Mutational analysis of the Ras converting enzyme reveals a requirement for glutamate and histidine residues

Journal of Biological Chemistry

Volumn 281, Issue 8, 2006, Pages 4596-4605

  Plummer, Lisa J ^a   Hildebrandt, Emily R ^a   Porter, Stephen B ^a   Rogers, Victoria A ^a   McCracken, Jay ^a   Schmidt, Walter K ^a  

^a University of Georgia ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; COMPUTATIONAL METHODS; ENZYME KINETICS; MUTAGENESIS; SUBSTITUTION REACTIONS; YEAST;

GLUTAMATE; HISTIDINE; MUTATIONAL ANALYSIS; RAS CONVERTING ENZYME;

ENZYMES;

ALANINE; ASPARAGINE; CAAX PROTEASE; GLUTAMIC ACID; HISTIDINE; MEMBRANE ENZYME; MEMBRANE PROTEIN; PHENYLALANINE; PROTEIN PRECURSOR; PROTEINASE; RAS CONVERTING ENZYME; RAS CONVERTING ENZYME 1P; RAS PROTEIN; TYROSINE; UNCLASSIFIED DRUG; LIGASE; METALLOPROTEINASE; PEPTIDE; RCE1 PROTEIN, ARABIDOPSIS; RCE1 PROTEIN, HUMAN; RCE1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; STE24 PROTEIN, S CEREVISIAE;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENETIC ANALYSIS; MUTATIONAL ANALYSIS; NONHUMAN; ORTHOLOGY; PLANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; WILD TYPE; WORM; YEAST; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; BIOLOGY; CELL MEMBRANE; CHEMISTRY; GENETICS; HUMAN; KINETICS; MATING FACTOR; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECTROFLUOROMETRY; TEMPERATURE;

EUKARYOTA; PROKARYOTA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DNA MUTATIONAL ANALYSIS; ENDOPEPTIDASES; GENES, REPORTER; GLUTAMIC ACID; HISTIDINE; HUMANS; KINETICS; LIGASES; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PLANTS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 33646192360     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506284200     Document Type: Article

References (49)

1. Boyartchuk, V. L., Ashby, M. N., and Rine, J. (1997) Science 275, 1796-1800
2. Young, S. G., Ambroziak, P., Kim, E., and Clarke, S. (2001) in The Enzymes (Tamanoi, F., and Sigman, D., eds) pp. 155-213, Academic Press, New York
3. Gibbs, J. (1991) Cell 65, 1-4
4. Bergo, M. O., Ambroziak, P., Gregory, C., George, A., Otto, J. C., Kim, E., Nagase, H., Casey, P. J., Balmain, A., and Young, S. G. (2002) Mol. Cell. Biol. 22, 171-181
5. Baum, C., and Kirschmeier, P. (2003) Curr. Oncol. Rep. 5, 99-107
6. Zhu, K., Hamilton, A. D., and Sebti, S. M. (2003) Curr. Opin. Investig. Drugs 4, 1428-1435
7. Kim, E., Ambroziak, P., Otto, J. C., Taylor, B., Ashby, M., Shannon, K., Casey, P. J., and Young, S. G. (1999) J. Biol. Chem. 274, 8383-8390
8. Schmidt, W. K., Tam, A., Fujimura-Kamada, K., and Michaelis, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11175-11180
9. Freije, J. M., Blay, P., Pendas, A. M., Cadinanos, J., Crespo, P., and Lopez-Otin, C. (1999) Genomics 58, 270-280
10. Otto, J. C., Kim, E., Young, S. G., and Casey, P. J. (1999) J. Biol.Chem. 274, 8379-8382
11. Cadiñanos, J., Schmidt, W. K., Fueyo, A., Varela, I., Lopez-Otin, C., and Freije, J. M. (2003) Biochem. J. 370, 1047-1054
12. Cadiñanos, J., Varela, I., Mandel, D., Schmidt, W. K., Díaz-Perales, A., López-Otín, C., and Freije, J. M. (2003) J. Biol. Chem. 278, 42091-42097
13. Maske, C. P., Hollinshead, M. S., Higbee, N. C., Bergo, M. O., Young, S. G., and Vaux, D. J. (2003) J. Cell Biol. 162, 1223-1232
14. Dolence, J. M., Steward, L. E., Dolence, E. K., Wong, D. H., and Poulter, C. D. (2000) Biochemistry 39, 4096-4104
15. Chen, Y., Ma, Y. T., and Rando, R. R. (1996) Biochemistry 35, 3227-3237
16. Ma, Y.-T., Gilbert, B., and Rando, R. (1993) Biochemistry 32, 2386-2393
17. Tam, A., Schmidt, W. K., and Michaelis, S. (2001) J. Biol. Chem. 276, 46798-46806
18. Weihofen, A., and Martoglio, B. (2003) Trends Cell Biol. 13, 71-78
19. Pei, J., and Grishin, N. V. (2001) Trends Biochem. Sci. 26, 275-277
20. Elble, R. (1992) BioTechniques 13, 18-20
21. Michaelis, S., and Herskowitz, I. (1988) Mol. Cell. Biol. 8, 1309-1318
22. Tam, A., Nouvet, F., Fujimura-Kamada, K., Slunt, H., Sisodia, S. S., and Michaelis, S. (1998) J. Cell Biol. 142, 635-649
23. Fujimura-Kamada, K., Nouvet, F. J., and Michaelis, S. (1997) J. Cell Biol. 136, 271-285
24. Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E., Li, J., Hieter, P., and Boeke, J. D. (1998) Yeast 14, 115-132
25. Kim, H., Melen, K., and von Heijne, G. (2003) J. Biol. Chem. 278, 10208-10213
26. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
27. Oldenburg, K. R., Vo, K. T., Michaelis, S., and Paddon, C. (1997) Nucleic Acids Res. 25, 451-452
28. Zhang, Y., Nijbroek, G., Sullivan, M. L., McCracken, A. A., Watkins, S. C., Michaelis, S., and Brodsky, J. L. (2001) Mol. Biol. Cell 12, 1303-1314
29. Nijbroek, G. L., and Michaelis, S. (1998) Methods Enzymol. 292, 193-212
30. Schmidt, W. K., Tam, A., and Michaelis, S. (2000) J. Biol. Chem. 275, 6227-6233
31. Marcus, S., Caldwell, G. A., Miller, D., Xue, C.-B., Naider, F., and Becker, J. M. (1991) Mol. Cell. Biol. 11, 3603-3612
32. Hollander, I., Frommer, E., and Mallon, R. (2000) Anal. Biochem. 286, 129-137
33. Rost, B., Fariselli, P., and Casadio, R. (1996) Prot. Sci. 5, 1704-1718
34. Tusnady, G. E., and Simon, I. (1998) J. Mol. Biol. 283, 489-506
35. Krogh, A., Larsson, B., von Heijne, G., and Sonnhammer, E. L. (2001) J. Mol. Biol. 305, 567-580
36. Hofmann, K., and Stoffel, W. (1993) Biol. Chem. Hoppe-Seyler 374, 166
37. von Heijne, G. (1992) J. Mol. Biol. 225, 487-494
38. Claros, M. G., and von Heijne, G. (1994) Comput. Appl. Biosci. 10, 685-686
39. Trueblood, C. E., Boyartchuk, V. L., Picologlou, E. A., Rozema, D., Poulter, C. D., and Rine, J. (2000) Mol. Cell. Biol. 20, 4381-4392
40. Bergo, M. O., Gavino, B., Ross, J., Schmidt, W. K., Hong, C., Kendall, L. V., Mohr, A., Meta, M., Genant, H., Jiang, Y., Wisner, E. R., Van Bruggen, N., Carano, R. A., Michaelis, S., Griffey, S. M., and Young, S. G. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13049-13054
41. Pendas, A. M., Zhou, Z., Cadinanos, J., Freije, J. M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodriguez, F., Tryggvason, K., and Lopez-Otin, C. (2002) Nat. Genet. 31, 94-99
42. Bergo, M. O., Lieu, H. D., Gavino, B. J., Ambroziak, P., Otto, J. C., Casey, P. J., Walker, Q. M., and Young, S. G. (2004) J. Biol. Chem. 279, 4729-4736
43. Corrigan, D. P., Kuszczak, D., Rusinol, A. E., Thewke, D. P., Hrycyna, C. A., Michaelis, S., and Sinensky, M. S. (2005) Biochem. J. 387, 129-138
44. Reid, T. S., Terry, K. L., Casey, P. J., and Beese, L. S. (2004) J. Mol. Biol. 343, 417-433
45. Le Moual, H., Roques, B. P., Crine, P., and Boileau, G. (1993) FEBS Lett. 324, 196-200
46. Vazeux, G., Wang, J., Corvol, P., and Llorens-Cortes, C. (1996) J. Biol. Chem. 271, 9069-9074
47. Bzymek, K. P., and Holz, R. C. (2004) J. Biol. Chem. 279, 31018-31025
48. Fujinaga, M., Cherney, M. M., Oyama, H., Oda, K., and James, M. N. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 3364-3369
49. Powers, S., Michaelis, S., Broek, D., Santa Anna, S., Field, J., Herskowitz, I., and Wigler, M. (1986) Cell 47, 413-422