Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor

Journal of Biological Chemistry

Volumn 288, Issue 50, 2013, Pages 36141-36148

  Daly, Norelle L ^a,b   Thorstholm, Louise ^a   Greenwood, Kathryn P ^a   King, Gordon J ^a   Rosengren, K Johan ^a   Heras, Begoña ^a,c   Martin, Jennifer L ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL TARGETS; CYCLIC PEPTIDES; DIRECT BINDINGS; HOMOLOGOUS PEPTIDE; PROTEOLYTIC STABILITY; STRUCTURAL INSIGHTS; TRYPSIN INHIBITOR; TRYPSIN INHIBITORY ACTIVITY;

BINDING ENERGY; PEPTIDES;

CYCLIZATION;

PEPTIDE MCOTI I; PEPTIDE MCOTI II; TRYPSIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; CYCLIZATION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOMORDICA COCHINCHINENSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PURIFICATION;

CYCLIC PEPTIDES; CYCLOTIDES; NMR; PEPTIDE CONFORMATION; PEPTIDE INTERACTIONS; PROTEASE INHIBITOR; STRUCTURAL BIOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; CYCLOTIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOMORDICA; TRYPSIN; TRYPSIN INHIBITORS;

EID: 84890416997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.528240     Document Type: Article

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