고
    • Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes.
    • Menge BA, Gruber L, Jorgensen SM et al. Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes. Diabetes 2011; 60: 2160-2168.
    • (2011) Diabetes , vol.60 , pp. 2160-2168
    • Menge, B.A.1    Gruber, L.2    Jorgensen, S.M.3
  • 39
    • 23944516266 scopus 로고    scopus 로고
    • Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus.
    • Henkel E, Menschikowski M, Koehler C, Leonhardt W, Hanefeld M. Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus. Metabolism 2005; 54: 1168-1173.
    • (2005) Metabolism , vol.54 , pp. 1168-1173
    • Henkel, E.1    Menschikowski, M.2    Koehler, C.3    Leonhardt, W.4    Hanefeld, M.5
  • 40
    • 12244284000 scopus 로고    scopus 로고
    • Beta- and alpha-cell dysfunction in type 2 diabetes.
    • Del Prato S, Marchetti P. Beta- and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res 2004; 36: 775-781.
    • (2004) Horm Metab Res , vol.36 , pp. 775-781
    • Del Prato, S.1    Marchetti, P.2
  • 41
    • 23044517378 scopus 로고    scopus 로고
    • Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?
    • Raju B, Cryer PE. Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon? Am J Physiol Endocrinol Metab 2005; 289: E181-E186.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Raju, B.1    Cryer, P.E.2
  • 42
    • 34848862525 scopus 로고    scopus 로고
    • Association of fasting glucagon and proinsulin concentrations with insulin resistance.
    • Ferrannini E, Muscelli E, Natali A et al. Association of fasting glucagon and proinsulin concentrations with insulin resistance. Diabetologia 2007; 50: 2342-2347.
    • (2007) Diabetologia , vol.50 , pp. 2342-2347
    • Ferrannini, E.1    Muscelli, E.2    Natali, A.3
  • 46
    • 0034935215 scopus 로고    scopus 로고
    • Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy.
    • Bertin E, Schneider N, Abdelli N et al. Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy. Diabetes Metab 2001; 27: 357-364.
    • (2001) Diabetes Metab , vol.27 , pp. 357-364
    • Bertin, E.1    Schneider, N.2    Abdelli, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.