메뉴 건너뛰기




Volumn 47, Issue 2, 2014, Pages 128-135

Epigenetic Alterations and MicroRNA Misexpression in Cancer and Autoimmune Diseases: a Critical Review

Author keywords

Autoimmunity; Cancer; Epigenetics; Methylation; MicroRNA

Indexed keywords


EID: 84890408443     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-013-8401-z     Document Type: Review
Times cited : (71)

References (65)
  • 1
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • PID: 15164071, COI: 1:CAS:528:DC%2BD2cXkt1Onsb0%3D
    • Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429:457–463
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 2
    • 39649122136 scopus 로고    scopus 로고
    • Cancer epigenetics: modifications, screening, and therapy
    • PID: 17937590, COI: 1:CAS:528:DC%2BD1cXis12nurw%3D
    • Gal-Yam EN, Saito Y, Egger G, Jones PA (2008) Cancer epigenetics: modifications, screening, and therapy. Annu Rev Med 59:267–280
    • (2008) Annu Rev Med , vol.59 , pp. 267-280
    • Gal-Yam, E.N.1    Saito, Y.2    Egger, G.3    Jones, P.A.4
  • 3
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • PID: 9662389, COI: 1:CAS:528:DyaK1cXls1Sns7w%3D
    • Okano M, Xie S, Li E (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19:219–220
    • (1998) Nat Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 4
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • PID: 12702868, COI: 1:CAS:528:DC%2BD3sXktlektb8%3D
    • Eden A, Gaudet F, Waghmare A, Jaenisch R (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300:455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 5
    • 2442454683 scopus 로고    scopus 로고
    • Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome
    • PID: 15123803, COI: 1:CAS:528:DC%2BD2cXksFaksLk%3D
    • Liang G, Lin JC, Wei V et al (2004) Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A 101:7357–7362
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7357-7362
    • Liang, G.1    Lin, J.C.2    Wei, V.3
  • 6
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • PID: 17320507, COI: 1:CAS:528:DC%2BD2sXis12ju7Y%3D
    • Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693–705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 7
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • PID: 11498575, COI: 1:CAS:528:DC%2BD3MXmtVWltro%3D
    • Jenuwein T, Allis CD (2001) Translating the histone code. Science 293:1074–1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 8
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • PID: 18488029, COI: 1:CAS:528:DC%2BD1cXmsVejtro%3D
    • Kondo Y, Shen L, Cheng AS et al (2008) Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 40:741–750
    • (2008) Nat Genet , vol.40 , pp. 741-750
    • Kondo, Y.1    Shen, L.2    Cheng, A.S.3
  • 9
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • PID: 17060945, COI: 1:CAS:528:DC%2BD28XhtFWhs7fM
    • Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6:857–866
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 10
    • 58849131081 scopus 로고    scopus 로고
    • The role of microRNAs in gastrointestinal cancers
    • PID: 19148788, COI: 1:CAS:528:DC%2BD1MXosVGqtw%3D%3D
    • Saito Y, Suzuki H, Hibi T (2009) The role of microRNAs in gastrointestinal cancers. J Gastroenterol 44(Suppl 19):18–22
    • (2009) J Gastroenterol , vol.44 , pp. 18-22
    • Saito, Y.1    Suzuki, H.2    Hibi, T.3
  • 11
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: small RNAs with a big role in gene regulation
    • PID: 15211354, COI: 1:CAS:528:DC%2BD2cXltVSmsbw%3D
    • He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522–531
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 12
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • PID: 16766263, COI: 1:CAS:528:DC%2BD28Xmt1eksLY%3D
    • Saito Y, Liang G, Egger G et al (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9:435–443
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 13
    • 68149126345 scopus 로고    scopus 로고
    • Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells
    • PID: 19503096, COI: 1:CAS:528:DC%2BD1MXntVWisL8%3D
    • Saito Y, Suzuki H, Tsugawa H et al (2009) Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene 28:2738–2744
    • (2009) Oncogene , vol.28 , pp. 2738-2744
    • Saito, Y.1    Suzuki, H.2    Tsugawa, H.3
  • 14
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • PID: 17308079, COI: 1:CAS:528:DC%2BD2sXhvVWrurk%3D
    • Lujambio A, Ropero S, Ballestar E et al (2007) Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 67:1424–1429
    • (2007) Cancer Res , vol.67 , pp. 1424-1429
    • Lujambio, A.1    Ropero, S.2    Ballestar, E.3
  • 15
    • 33847748913 scopus 로고    scopus 로고
    • The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
    • PID: 17308078, COI: 1:CAS:528:DC%2BD2sXhvVWruro%3D
    • Brueckner B, Stresemann C, Kuner R et al (2007) The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 67:1419–1423
    • (2007) Cancer Res , vol.67 , pp. 1419-1423
    • Brueckner, B.1    Stresemann, C.2    Kuner, R.3
  • 16
    • 51649083501 scopus 로고    scopus 로고
    • A microRNA DNA methylation signature for human cancer metastasis
    • PID: 18768788, COI: 1:CAS:528:DC%2BD1cXhtFeqs7bF
    • Lujambio A, Calin GA, Villanueva A et al (2008) A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A 105:13556–13561
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13556-13561
    • Lujambio, A.1    Calin, G.A.2    Villanueva, A.3
  • 17
    • 38049044753 scopus 로고    scopus 로고
    • Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    • PID: 17948228, COI: 1:CAS:528:DC%2BD1cXhtlynu7g%3D
    • Lehmann U, Hasemeier B, Christgen M et al (2008) Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer. J Pathol 214:17–24
    • (2008) J Pathol , vol.214 , pp. 17-24
    • Lehmann, U.1    Hasemeier, B.2    Christgen, M.3
  • 18
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • PID: 17554337, COI: 1:CAS:528:DC%2BD2sXmvFKmu7c%3D
    • He L, He X, Lim LP et al (2007) A microRNA component of the p53 tumour suppressor network. Nature 447:1130–1134
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3
  • 19
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • PID: 17875987, COI: 1:CAS:528:DC%2BD2sXhtFWqu7vL
    • Tazawa H, Tsuchiya N, Izumiya M, Nakagama H (2007) Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A 104:15472–15477
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 20
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • PID: 18719384, COI: 1:CAS:528:DC%2BD1cXht1elsbnO
    • Lodygin D, Tarasov V, Epanchintsev A et al (2008) Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7:2591–2600
    • (2008) Cell Cycle , vol.7 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3
  • 21
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • PID: 18519671, COI: 1:CAS:528:DC%2BD1cXmsFKmtLo%3D
    • Toyota M, Suzuki H, Sasaki Y et al (2008) Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68:4123–4132
    • (2008) Cancer Res , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3
  • 22
    • 48549091046 scopus 로고    scopus 로고
    • Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis
    • PID: 18593903, COI: 1:CAS:528:DC%2BD1cXnvFOqtLg%3D
    • Datta J, Kutay H, Nasser MW et al (2008) Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68:5049–5058
    • (2008) Cancer Res , vol.68 , pp. 5049-5058
    • Datta, J.1    Kutay, H.2    Nasser, M.W.3
  • 23
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • PID: 15364901, COI: 1:CAS:528:DC%2BD2cXotl2hu7w%3D
    • Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14:1902–1910
    • (2004) Genome Res , vol.14 , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 24
    • 33846945735 scopus 로고    scopus 로고
    • Processing of intronic microRNAs
    • PID: 17255951, COI: 1:CAS:528:DC%2BD2sXhtlOktrs%3D
    • Kim YK, Kim VN (2007) Processing of intronic microRNAs. EMBO J 26:775–783
    • (2007) EMBO J , vol.26 , pp. 775-783
    • Kim, Y.K.1    Kim, V.N.2
  • 25
    • 58549108465 scopus 로고    scopus 로고
    • Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells
    • PID: 19116145, COI: 1:CAS:528:DC%2BD1MXhtFemt7w%3D
    • Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G (2009) Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 379:726–731
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 726-731
    • Saito, Y.1    Friedman, J.M.2    Chihara, Y.3    Egger, G.4    Chuang, J.C.5    Liang, G.6
  • 26
    • 44449125989 scopus 로고    scopus 로고
    • Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer
    • PID: 18264139, COI: 1:CAS:528:DC%2BD1cXntlCqurc%3D
    • Grady WM, Parkin RK, Mitchell PS et al (2008) Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene 27:3880–3888
    • (2008) Oncogene , vol.27 , pp. 3880-3888
    • Grady, W.M.1    Parkin, R.K.2    Mitchell, P.S.3
  • 27
    • 77954234485 scopus 로고    scopus 로고
    • Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
    • PID: 20578129, COI: 1:CAS:528:DC%2BC3cXpsFSht78%3D
    • Huang J, Wang Y, Guo Y, Sun S (2010) Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology 52:60–70
    • (2010) Hepatology , vol.52 , pp. 60-70
    • Huang, J.1    Wang, Y.2    Guo, Y.3    Sun, S.4
  • 28
    • 80054047147 scopus 로고    scopus 로고
    • miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer
    • PID: 21868754, COI: 1:CAS:528:DC%2BC3MXhtlSltLnK
    • Tsuruta T, Kozaki K, Uesugi A et al (2011) miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res 71:6450–6462
    • (2011) Cancer Res , vol.71 , pp. 6450-6462
    • Tsuruta, T.1    Kozaki, K.2    Uesugi, A.3
  • 29
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • PID: 17890317, COI: 1:CAS:528:DC%2BD2sXhtFGns7zL
    • Fabbri M, Garzon R, Cimmino A et al (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 104:15805–15810
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 30
    • 84884532954 scopus 로고    scopus 로고
    • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
    • Kim W, Bird GH, Neff T, et al. (2013) Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 9:643–650
    • (2013) Nat Chem Biol , vol.9 , pp. 643-650
    • Kim, W.1    Bird, G.H.2    Neff, T.3
  • 31
    • 65549083102 scopus 로고    scopus 로고
    • The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2
    • PID: 19258506, COI: 1:CAS:528:DC%2BD1MXjtF2jsr4%3D
    • Friedman JM, Liang G, Liu CC et al (2009) The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res 69:2623–2629
    • (2009) Cancer Res , vol.69 , pp. 2623-2629
    • Friedman, J.M.1    Liang, G.2    Liu, C.C.3
  • 32
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • PID: 19008416, COI: 1:CAS:528:DC%2BD1cXhsVOgtbvO
    • Varambally S, Cao Q, Mani RS et al (2008) Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322:1695–1699
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3
  • 33
    • 80051590718 scopus 로고    scopus 로고
    • Coordinated regulation of polycomb group complexes through microRNAs in cancer
    • PID: 21840484, COI: 1:CAS:528:DC%2BC3MXhtVWrt7nE
    • Cao Q, Mani RS, Ateeq B et al (2011) Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell 20:187–199
    • (2011) Cancer Cell , vol.20 , pp. 187-199
    • Cao, Q.1    Mani, R.S.2    Ateeq, B.3
  • 34
    • 77954087192 scopus 로고    scopus 로고
    • Epigenetics lessons from twins: prospects for autoimmune disease
    • PID: 19653134, COI: 1:CAS:528:DC%2BC3cXnvVeku7Y%3D
    • Ballestar E (2010) Epigenetics lessons from twins: prospects for autoimmune disease. Clin Rev Allergy Immunol 39:30–41
    • (2010) Clin Rev Allergy Immunol , vol.39 , pp. 30-41
    • Ballestar, E.1
  • 35
    • 0034541591 scopus 로고    scopus 로고
    • Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression
    • PID: 11145021, COI: 1:CAS:528:DC%2BD3MXhtlOlsA%3D%3D
    • Neidhart M, Rethage J, Kuchen S et al (2000) Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 43:2634–2647
    • (2000) Arthritis Rheum , vol.43 , pp. 2634-2647
    • Neidhart, M.1    Rethage, J.2    Kuchen, S.3
  • 36
    • 73249146755 scopus 로고    scopus 로고
    • DNA hypomethylation in rheumatoid arthritis synovial fibroblasts
    • PID: 19950268, COI: 1:CAS:528:DC%2BC3cXhtFKhtb7K
    • Karouzakis E, Gay RE, Michel BA, Gay S, Neidhart M (2009) DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 60:3613–3622
    • (2009) Arthritis Rheum , vol.60 , pp. 3613-3622
    • Karouzakis, E.1    Gay, R.E.2    Michel, B.A.3    Gay, S.4    Neidhart, M.5
  • 37
    • 49449106856 scopus 로고    scopus 로고
    • Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    • PID: 18759290
    • Nile CJ, Read RC, Akil M, Duff GW, Wilson AG (2008) Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis Rheum 58:2686–2693
    • (2008) Arthritis Rheum , vol.58 , pp. 2686-2693
    • Nile, C.J.1    Read, R.C.2    Akil, M.3    Duff, G.W.4    Wilson, A.G.5
  • 38
    • 33744936286 scopus 로고    scopus 로고
    • The epigenetic face of systemic lupus erythematosus
    • PID: 16751355, COI: 1:CAS:528:DC%2BD28Xlt1CltLs%3D
    • Ballestar E, Esteller M, Richardson BC (2006) The epigenetic face of systemic lupus erythematosus. J Immunol 176:7143–7147
    • (2006) J Immunol , vol.176 , pp. 7143-7147
    • Ballestar, E.1    Esteller, M.2    Richardson, B.C.3
  • 39
    • 0035096761 scopus 로고    scopus 로고
    • Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients
    • PID: 11229472, COI: 1:CAS:528:DC%2BD3MXitlCgurw%3D
    • Deng C, Kaplan MJ, Yang J et al (2001) Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 44:397–407
    • (2001) Arthritis Rheum , vol.44 , pp. 397-407
    • Deng, C.1    Kaplan, M.J.2    Yang, J.3
  • 40
    • 70350049103 scopus 로고    scopus 로고
    • Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis
    • PID: 19444718, COI: 1:CAS:528:DC%2BD1MXht1CrsbnM
    • Lei W, Luo Y, Lei W et al (2009) Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheum 38:369–374
    • (2009) Scand J Rheum , vol.38 , pp. 369-374
    • Lei, W.1    Luo, Y.2    Lei, W.3
  • 41
    • 0026741293 scopus 로고
    • Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus
    • PID: 1376122, COI: 1:CAS:528:DyaK38Xlt12ksbg%3D
    • Richardson BC, Strahler JR, Pivirotto TS et al (1992) Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus. Arthritis Rheum 35:647–662
    • (1992) Arthritis Rheum , vol.35 , pp. 647-662
    • Richardson, B.C.1    Strahler, J.R.2    Pivirotto, T.S.3
  • 42
    • 75649151209 scopus 로고    scopus 로고
    • Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    • PID: 20028698, COI: 1:CAS:528:DC%2BC3cXhs1GhtLg%3D
    • Javierre BM, Fernandez AF, Richter J et al (2010) Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 20:170–179
    • (2010) Genome Res , vol.20 , pp. 170-179
    • Javierre, B.M.1    Fernandez, A.F.2    Richter, J.3
  • 43
    • 1542724431 scopus 로고    scopus 로고
    • Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells
    • PID: 15004168, COI: 1:CAS:528:DC%2BD2cXhvVKisrw%3D
    • Kaplan MJ, Lu Q, Wu A, Attwood J, Richardson B (2004) Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. J Immunol 172:3652–3661
    • (2004) J Immunol , vol.172 , pp. 3652-3661
    • Kaplan, M.J.1    Lu, Q.2    Wu, A.3    Attwood, J.4    Richardson, B.5
  • 44
    • 0036095885 scopus 로고    scopus 로고
    • Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus
    • PID: 12115234, COI: 1:CAS:528:DC%2BD38XksVynsrs%3D
    • Lu Q, Kaplan M, Ray D et al (2002) Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 46:1282–1291
    • (2002) Arthritis Rheum , vol.46 , pp. 1282-1291
    • Lu, Q.1    Kaplan, M.2    Ray, D.3
  • 45
    • 38449116161 scopus 로고    scopus 로고
    • Demethylation of CD40LG on the inactive X in T cells from women with lupus
    • PID: 17947713, COI: 1:CAS:528:DC%2BD2sXhtFyksr3E
    • Lu Q, Wu A, Tesmer L, Ray D, Yousif N, Richardson B (2007) Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol 179:6352–6358
    • (2007) J Immunol , vol.179 , pp. 6352-6358
    • Lu, Q.1    Wu, A.2    Tesmer, L.3    Ray, D.4    Yousif, N.5    Richardson, B.6
  • 46
    • 2642556447 scopus 로고    scopus 로고
    • Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
    • PID: 15188362, COI: 1:CAS:528:DC%2BD2cXlsFaqtLc%3D
    • Oelke K, Lu Q, Richardson D et al (2004) Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum 50:1850–1860
    • (2004) Arthritis Rheum , vol.50 , pp. 1850-1860
    • Oelke, K.1    Lu, Q.2    Richardson, D.3
  • 47
    • 66949176660 scopus 로고    scopus 로고
    • IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation
    • PID: 19380809, COI: 1:CAS:528:DC%2BD1MXkslKhsr4%3D
    • Garaud S, Le Dantec C, Jousse-Joulin S et al (2009) IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol 182:5623–5632
    • (2009) J Immunol , vol.182 , pp. 5623-5632
    • Garaud, S.1    Le Dantec, C.2    Jousse-Joulin, S.3
  • 48
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • PID: 20098459
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D (2010) Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10:111–122
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 49
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • PID: 20483747, COI: 1:CAS:528:DC%2BC3cXmvFejsrw%3D
    • Pan W, Zhu S, Yuan M et al (2010) MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184:6773–6781
    • (2010) J Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3
  • 50
    • 79955569628 scopus 로고    scopus 로고
    • MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1
    • PID: 21538319, COI: 1:CAS:528:DC%2BC3MXltlGht70%3D
    • Zhao S, Wang Y, Liang Y et al (2011) MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum 63:1376–1386
    • (2011) Arthritis Rheum , vol.63 , pp. 1376-1386
    • Zhao, S.1    Wang, Y.2    Liang, Y.3
  • 51
    • 37849031502 scopus 로고    scopus 로고
    • Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients
    • PID: 18042587, COI: 1:CAS:528:DC%2BD1cXhtlOqs7w%3D
    • Dai Y, Huang YS, Tang M et al (2007) Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 16:939–946
    • (2007) Lupus , vol.16 , pp. 939-946
    • Dai, Y.1    Huang, Y.S.2    Tang, M.3
  • 52
    • 65249138193 scopus 로고    scopus 로고
    • MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    • PID: 19333922, COI: 1:CAS:528:DC%2BD1MXltFemsr8%3D
    • Tang Y, Luo X, Cui H et al (2009) MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum 60:1065–1075
    • (2009) Arthritis Rheum , vol.60 , pp. 1065-1075
    • Tang, Y.1    Luo, X.2    Cui, H.3
  • 53
    • 84857887315 scopus 로고    scopus 로고
    • Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance
    • PID: 22161761, COI: 1:CAS:528:DC%2BC38XnsFOltb4%3D
    • Niederer F, Trenkmann M, Ospelt C et al (2012) Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum 64:1771–1779
    • (2012) Arthritis Rheum , vol.64 , pp. 1771-1779
    • Niederer, F.1    Trenkmann, M.2    Ospelt, C.3
  • 54
    • 42449156220 scopus 로고    scopus 로고
    • Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    • PID: 18383392
    • Stanczyk J, Pedrioli DM, Brentano F et al (2008) Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 58:1001–1009
    • (2008) Arthritis Rheum , vol.58 , pp. 1001-1009
    • Stanczyk, J.1    Pedrioli, D.M.2    Brentano, F.3
  • 55
    • 79551655444 scopus 로고    scopus 로고
    • Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
    • PID: 21279994
    • Stanczyk J, Ospelt C, Karouzakis E et al (2011) Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum 63:373–381
    • (2011) Arthritis Rheum , vol.63 , pp. 373-381
    • Stanczyk, J.1    Ospelt, C.2    Karouzakis, E.3
  • 56
    • 43949136123 scopus 로고    scopus 로고
    • Expression of microRNA-146 in rheumatoid arthritis synovial tissue
    • PID: 18438844, COI: 1:CAS:528:DC%2BD1cXms1ehu7w%3D
    • Nakasa T, Miyaki S, Okubo A et al (2008) Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum 58:1284–1292
    • (2008) Arthritis Rheum , vol.58 , pp. 1284-1292
    • Nakasa, T.1    Miyaki, S.2    Okubo, A.3
  • 57
    • 52249094653 scopus 로고    scopus 로고
    • Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    • Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK (2008) Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 10(4):R101
    • (2008) Arthritis Res Ther , vol.10 , Issue.4 , pp. R101
    • Pauley, K.M.1    Satoh, M.2    Chan, A.L.3    Bubb, M.R.4    Reeves, W.H.5    Chan, E.K.6
  • 58
    • 67651113615 scopus 로고    scopus 로고
    • Differential micro RNA expression in PBMC from multiple sclerosis patients
    • PID: 19617918
    • Otaegui D, Baranzini SE, Armananzas R et al (2009) Differential micro RNA expression in PBMC from multiple sclerosis patients. PloS One 4:e6309
    • (2009) PloS One , vol.4 , pp. e6309
    • Otaegui, D.1    Baranzini, S.E.2    Armananzas, R.3
  • 59
    • 70449716915 scopus 로고    scopus 로고
    • MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
    • PID: 19838199, COI: 1:CAS:528:DC%2BD1MXht1Ogsr3F
    • Du C, Liu C, Kang J et al (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol 10:1252–1259
    • (2009) Nat Immunol , vol.10 , pp. 1252-1259
    • Du, C.1    Liu, C.2    Kang, J.3
  • 60
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • PID: 17320506, COI: 1:CAS:528:DC%2BD2sXis12ju7k%3D
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128:683–692
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 61
    • 55749110754 scopus 로고    scopus 로고
    • Demethylating agents in myeloid malignancies
    • PID: 18841054, COI: 1:CAS:528:DC%2BD1cXht1SntLfL
    • Garcia-Manero G (2008) Demethylating agents in myeloid malignancies. Curr Opin Oncol 20:705–710
    • (2008) Curr Opin Oncol , vol.20 , pp. 705-710
    • Garcia-Manero, G.1
  • 62
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • COI: 1:CAS:528:DC%2BD1MXhsFKkt7vE
    • Lane AA, Chabner BA (2009) Histone deacetylase inhibitors in cancer therapy. J Clin Oncol: Off J Am Soc Clin Oncol 27:5459–5468
    • (2009) J Clin Oncol: Off J Am Soc Clin Oncol , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 63
    • 79955552937 scopus 로고    scopus 로고
    • Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis
    • PID: 21538322, COI: 1:CAS:528:DC%2BC3MXltlGhtrw%3D
    • Vojinovic J, Damjanov N, D'Urzo C et al (2011) Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 63:1452–1458
    • (2011) Arthritis Rheum , vol.63 , pp. 1452-1458
    • Vojinovic, J.1    Damjanov, N.2    D'Urzo, C.3
  • 64
    • 84884908851 scopus 로고    scopus 로고
    • MiR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer
    • Su SF, Chang YW, Andreu-Vieyra C, et al. (2012) 32(39):4694–701
    • Su SF, Chang YW, Andreu-Vieyra C, et al. (2012) miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene 32(39):4694–701
    • Oncogene
  • 65
    • 79960839564 scopus 로고    scopus 로고
    • Creating a flexible multiple microRNA expression vector by linking precursor microRNAs
    • PID: 21726537, COI: 1:CAS:528:DC%2BC3MXps1aku7c%3D
    • Qiu X, Friedman JM, Liang G (2011) Creating a flexible multiple microRNA expression vector by linking precursor microRNAs. Biochem Biophys Res Commun 411:276–280
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 276-280
    • Qiu, X.1    Friedman, J.M.2    Liang, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.