K-685, a TRPV1 antagonist, blocks PKC-sensitized TRPV1 activation and improves the inflammatory pain in a rat complete Freund's adjuvant model

Journal of Pharmacological Sciences

Volumn 123, Issue 3, 2013, Pages 256-266

  Sugimoto, Yoshiyuki ^a   Kojima, Yozo ^a   Inayoshi, Atsushi ^a   Inoue, Kazuaki ^a   Miura Kusaka, Hiroko ^a   Mori, Kiyotoshi ^a   Saku, Osamu ^a   Ishida, Hiroshi ^a   Atsumi, Eri ^a   Nakasato, Yoshisuke ^a   Shirakura, Shiro ^a   Toki, Shin Ichiro ^a   Shinoda, Katsumi ^a   Suzuki, Nobuyuki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Complete Freund's adjuvant (CFA); Inflammation; Pain; Protein kinase C (PKC); TRPV1 antagonist

Indexed keywords

ANALGESIC AGENT; DICLOFENAC; FREUND ADJUVANT; K 685; MITOGEN ACTIVATED PROTEIN KINASE; N (3 HYDROXY 2 OXO 1,2,3,4 TETRAHYDRO 5 QUINOLYL) 5 (4 ISOPROPOXYPHENYL) 5 (4 TRIFLUOROMETHYLPHENYL) 2,4 PENTADIENAMIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; HEAT; HYPERALGESIA; INFLAMMATORY PAIN; MALE; NONHUMAN; PAW EDEMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SENSITIZATION; SPINAL GANGLION;

ANALGESICS; ANIMALS; CHRONIC PAIN; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; INFLAMMATION; MALE; PENTANOIC ACIDS; PROTEIN KINASE C; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS;

EID: 84890508541     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13088FP     Document Type: Article

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