The structural basis of ZMPSTE24-dependent laminopathies

Science

Volumn 340, Issue 6127, 2013, Pages 1604-1607

  Quigley, Andrew ^a   Dong, Yin Yao ^a   Pike, Ashley C W ^a   Dong, Liang ^a   Shrestha, Leela ^a   Berridge, Georgina ^a   Stansfeld, Phillip J ^a   Sansom, Mark S P ^a   Edwards, Aled M ^b   Bountra, Chas ^a   Von Delft, Frank ^a   Bullock, Alex N ^a   Burgess Brown, Nicola A ^a   Carpenter, Elisabeth P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPROTEINASE; UNCLASSIFIED DRUG; ZINC; ZINC METALLOPROTEASE ZMPSTE24; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PRELAMIN A; PROTEIN PRECURSOR; THERMOLYSIN; ZMPSTE24 PROTEIN, HUMAN;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; INHIBITOR; MEMBRANE; MUTATION; SUBSTRATE;

ALPHA HELIX; ARTICLE; CELL NUCLEUS MEMBRANE; ENZYME STRUCTURE; GENE MUTATION; HUMAN; LAMINOPATHY; METABOLIC DISORDER; NUCLEAR LAMINA; PRIORITY JOURNAL; PROGERIA; AMINO ACID SEQUENCE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; INBORN ERROR OF METABOLISM; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

HEXAPODA;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEMBRANE PROTEINS; METABOLISM, INBORN ERRORS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROGERIA; PROTEIN CONFORMATION; PROTEIN PRECURSORS; SUBSTRATE SPECIFICITY; THERMOLYSIN;

MLCS; MLOWN;

EID: 84875511387     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1231513     Document Type: Article

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