The polarity protein Par-3 directly interacts with p75 NTR to regulate myelination

Science

Volumn 314, Issue 5800, 2006, Pages 832-836

  Chan, Jonah R ^a   Jolicoeur, Christine ^b   Yamauchi, Junji ^c   Elliott, Jimmy ^b   Fawcett, James P ^d,f   Ng, Benjamin K ^a   Cayouette, Michel ^b,e  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d MOUNT SINAI HOSPITAL   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AXON; CELL DIVISION; DENDRITE; MYELINATION;

BIOTECHNOLOGY; CELLS;

PROTEINS;

CELL PROTEIN; PROTEIN P75; PROTEIN PAR 3; UNCLASSIFIED DRUG;

CELL ORGANELLE; POLARIZATION; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; DENDRITE; EMBRYO; MYELINATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SCHWANN CELL;

AMINO ACID MOTIFS; ANIMALS; AXONS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARRIER PROTEINS; CELL POLARITY; CELLS, CULTURED; COCULTURE TECHNIQUES; GANGLIA, SPINAL; INTERCELLULAR JUNCTIONS; MICE; MYELIN SHEATH; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GROWTH FACTOR; SCHWANN CELLS;

EID: 33750681355     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1134069     Document Type: Article

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22. We dedicate this manuscript to E. M. Shooter for his endless support, encouragement, and wisdom. We thank P. Barker for the p75 knockout mice, I. Macara for the Par-3 shRNA constructs, T. Pawson for the Par-3 antibody, D. Meijer for the Krox-20 antibody, and A. Vallée of the IRCM histology core facility for expert technical assistance with electron microscopy. We are grateful to W. Mandemakers and A. Kania for reviewing this manuscript. This work was supported by the National Multiple Sclerosis Society Career Transition Award (J.R.C.) and the Canadian Institutes of Health Research (M.C).